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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-xia yang Li-Ting Zhang xiao-Jun Liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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One-pot calcination synthesis of Cd_(0.5)Zn_(0.5)S/g-C_(3)N_(4) photocatalyst with a step-scheme heterojunction structure

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Journal of Materials Science & Technology 2020年第21期56卷 206-215页

作者： Dongran Qin yang xia Qin Li Chao yang Yanmin Qin Kangle Lv Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education&Hubei Key Laboratory of Catalysis and Materials Science South-Central University for NationalitiesWuhan 430074China

Cd_(0.5)Zn_(0.5)S/g-C_(3)N_(4)(CZS/CN)step-like heterojunction composites were facilely synthesized by annealing a sandwich of cadmium-zinc-thiourea precursors in one *** types of the used raw materials and the preparation procedure were simplified as much as possible in this *** obtained hybrid exhibited enlarged specific surface area and higher separation/transfer efficiency of charge carriers compared to pure Cd_(0.5)Zn_(0.5)S and g–C_(3)N_(4),thus exhibited much enhanced photocatalytic efficiency for dye degradation under visible-light *** interfacial charge-transfer mechanism of the formed step-scheme(Sscheme)heterojunction between Cd_(0.5)Zn_(0.5)S and g–C_(3)N_(4) were carefully investigated and *** work could widen the application prospect of the Cd_(x)Zn_(1-x)S/g-C_(3)N_(4) composite and provide new ideas to the design and fabrication of novel heterojunctions with robust photocatalytic performance.

关键词： Cd_(0.5)Zn_(0.5)S g-C_(3)N_(4) S-scheme heterojunction Photocatalysis Visible light

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Fe-Mo-B Enhanced Sintering of P/M 316L Stainless Steel

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Journal of Iron and Steel Research International 2008年第1期15卷 10-14页

作者： yang xia GUO Shi-ju Institute of Powder Metallurgy University of Science and Technology Beijing Beijing 100083 China

Liquid-phase enhanced sintering of powder metallurgy（P/M）316L stainless steel by addition of sintering aids was studied.2%-8% of pre-alloyed Fe-Mo-B powder with two different particle sizes was added as sintering aids,and the specimens were sintered in vacuum at 1 200-1 350 ℃.The results show that the fine Fe-Mo-B powder（5-10 μm）has stronger activated *** sintered density increases with the increase in sintering aid content or sintering *** compaction has a better effect on the control of dimensional precision of *** prealloyed Fe-Mo-B powder deviated from Mo2FeB2 component can also be sintering aid of P/M 316L stainless steel.

关键词： P/M 316L stainless steel liquid-phase sintering activated sintering Fe-Mo-B sintering aid

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Some Ergodic Theorems for a Parabolic Anderson Model

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Acta Mathematica Sinica,English Series 2012年第12期28卷 2443-2462页

作者： Yong LIU LMAM Feng xia yang School of Mathematical Sciences and Institute of Mathematicsand Center for Statistical SciencePeking University LMAM School of Mathematical SciencesPeking University

In this paper, we study some ergodic theorems of a class of linear systems of interacting diffusions, which is a parabolic Anderson model. First, under the assumption that the transition kernel a = （a（i,j））i,j∈s is doubly stochastic, we obtain the long-time convergence to an invariant probability measure Vh starting from a bounded a-harmonic function h based on self-duality property, and then we show the convergence to the invariant probability measure Uh holds for a broad class of initial distributions. Second, if （a（i, j））i,j∈s is transient and symmetric, and the diffusion parameter c remains below a threshold, we are able to determine the set of extremal invariant probability measures with finite second moment. Finally, in the case that the transition kernel （a（i,j））i,j∈s is doubly stochastic and satisfies Case I （see Case I in [Shiga, T.： An interacting system in population genetics. J. Math. Kyoto Univ., 20, 213-242 （1980）]）, we show that this parabolic Anderson model locally dies out independent of the diffusion parameter c.

