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分流叶片长度及周向偏移量对ORC向心透平性能的影响

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动力工程学报 2024年第5期44卷 759-769页

作者：韩旭李奇杨依栋刘树华李鹏华北电力大学河北省低碳高效发电技术重点实验室河北保定071003

利用分流叶片能有效改善叶片通道内的流动阻塞问题,降低流动损失。针对某带分流叶片的有机朗肯循环(ORC)向心透平,研究了不同分流叶片长度和周向偏移量对透平性能的影响,对不同叶片布置方案进行数值模拟,分析了内部流动状况、叶片载荷... 详细信息

利用分流叶片能有效改善叶片通道内的流动阻塞问题,降低流动损失。针对某带分流叶片的有机朗肯循环(ORC)向心透平,研究了不同分流叶片长度和周向偏移量对透平性能的影响,对不同叶片布置方案进行数值模拟,分析了内部流动状况、叶片载荷和损失分布。结果表明:分流叶片能有效削弱通道中的涡流,改善流动状况,使通道内部的压力分布合理;同时在一定程度上分担了主叶片的载荷。与分流叶片长度系数相比,周向偏移量对熵产率的影响较为明显;随着长度系数和周向偏移量的增加,高熵产率范围和总压损失系数均呈现先减后增的趋势,等熵效率的变化则相反,当l=0.5、d=0.5时等熵效率最大,为91.26%,而功率与叶片长度大体呈正相关;将长度系数和周向偏移量分别控制在0.5~0.6时,能保持较为理想的流动状况及叶片载荷分布,高熵产率范围较小,有利于透平性能的提升。

关键词：向心透平分流叶片熵产法数值模拟

有机工质向心透平数值模拟及变工况内流特性研究

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动力工程学报 2024年第2期44卷 260-269页

作者：韩旭李奇杨依栋李鹏刘树华韩中合华北电力大学河北省低碳高效发电技术重点实验室河北保定071003

基于国内外研究现状,分别对设计工况下和非设计工况下有机朗肯循环向心透平的工作状态进行了三维数值模拟。以透平功率、效率、反动度、静叶损失系数、动叶损失系数作为评价指标,分析了透平在非设计工况下的性能;同时开展了透平在非设... 详细信息

基于国内外研究现状,分别对设计工况下和非设计工况下有机朗肯循环向心透平的工作状态进行了三维数值模拟。以透平功率、效率、反动度、静叶损失系数、动叶损失系数作为评价指标,分析了透平在非设计工况下的性能;同时开展了透平在非设计工况下流动状况的描述。结果表明:设计工况下透平输出功率为122.3 kW,透平等熵效率为83.54%;在非设计工况下,透平功率和效率在转速比为0.8~1.0时的增幅较大,透平反动度和静叶损失系数均与转速呈线性关系,而动叶损失系数在转速比为0.8~1.2时存在最小值;当转速低于设计转速时,在动叶前缘吸力面存在涡流,当转速高于设计转速时,涡流存在于动叶压力面的前缘,造成此现象的主要原因是动叶转速与静叶出口流速的周向分量之间存在差值。

关键词：有机朗肯循环向心透平非设计工况流动状况数值模拟

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X射线CT引导的小鼠皮下肿瘤精准照射

核电子学与探测技术 2024年第2期44卷 214-222页

作者：吴其蔚郑澄陈家豪杨益东中国科学技术大学物理学院工程与应用物理系合肥10358

临床前小动物放射治疗是探索放射生物学机制和开发新的癌症治疗方法的重要手段。传统的小动物放疗研究由于缺乏图像引导,剂量递送误差较大,影响治疗效果和实验效率。为了克服这一限制,本研究基于实验室自主研制的小动物精准放射治疗研... 详细信息

