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三级AO生物接触氧化工艺处理农村生活污水试验

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湖南科技大学学报（自然科学版） 2024年第2期39卷 118-124页

作者：齐晓丹杨秀伟刘俊良李馨娜河北农业大学城乡建设学院河北保定071001

为降低农村污水处理的运行成本,探究最适宜农村污水处理的最佳运行条件,采用三级AO生物接触氧化工艺处理农村生活污水,利用自然跌水的方式来补充溶解氧,并对跌水的影响因子进行试验研究.结果表明:在试验环境温度为24~30℃,pH为7~8,溶解... 详细信息

为降低农村污水处理的运行成本,探究最适宜农村污水处理的最佳运行条件,采用三级AO生物接触氧化工艺处理农村生活污水,利用自然跌水的方式来补充溶解氧,并对跌水的影响因子进行试验研究.结果表明:在试验环境温度为24~30℃,pH为7~8,溶解氧质量浓度为3.0~3.5 mg/L,辅助曝气量为500 L/h,最佳水力停留时间为6 h时,化学需氧量(COD)的平均去除率为88.98%,氨氮的平均去除率为83.56%,总磷的平均去除率为77.78%,达到河北省《农村生活污水排放标准》(DB13/2171—2020)一级标准,并结合Box-Behnken响应曲面模型原理,得出三级生物接触氧化工艺的COD去除率模型学方程.

关键词：农村生活污水接触氧化工艺跌水曝气三级反应器响应曲面模型

基于国家名中医验方“参术止咳丸”院内制剂的研制

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系统医学 2024年第8期9卷 16-20页

作者：王丽娜杨秀微赵继福长春市中医院平阳部肺病科吉林长春130022 长春市中医院专家门诊吉林长春130022

目的优选参术止咳丸的提取工艺及成型工艺,为制剂开发及试生产提供基础研究。方法采用紫外分光光度法建立参术止咳丸制剂质量检测标准。确定参术止咳丸的处方与制备工艺。以重金属、砷盐、性状、水分、重量差异、装量和微生物限量等作... 详细信息

目的优选参术止咳丸的提取工艺及成型工艺,为制剂开发及试生产提供基础研究。方法采用紫外分光光度法建立参术止咳丸制剂质量检测标准。确定参术止咳丸的处方与制备工艺。以重金属、砷盐、性状、水分、重量差异、装量和微生物限量等作为考察指标,对参术止咳丸相关质量进行了检测。结果参术止咳丸在251 nm处有最大吸收峰,在0.0214~0.1824 mg/mL浓度范围内线性关系良好。所制备的参术止咳丸重金属、砷盐、性状、水分、重量差异、装量和微生物限量等各项指标均符合要求。结论本研究开发的参术止咳丸制剂优化了提取工艺及成型工艺,为制剂开发及生产提供基础研究。

关键词：参术止咳丸咳嗽变异性哮喘稳定性制备工艺质量标准

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Simultaneous quantification of evodiamine,rutaecarpine,and dehydroevodiamine in rat cerebrospinal fluid and cerebral nuclei after oral administration by UPLC-MS/MS

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Journal of Chinese Pharmaceutical Sciences 2022年第1期31卷 13-22页

作者： Yanfang yang Yinan Zhang Youbo Zhang xiuwei yang State Key Laboratory of Natural and Biomimetic Drugs Department of Natural MedicinesSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

Evodiamine,rutaecarpine,and dehydroevodiamine have been demonstrated as the major alkaloids in the fruits of Euodia rutaecarpa,a well-known traditional Chinese medicine with central nervous system *** study their cerebrospinal fluid pharmacokinetics and cerebral nuclei distribution,the alkaloids were mixed at the weight ratio of 1:1:1 and orally administered via gavage to the rats at each dose of 15 mg/kg.A quick and reliable ultra-performance liquid chromatographic-tandem mass spectrometry method was developed and applied for the simultaneous analysis of the alkaloids in rat cerebrospinal fluid and cerebral nuclei collected at different time ***-compartmental pharmacokinetic profiles were calculated,and the distribution in cerebral nuclei was *** the tested compounds were absorbed into rat cerebrospinal fluid and distributed to the brain nuclei *** distribution in different nuclei varied,as evodiamine mainly in cerebellum and brainstem,rutaecarpine with its maximum in the brainstem,and dehydroevodiamine mostly in the cerebellum and *** were eliminated from the brain rapidly without long-time *** summary,this study revealed the targeting discrepancy of evodiamine,rutaecarpine,and dehydroevodiamine in the brain,and highlighted the possibility for drug candidates in the encephalopathy treatment of the fruits of ***.

