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化学疗法所致卵巢损伤的防治研究进展

浙江大学学报（医学版） 2024年第3期53卷 288-296页

作者：查雨欣李阳吕卫国浙江大学医学院附属妇产科医院肿瘤科浙江杭州310006 浙江省妇产疾病临床医学研究中心浙江杭州310006 浙江省女性生殖健康研究重点实验室浙江杭州310006

化学疗法(简称化疗)是治疗恶性肿瘤的重要方法,但其在发挥疗效的同时,也导致许多副作用,包括对女性内分泌和生育能力的影响。除了现存的卵巢保存措施,防治卵巢功能损伤更为关键。化疗致卵巢功能损伤的机制包括卵泡及支持细胞的直接凋亡... 详细信息

化学疗法(简称化疗)是治疗恶性肿瘤的重要方法,但其在发挥疗效的同时,也导致许多副作用,包括对女性内分泌和生育能力的影响。除了现存的卵巢保存措施,防治卵巢功能损伤更为关键。化疗致卵巢功能损伤的机制包括卵泡及支持细胞的直接凋亡、卵泡“耗竭效应”、卵巢基质和微血管损伤,并与患者初诊年龄、初始低水平抗米勒管激素、化疗药物毒性和剂量、化疗方案等因素有关。防治卵巢功能损伤的措施包括应用促性腺激素释放激素激动剂或拮抗剂、酪氨酸激酶抑制剂、抗氧化剂、鞘氨醇-1-磷酸、神经酰胺-1-磷酸、哺乳动物雷帕霉素靶蛋白抑制剂、粒细胞集落刺激因子、干细胞疗法和人工卵巢等。本文通过文献综述以期为化疗所致卵巢损伤的防治提供思路和参考。

关键词：化学疗法卵巢损伤卵巢保护机制综述

Robust and Tunable Ferroelectricity in Ba/Co Codoped (K_(0.5)Na_(0.5))NbO_(3) Ceramics

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Chinese Physics Letters 2024年第7期41卷 152-160页

作者：刘佳讯查节林杨玉龙吕笑梅胡雪莉阎朔吴子敬黄凤珍 National Laboratory of Solid State Microstructures and School of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

The 0.98(K_(0.5)Na_(0.5))NbO_(3)-0.02Ba(Nb_(0.5)Co_(0.5))O_(3-δ) ceramics with doped Ba^(2+) and Co^(2+) ions are fabricated,and the impacts of the thermal process are *** with the rapidly cooled (RC) sample,the slowly cooled (SC) sample possesses superior dielectric and ferroelectric properties,and an 11 K higher ferroelectricparaelectric phase transition temperature,which can be attributed to the structural characteristics such as the grain size and the degree of *** treatment can reversibly modulate the content of the oxygen vacancies,and in turn the ferroelectric hysteresis loops of the ***,robust and tunable ferroelectric property is achieved in SC samples with good structural integrity.

关键词： ceramics ferroelectric treatment

复方蜘蛛香凝胶贴膏质量控制方法研究及多元成分含量测定

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中国医院药学杂志 2024年

作者： MEI Jiahua zhaO Ji XUE Rui ZHOU Yi yang Lijuan LUO Liqing zha Xuezhi MA Yunshu Yunnan University of Chinese Medicine，Yunnan Key Laboratory of Southern Medicinal Utilization The Key Laboratory of External Drug Delivery System and Preparation Technology in University of Yunnan Province， Yunnan Key Laboratory of Dai and Yi medicines，Engineering Research Center for Medicine and Food Homologous Beverage of Yunnan Province

目的：建立复方蜘蛛香凝胶贴膏（Compound Zhizhuxiang gel Plaster，CZgP）的质量控制及多元成分含量测定方法。方法：采用薄层色谱法对凝胶贴膏中橙皮苷（hesperidin，HSP）、木香烃内酯（costunolide，CL）及去氢木香内酯（dehydroco... 详细信息