临床前小动物放射治疗是探索放射生物学机制和开发新的癌症治疗方法的重要手段。传统的小动物放疗研究由于缺乏图像引导,剂量递送误差较大,影响治疗效果和实验效率。为了克服这一限制,本研究基于实验室自主研制的小动物精准放射治疗研究平台,针对小鼠皮下肿瘤模型开发了一种图像引导放射治疗的方法。本方法在保证肿瘤控制的同时,可以最大限度减少对健康组织的损伤,更好地满足动物皮下肿瘤照射的需求。

关键词：放射治疗图像引导动物皮下肿瘤

Effects of kallikrein gene transfer on penumbral microvascular proliferation and on regional cerebral blood flow following cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2008年第10期3卷 1045-1050页

作者： Ruiyan Lu Qingyu Shen Lianhong yang Mei Li yidong Wang Ying Peng Department of Neurology Second Affiliated Hospital of Sun Yat-sen University Guangzhou 510120 Guangdong Province China

BACKGROUND： Recent findings have demonstrated that the kallikrein-kinin system （KKS） participates in the pathological process of cerebral ischemia/reperfusion injury. Kallikrein gene transfer exhibits neural protective effects following cerebral infarction. OBJECTIVE： To observe the effects of kallikrein gene transfer on vascular proliferation in the peripheral infarct focus and on regional cerebral blood flow （rCBF） following cerebral ischemia/reperfusion injury. DESIGN, TIME AND SETTING： The completely randomized, controlled experiment was performed at the Lin Baixin Laboratory Center, the Second Affiliated Hospital of Sun Yat-sun University between September 2007 and April 2008. MATERIALS： pUCI9-HTK plasmid was constructed and maintained in the Laboratory for Neurology, the Second Affiliated Hospital of Sun Yat-sen University, China. Mouse anti-human kallikrein 1 monoclonal antibody was purchased from R＆D Systems, USA. METHODS Ninety healthy, male, Sprague Dawley rats were used. Middle cerebral artery occlusion （MCAO） was established in all rats to induce cerebral ischemia/reperfusion injury. Following MCAO establishment, all rats were randomly divided into three groups （n = 30）： blank control, saline, and pAdCMV-HTK. The saline and pAdCMV-HTK groups were stereotactically micro-injected with 5μL of physiological saline or with pAdCMV-HTK [multiplicity of infection （MOI） = 20], respectively, into the ischemic penumbra. In the blank control group, only sham injection was performed. MAIN OUTCOME MEASURES： At 12, 24, and 72 hours after treatment, cerebral infarction volume was measured by 2, 3, 5-triphenyltetrazolium chloride （TTC） staining. Exogenous HTK expression, as well as regional vascular endothelial growth factor （VEGF） expression, was detected by immunohistochemistry. rCBF was examined by 14C-iodoantipyrine micro tracing. In addition, neurological severity score （NSS） was performed. Higher scores indicated more severe neurological deficits. RESULTS： NSS resu

关键词： cerebral ischemia ischemia/reperfusion injury adenovirus gene transfer kallikrein vascular endothelial growth factor perfusion, regional

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肉羊粗饲料资源开发与利用研究进展

现代农业科技 2024年第4期 146-149,163页

作者：孙华杨义东葛兆建唐正龙杨智青江苏沿海地区农业科学研究所江苏盐城224002 射阳县动物疫病预防控制中心江苏射阳224051 盐城市科学技术局江苏盐城224002 射阳川彭山羊养殖有限公司江苏射阳224051

随着江苏省肉羊产业的快速发展,粗饲料资源缺乏等问题日益凸显。本文总结了江苏省粗饲料资源现状,介绍了粗饲料资源的不同加工处理方法(包括物理法、化学法、生物法、复合处理法),并简要介绍了农作物秸秆在肉羊生产中的应用,以期为江苏... 详细信息

随着江苏省肉羊产业的快速发展,粗饲料资源缺乏等问题日益凸显。本文总结了江苏省粗饲料资源现状,介绍了粗饲料资源的不同加工处理方法(包括物理法、化学法、生物法、复合处理法),并简要介绍了农作物秸秆在肉羊生产中的应用,以期为江苏省肉羊产业的发展和粗饲料资源的高效开发利用提供参考。