关键词： Evodiamine Rutaecarpine Dehydroevodiamine Cerebrospinal fluid Cerebral nuclei UPLC-MS/MS

苗药五香血藤对痛风性关节炎大鼠体质量及脏器指数的影响

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智慧健康 2024年第2期10卷 166-169,173页

作者：尹雄英杨秀伟帅光平党荣敏黔南民族医学高等专科学校贵州都匀558000

目的分析苗药五香血藤对痛风性关节炎大鼠体质量及脏器指数的影响,并探讨苗药五香血藤对痛风性关节炎的可能作用机制。方法本次研究时间:2019年7月-2022年12月,研究对象为60只大鼠,通过尿酸盐诱导建立急性痛风性关节炎大鼠模型,随机... 详细信息

目的分析苗药五香血藤对痛风性关节炎大鼠体质量及脏器指数的影响,并探讨苗药五香血藤对痛风性关节炎的可能作用机制。方法本次研究时间:2019年7月-2022年12月,研究对象为60只大鼠,通过尿酸盐诱导建立急性痛风性关节炎大鼠模型,随机将其分为6组并对其实施不同措施,包括空白对照组(10只)、模型对照组(10只)、低剂量组(10只,五香血藤63mg/kg)、中剂量组(10只,五香血藤126mg/kg)、高剂量组(10只,五香血藤252mg/kg)、秋水仙碱组(10只,秋水仙碱0.3mg/kg),分析不同模型大鼠的各项指标变化。结果空白对照组与秋水仙碱组无大鼠死亡,其余各组不同程度存在大鼠死亡情况;与空白对照组相比,其余各组大鼠的脏器指数与体重发生不同程度变化,与模型对照组相比,不同用药治疗后大鼠在脏器指数与体重变化特点方面有所不同。与空白对照组相比,不同模型大鼠出现炎症因子水平的升高,其中中等剂量苗药五香血藤对痛风性关节炎大鼠炎症因子抑制情况同秋水仙碱基本一致,低剂量、高剂量苗药五香血藤对痛风性关节炎大鼠炎症因子抑制效果有限,不如中剂量苗药五香血藤(P<0.05)。结论不同剂量苗药五香血藤对痛风性关节炎大鼠体质量及脏器指数的影响不同,同时对炎症因子的抑制效果也有所不同,选择中等剂量苗药五香血藤能够更好地抑制急性痛风性关节炎模型大鼠的炎症因子,同时保证对肝脏、脾脏与肾脏的影响,后续应持续加大对这一方面的研究,为苗药五香血藤治疗痛风性关节炎提供参考。

关键词：苗药五香血藤痛风性关节炎大鼠体质量脏器指数

Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2224-2238页

作者： Youbo Zhang Tingting Yan Tianxia Wang Xiaoyan Liu Keisuke Hamada Dongxue Sun Yizheng Sun Yanfang yang Jing Wang Shogo Takahashi Qiong Wang Kristopher W.Krausz Changtao Jiang Cen Xie xiuwei yang Frank J.Gonzalez State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA School of Life Science and Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking Universitythe Key Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing 100191China

Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been *** ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2 E1 in mice markedly induced adipose browning and increased energy expenditure to improve obesity. CYP2 E1 deficiency activated the expression of hepatic peroxisome proliferator-activated receptor alpha(PPARa) target genes,including fibroblast growth factor(FGF) 21, that upon release from the liver, enhanced adipose browning and energy expenditure to decrease obesity. Nineteen metabolites were increased in Cyp2 e1-null mice as revealed by global untargeted metabolomics, among which four compounds, lysophosphatidylcholine and three polyunsaturated fatty acids were found to be directly metabolized by CYP2 E1 and to serve as PPARa agonists, thus explaining how CYP2 E1 deficiency causes hepatic PPARa activation through increasing cellular levels of endogenous PPARa agonists. Translationally, a CYP2 E1 inhibitor was found to activate the PPARa-FGF21-beige adipose axis and decrease obesity in wild-type mice, but not in liver-specific Pparanull mice. The present results establish a metabolic crosstalk between PPARa and CYP2 E1 that supports the potential for a novel anti-obesity strategy of activating adipose tissue browning by targeting the CYP2 E1 to modulate endogenous metabolites beyond its canonical role in xenobiotic-metabolism.

