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Cloning,Characterization and Primary Function Study of a Novel Gene,Cymg1,Related to Family 2 Cystatins

Acta Biochimica et Biophysica Sinica 2005年第1期37卷 11-18页

作者： yang xiang dong-song nie jian wang xiao-jun tan yun deng shu-wei luo guang-xiu lu~* human reproductive and stem cell engineering institute,central south university,changsha 410078,china human reproductive and stem cell engineering institute Central South UniversityChangsha 410078 China

Cystatins are cysteine proteinase inhibitors,We found two expression sequence tags (ESTs),CA463109 and AV042522,from a mouse testis library using Digital differential display (DDD).By electricalhybridization,a novel gene,Cymgl(GenBank accession ***600990),which has a full length of 0.78 kb,and contains four exons and three introns,was cloned from a mouse testis eDNA *** gene is locatedin the 2G3 area of chromosome *** full eDNA encompasses the entire open reading frame,encoding 141amino acid *** protein has a cysteine protease inhibitor domain that is related to the family 2cystatins but lacks critical consensus sites important for cysteine protease *** characteristicsare seen in the CRES subfamily,which are related to the family 2 cystatins and are expressed specifically inthe male reproductive ***1 has a 44%(48/108)identity with mouse CRES and 30%(42/140)identity with mouse cystatin *** blot analysis showed that the Cymgl is specifically expressed inadult mouse *** location studies showed that the GFP-tagged CYMG 1 protein was localized in thecytoplasm of HeLa cells,lmmunohistochemistry revealed that the CYMG1 protein was expressed in mousetestes spermatogonium,spermatocytes,round spermatids,elongating spermatids and ***-PCRresults also showed that Cymgl was expressed in mouse testes and *** Cymgl expressionlevel varied in different developmental stages:it was low 1 week postpartum,steadily increased 2 to 5 weekspostpartum,and was highest 7 weeks *** expression level at 5 weeks postpartum was main-tained during 13 to 57 weeks *** Cymgl expression level in the testes over different develop-mental stages correlates with the mouse spermatogenesis and sexual maturation *** these indicatethat Cymgl might play an important role in mouse spermatogenesis and sexual maturation. Cystatins are cysteine proteinase inhibitors,We found two expression sequence tags(EST

关键词： cystatins gene cloning testis spermatogenesis sexual maturation

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core shuangxue deng wei-Tian deng Zhi deng Ziyan deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi dong jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research institute Co. LtdBeijing Beijing institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu central china Normal university WuhanHubei central south university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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一个新的睾丸特异表达基因的克隆及功能的初步分析(英文)

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Acta Genetica Sinica 2005年第4期32卷 337-345页

作者：聂东宋朱文兵向阳王建谭小军邓云卢光琇中南大学生殖与干细胞工程研究所长沙410078

运用'数据库消减杂交'(digital differential display )方法来筛选人类睾丸特异表达新基因,获得了有差异显示的代表新基因的克隆重叠群.挑选其中一个克隆重叠群HS.326528进行多组织RT-PCR,初步获得该重叠群在人睾丸中有高表达.从该重叠... 详细信息

运用'数据库消减杂交'(digital differential display )方法来筛选人类睾丸特异表达新基因,获得了有差异显示的代表新基因的克隆重叠群.挑选其中一个克隆重叠群HS.326528进行多组织RT-PCR,初步获得该重叠群在人睾丸中有高表达.从该重叠群的IMAGE出发,采用生物信息学的方法快速克隆了一个人类新基因的全长cDNA序列,其全长1 044 bp,开放阅读框为214～529 bp,定位于15q26.2,编码由105个氨基酸组成、分子量为11.7 kD、等电点为10.09的一个碱性蛋白,该蛋白与已知蛋白无明显的同源性,克隆实验证明该基因的阅读框完全正确,RT-PCR和Northern blot显示该基因在人类睾丸中特异表达,实时PCR结果表明:该基因在成人睾丸中高表达,在精子中有中度表达,在胚胎睾丸中低表达,推测该基因与精子的生成有关,命名为SRG8(homo sapiens spermatogenesis -related gene 8)(GenBank登录号:AY489187),该基因编码的蛋白定位于细胞核.流式结果分析表明,SRG8基因能够促使HeLa细胞由S期向G2期的转变,从而加速细胞的分裂.这些结果表明SRG8基因可能在睾丸的发育及精子的形成过程中起重要的作用.