关键词：肉羊粗饲料开发利用

基于列线图模型对慢性乙型肝炎合并肝脏脂肪变性患者并发晚期肝纤维化的临床预测

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中华消化病与影像杂志（电子版） 2024年第2期14卷 114-120页

作者：江浩余宏圣杨碧兰阿布都克尤木·斯马依吴斌杨逸冬中山大学附属第三医院消化内科广州510630 广东省肝病重点实验室广州510630

目的探讨慢性乙型肝炎(CHB)合并肝脏脂肪变性患者并发晚期肝纤维化(S3~S4)的独立危险因素,构建及验证列线图风险预测模型。方法选取2008年8月至2020年12月在中山大学附属第三医院就诊并行经皮肝脏穿刺活检的439例未经抗病毒治疗的CHB合... 详细信息

目的探讨慢性乙型肝炎(CHB)合并肝脏脂肪变性患者并发晚期肝纤维化(S3~S4)的独立危险因素,构建及验证列线图风险预测模型。方法选取2008年8月至2020年12月在中山大学附属第三医院就诊并行经皮肝脏穿刺活检的439例未经抗病毒治疗的CHB合并肝脏脂肪变性患者作为研究对象,按2∶1随机分为训练组293例和验证组146例。采用logistic回归筛选出晚期纤维化的相关危险因素并构建列线图风险预测模型。结果logistic回归分析显示血小板(OR=0.987,P=0.003)、凝血酶原时间(OR=1.952,P=0.011)、球蛋白(OR=1.260,P=0.001)是晚期纤维化的独立危险因素。列线图风险预测模型在训练组中预测晚期纤维化的曲线下面积为0.866,显著优于天冬氨酸转氨酶和血小板比率指数(0.782,P=0.017)、γ-谷氨酰转肽酶/血小板比值(0.753,P=0.004)、肝纤维化4因子指数(0.780,P=0.024)、非酒精性脂肪肝纤维化评分(0.737,P<0.001)、BARD评分(0.595,P<0.005)模型;在验证组中也得到了类似的结果(P<0.05)。校准曲线和决策曲线显示列线图模型具有较高的一致性和临床净收益。结论本研究基于CHB合并肝脏脂肪变性的晚期肝纤维化患者的独立危险因素构建了列线图风险预测模型,经验证,该模型具有较高的预测效能、一致性和临床净收益。

关键词：慢性乙型肝炎非酒精性脂肪性肝病晚期肝纤维化列线图

THE RESEARCH OF THE AIRCRAFT NEUTRAL STABILITY

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Chinese Journal of Aeronautics 1989年第1期 23-31页

作者： yang yidong , Zhang Shumei and Guo Suofeng Nanjing Aeronautical Institute

This paper presents a new fuselage aiming mode of neutral stable aircraft,which is achievedwith the symmetric deflection of flaps and dynamic decoupling for minor disturbance of the angle of *** mode transfers an aircraft’s model from a short-period oscillation model into anon - oscillation model,which then effectively speeds up the dynamic process of the attitude trackingat the area of attacking,decreases the dynamic error,increases the gust- rejection capability apparently ,and achieves the result that the flight path does not change significantly during the process of attitudecontrol,which is the demand of fiiselage aiming mode *** paper takes an aircraft as an example,designs its pitch control system with neutral stabilityand with quasi-neutral *** this paper also gives the corresponding results ofdigital-analog hybrid simulation.