关键词： Linear system of interacting diffusion parabolic Anderson model ergodic invariant measures clustering phenomena

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A modified logarithmic spiral method for determining passive earth pressure

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1171-1182页

作者： Shiyi Liu yang xia Li Liang School of Resources and Civil Engineering Northeastern University State Key Laboratory of Structural Analysis for Industrial Equipment School of Automotive Engineering Dalian University of Technology

In this study, a modified logarithmic spiral method is proposed to determine the passive earth pressure and failure surface of cohesionless sloping backfill, with presence of wallesoil interface friction. The proposed method is based on a limit equilibrium analysis wherein the assumed profile of the backfill failure surface is a composite of logarithmic spiral and its tangent. If the wallesoil interface is smooth, a straight line does not need to be assumed for the failure surface. The geometry of the failure surface is determined using the Mohr circle analysis of the soil. The resultant passive earth thrust is computed considering equilibrium of moments. The passive earth pressure coefficients are calculated with varied values of soil internal friction angle and cohesion, wall friction angle and inclination angle, and sloping backfill angle. This method is verified with the finite element method(FEM) by comparing the horizontal passive earth pressure and failure surface. The results agree well with other solutions, particularly with those obtained by the FEM. The implementation of the present method is efficient. The logarithmic spiral theory is rigorous and self-explanatory for the geotechnical engineer.

关键词： Passive earth pressure Logarithmic spiral method Finite element method(FEM) Sloping backfill Retaining wall

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Development characteristics of interlayer oxidation zone type of sandstone uranium deposits in the southwestern Turfan-Hami basin

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Science China Earth Sciences 2004年第5期47卷 419-426页

作者： yang Dianzhong xia Bin WU Guogan Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

The Turfan-Hami basin is the key area for the exploration of sandstone uranium deposits of the leachable interlayered oxidation zone type. The aim of this study is to shed light on the development characteristics of this type of uranium deposits and provide new clues to further exploration. Detailed study led to the following conclusions: (1) uranium orebodies are hosted mainly in the lower Middle Jurassic Xishanyao Formation and the lower Lower Jurassic Badaowan Formation; (2) the formation of uranium orebodies is closely related to organic matter; (3) the front of the interlayered oxidation zone is snake-shaped in plane and imbricated in the section; the more the interlayered oxidation zone and zonation are developed, the better the uranium mineralization will be; according to lithological and geochemical characteristics, the oxidation zone, the oxidation-reduction transitional zone and the reduction zone can be distin-guished; (4) the development of interlayered oxidation zone is controlled by geological structure, underground water, sandstone permeability and other factors; (5) sandstone uranium orebodies hosted in the interlayered oxidation zone are very complicated in spatial distribution, of which some are rolled and plated in shape and some are highly variable in shape.

关键词： Turfan-Hami basin, interlayered oxidation zone, sandstone uranium deposit, development characteristics.

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Analysis-Aware Modelling of Spacial Curve for Isogeometric Analysis of Timoshenko Beam

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Computer Modeling in Engineering & Sciences 2020年第8期124卷 605-626页

作者： yang xia Luting Deng Jian Zhao School of Automotive Engineering State Key Laboratory of Structural Analysis for Industrial EquipmentDalian University of TechnologyDalian116024China

Geometric fitting based on discrete points to establish curve structures is an important problem in numerical *** purpose of this paper is to investigate the geometric fitting method for curved beam structure from points,and to get high-quality parametric model for isogeometric *** beam element is established for an initially curved spacial beam with arbitrary *** approximation and interpolation methods to get parametric models of curves from given points are examined,and three strategies of parameterization,meaning the equally spaced method,the chord length method and the centripetal method are *** influences of the different geometric approximation algorithms on the precision of isogeometric analysis are *** static analysis and the modal analysis with the established parametric models are carried *** examples with different complexities,the quarter arc curved beam,the Tschirnhausen beam and the Archimedes spiral beam are *** results show that for the geometric approximation the interpolation method performs good and maintains high *** fitting algorithms are able to provide parametric models for isogeometric analysis of spacial beam with Timoshenko *** equally spaced method and centripetal method perform better than the chord length method for the algorithm to carry out the parameterization for the sampling points.

