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HPS教育融入中专“药物化学”教学的应用研究——以阿司匹林的合成为例

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广东化工 2024年第6期51卷 168-170页

作者：杨元华新疆维吾尔自治区伊宁卫生学校新疆·伊宁835000

随着经济社会的持续发展提高,人类的教学理论与教学方法都出现了巨大的变革,传统的教学方法已经无法充分满足当前中职专业课程的教学。HPS教育作为一种与时俱进的教学理念,在教学中能够提高学生的人文素养,培养其正确的科学态度。在中... 详细信息

随着经济社会的持续发展提高,人类的教学理论与教学方法都出现了巨大的变革,传统的教学方法已经无法充分满足当前中职专业课程的教学。HPS教育作为一种与时俱进的教学理念,在教学中能够提高学生的人文素养,培养其正确的科学态度。在中职“药物化学”教学中应用HPS教学模式进行教学,在一定程度上能够有效地提升中职学生学习“药物化学”的积极性,提高“药物化学”的教学质量。

关键词： HPS教育药物化学应用研究

Observer-based robust predictive control of singular systems with time-delay and parameter uncertainties

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Journal of Systems Engineering and Electronics 2009年第3期20卷 590-597页

作者： Liu Xiaohua yang yuanhua School of Mathematics and Information Ludong Univ. Yantai 264025 P. R. China School of Control Science and Engineering Shandong Univ. Jinan 250061 P. R. China

The problem of observer-based robust predictive control is studied for the singular systems with norm-bounded uncertainties and time-delay, and the design method of robust predictive observer-based controller is proposed. By constructing the Lyapunov function with the error terms, the infinite time domain ＂min-max＂ optimization problems are converted into convex optimization problems solving by the linear matrix inequality （LMI）, and the sufficient conditions for the existence of this control are derived. It is proved that the robust stability of the closed-loop singular systems can be guaranteed by the initial feasible solutions of the optimization problems, and the regular and the impulse-free of the singular systems are also guaranteed. A simulation example illustrates the efficiency of this method.

关键词： predictive control singular systems linear matrix inequality state observer time-delay uncertainty

科技助力体育的时代背景、现实困境与路径优化

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天津体育学院学报 2024年第2期39卷 154-160页

作者：曾洪涛杨远华栾丽霞华中科技大学体育学院湖北武汉430074 光谷实验室运动与健康智能化技术创新中心湖北武汉430074

在科技赋能的时代背景下,科技已成为体育领域优化和升级的重要驱动力。理清科技助力体育领域的外在条件与内生需求,科技推动体育发展变化的动力逻辑、运动场景需要的应用逻辑及体育产业转型的变革逻辑;着重以透过客观事实探究问题本原,... 详细信息

在科技赋能的时代背景下,科技已成为体育领域优化和升级的重要驱动力。理清科技助力体育领域的外在条件与内生需求,科技推动体育发展变化的动力逻辑、运动场景需要的应用逻辑及体育产业转型的变革逻辑;着重以透过客观事实探究问题本原,剖析体育科技研究与应用困境的主要表现、重要问题和本质原因;在紧抓自身治理与侧重社会协同的内外路径下,结合政策手段提出综合思路对策,以此引导支持科技助力体育,持续推进体育发展。目前,体育科技战略体系在依托现有社会经济基础与分配关系上,无法支撑其克服研发应用的粗放局面,以实现长效稳态运行,这一问题解决对于体育领域各项工作能否有效实现社会化与市场化亦至关重要。在治本上,应加强民生建设,壮大实体经济,完善分配机制,合理制度安排,实现体育与民生联动发展;在治标上,集中体育科研力量于专门分工具体领域,再过渡覆盖到整个体育领域,研发体系重视基础科学研究、完善成果转化和人才绩效的评价机制。

关键词：体育科技科技政策科技赋能体育治理

退火工艺对电池壳用钢XDCK第二相粒子影响的研究

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热处理技术与装备 2024年第4期45卷 14-17,22页

作者：杨源华吴春红彭冲新余钢铁集团有限公司江西新余338001

为了研究退火工艺对电池壳用钢XDCK第二相粒子的影响,在连续退火条件下对XDCK进行模拟试验和工业试验。采用连续退火模拟试验机模拟连续退火生产工艺,对不同退火温度和退火保温时间试样中第二相粒子的尺寸、数量和分布情况进行研究。结... 详细信息

为了研究退火工艺对电池壳用钢XDCK第二相粒子的影响,在连续退火条件下对XDCK进行模拟试验和工业试验。采用连续退火模拟试验机模拟连续退火生产工艺,对不同退火温度和退火保温时间试样中第二相粒子的尺寸、数量和分布情况进行研究。结果表明电池壳用钢XDCK中第二相粒子为TiC,随着退火温度的升高和保温时间的延长,第二相粒子尺寸逐渐增大。

关键词：电池壳用钢XDCK 第二相粒子退火工艺

逐步肺动脉球囊扩张成形术治疗慢性血栓栓塞性肺动脉高压血流动力学变化的研究

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中华结核和呼吸杂志 2024年第2期47卷 120-125页