关键词： mode Figure THE RESEARCH OF THE AIRCRAFT NEUTRAL STABILITY NSA NEB

Biotreatment of incinerated bottom ash and biocementation of sand blocks using soybean urease

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 36-46页

作者： Xiaoniu YU yidong XU Jiangsu Key Laboratory of Construction Materials Southeast UniversityNanjing211189China School of Civil Engineering and Architecture NingboTech UniversityNingbo315100China

Because of the high cost of cultivating urease-producing bacteria(UPB),this paper proposes soybean-urease-induced carbonate precipitation(SUICP)as a novel biocement for treatment of nickel contaminants and cementation of sandy *** found the optimal soaking time and soybean-powder content to be 30 min and 130 g/L,respectively,based on a standard of 5 U of urease *** most efficient removal of nickel ions is obtained with an ideal mass ratio of urea to nickel ions to soybean-powder filtrate(SPF)of 1:2.4:*** removal efficiency of nickel ions can reach 89.42%when treating 1 L of nickel-ion solution(1200 mg/L with the optimal mass ratio).In incinerated bottom ash(IBA),the removal efficiency of nickel ions is 99.33%with the optimal mass *** biocemented sandy soil,the average unconfined compressive strength(UCS)of sand blocks cemented with soybean urease-based biocement can reach 118.89 kPa when the cementation level is ***,the average content of CaCO_(3)in sand blocks is 2.52%.As a result,the SUICP process can be applied to remove heavy metal ions in wastewater or solid waste and improve the mechanical properties of soft soil foundations.

关键词： Biocement Soybean-powder filtrate(SPF) Removal efficiency Sandy soil Unconfined compressive strength(UCS)

Optimal use of red cell volume distribution width-to-platelet ratio to exclude cirrhosis in patients with chronic hepatitis B

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Liver Research 2023年第3期7卷 244-251页

作者： Hongsheng Yu Chao Li Mingkai Li Zixi Liang Abdukyamu Smayi Bilan yang Kodjo-Kunale Abassa Jianning Chen Bin Wu yidong yang Department of Gastroenterology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Liver Disease Research GuangzhouGuangdongChina Department of Radiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Pathology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and aims:Hepatitis B virus(HBV)infection is a major public health issue worldwide as it may cause serious liver diseases such as cirrhosis and hepatocellular carcinoma(HCC).Ruling out cirrhosis is important when treating chronic hepatitis B(CHB).The aim of this study was to compare the performance of the aspartate aminotransferase-to-platelet ratio index(APRI),fibrosis score based on four factors(FIB-4),and red cell volume distribution width-to-platelet ratio(RPR)in diagnosing liver fibrosis stages and to identify new cut-off values to rule out ***:Between 2005 and 2020,2182 eligible individuals who underwent liver biopsy were randomly assigned to derivation and validation cohorts in a 6:4 ratio.A grid search was applied to identify optimal cut-off values with a sensitivity of>90% and a negative predictive value(NPV)of at least 95%.Results:Overall,1309 individuals(175 patients with cirrhosis)were included in the derivation dataset,and 873(117 patients with cirrhosis)were included in the validation *** area under the receiver operating characteristic curve of RPR for diagnosing cirrhosis was 0.821,which was comparable to that of APRI(0.818,P=0.7905)and FIB-4(0.803,P=0.2395).When applying an RPR of 0.06,cirrhosis was correctly identified with a sensitivity of 93.1% and an NPV of 97.1%,while it misclassified 12 of 175(6.9%)patients in the derivation *** the validation cohort,RPR had a sensitivity and NPV of 97.4% and 99.0%,respectively,and only misclassified 3 of 117(2.6%)*** analysis indicated that the new RPR cut-off value performed more consistently than that of APRI and FIB-4 in all ***:A recently established cut-off value for RPR(≤0.06)was validated and was more effective than APRI and FIB-4 in excluding patients with cirrhosis due to a higher sensitivity and NPV and a lower misclassification *** simple and dependable test could have significant clinical implications in identifying patients

关键词： Red cell volume distribution width(RDW) Aspartate aminotransferase-to-platelet ratio index(APRI) Fibrosis score based on four factors(FIB-4) Chronic hepatitis B(CHB) Cirrhosis