关键词： Analysis-aware modelling curve fitting Timoshenko beam spatial curve isogeometric analysis

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Genetic algorithms for determining the parameters of cellular automata in urban simulation

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Science China Earth Sciences 2007年第12期50卷 1857-1866页

作者： LI xia yang QingSheng LIU xiaoPing School of Geography and Planning Sun Yat-sen University Guangzhou 510275 China School of Geography and Planning Sun Yat-sen University Guangzhou 510275 China School of Geography and Planning Sun Yat-sen University Guangzhou 510275 China

This paper demonstrates that cellular automata(CA) can be a useful tool for analyzing the process of many geographical *** are many studies on using CA to simulate the evolution of *** dynamics is determined by many spatial *** contribution of each spatial variable to the simulation is quantified by its parameter or *** procedures are usually required for obtaining a suitable set of parameters so that the realistic urban forms can be *** pa-rameter has a unique role in controlling urban morphology in the *** this paper,these pa-rameters for urban simulation are determined by using empirical *** algorithms are used to search for the optimal combination of these *** are spatial variations for urban dynam-ics in a large *** sets of parameters can be used to represent the unique features of urban dynamics for various subregions.A further experiment is to evaluate each set of parameters based on the theories of compact *** is considered that the better set of parameters can be identified ac-cording to the utility function in terms of compact *** set of parameters can be cloned to other regions to improve overall urban *** original parameters can be also modified to produce more compact urban forms for planning *** approach can provide a useful ex-ploratory tool for testing various planning scenarios for urban development.

关键词： Cellular automata, genetic algorithms, planning scenarios, compact development

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COMP ARISON OF MACROMOLECULAR COMPONENT DISTRIBUTIONS IN OSTEOARTHRITIC AND HEALTHY CARTILAGES BY FOURIER TRANSFORM INFRARED IMAGING

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Journal of Innovative Optical Health Sciences 2013年第4期6卷 84-90页

作者： JIANHUA YIN yang xia ZHIYAN xiaO Department of Biomedical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 P.R.China Department of Physics and Center for Biomedical Research Oakland University RochesterMI 48309USA Department of Radiation Oncology Washington University School of Medicine St.Louis MO 63110USA

Fourier transform infrared imaging(FTIRI)was used to examine the depth-dependent content variations of macromolcular components,ollagen and protooglycan(PG),in osteoarthritic and healthy *** 6 pmm thick sections of canine knee cartilages were imaged at 6.25 pμrm pixel-size in *** analyzing the infrared(IR)images and spectra,the depth dependence of characteristic band(sugar)intensity of PG show obvious difference bet ween the cartilage sections of(OA)and *** result confimns that PG content decreases in the ostcoarthritic ***,no clear change occurs to collagen,suggesting that the OA influences little on the collagen content at early stage of *** observation will be helpful to further understand PG loss associated with pathological conditions in OA,and demonstrates that FIIRI has the po-tential to become an important analytical tool to identify early clinical signs of tissue degna-dation,such as PG loss even collagen disruption.

关键词： Macromolecular component osteoarthritis articular cartilage Fourier transform infrared imaging(FTIRI)

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Positive solutions of second-order differential systems with nonhomogeneous boundary conditions

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Applied Mathematics(A Journal of Chinese Universities) 2012年第3期27卷 253-267页

作者： SUN Jin-yi yang Bian-xia Department of Mathematics Northwest Normal UniversityLanzhou 730070China

This paper is to investigate the positive solutions of the systems of second-order ordinary differential equations with nonhomogeneous multi-point boundary conditions. By the lower and upper solutions method, Schauder fixed point theorem and fixed point index theory, under certain conditions, it is proved that there exist appropriate regions of parameters in which the problem has at least two, at least one or no positive solution.

关键词： nonhomogeneous boundary condition second-order differential system positive solution lowerand upper solutions Schauder fixed point theorem fixed point index

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