检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

递归神经网络下混合属性信息推荐仿真

计算机仿真 2024年第6期41卷 544-548页

作者：乔阳阳刘楷正董涛王丽娟郑州工商学院信息工程学院河南郑州451400 华北水利水电大学电力学院河南郑州450046

信息量的大幅增加,导致用户无法从推荐的海量数据中提取到所需的信息。为了解决上述问题,提出一种基于递归神经网络的混合属性信息推荐算法。通过数据预处理方法,删除没有任何信息评分的混合属性信息,并挖掘用户和混合属性信息之间的关... 详细信息

信息量的大幅增加,导致用户无法从推荐的海量数据中提取到所需的信息。为了解决上述问题,提出一种基于递归神经网络的混合属性信息推荐算法。通过数据预处理方法,删除没有任何信息评分的混合属性信息,并挖掘用户和混合属性信息之间的关系。采用已评分混合属性信息,融合极度梯度提升树(eXtreme Gradient Boosting, XGBoost)算法对混合属性信息分类。构建递归神经网络模型,采用梯度下降法对模型训练,获取用户对各个混合属性信息的概率值,并将其按照从大到小的顺序排列,形成推荐列表直接推送给用户完成推荐。实验结果表明,所提方法的HR值得到了提高,且NDCG取值的平均值为0.805,全面提升推荐结果的准确性。

关键词：递归神经网络混合属性信息推荐算法梯度下降

在线全文

学校读者我要写书评

暂无评论

基于改进YOLOv5车辆检测方法

计算机工程与设计 2024年第6期45卷 1705-1712页

作者：吕宏泽李继财杨乔楠陈学永李西兵福建农林大学机电工程学院福建福州350100 福建农林大学福建省农业信息感知技术重点实验室福建福州350100 山东劳动职业技术学院智能制造系山东济南250022

针对现有目标检测在智能交通系统和自动驾驶等领域存在车辆目标检测精度低、鲁棒性较差等问题,提出一种基于YOLOv5的车辆目标检测算法。在YOLOv5s网络模型框架中,添加注意力机制增强特征,提取重要特征;添加小目标检测层提升对遮挡重叠... 详细信息

针对现有目标检测在智能交通系统和自动驾驶等领域存在车辆目标检测精度低、鲁棒性较差等问题,提出一种基于YOLOv5的车辆目标检测算法。在YOLOv5s网络模型框架中,添加注意力机制增强特征,提取重要特征;添加小目标检测层提升对遮挡重叠弱小目标识别的准确率;引入金字塔池化(SPPFCSPC),提高网络空间特征提取能力;引入损失函数(SIoU_Loss)加快边界框回归速率,提高定位精度,消除重叠检测。基于自制车辆检测数据集进行实验,其结果表明,改进网络模型与原YOLOv5s网络模型相比,不同目标类的平均准确率均有明显提高,平均准确率均值提升3.25%,查准率提高4.14%,召回率提高3.05%,检测速度满足实时性要求。

关键词：车辆检测深度学习损失函数特征增强图像处理神经网络智能交通

A 10-Year Retrospective Cohort Study of Real-World Effectiveness of Sofosbuvir-Based Regimens for Hepatitis C in a Single Center in China

在线全文

学校读者我要写书评

暂无评论

Infectious Microbes & Diseases 2023年第4期5卷 180-185页

作者： qiao yang Fangping Xu Yi Shen Borui Pi Fangfang Lv Department of Infectious Diseases Sir Run Run Shaw Alar HospitalSchool of MedicineZhejiang UniversityAlarChina Department of Infectious Diseases Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina Biomedical Research Center Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina

This study aimed to review the trends of hepatitis C virus(HCV)treatment over the past decade and to analyze the effectiveness of sofosbuvir(SOF)–based direct-acting antiviral regimens in the heterogeneous population of patients with chronic hepatitis C(CHC)in clinical practice.This retrospective cohort study included CHC patients attending the Sir Run Run Shaw Hospital between January 1,2012,and December 31,2022.All of the 194 patients treatedwith SOF-based regimens completed 12weeks of treatment and were followed up for at least 12 weeks after completion of the therapy.Sustained virologic response(SVR)12 weeks after the end of treatment was the primary endpoint.A total of 194 patients treated with SOF-based regimens were included,among which 121,56,10 and 7 patients received SOF+velpatasvir±ribavirin,SOF+daclatasvir,SOF+ledipasvir or SOF+ribavirin,respectively.With 36.1%,HCV Genotype 1 predominated in CHC patients treated with SOF-based regimens,followed by Genotype 2a with 17.5%and Genotype 3 with 14.9%.Comorbidities among patients included hypertension(4.1%),diabetes(2.1%),depression(1.0%)and neoplastic disease(2.6%).All patients treated with SOF-based regimens achieved SVR.There was no association between SVR and factors such as HCV genotype,sex,age,presence of cirrhosis or previous treatment history.There were no reports of any serious adverse events in the study.This single-center retrospective study represented the latest 10-year treatment trends for HCV in real-world clinical practice and provided useful information on the excellent efficacy of SOF-based direct-acting antiviral regimens for treatment of CHC patients in Eastern China.

关键词： hepatitis C virus sofosbuvir direct-acting antiviral agent China

不同影像学方法在脊髓型颈椎病患者颈椎功能及临床疗效评估中的应用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川生理科学杂志 2024年第2期46卷 407-410页

作者：张辰尧余博臣鲁强杨巧上饶市人民医院影像科江西上饶334000 上饶市人民医院骨科江西上饶334000

目的:探讨不同影像学方法在脊髓型颈椎病患者颈椎功能及临床疗效评估中的应用。方法:选取2020年1月~2023年1月本院收治的120例脊髓型颈椎病患者作为研究对象的观察组,选取同期在本院体检的103例健康人群作为研究对象的对照组,两组人群... 详细信息

目的:探讨不同影像学方法在脊髓型颈椎病患者颈椎功能及临床疗效评估中的应用。方法:选取2020年1月~2023年1月本院收治的120例脊髓型颈椎病患者作为研究对象的观察组,选取同期在本院体检的103例健康人群作为研究对象的对照组,两组人群均进行电子计算机断层扫描(Computerized tomography,CT)、磁共振弥散张量成像(Diffusion tensor imaging,DTI)扫描检查以及颈椎日本骨协会(Japanese orthopedic association,JOA)评分。比较脊髓型颈椎病患者和健康人群的CT量化参数(骨性椎管容积、纤维性椎管容积以及椎管容积占有率)及DTI参数[表观弥散系数(Apparent dispersion coefficient,ADC值)、各向异性分数(Fractional anisotropy,FA值)]、手术前后脊髓型颈椎病患者CT量化参数和DTI参数。随后根据临床疗效将120例脊髓型颈椎病患者分为有效组(n=97),无效组(n=23)。比较两组CT量化及DTI参数,并分析影像学参数与JOA评分的关系。结果:观察组骨性椎管容积、纤维性椎管容积、椎管容积占有率以及FA值均低于对照组,ADC值高于对照组(P0.05)。术后脊髓型颈椎病患者纤维性椎管容积、椎管容积占有率及FA值与JOA评分呈正相关(r=0.422、0.403、0.539,P<0.05),ADC值则与JOA评分呈负相关(r=-0.598,P<0.05)。结论:CT和DTI均能够有效反映出脊髓型颈椎病患者的颈椎功能与临床疗效。

关键词：脊髓型颈椎病电子计算机断层扫描磁共振弥散张量成像颈椎功能疗效

老年人急性下消化道穿孔的临床特点及治疗分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

临床急诊杂志 2024年第5期25卷 225-228,234页

作者：张瑞军冯涛杨桥王鑫杨光金红旭中国人民解放军北部战区总医院急诊科沈阳110000

目的:探讨老年人下消化道穿孔的病因、临床特点、手术方式及结局,为临床治疗该病提供参考。方法:选取2018年1月—2023年6月医院急诊收治的老年急性下消化道穿孔患者54例为研究对象。采取回顾性分析方法,根据患者的消化道穿孔不同部位,... 详细信息