关键词：数据库消减杂交睾丸实时定量PCR 组织特异表达

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lung-protective Ventilation in Patients with Brain Injury： A Multicenter Cross-sectional Study and Questionnaire Survey in china

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Chinese Medical Journal 2016年第14期129卷 1643-1651页

作者： Xu-Ying luo Ying-Hong Hu xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong wang Rong-Guo Yu xiang-You Yu Xia Zhang Bao-Shan Li Zeng-xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen wei Chen Wen-Jin Chen xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu yun-Feng Hoang Gui-jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-dong wang jian Xiong Li-Mei Yan Zheng-Ping yang Chen-Ming dong dong-Xin wang Qing-Yuan Zhan shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-guang Xie xiao-Bo Huang Guo-Bin Zhang wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu xiao-Feng yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin yang guang-Qiang Chen xiu-Mei Sun jian-Xin Zhou Department of Critical Care Medicine Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Critical Care Medicine General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China Neurological Intensive Care Unit Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Guangdong General Hospital Guangzhou Guangdong 510000 China Surgical Intensive Care Unit Fujian Province Hospital Fuzhou Fujian 350000 China Department of Critical Care Medicine First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Critical Care Medicine Bethune International Peace Hospital Shijiazhuang Hebei 050000 China Department of Critical Care Medicine Yuncheng Central Hospital Yuncheng Shanxi 044000 China Department of Emergency and Critical Care Medicine Cangzhou People's Hospital Cangzhou Hebei 061000 China Department of Critical Care Medicine Beijing Luhe Hospital Capital Medical University Beijing 101100 China Department of Critical Care Medicine First Hospital of China Medical University Shenyang Liaoning 110000 China Department of Critical Care Medicine Shanghai Changzheng Hospital Shanghai 200000 China Department of Critical Care Medicine Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Critical Care Medicine Miyun County Hospital Beijing 100038 China Medical Intensive Care Unit Peking Union Medical College Hospital Beijing 101500 China Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 Chin

Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, among brain-injured patients in china. Methods： This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units （ICUs） across china. Mechanically ventilated patients （18 years and older） with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV. Results： A total of 104 patients were enrolled in the present study, 87 （83.7%） of whom were identified with severe brain injury based on a Glasgow Coma Scale 〈8 points. Synchronized intermittent mandatory ventilation （SIMV） was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg （interquartile range [IQR], 7.0-8.9 ml/kg） of the predicted body weight; 50 （48.1%） patients received LPV. The median positive end-expiratory pressure （PEEP） was set to 5 cmH20 （IQR, 5-5 cmH20）. No PEEP values were higher than 10 cmH20. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not. Conclusions： Among brain-injured patients in china, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.

关键词： Brain Injury Epidemiology lung-protective Ventilation Mechanical Ventilation

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Biomarkers of aging

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Science china(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao jiani Cao Mengting Chen Min Chen wei Chen xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding junlin Feng jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu xiaoqian Liu Zuojun Liu Oscar junhong luo jianwei Lv Jingyi Ma Kehang Mao Jiawei nie Xinhua Qiao Xinpei Sun xiaoqiang tang jianfang wang Qiaoran wang Siyuan wang Xuan wang Yaning wang Yuhan wang Rimo Wu Kai Xia Fu-Hui xiao Lingyan Xu Yingying Xu Haoteng Yan Liang yang Ruici yang Yuanxin yang Yilin Ying Le Zhang weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen jun Chen weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu xianghang luo shuai Ma Xinran Ma Zhiyong Mao Jing nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi song Zhou songyang Yi Eve Sun Yu Sun Mei Tian shusen wang Si wang Xia wang xiaoning wang Yan-jiang wang yunfang wang Catherine CL Wong Andy Peng xiang Yichuan xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang weiqi Zhang Yong Zhang yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu weiguo Zou Gang Pei guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of stem cell and reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China stem cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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Consensus statement on layout and delivery of automatic external defibrillator in china

