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A flexible skin-mounted wireless acoustic device for bowel sounds monitoring and evaluation

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Science China(Information Sciences) 2019年第10期62卷 171-181页

作者： Fengle WANG Dong WU Peng JIN Yingchao ZHANG yingyun yang Yinji MA Aiming yang Ji FU Xue FENG Key Laboratory of Applied Mechanics Department of Engineering MechanicsTsinghua University Department of Gastroenterology Peking Union Medical College Hospital

Conventional methods of intestinal inspection play an essential role in the assessment of bowel diseases and other relevant health issues, yet fail to obtain intestinal conditions in real time because of radiation limits and operation inconvenience. Herein, a flexible, skin-mounted device is developed for longterm, real-time monitoring, and for the evaluation of bowel sounds based on the integration of a threedimensional printed elastomeric resonator with flexible electronics. The device is capable of being flexibly attached to abdominal surfaces without performance degradation during breathing. Clinical tests conduct in a normal volunteer and in patients with mechanical intestinal obstruction or paralytic ileus illustrate the usefulness of the device in capturing the characteristics of bowel sounds. Furthermore, a demonstration of collection and classification of bowel sounds by the flexible device based on machine learning methods can serve as a reference for possible applications of the system in the auxiliary diagnosis of bowel problems.

关键词： flexible wearable device bowel sounds long-term monitoring machine learning intestinal motility

LC contact lens sensor for ultrasensitive intraocular pressure monitoring

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npj Flexible Electronics 2024年第1期8卷 357-370页

作者： Hongbin An Xian Wang Zhikang Liao Liang Zhang Hui Zhao yingyun yang Jizhou Song Yinji Ma Laboratory of Flexible Electronics Technology Tsinghua University(THU)Beijing100084P.R.China Department of Engineering Mechanics Zhejiang UniversityHangzhou310027P.R.China Institute of Flexible Electronics Technology of THU Jiaxing314000P.R.China Department of Military Traffic Injury Prevention and Control Daping HospitalArmy Medical UniversityChongqing400042P.R.China Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100084P.R.China AML Department of Engineering MechanicsTsinghua UniversityBeijing100084P.R.China

Twenty-four hours continuous intraocular pressure(IOP)monitoring is beneficial for glaucoma *** lens sensors using LC technology can achieve non-invasive continuous IOP measuring around the clock and are relatively simple in principle and structure,thus dominating the *** them,stretchable inductive LC contact lens sensors constructed with liquid metal have advantages in signal quality as well as wearing comfort,but currently its sensitivity is slightly ***,we propose an LC sensor that constructed with liquid metal to form the stretchable inductance and capacitance *** capacitive plate and inductive coil can response to IOP changes simultaneously,thus able to enhance the sensitivity in *** modeled the sensing mechanism and conducted design,fabrication,as well as various *** device exhibits good characteristics,including reliability,good signal quality,***,it has a threefold increase in sensitivity,exceeding the current state-of-the-art contact lens sensors.

关键词： inductive exceeding slightly

Peripancreatic vascular involvement in patients with type 1 autoimmune pancreatitis

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 355-362页

作者： Meizi Li Xiaoyin Bai Kai Xu Xi Wu Tao Guo Qingwei Jiang Qiang Wang Shengyu Zhang yingyun yang Yunlu Feng Aiming yang Department of Gastroenterology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina Department of Radiology Peking Union Medical College HospitalBeijingChina