关键词： CYP2E1 PPARa FGF21 Metabolic enzyme Nuclear receptor Obesity

3种植物生长调节剂对遵义红花椒抑芽控梢及产量的影响

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贵州农业科学 2024年第4期52卷 12-21页

作者：黎礼谦张付豪罗英舰姚华开徐青郑元利杨秀伟李小静贵州省遵义市农业科学研究院贵州遵义563000

【目的】探明植物生长调节剂对遵义红花椒控梢保果效果,为遵义红花椒丰产栽培提供理论依据。【方法】以3年生遵义红花椒树为材料,采用50%噻苯隆(C9H8N4OS)、98%磷酸二氢钾(KH_(2)PO_(4))和8%对氯苯氧乙酸钠(C_(8)H_(6)ClNaO_(3))进行3因... 详细信息

【目的】探明植物生长调节剂对遵义红花椒控梢保果效果,为遵义红花椒丰产栽培提供理论依据。【方法】以3年生遵义红花椒树为材料,采用50%噻苯隆(C9H8N4OS)、98%磷酸二氢钾(KH_(2)PO_(4))和8%对氯苯氧乙酸钠(C_(8)H_(6)ClNaO_(3))进行3因素3水平正交试验设计,以不使用植物生长调节剂为对照(CK),共10个处理,通过对各处理间新梢生长量、单穗座果率变化量、单株产量、单粒直径和百粒重进行极差分析、方差分析和相关性分析,筛选出遵义红花椒抑芽控梢和提升产量的最佳方案。【结果】施用植物生长调节剂KH2PO4、C_(9)H_(8)N_(4)OS和C_(8)H_(6)ClNaO_(3)不同浓度组合对遵义红花椒新梢生长量抑制效果显著(P<0.05)。C_(9)H_(8)N_(4)OS是抑制花椒新梢生长,导致叶片脱落的主要因素。红花椒新梢生长量随C9H8N4OS浓度增加而逐渐减小,但高浓度C9H8N4OS会导致花椒树势衰弱,宜选用0.25 g/L C_(9)H_(8)N_(4)OS作为遵义红花椒的抑芽控梢浓度。KH2PO4是影响遵义红花椒单穗座果率变化量和单株产量的主要因素。单穗座果率变化量和单株产量均以处理2(1.33 g/L KH_(2)PO_(4)+0.25 g/L C_(9)H_(8)N_(4)OS+0.05 g/L C_(8)H_(6)ClNaO_(3))最高,分别为0.68%和2.02 kg。3种植物生长调节剂均不是影响花椒单粒直径和百粒重的主要因素。【结论】遵义红花椒在坐果期喷施1.33 g/L KH_(2)PO_(4)+0.25 g/L C_(9)H_(8)N_(4)OS+0.05 g/L C_(8)H_(6)ClNaO_(3)可有效抑制新梢生长,单穗座果率变化量及单株产量最高,宜在贵州省遵义地区推广使用。

关键词：遵义红花椒产量植物生长调节剂抑芽控梢噻苯隆磷酸二氢钾对氯苯氧乙酸钠

Error analysis of polyamide plate thickness detection based on Terahertz Time Domain System

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太赫兹科学与电子信息学报 2020年第5期18卷 775-779页

作者： yang xiuwei ZHANG Dehai JI Guangyu Key Laboratory of Microwave Remote Sensing Chinese Academy of SciencesBeijing 100190China National Space Science Center Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The analysis on the thickness of polyamide plate using Terahertz Time Domain System(THz-TDS)in reflection mode is carried *** refractive index,one of the optical parameters in terahertz band,is solved through the mathematics model,and its value is 1.88.A kind of polyamide plate sample with four kinds of thickness is designed and the ability of THz-based method to detect defects or foreign bodies in fiber glass is verified by attaching metal plates to the back of *** the comparison of traditional method and THz method,the terahertz method has a measurement error between 2.5%and 10%.As the thickness increases,the error tends to *** reason about the deviations is analyzed,as well as the systematic factors affecting the thickness measurement accuracy,in order to improve the accuracy of THz thickness measurement system and provide theoretical basis for designing terahertz thickness measurement system in the future.