作者：汪薇龚娟妮王剑锋丁媛张一笑刘佳玉杨媛华首都医科大学附属北京朝阳医院呼吸与危重症医学科、北京呼吸疾病研究所北京100020 首都医科大学附属北京朝阳医院介入医学科北京100020

目的观察连续性球囊肺动脉扩张成形术(BPA)治疗慢性血栓栓塞性肺动脉高压(CTEPH)患者血流动力学变化。方法收集北京朝阳医院2017年10月至2022年1月确诊的CTEPH患者一般临床资料,纳入83例至少进行1次BPA治疗的患者,其中男27例,女56例,年... 详细信息

目的观察连续性球囊肺动脉扩张成形术(BPA)治疗慢性血栓栓塞性肺动脉高压(CTEPH)患者血流动力学变化。方法收集北京朝阳医院2017年10月至2022年1月确诊的CTEPH患者一般临床资料,纳入83例至少进行1次BPA治疗的患者,其中男27例,女56例,年龄53~68岁,中位年龄60岁。分析患者基线及每个疗程BPA前、最后1次BPA治疗后至少随访1个月时的6 min步行距离、WHO功能分级、N末端B型利钠肽前体(NT-proBNP)、肌钙蛋白I(cTnI)及血流动力学指标。收集手术次数、扩张血管根数,每次BPA围术期的并发症情况,记录并发症的处理措施。结果本研究83例患者共进行BPA治疗340例次,治疗中位次数为4.0次,扩张了2104根病变血管。BPA治疗前后,患者mPAP从50.0(42.0~55.3)mmHg(1 mmHg=0.133 kPa)降至32.0(27.0~42.0)mmHg,PVR从(806.6±323.2)dyn·s·cm^(-5)降至420.0(295.0~613.5)dyn·s·cm^(-5);WHO功能分级Ⅰ、Ⅱ、Ⅲ、Ⅳ级患者数量从0、35、34、14例改变为43、32、7、1例,6 min步行距离从364.5(300.0~429.5)m增加至461.0(409.0~501.0)m、NT-proBNP从1357.0(232.0~2715.0)ng/L降至141.0(57.0~627.8)ng/L(均P<0.001)。PVR和mPAP等血流动力学指标在前3疗程治疗后改善最显著,存在剂量-疗效关系:治疗血管支数越多,PVR和mPAP下降幅度越大。出现32例次与BPA治疗相关的并发症,发生率为9.4%(32/340),主要并发症为导管相关血管损伤引起肺出血。结论BPA可安全有效地治疗CTEPH患者,血流动力学改善具有累积效应,与总治疗的血管数相关。

关键词：高血压,肺性肺动脉球囊扩张成形术慢性血栓栓塞性肺动脉高压连续性血流动力学

Preparation and characterization of chitosan/nano-hydroxyapatite composite used as bone substitute materials

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High Technology Letters 2007年第1期13卷 31-35页

作者：张利 Li Yubao　 Zhou Gang　 Wu Lan　 Mu yuanhua　 yang Zheng Research Center for Nano-Biomaterials Analytical ＆ Testing Center Siehuan University Chengdu 610064 P.R. China

Chitosan/nano-hydroxyapatite composites with different weight ratios were prepared through a co-precipitation method using Ca（OH）2, H3PO4 and chitosan as starting materials. The properties of these composites were characterized by means of TEM, IR, XRD, TGA, burn-out tests and universal matertial testing machine. The results showed that the HA synthesized here was poorly crystalline carbonated nanometer crystals and dispersed uniformly in chitosan phase and there was no phase-separation between the two phases. The addition of n-HA resulted in a decrease of decomposing temperature of chitosan. Because of the interactions between chitosan and n-HA, the mechanical properties of these composites were improved, and the maximum value of the compressive strength was measured to be about 120MPa corresponding to the chitosan/n-HA composite with a weight ratio of 30/70.

关键词： chitosan nano-hydroxyapatite composite co-precipitation

PVP/PKP联合唑来膦酸对骨质疏松症压缩性骨折患者治疗效果分析

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宁夏医学杂志 2024年第4期46卷 326-329页

作者：杨元华田娟娟蒋天琪赵志明宁夏固原市人民医院骨科宁夏固原756000 宁夏固原市人民医院消化内科宁夏固原756000

目的评估经皮椎体成形术(PVP)/球囊扩张椎体后凸成形术(PKP)联合唑来膦酸治疗骨质疏松症压缩性骨折的疗效,并探讨其对术后再骨折发生率的影响。方法选取110例患骨质疏松症的压缩性骨折患者,分为观察组和对照组,每组各55例。对照组接受PV... 详细信息