Background:Type 1 autoimmune pancreatitis(AIP)is the pancreatic manifestation of IgG4-related ***,this benign disease can result in the peripancreatic vascular involvement(PVI)on occasion,which increases the difficulty of diagnosis and treatment of this clinical entity as well as for differentiating it from pancreatic ***:We retrospectively reviewed the information on demographics,clinical presentation,laboratory,imaging and endoscopic findings of 101 hospitalized patients with type 1 AIP treated in our *** the patients were divided into non-PVI and PVI groups according to the first hospitalized medical *** and multivariate analyses were performed to analyse the potential predictive parameter(s)of PVI in AIP ***:Among the 101 type 1 AIP patients,52(51.5%)exhibited PVI,with a male/female ratio 5.5:*** average age was 58.37±8.68 years *** analysis revealed that the location of pancreatitis lesions,including the pancreatic tail(P=0.010),the presence of splenomegaly(P=0.001)and the white blood cell(WBC)number in peripheral blood(P=0.020),were significantly associated with *** location of pancreatitis lesions,including the pancreatic tail(P=0.023),and the presence of splenomegaly(P=0.010)were found to be independent predictors of the development of PVI by a multivariable regression analysis.A total of 18 out of 25 patients in PVI group who underwent corticosteroid treatment and no less than 6 months radiological follow-up showed improvement in vascular lesions,and no case exhibited exacerbation of PVI lesions during *** 36 patients in non-PVI group who were followed up for no less than 6 months,only one case exhibited ***:This retrospective study demonstrated that type 1 AIP was associated with a high proportion of *** tail involvement and splenomegaly may predict the PVI in type 1 *** lesions are reversible in a subset of patients.

关键词： Autoimmune pancreatitis(AIP) peripancreatic vascular involvement(PVI) IgG4-related disease(IgG4-RD) splenomegaly corticosteroid treatment

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齿轮钢渗碳热处理组织与性能研究

铸造技术 2014年第6期35卷 1213-1215页

作者：杨英芸保定职业技术学院河北保定071000

对20CrNi2Mo和20Cr2Ni4钢进行渗碳热处理,研究了其微观组织、硬度、抗拉强度和伸长率等性能。结果表明,钢材的表层硬度由表及里逐渐降低,同一深度下,20CrNi2Mo钢的硬度要高于20Cr2Ni4钢。20CrNi2Mo钢渗碳热处理后具有更好的综合性能。

关键词：齿轮钢热处理性能

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Enhancing diagnostic strategies for biliary strictures:an evolving landscape

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 885-887页

作者： Wanying Liao Qiang Wang Qingwei Jiang Xi Wu yingyun yang Aiming yang Department of Gastroenterology Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)BeijingChina

The diagnosis of patients with biliary strictures of undetermined etiology remains a significant *** strictures,whether benign or malignant,often present with similar clinical features and imaging *** patients,this uncertainty can lead to repeated laboratory and radiological tests,invasive procedures,as well as delayed treatment and considerable *** complexity of these cases necessitates the integration of multiple diagnostic modalities to enhance accuracy while balancing patient safety and resource utilization.

关键词： Diagnosis biliary stricture endoscopic techniques

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退火参数对65Mn钢丝组织和性能的影响

铸造技术 2014年第9期35卷 2002-2004页

作者：杨英芸保定职业技术学院河北保定071000

研究了不同直径65Mn钢丝在不同退火工艺下的力学性能与显微组织。结果表明:DV值、退火温度与保温时间是影响65Mn钢丝抗拉强度的主要因素。随着退火温度的升高和退火时间的延长,65Mn钢丝组织中的珠光体不断粗化,抗拉强度不断降低。

关键词： 65Mn钢丝退火微观组织力学性能

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Interferon-inducible downregulation of micro RNA-27a feedback inhibits antiviral type I interferon production by upregulating Siglec1/TRIM27

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Interferon-inducible downregulation of micro RNA-27a feedbac...

Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma

第十届全国免疫学学术大会

作者： Jin Hou Qingliang Zheng Ye Zhou yingyun yang Xuetao Cao National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University

Type Ⅰ interferon(IFN) production plays key roles in host antiviral innate immune response, but the mechanisms for regulation of antiviral type Ⅰ interferon(IFN) production remain to be fully elucidated. By screening the micro RNAs modulated by viral infection in macrophages, we identified that mi R-27 awas significantly downregulated via IFN/JAK/STAT1/Runx1 pathway. Inducible downregulation of mi R-27 ain turn negatively regulated VSV-triggered type Ⅰ IFN production, thus promoting VSV replication in macrophages. Furthermore, we found that mi R-27 atargets Siglec1 and E3 ubiquitin ligase TRIM27, both of which were verified as negative regulators of type Ⅰ IFN production through inhibiting IRF3 activation by reducing TBK1 protein level. These observations were confirmed in mi R-27asponge-containing transgenic mice with suppressed expression of mi R-27 aand challenged by viral infection. Therefore, IFN-inducible downregulation of mi R-27 acan upregulate Siglec1 and TRIM27, feedback inhibit type Ⅰ IFN production in antiviral innate response. Our study outlines a new negative way to feedback regulate type Ⅰ IFN production.