关键词： time-domain spectroscopy thickness testing terahertz imaging

Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway

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Oncology Research 2024年第2期32卷 353-360页

作者： ZHI ZHANG XIAOSONG LI YING ZHANG HAO ZHU ZHENGUO QIAO yang LU xiuwei MI HUIHUA CAO GENHAI SHEN SONGBING HE Department of General Surgery Suzhou Ninth People’s HospitalSuzhou Ninth Hospital Affiliated to Soochow UniversitySuzhouChina Medical College of Nantong University NantongChina Department of Gastroenterology Suzhou Ninth People’s HospitalSuzhou Ninth Hospital Affiliated to Soochow UniversitySuzhouChina Department of General Surgery The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncological Surgery Kunshan Traditional Hospital Affiliated to Nanjing University of Chinese MedicineKunshanChina

Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality *** in melanoma 2(AIM2),a constituent of the interferoninducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family,contributes to both cancer progression and inflammasome *** this understanding,the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain ***,this study endeavors to assess AIM2’s expression levels,explore its potential antitumor effects,elucidate associated cancer-related processes,and decipher the underlying signaling pathways in *** findings showed a reduced AIM2 expression in most CRC cell *** of AIM2 levels suppressed CRC cell proliferation and migration,altered cell cycle by inhibiting G1/S transition,and induced cell *** research uncovered the participation of P38 mitogen-activated protein kinase(P38MAPK)in AIM2-mediated modulation of CRC cell apoptosis and ***,our achievements distinctly underscored AIM2’s antitumor role in ***2 overexpression inhibited proliferation and migration and induced apoptosis of CRC cells via activating P38MAPK signaling pathway,indicating AIM2 as a prospective and novel therapeutic target for CRC.

关键词： Absent in melanoma 2 Proliferation Migration Apoptosis P38MAPK Colorectal cancer

A New Indole Derivative Isolated from the Root of Tuber Fleeceflower(Polygonum multiflorum)

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中草药 1998年第1期29卷 5-11页

作者： yang xiuwei Gu Zheming Ma Chaomei Masao Hattori Tsuneo Namba 北京医科大学天然药物及仿生药物国家重点实验室!北京100083

从何首乌（PolygonummultiflorumThunb.）的根中分离出11个化合物，根据光谱学分析分别鉴定为：大黄酚（chrysophanol，Ⅰ）、大黄素甲醚（physcione，Ⅱ）、大黄素（emodin，Ⅲ）、ω-羟基大黄素（citreorosein，Ⅳ）、大黄酚8－O-β-D... 详细信息

从何首乌（PolygonummultiflorumThunb.）的根中分离出11个化合物，根据光谱学分析分别鉴定为：大黄酚（chrysophanol，Ⅰ）、大黄素甲醚（physcione，Ⅱ）、大黄素（emodin，Ⅲ）、ω-羟基大黄素（citreorosein，Ⅳ）、大黄酚8－O-β-D-吡喃葡萄糖苷（chrysophanol8-O-β-D-glucopyranoside，Ⅴ）、大黄素甲醚8-O-β-D-吡喃葡萄糖苷（Physcione8-O-β-D-glucopyranoside，Ⅵ）、大黄素8-O-β-D-吡喃葡萄糖苷（emodin8-O-β-D-glucopyranoside，Ⅶ）、决明酮8-O-β-D-吡喃葡萄糖苷（torachrysone8-O-β-D-glucopyranoside,Ⅷ）、2，3，5，4′-四羟基芪2-O-β-D-吡喃葡萄糖苷（2，3，5，4′－tetrahydroxystilbene2-O-β-D-glucopyranoside，Ⅸ）、没食子酸甲基酯（methylgallate，Ⅹ）和吲哚-3－（L-α-氨基-α-羟基内酸）甲酯[Indole－3－（L－α－amino－α－hydroxypropionicacid）methylester]。其中，化合物Ⅺ为新的天然产物。上述蒽醌和萘类化合物以及芦荟大黄素（aloe－emodin，Ⅻ）、大黄酸（rhein，）、芦荟大黄素8－O-β-D-吡喃葡萄糖苷（aloe－emodin8－O-β-D－glucopyranoside，）、大黄酚8－O-β-D－（6′－O-丙酰基）吡喃葡萄糖苷（chrysophanol8-O-β-D-（6′－O－malonyl）glucopyra－

关键词：何首乌吲哚衍生物吲哚-3-(L-α-氨基-α-羟基丙酸)甲酯重组HIV-Ⅰ蛋白酶