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不同妊娠状态下女性口腔微生物的结构差异性

微生物学通报 2024年第1期51卷 323-339页

作者：冉丽华冯阳杨正艳李月恒蒋丹重庆医科大学附属口腔医院重庆401147 重庆市长寿区妇幼保健院重庆401220

【背景】妊娠期妇女口腔微生物改变与口腔疾病及全身性疾病之间有显著相关性。【目的】比较不同妊娠状态下女性口腔微生物结构的差异,探讨该差异与不同妊娠状态间的关联性。【方法】选取18名孕妇和9名非孕妇为研究对象[(28.2±3)岁],分... 详细信息

【背景】妊娠期妇女口腔微生物改变与口腔疾病及全身性疾病之间有显著相关性。【目的】比较不同妊娠状态下女性口腔微生物结构的差异,探讨该差异与不同妊娠状态间的关联性。【方法】选取18名孕妇和9名非孕妇为研究对象[(28.2±3)岁],分为妊娠期糖尿病组[gestational diabetesmellitus,GDM,年龄(28.9±3.6)岁,孕周(30.1±3.2)周]、妊娠期非糖尿病组[non-diabetic pregnantwomen,PW,年龄(27.9±3.0)岁,孕周(28.6±4.7)周]和非妊娠期非糖尿病组[non-pregnant women,NPW,年龄(27.7±2.1)岁],每组9名,收集口腔唾液(saliva,S)和龈上牙菌斑(supragingival dental plaque,D),采取Illumina NovaSeq测序平台针对细菌16S rRNA基因的V3-V4可变区进行测序,以SILVA为参考数据库使用朴素贝叶斯分类器对特征序列进行分类学注释,利用QIIME软件对样本进行生物信息学分析。【结果】三组中唾液及牙菌斑微生物差异比较显示:D-GDM中二氧化碳嗜纤维菌属检出量高于D-PW,而月形单胞菌属检出量显著低于D-PW;S-GDM中产气单胞菌属、拟杆菌属等厌氧菌属检出量高于S-PW,韦荣氏菌属检出量低于S-PW;D-PW中纤毛菌属、普氏菌属和月形单胞菌属检出量显著高于D-NPW;D-NPW中产气单胞菌属、放线杆菌属、二氧化碳嗜纤维杆菌属、奈瑟菌属、链球菌属和劳特罗氏菌属等检出量高于D-PW;S-PW中韦荣菌属、普氏菌属、链球菌属和卟啉单胞菌属检出量低于S-NPW;D-GDM中福赛斯坦纳菌属、纤毛菌属检出量高于D-NPW,劳特罗氏菌属检出量低于D-NPW;S-GDM中密螺旋体属、弯曲杆菌属检出量高于S-NPW,链球菌属低于S-NPW。在种水平上,S-GDM菌群中具核梭杆菌检出量显著高于S-PW,S-GDM菌群中牙龈卟啉单胞菌及福赛斯坦纳菌检出量与S-PW差异无统计学意义,产黑普氏菌检出量低于S-PW;S-PW中牙龈卟啉单胞菌、产黑普氏菌和福赛斯坦纳菌检出量均显著高于S-NPW。【结论】孕妇妊娠期糖尿病将增加口腔微生物群厌氧菌检出率,GDM与牙龈卟啉单胞菌、福赛斯坦纳菌和产黑普氏菌等牙周炎致病菌相关性不能确定。

关键词：妊娠期糖尿病口腔微生物唾液龈上牙菌斑

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飞行器结构健康监测技术研究进展

航空制造技术 2024年第13期67卷 41-67,98页

作者：田童李建乐邓德双曾旭林奎旭董珊珊杨雷徐浩杨正岩武湛君大连理工大学力学与航空航天学院大连116024 大连理工大学材料科学与工程学院大连116024 江南大学无锡214122

结构健康监测技术有望在飞行器设计、服役和维护中发挥关键作用,提高飞行器结构效率,确保飞行器结构的安全性和可靠性。本文首先概述结构健康监测的基本概念及其适用范围,强调其在航空航天领域中的重要性。随后,针对结构健康监测技术在... 详细信息