目的:探讨老年人下消化道穿孔的病因、临床特点、手术方式及结局,为临床治疗该病提供参考。方法:选取2018年1月—2023年6月医院急诊收治的老年急性下消化道穿孔患者54例为研究对象。采取回顾性分析方法,根据患者的消化道穿孔不同部位,将其分为小肠穿孔组与结直肠穿孔组,并对两组患者的一般资料、辅助检查、病因、治疗方案及结局等进行分析。结果:54例患者中,小肠穿孔20例,穿孔原因分别为异物9例、淋巴瘤4例、不明原因4例、憩室炎2例、炎症性肠病1例;结直肠穿孔34例,穿孔原因分别为结肠肿瘤19例、粪石性6例、医源性5例、憩室炎3例、异物1例。两组患者CT检查的阳性率均为100%;结直肠组炎症指标及乳酸水平高于小肠组。小肠穿孔组患者均通过穿孔修补或病变肠管切除吻合获得治愈,并发切口感染2例、腹腔残余脓肿1例。结直肠组行穿孔修补6例(5例医源性穿孔和1例憩室穿孔),病变肠管切除、Ⅰ期吻合16例,病灶切除、肠造口术8例,仅肠造口术4例;结肠直组治愈28例,死亡6例;切口感染6例。结论:异物是导致老年人小肠穿孔的主要原因之一,肿瘤是结直肠穿孔的最主要原因,粪石、医源性所致结直肠肠穿孔亦占较高的比例。腹部CT阳性率较高,可作为首选辅助检查。对于小肠穿孔、右半结肠及憩室炎穿孔、医源性穿孔以及无合并严重营养不良、低蛋白血症、待吻合肠管血供良好的可切除肿瘤穿孔修补或切除后Ⅰ期吻合是安全的。

关键词：老年人小肠结直肠穿孔

Role of duck plague virus glycoprotein C in viral adsorption:Absence of specific interactions with cell surface heparan sulfate

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2017年第5期16卷 1145-1152页

作者： JING Yan-chun WU Ying SUN Kun-feng WANG Ming-shu CHENG An-chun CHEN Shun JIA Ren-yong ZHU De-kang LIU Ma-feng yang qiao JING Bo CHEN Xiao-yue Institute of Preventive Veterinary Medicine Sichuan Agricultural UniversityChengdu 611130P.R.China Key Laboratory of Animal Diseases and Human Health of Sichuan Province Chengdu 611130P.R.China Avian Diseases Research Center College of Veterinary MedicineSichuan Agricultural UniversityChengdu 611130P.R.China

Many mammalian herpes viruses utilize heparan sulfate （HS） moieties present on cell surface proteoglycans as receptors for cell entry, and this process also requires viral glycoprotein C （gC） homologues. However, our understanding of the role of gC in facilitating attachment of other alpha-herpes viruses such as the duck plague virus （DPV） remains preliminary. To study the role of gC during DPV infection, we used a gC-deleted mutant virus （DPV-AgC-EGFP）. Examination of the viral copy number by real-time PCR, as well as time course studies of viral adsorption and proliferation revealed that gC was involved in the viral binding to the cell surface. The affinity of viral glycoproteins （gB-DPV, gC-DPV, and gE-DPV） to HS was assessed using a prokaryotic expression system and HJTrapTM HeparJn HP column chromatography. In addition, to confirm that gC played a role in the interaction between DPV and HS, viruses were treated with the HS analogue heparin and host cells were treated with its inhibitors heparinase prior to exposure to DPV-△gC-EGFP or wild-type strain Chinese virulent duck plague virus （DPV-CHv）. The effects of heparin and heparinase on virus infectivity demonstrated that function of gC on Viral adsorption is independent of interactions between gC and heparin sulfate on cell surface. All in all, this study demonstrated that the gC of DPV can mediate viral adsorption in an HS-independent manner, which distinguish it from the gC of some other alpha-herpes viruses. Future studies will be required to identify the receptors involved in gC protein binding to cells. This work provides us a foundation for further studies of examining the roles of gC in the adsorption during duck plague virus infection.