关键词： micro RNA-27a innate response type Ⅰ interferon viral infection Siglec1 TRIM27

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Hepatic IFIT3 predicts interferon-α therapeutic response in...

第十三届全国免疫学学术大会

作者： Ye Zhou yingyun yang Jin Hou Zhengyang Li Nan Li Xuetao Cao Naval Medical University of PLA Chinese Academy of Medical Sciences

Adjuvant interferon-α(IFN-α) therapy is used to control certain types of cancer in clinics. For hepatocellular carcinoma(HCC), IFN-α therapy is effective in only a subgroup of HCC patients, therefore identifying biomarkers to predict the response to IFN-α therapy is of high significance and clinical utility. As the induced IFN-stimulated genes(ISGs) expression following IFN-α treatment plays pivotal roles in IFN-α effects, we screened ISGs expression in HCC tissues and found several ISGs were significantly decreased in HCC. Interestingly, expressions of IFN-induced proteins with tetratricopeptide repeats(IFIT) family members, including IFIT1, IFIT2, IFIT3, and IFIT5, were all decreased in HCC tissues. We further analyzed the expressions of IFIT family members in HCC and their roles in patients’ responses to IFN-α therapy in two independent randomized controlled IFN-α therapy clinical trials of HCC patients, and found that higher expression of IFIT3, but not other IFITs, in HCC tissues predicts better response to IFN-α therapy, suggesting that IFIT3 may be a useful predictor of the response to IFN-α therapy in HCC patients. Mechanistically, IFIT3 enhanced the antitumor effects of IFN-α by promoting IFN-α effector responses both in vitro and in vivo. IFIT3 could bind signal transducer and activator of transcription 1(STAT1) and STAT2 to enhance STAT1/STAT2 hetero-dimerization and nuclear translocation upon IFN-α treatment, thus promoting IFN-α effector ***: Higher IFIT3 expression in HCC tissues predicts better response to IFN-α therapy in HCC patients. IFIT3 promotes IFN-α effector responses and therapeutic effects by strengthening IFN-α effector signaling in HCC.

关键词： interferon-α immunotherapy hepatocellular carcinoma biomarker STAT1 STAT2

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系统性疾病的肝胆受累

胃肠病学 2020年第9期25卷 513-520页

作者：杨莹韵钱家鸣中国医学科学院北京协和医学院北京协和医院消化内科100730

肝脏在维持稳态和机体健康中发挥重要作用,包括合成多种必须蛋白质、生成胆汁及其载体、调节营养成分、代谢和结合亲脂化合物并通过胆汁或尿液排泌等。认识系统性疾病的肝胆受累表现,对于诊断和鉴别系统性疾病,以及肝胆结构、功能改变... 详细信息

肝脏在维持稳态和机体健康中发挥重要作用,包括合成多种必须蛋白质、生成胆汁及其载体、调节营养成分、代谢和结合亲脂化合物并通过胆汁或尿液排泌等。认识系统性疾病的肝胆受累表现,对于诊断和鉴别系统性疾病,以及肝胆结构、功能改变的诊治具有重要意义。本文对自身免疫性疾病、肿瘤和血液系统疾病、内分泌系统疾病、神经系统疾病、危重病(如脓毒症)、心血管系统疾病、浸润性疾病(如淀粉样变性)和肉芽肿性疾病累及肝胆的临床表现作一概述。

关键词：系统性疾病自身免疫疾病肿瘤血液和淋巴系统疾病内分泌系统疾病神经系统疾病危重病肝胆表现

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