结构健康监测技术有望在飞行器设计、服役和维护中发挥关键作用,提高飞行器结构效率,确保飞行器结构的安全性和可靠性。本文首先概述结构健康监测的基本概念及其适用范围,强调其在航空航天领域中的重要性。随后,针对结构健康监测技术在飞行器典型结构中的研究工作情况,重点围绕冲击监测、超声导波损伤监测以及光纤传感器应变监测等先进技术进行详细讨论,总结国内外研究现状、技术能力以及典型应用。最后,指出飞行器结构健康监测面临的挑战性问题,展望该技术在航空航天领域的应用前景。

关键词：结构健康监测(SHM) 冲击监测超声导波光纤光栅分布式光纤损伤诊断

浅析反相高效液相色谱中样品溶剂对中药成分色谱保留行为的影响

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世界科学技术-中医药现代化 2024年第4期26卷 1017-1027页

作者：张冬旭张彤丁越张永杨正燕王申澍张新华上海中医药大学中药学院上海201203 上海谱宁分析技术有限公司上海201202

目的探究反相高效液相色谱(RP-HPLC)中样品溶剂对中药成分色谱保留行为的影响。方法选取2020版《中国药典》一部收载的5种中药,参照各药材含量测定项下要求进行HPLC法测定,初步研究龙胆苦苷-龙胆、紫丁香苷-刺五加、松脂醇二葡萄糖苷-... 详细信息

目的探究反相高效液相色谱(RP-HPLC)中样品溶剂对中药成分色谱保留行为的影响。方法选取2020版《中国药典》一部收载的5种中药,参照各药材含量测定项下要求进行HPLC法测定,初步研究龙胆苦苷-龙胆、紫丁香苷-刺五加、松脂醇二葡萄糖苷-杜仲、秦皮甲素-秦皮、腺苷-冬虫夏草受样品溶剂影响产生的色谱峰异常行为,深入探讨溶剂效应的机理,并提出解决方案。结果5种中药化学成分的色谱异常行为表现为保留时间漂移、色谱峰展宽、前延及裂分,产生上述异常现象的根本原因是溶解样品的溶剂和流动相存在某种不匹配,导致样品在溶剂与流动相中所处状态出现差异(溶剂效应)。消除溶剂效应的首选方法是用流动相或相近的溶剂溶解样品,此外,减小进样量和使用溶剂效应消除器可作为辅助手段。结论溶剂效应容易引起色谱峰异常,影响对化学成分定性和定量的准确性,应该在日常中药分析工作中予以重视。

关键词：反相高效液相色谱样品溶剂溶剂效应流动相峰形异常溶剂效应消除器

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Dynamics of chip formation during the cutting process using imaging techniques: A review

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International Journal of Mechanical System Dynamics 2022年第1期2卷 27-49页

作者： Guangchao Nie zhengyan yang Dong Zhang Xiaoming Zhang José Outeiro Han Ding State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanChina Arts et Metiers Institute of Technology LaBoMaPHESAM UniversityClunyFrance

Imaging techniques have been widely implemented to study the dynamics of chip *** can offer a direct method and a full field measurement of the cutting process,providing kinematic information of the chip formation *** this article,the state of the art of the imaging techniques reported in the literature has been summarized and *** imaging techniques have been applied to study the chip formation mechanism,friction behavior,strain/strain rate,and stress ***,the study of surface integrity has been advanced by deriving the thermo‐mechanical loading,subsurface deformation,and material constitutive model from the imaging ***,achievements in the area of imaging techniques have been summarized,followed by future directions for their application in the study of surface integrity.

关键词： chip formation imaging techniques strain rate stress surface integrity

Leaching kinetics and permeability of polyethyleneimine added ammonium sulfate on weathered crust elution-deposited rare earth ores

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Journal of Rare Earths 2024年第8期42卷 1610-1619,I0008页

作者： Huifang yang Aoyang Sha zhengyan He Chenjie Wu Yuanlai Xu Jingjing Hu Zhigao Xu Ru'an Chi Key Laboratory for Green Chemical Process of Ministry of Education School of Resources&Safety EngineeringWuhan Institute of TechnologyWuhan 430073China Key Laboratory of Resources Conversion and Pollution Control of the State Ethnic Affairs Commission College of Resources and Environmental ScienceSouth-Central MinzuUniversityWuhan430074China