关键词： duck plague virus （DPV） glycoprotein C （gC） heparan sulfate （HS） viral adsorption

Development and optimization of a double antibody sandwich ELISA for the detection of goose T cell surface CD8α molecule

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2016年第10期15卷 2363-2368页

作者： ZHANG Wei CHENG Bei-bei CHEN Shun WANG Ming-shu JIA Ren-yong ZHU De-kang LIU Ma-feng LIU Fei SUN Kun-feng yang qiao WU Ying CHEN Xiao-yue CHENG An-chun Institute of Preventive Veterinary Medicine Sichuan Agricultural University Avian Disease Research Center College of Veterinary Medicine Sichuan Agricultural University Key Laboratory of Animal Disease and Human Health of Sichuan Province Sichuan Agricultural University

CD8, a glycoprotein on the surface of T cells, is involved in the defense against viral infection and plays significant roles in antigen presentation and in the antiviral immune response. CD8 is composed of two chains. Of these, the CD8α chain was chosen for the detection because it involved in both the CD8αα homodimer and the CD8αβ heterodimer. Here, we established a double antibody sandwich enzyme-linked immunosorbent assay（DAS-ELISA） for specific detection of goose CD8α（go CD8α）. The results showed that the optimal coated antibody and antigen dilutions were 1：50（the antibody titer was 1：12 800） and 1：32（0.3 ng m L^–1）, respectively, while the optimal capture antibody and horseradish peroxidase（HRP）-labelled goat anti-rabbit Ig G dilutions were 1：50（the antibody titer was 1：51 200） and 1：4 000（the antibody titer was 1：5 000）, respectively. The optimal blocking buffer was 5% bovine serum albumin（BSA）. The best incubating condition was overnight at 4℃, the best blocking time was 120 min and the best anti-capture antibody working time was 150 min. In addition, the minimum dose detectable by DAS-ELISA was 5×10^–3 ng m L^–1. Most importantly, go CD8α expression levels in goose spleen mononuclear cells（MNCs） post-Goose parvoviruse（GPV） infection were found to be significantly up-regulated using the DAS-ELISA method, which was consistent with previous results obtained using real-time quantitative PCR. In conclusion, the DAS-ELISA method reported here is a novel, specific technique for the clinical detection of go CD8α.

关键词： T cells goose CD8α polyclonal antibody double antibody sandwich ELISA

Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 4-13页

作者： Ji-Yao Sheng Zi-Fan Meng qiao Li Yong-Sheng yang Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun 130041China Jilin Engineering Laboratory for Translational Medicine of Hepatobiliary and Pancreatic Diseases the Second Hospital of Jilin UniversityChangchun 130041China

Background:Gastroesophageal variceal bleeding is one of the most severe complications of patients with cirrhosis.Although primary prevention drugs,including non-selectiveβ-blockers,have effectively reduced the incidence of bleeding,their efficacy is limited due to side effects and related contraindications.With recent advances in precision medicine,precise drug treatment provides better treatment efficacy.Data sources:Literature search was conducted in PubMed,MEDLINE and Web of Science for relevant articles published up to May 2022.Information on clinical trials was obtained from https://clinicaltrials.gov/and http://***/.Results:The in-depth understanding of the pathogenesis and advances of portal hypertension has enabled the discovery of multiple molecular targets for promising drugs.According to the site of action,these drugs could be classified into four classes:intrahepatic,extrahepatic,both intrahepatic and extrahepatic targets and others.All these classes of drugs offer advantages over traditional treatments in prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.Conclusions:This review classified and summarized the promising drugs,which prevent gastroesophageal variceal bleeding by targeting specific markers of pathogenesis of portal hypertension,demonstrating the significance of using the precision medicine strategy to discover and develop promising drugs for the primary prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.

关键词： Cirrhotic portal hypertension Target drug Primary prevention Bleeding

Acyclic Edge Coloring of 1-planar Graphs without 4-cycles

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第1期40卷 35-44页

作者： Wei-fan Wang Yi-qiao Wang Wan-shun yang Department of Mathematics Zhejiang Normal UniversityJinhua321004China School of Management Beijing University of Chinese MedicineBeijing100029China School of Mathematics and Information Science Weifang UniversityWeifang261061China

An acyclic edge coloring of a graph G is a proper edge coloring such that there are no bichromatic cycles in G.The acyclic chromatic index χ'α(G) of G is the smallest k such that G has an acyclic edge coloring using k colors.It was conjectured that every simple graph G with maximum degree Δ has χ'_α(G) ≤Δ+2.A1-planar graph is a graph that can be drawn in the plane so that each edge is crossed by at most one other edge.In this paper,we show that every 1-planar graph G without 4-cycles has χ'_α(G)≤Δ+22.

关键词： 1-planar graph acyclic edge coloring acyclic chromatic index