目的评估经皮椎体成形术(PVP)/球囊扩张椎体后凸成形术(PKP)联合唑来膦酸治疗骨质疏松症压缩性骨折的疗效,并探讨其对术后再骨折发生率的影响。方法选取110例患骨质疏松症的压缩性骨折患者,分为观察组和对照组,每组各55例。对照组接受PVP/PKP治疗,观察组在此基础上术后给予唑来膦酸静脉滴注。比较2组患者术前、术后1周、术后3个月和术后6个月的Cobb角和椎体前缘高度,评估疼痛程度(VAS),功能障碍,以及血清骨碱性磷酸酶(BALP)、Ⅰ型胶原C端肽(CTX-1)水平和椎体骨密度(BMD),并记录再骨折发生情况。结果观察组患者术后Cobb角显著小于对照组,而椎体前缘高度则显著高于对照组(P<0.05)。观察组患者在术后的VAS评分和功能障碍评分均显著优于对照组(P<0.05)。此外,观察组患者术后3个月和6个月的BALP和CTX-1水平较对照组低,而BMD则较对照组高(P<0.05)。在6个月的随访中,观察组患者的再骨折发生率明显低于对照组。结论PVP/PKP联合唑来膦酸治疗骨质疏松症压缩性骨折能够有效缓解术后疼痛,改善椎体功能,并调节骨代谢,提高骨密度。此外,该联合治疗方案还能有效降低术后再骨折发生率。因此,PVP/PKP联合唑来膦酸可能是一种可行的治疗选择,有助于改善骨质疏松症压缩性骨折的预后。

关键词：经皮椎体成形术球囊扩张椎体后凸成形术唑来膦酸骨质疏松症压缩性骨折

Generative adversarial networks based motion learning towards robotic calligraphy synthesis

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 452-466页

作者： Xiaoming Wang Yilong yang Weiru Wang yuanhua Zhou Yongfeng Yin Zhiguo Gong Department of Computer and Information Science University of MacaoMacaoChina School of Software Beihang UniversityBeijingChina Department of Computer Science and Technology Faculty of Information TechnologyBeijing University of TechnologyBeijingChina School of Foreign Languages Guangzhou Huashang CollegeGuangzhouChina

Robot calligraphy visually reflects the motion capability of robotic *** traditional researches mainly focus on image generation and the writing of simple calligraphic strokes or characters,this article presents a generative adversarial network(GAN)-based motion learning method for robotic calligraphy synthesis(Gan2CS)that can enhance the efficiency in writing complex calligraphy words and reproducing classic calligraphy *** key technologies in the proposed approach include:(1)adopting the GAN to learn the motion parameters from the robot writing operation;(2)converting the learnt motion data into the style font and realising the transition from static calligraphy images to dynamic writing demonstration;(3)reproducing high-precision calligraphy works by synthesising the writing motion data *** this study,the motion trajectories of sample calligraphy images are firstly extracted and converted into the robot *** robot performs the writing with motion planning,and the writing motion parameters of calligraphy strokes are learnt with *** the motion data of basic strokes is synthesised based on the hierarchical process of‘stroke-radicalpart-character’.And the robot re-writes the synthesised characters whose similarity with the original calligraphy characters is *** calligraphy characters have been tested in the experiments for method validation and the results validated that the robot can actualise the robotic calligraphy synthesis of writing motion data with GAN.

关键词： calligraphy synthesis generative adversarial networks Motion learning robot writing

Rhizosphere microbes influence wogonoside accumulation in perennial Scutellaria baicalensis

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Pedosphere 2024年第3期34卷 553-566页

作者： yang SUN Hong LIU Junwei PENG Minchong SHEN yang HU Dongsheng YU Jiangang LI yuanhua DONG CAS Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) University of Chinese Academy of Sciences Beijing 100049(China) Tobacco Research Institute of Chinese Academy of Agricultural Sciences Qingdao 266101(China)

Dried roots of Scutellaria baicalensis Georgi are an acclaimed traditional Chinese medicine,and wogonoside content is a key indicator used to evaluate *** *** than rising linearly with cultivation years,*** quality initially increases and then ***,little is known regarding the dynamic variations in *** rhizosphere microorganisms under long-term cultivation and underlying mechanisms of their effects on wogonoside formation and *** aim of this study was to investigate the roles of soil nutrients and rhizosphere microbes on *** quality across different cultivation years(1-4 years).The wogonoside content(25.14 mg g^(-1))was highest in the biennial *** and then decreased following long-term *** soil nutrients(available nitrogen,available phosphorus,available iron,available manganese,and available zinc)were reduced significantly as cultivation years *** also affected rhizosphere bacterial community structure significantly,driving it toward deterministic process(i.e.,β-nearest taxon index<-2).Available manganese and exchangeable calcium indirectly affected wogonoside formation and *** inhibition was driven by the reduction in rhizosphere bacterial diversity,which significantly increased the relative abundance of beta-glucosidase and decreased the relative abundance of phenylalanine *** rhizosphere microenvironment was altered under long-term cultivation,thereby shaping rhizosphere bacterial community,reducing the community diversity,and ultimately inhibiting wogonoside formation and *** findings may aid in understanding of the mechanisms and reasons for the reduction in *** quality under long-term cultivation from the perspective of soil nutrients and microorganisms,which may theoretically support the future artificial cultivation and management of Chinese medicinal plants.

关键词： bacterial diversity medicinal plant rhizosphere bacterial community soil nutrient wogonoside content wogonoside formation