At present,in-situ leaching of weathered crust elution-deposited rare earth ores(WCE-DREOs) encounter with problems such as long leaching cycles,slow infiltration rate and low product *** order to solve the above problems,the conventional leaching agent ammonium sulfate((NH_(4))_(2)SO_(4)) was compounded with polymeric surfactant polyethyleneimine(PEI) to form a composite leaching *** effects of leaching temperature,PEI *** rate and pH on leaching kinetics and permeability of rare earths(RE) and aluminum(AI) in orebody were *** is found that with temperature increasing,the time required to reach leaching equilibrium for both RE and Al is shortened,the apparent activation energies of RE and AI are 14.79 and 13.45 kJ/mol,respectively,and the leaching processes are in accordance with the outer diffusion control,When the concentrations of(NH_(4))_(2)SO_(4) and PEI in the composite leaching agent are 2.0 wt% and 0.4 wt%;the time required to reach leaching equilibrium for RE and AI is about 50% shorter than that using(NH_(4))_(2)SO_(4) alone,and the leaching efficiencies of RE are slightly higher than that of *** increasing the temperature and flow rate of the composite leaching agent can improve the leaching efficiencies of RE and Al,but pH has neglected effects on the leaching efficiencies of *** PEI concentrations below 0,4 wt%, the addition of PEI promotes the leaching of RE and *** column leaching studies of the WCE-DREO,the addition of 0.4 wt% PEI to the traditional leaching agent(NH_(4))_(2)SO_(4) has no impact on the leaching efficiencies of ***,it can significantly increase the infiltration rate of WCE-DREO,shortening the leaching time per 10 mL effluent from about 30 min for(NH_(4))_(2)SO_(4) leaching system to 20 min for the composite leaching *** leaching time is shortened by one-third,and the leaching cost is reduced,which can provide theoretical guidance for the development and commercial implementa

关键词： Polyethyleneimine Kinetics Rare earths Permeability Activation energy

基于表里关联分析比较不同炮制程度焦栀子炮制过程中的质量变化规律

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上海中医药杂志 2024年第9期58卷 70-79页

作者：沈一琦丁越张彤余乐洋周佳怡张寒晴杨正燕张永康萍上海中医药大学上海201203

目的通过对不同炮制程度焦栀子色度值及内在成分的定量分析,研究栀子炮制过程中外表色泽和成分的关联性与内在成分变化规律,为焦栀子的质量评价提供参考。方法采用色差仪测量3种不同炮制程度焦栀子样品粉末的色度值(L*、a*、b*、E*ab),... 详细信息

目的通过对不同炮制程度焦栀子色度值及内在成分的定量分析,研究栀子炮制过程中外表色泽和成分的关联性与内在成分变化规律,为焦栀子的质量评价提供参考。方法采用色差仪测量3种不同炮制程度焦栀子样品粉末的色度值(L*、a*、b*、E*ab),通过高效液相色谱(HPLC)法测定焦栀子中8个指标性成分的含量,并采用主成分分析(PCA)、正交偏最小二乘法-判别分析(OPLS-DA)、Pearson法等分析方法分析色度和成分之间的相关性。结果各个地区饮片厂因缺乏直观统一的标准,致使所生产的样品炮制程度差异较大。随着炮制的进行,焦栀子的表观颜色逐渐由红黄色转变为焦褐色。焦栀子的粉末色度值与内在成分之间高度相关。所测得的色度值参数和8个成分含量均呈下降趋势,其中与表观颜色变化最明显的a*呈极显著正相关性的成分异栀子苷、栀子苷和西红花苷Ⅰ可以作为栀子炮制过程监控及质量控制的标志物。结论通过建立焦栀子炮制过程中颜色与成分变化的对应关系,弥补了传统经验鉴别的主观模糊性,为焦栀子炮制程度的判别和标志成分含量的预测提供线索。

关键词：焦栀子表里关联分析炮制色度值质量评价中药研究

260 fs,403 W coherently combined fiber laser with precise high‑order dispersion management

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Frontiers of Optoelectronics 2024年第1期17卷 21-27页

作者： Shuangxi Peng Zhihao Wang Feilong Hu zhengyan Li Qingbin Zhang Peixiang Lu Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

An ultrafast fiber laser system comprising two coherently combined amplifier channels is *** this system,each channel incorporates a rod-type fiber power amplifier,with individual operations reaching approximately 233 *** active-locking of these coherently combined channels,followed by compression using gratings,yields an output with a pulse energy of 504μJ and an average power of 403 *** stability is maintained,with a 0.3%root mean square(RMS)deviation and a beam quality factor M^(2)<***,precise dispersion management of the front-end seed light effectively compensates for the accumulated high-order dispersion in subsequent amplification *** strategic approach results in a significant reduction in the final output pulse duration for the coherently combined laser beam,reducing it from 488 to 260 fs after the gratings compressor,while concurrently enhancing the energy of the primary peak from 65%to 92%.