目的：建立复方蜘蛛香凝胶贴膏（Compound Zhizhuxiang gel Plaster，CZgP）的质量控制及多元成分含量测定方法。方法：采用薄层色谱法对凝胶贴膏中橙皮苷（hesperidin，HSP）、木香烃内酯（costunolide，CL）及去氢木香内酯（dehydrocostus lactone，DCL）进行定性鉴别；以HSP为内标，采用一测多评法，利用HPLC法测定HSP、CL及DCL的含量，并对CZgP进行含膏量、耐热性、含量均匀度及黏附力检查。结果：薄层色谱中，各成分与对照品在相同位置显示相同颜色的斑点，清晰可见，分离效果良好；HSP、CL和DCL分别在13.20～1689.00 μg·mL-1（r =0.999 6）、2.85～365.40 μg·mL-1（r =0.999 8）、4.14～530.40 μg·mL-1（r =0.999 9）范围内线性关系良好，平均加样回收率分别为97.820%、101.38%、102.19%，RSD分别为1.62%、1.36%、1.42%，测得3个成分的含量分别为11.183、1.707 0、1.921 0 mg·g-1，且一测多评法和外标法结果接近，可见一测多评法可用于制剂的含量测定；每贴CZgP平均含膏量为24.300 g，黏附力、耐热性及含量均匀度检查均符合《中国药典》（2020年版）要求。结论：所建立的质量控制方法稳定可靠，能有效控制CZgP的质量。

关键词：复方蜘蛛香凝胶贴膏质量控制一测多评法橙皮苷木香烃内酯去氢木香内酯

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结合色彩补偿与双背景光融合的水下图像复原

光学精密工程 2024年第7期32卷 1059-1074页

作者：林森查子月沈阳理工大学自动化与电气工程学院辽宁沈阳110159

针对复杂成像环境下,水下图像存在颜色失真、细节模糊以及对比度低的问题,提出结合色彩补偿与双背景光融合的水下图像复原方法。通过分析光在水中的吸收衰减特性,提出改进的水下成像模型,基于Retinex理论与白平衡算法引入色彩补偿分量,... 详细信息

针对复杂成像环境下,水下图像存在颜色失真、细节模糊以及对比度低的问题,提出结合色彩补偿与双背景光融合的水下图像复原方法。通过分析光在水中的吸收衰减特性,提出改进的水下成像模型,基于Retinex理论与白平衡算法引入色彩补偿分量,降低水体背景颜色影响;根据背景光强度和颜色分布特性,提出双候选背景光融合方法,准确估计全局背景光;不依赖任何水体环境参数,根据背景颜色与散射系数的内在关系,采用引导-高通滤波,优化并增强各通道透射率;最后,逆求解成像模型复原水下图像。实验结果表明,在4个不同的水下数据集上与经典及新颖方法对比,所提方法恢复的图像颜色更自然,纹理细节更丰富清晰;色差值改善幅度达5.4%,UCIQE及FDUM指标提升幅度分别达8.3%和4.5%。所提方法在定性和定量实验中更具优势,能够显著提高水下图像质量。

关键词：水下图像复原色彩补偿背景光融合透射率估计

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无菌性骨折不愈合的治疗

中华骨科杂志 2024年第9期44卷 644-650页

作者：查晔军蒋协远首都医科大学附属北京积水潭医院创伤骨科、骨科冲击波诊疗中心北京100035

骨折不愈合指骨折在预期时间内未能愈合,且无新的干预下不可能愈合的情况。骨折不愈合可根据有无感染和骨折部位的生物活性进行分类。无菌性骨折不愈合主要分为萎缩性、营养不良性、肥大性骨折不愈合以及假性关节和骨缺损,不同类型的骨... 详细信息