关键词： Fiber lasers amplifier Power scaling Coherent beam combination Dispersion compensation

PRMT5 Regulates Polysaccharide Content by Controlling the Splicing of Thaumatin-Like Protein in Ganoderma lucidum

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PRMT5 Regulates Polysaccharide Content by Controlling the Sp...

Comprehensive Treatment and Prognostic Factors in Patients with Carcinoma of the Cervical Stump

中国菌物学会2023年学术年会

作者： Rui Liu zhengyan yang Tao yang Jing Zhu Ang Ren Liang Shi Mingwen Zhao

In the current study,silencing of Protein arginine methyltransferase 5(PRMT5) decreased the polysaccharide content in Ganoderma lucidum compared that in the WT *** RNA-seq screening showed that the glycan degradation process-related gene thaumatin-like protein(TLP) was alternatively spliced in WT strains via retained introns,leading to the production of a longer TLP1 isoform and a shorter TLP2 isoform;however,only the TLP2 isoform was observed in PRMT5i *** examining the polysaccharide content of the TLP silencing(TLPi),TLP1 overexpression(OE-TLP1) and TLP2 overexpression(OE-TLP2) transformants revealed that TLP2 plays a more important role than TLP1 in polysaccharide *** a combination of yeast two-hybrid,bimolecular fluorescence complementation and surface plasmon resonance assays,we found that TLP2 directly physically interacts with phosphoglucose isomerase(PGI),a key enzyme in polysaccharide synthesis,and thereby increases PGI ***,TLP1 failed to interact with PGI,and PGI activity was not *** inspection showed that the polysaccharide content was decreased in the OE-TLP2 strains but not significantly changed in the OE-TLP1 strains compared with that in the WT *** addition,the polysaccharide content of the PRMT5-TLP-cosilenced strains was not significantly different from that of the WT *** results demonstrate that PRMT5 modulates TLP processing of pre-mRNA transcripts thereby decreasing the polysaccharide content.

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Clinical oncology and cancer resexreh 2009年第6期6卷 426-429页

作者： Lu Chen Ting Xia zhengyan yang Jianqing Zhu Department of Gynecologic Oncology Zhejiang Cancer Hospital Hangzhou 310022 Zhejiang Province China

OBJECTIVE To evaluate the applicability of combined therapyand the prognostic factors in patients with carcinoma of thecervical stump (CCS).METHODS The clinical records of 60 CCS patients whounderwent combined treatment in our hospital during a periodfrom January 2000 to December 2007, were collected andretrospectively analyzed. The prognostic factors were studiedusing univariate analysis. Analytical evaluation of the independentprognostic factors was performed using COX proportionalhazardsregression *** The 1-, 3- and 5-year survival rates of the 60 patientswere 95%, 78% and 68%, respectively, with a median survivaltime of 32 months. Univariate survival analysis showed thatthese independent prognostic factors included positive pelviclymph nodes (P = 0.001), lymphovascular tumor embolus (P =0.001), and adjuvant chemotherapy (P = 0.011). In the 60 cases,postoperative local recurrence in the pelvic cavity occurred in1 and distant metastasis in 3. Related complications, such asradiocystitis, recto-vaginal fistula and vesico-vaginal fistula werefound in 6 of the total cases (10%). The serum levels of squamousepithelium antigen detected before and after treatment weresignificantly different (P = 0.000). The incidence of CCS is low;however, the disease is difficult to cure due to the high incidenceof complications and to the frequency of distant ***, individualized treatment is needed. Complications fromsubtotal hysterectomy (STH) should be treated and controlledaggressively. Careful follow-up as well as close monitoring andobservation for significant symptoms in the postoperative coursewill enhance clinical *** Cancer of the cervical stump has a lowmorbidity and severe complications, and most recurrences aredistant metastases. Because it is difficult to cure, there is a needto design a treatment regimen for each individual patient basedon the factors deemed as high risk. The surgical indications forsubtotal uterine resection shou

关键词：综合治疗单因素分析直肠阴道瘘子宫切除术平均存活时间并发症 CCS 临床资料