骨折不愈合指骨折在预期时间内未能愈合,且无新的干预下不可能愈合的情况。骨折不愈合可根据有无感染和骨折部位的生物活性进行分类。无菌性骨折不愈合主要分为萎缩性、营养不良性、肥大性骨折不愈合以及假性关节和骨缺损,不同类型的骨折不愈合采用不同的治疗策略。治疗骨折不愈合的关键在于准确诊断、控制感染、矫正畸形,并根据患者的具体情况选择合适的治疗方法。软组织管理在骨折不愈合的治疗中也起着重要作用,有时需要进行软组织修复以提供良好的愈合环境。骨折不愈合的治疗方法分为非手术和手术治疗。非手术治疗的优势在于避免可能的手术并发症,可分为直接干预和间接干预。间接干预方式包括:戒烟、优化营养、纠正内分泌和代谢紊乱、消除或减少某些药物;直接干预措施包括:负重、外固定、电磁刺激、超声波刺激、冲击波治疗、甲状旁腺激素。在手术干预之前应先尝试保守治疗,保守治疗无效或需行积极干预时再考虑行手术治疗。手术治疗方案包括更换髓内钉、髓内钉动力化、钢板固定、环形外固定架、关节置换等,需根据软组织的完整性、骨质缺损程度和合并疾病进行选择。自体骨移植是治疗骨折不愈合的金标准,另外同种异体骨移植和其他骨移植替代品也是治疗不愈合的选择。最理想的治疗方法需同时考虑外科医生的经验和技能、治疗方法的相对风险和益处以及患者的耐受性。

关键词：骨折,不愈合体外冲击波疗法骨折固定术骨移植

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo Xueying Zheng Wei Bao Sheng Nie Yu Ding Tong Yue Yilun Zhou Ying Hu Hua Li Qiongqiong yang Qijun Wan Bicheng Liu Hong Xu guisen Li gang Xu Chunbo Chen Huafeng Liu Yongjun Shi Yan zha Yaozhong Kong guobin Su Ying Tang Mengchun gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

长株潭城市群人居环境质量评价及空间分异研究

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水土保持研究 2024年第5期31卷 365-375页

作者：钟洋查海焱吴智朋湖南师范大学地理科学学院长沙410081 湖南师范大学城乡转型过程与效应校级重点实验室长沙410081

[目的]分析长株潭城市群内各市县之间人居环境质量的时空演变差异,探究其空间分异格局的成因,为未来长株潭城市群缩小人居环境差距,构建良好人居环境提供科学支撑。[方法]选取长株潭城市群2013年、2015年、2017年、2019年、2021年相关... 详细信息

[目的]分析长株潭城市群内各市县之间人居环境质量的时空演变差异,探究其空间分异格局的成因,为未来长株潭城市群缩小人居环境差距,构建良好人居环境提供科学支撑。[方法]选取长株潭城市群2013年、2015年、2017年、2019年、2021年相关人居环境指标,运用熵值法、耦合协调度和地理探测器模型等研究方法,对长株潭城市群包括23个区市县人居环境质量及其分异机理展开探究。[结果](1)总体上研究区内人居环境质量都得到不同程度的改善,但有差距扩大的趋势;(2)空间分布呈“中心高、周边低”向“均衡”的格局发展;(3)城市群各市县人居环境耦合度高但协调度较低;(4)从自然生态环境、经济发展环境、社会保障环境和个人居住环境等方面进行影响因素分析发现:自然生态环境对人居环境的改善起着底托作用;经济发展环境是人居环境改善的关键;社会保障环境是人居环境的后盾;个人居住环境是人居环境质量高低的直接体现。[结论]长株潭城市群内各市县间的人居环境在时空发展过程中没有达到一个较好的协调发展阶段,人居环境的质量是一个多因素综合作用的结果,长株潭城市群各地区要自觉承担“三高四新”和强省会战略的历史使命,依托各自的优势实现经济错位发展和高质量发展;进一步完善各地区的基础设施和城市更新行动,加强生态环境建设,实现资源的均等性;党和政府工作重心下沉,关注基层群众的基本民生问题,从而建成高质量的人居环境。

关键词：人居环境耦合协调度空间分异地理探测器模型长株潭城市群

Ternary NiCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic/chemodynamic synergistic therapy

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Fundamental Research 2024年第4期4卷 926-933页

作者： Tingting Hu zhan Zhou Jiajia zha.gareth RWilliams Zhikang Wu Wei zhao Weicheng Shen Hai Li Xisheng Weng Ruizheng Liang Chaoliang Tan State Key Laboratory of Chemical Resource Engineering Bejing Advanced Innovation Center for Soft Matter Science and EngineeringBejing University of Chemical TechnologyBeijing100029China College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China Department of Electrical Engineering City University of Hong KongHong Kong SAR 999077China UCL School of Pharmacy University College LondonLondon WCIN 1AXUnited Kingdom Institute of Advanced Materials(IAM)and Key Laboratory of Flexible Electronics(KLoFE) Nanjing Tech University(NanjingTech)Nanjing 211816China Department of Orthopedic Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong SAR 999077China Shenzhen Research Institute City University of Hong KongShenzhen 518057China

Combining photodynamic therapy(PDT)with chemodynamic therapy(CDT)has been proven to be a promising strategy to improve the treatment efficiency of cancer,because of the synergistic therapeutic effect arising between the two ***,we report an inorganic nanoagent based on ternary NiCoTi-layered double hydroxide(NiCoTi-LDH)nanosheets to realize highly efficient photodynamic/chemodynamic synergistic *** NiCoTi-LDH nanosheets exhibit oxygen vacancy-promoted electron-hole separation and photogenerated holeinduced O_(2)-independent reactive oxygen species(ROS)generation under acidic circumstances,realizing in situ pH-responsive ***,due to the effective conversion between Co^(3+)and Co^(2+)caused by photogenerated electrons,the NiCoTi-LDH nanosheets catalyze the release of hydroxyl radicals(-OH)from H_(2)O_(2)through Fenton reactions,resulting in *** irradiation enhances the catalyzed ability of the NiCoTi-LDH nanosheets to promote the ROS generation,resulting in a better performance than TiO_(2)nanoparticles at pH *** vitro and in vivo experimental results show conclusively that NiCoTi-LDH nanosheets plus irradiation lead to efficient cell apoptosis and significant inhibition of tumor *** study reports a new pH-responsive inorganic nanoagent with oxygen vacancy-promoted photodynamic/chemodynamic synergistic performance,offering a potentially appealing clinical strategy for selective tumor elimination.

关键词： Layereddouble hydroxides Photodynamic therapy pH-responsive Chemodynamic therapy Oxygen vacancy

Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway

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World Journal of Diabetes 2024年第1期15卷 105-125页

作者： Wei-Long Xu Pei-Pei Zhou Xu Yu Ting Tian Jin-Jing Bao Chang-Rong Ni Min zha Xiao Wu Jiang-Yi Yu Department of Endocrinology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pharmacy Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pneumology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKgROUND Development of end-stage renal disease is predominantly attributed to diabetic nephropathy(DN).Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal ***-theless,the precise molecular mechanism through which myricetin influences the progression of DN remains *** To investigate the effects of myricetin on DN and explore its potential therapeutic *** Db/db mice were administered myricetin intragastrically on a daily basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 ***,blood and urine indexes were assessed,along with examination of renal tissue *** morphology and fibrosis were evaluated using various staining techniques including hematoxylin and eosin,periodic acid–Schiff,Masson’s trichrome,and ***,high-glucose culturing was conducted on the RAW 264.7 cell line,treated with 25 mM myricetin or co-administered with the PI3K/Akt inhibitor LY294002 for a period of 24 *** both in vivo and in vitro settings,quantification of inflammation factor levels was conducted using western blotting,real-time qPCR and *** In db/db mice,administration of myricetin led to a mitigating effect on DN-induced renal dysfunction and ***,we observed a significant reduction in expressions of the kidney injury markers kidney injury molecule-1 and neutrophil gelatinase associated lipocalin,along with a decrease in expressions of inflammatory cytokine-related ***,myricetin treatment effectively inhibited the up-regulation of tumor necrosis factor-alpha,interleukin-6,and interluekin-1βinduced by high glucose in RAW 264.7 ***,myricetin modulated the M1-type polarization of the RAW 264.7 *** docking and bioinformatic analyses revealed Akt as the target of *** protective effect of myricetin was nullified upon blocking the polarization of RAW 264.7 via inh

关键词： Myricetin Diabetic nephropathy PI3K/Akt pathway Renal tubulointerstitial fibrosis Macrophage Polarization