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Journal of Hainan Medical university 2020年第15期26卷 18-23页

作者： Yu Cao song Chen Yan-Fen Chai xiao-Hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-wei Cheng Bang-Han Ding yang deng Jie Fu Bang-jiang Fang Mai-Ying Fan Li Gui Ping Gong wei Guo shu-Bin Guo Liang Huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-jun jiang wang-xiang jiang Jia-Liang Liu xiao-Ran Liu Zhi Liu Chuan-Zhu Lv Feng lu tan-Shi Li Xin Li Yong Li Shang-lun Li shuang-Ming Li xiao-Gang Li Bao-jun Li Pei-Wu Li Chun-Sheng Li Zhi-jun Li Chang-luo Li xiang-Min Li Yin-Ping Li Zong-jun lu Zu-Xun lu Zhong-Qiu lu Zhi-Qian luo xiao-Xing Liao jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma Lin-Hao Ma jun-Qi Ma Shi-Nan nie Jie-Miao Ou-yang Peng Peng Qiao Pei shu-Ming Pan Guo-Zhong Qing Li-Jie Qin Wu-Ying Qiao Fei Shao wei song Xing-Yue song Zhen-Ju song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian Ying-Ping Tian jian-guang Tian Chao-yang Tong Zi-Ren tang Meng-Xiong tang Guo-Ping Wu Zhi Wan Tao wang Xin wang Peng wang Zhong wang Tong wang Ri-Xing wang Yi-Xin wang xiao-Dan wang Ling Wu wei wei Hua xiang Feng Xu jun Xu Jie Xu Miao-Rong Xie shuo-Gui Xu Tie Xu Feng Yu Wen Yi Li-Shan yang Shi-Jiao Yan Jin-jian Yao Shou-Chun Yan Xue-Zhong Yu Xian-Zhi Ye Xian-Liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu Hua-dong Zhu Ji-Hong Zhu Hong Zhang Mao Zhang Hua Zhang Na Zhang Guo-Qiang Zhang Guo-xiu Zhang Jin-song Zhang Wen-Wu Zhang Wen-Zhong Zhang jian-Feng Zhang Yi-Min Zhu jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao xiao-dong Zhao xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical university

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in china[2].

关键词： cardiac death respiratory

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新型冠状病毒肺炎药物预防、诊断、治疗与出院管理循证临床实践指南(更新版)

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解放军医学杂志 2020年第10期45卷 1003-1031页

作者：靳英辉詹庆元彭志勇任学群尹训涛蔡林袁玉峰岳冀蓉张笑春杨启文纪建光夏剑李一荣周福祥高亚东余追徐峰涂明利谭力铭杨旻陈芳张晓菊曾玫朱渝刘新灿杨简赵东赤丁玉峰侯宁汪付兵陈昊张永刚李玮陈文施月仙杨秀芝王学军钟燕军赵明娟李柄辉马琳璐訾豪王娜王云云余绍福李路遥黄桥翁鸿任相颖罗丽莎范曼如黄笛薛竑飏余临心高锦萍邓通曾宪涛李宏军程真顺姚晓梅王行环无武汉大学中南医院循证与转化医学中心武汉430071 中日友好医院国家呼吸系统疾病临床研究中心北京100029 中日友好医院呼吸与危重症医学科北京100029 武汉雷神山医院武汉430200 武汉大学中南医院重症医学科武汉430071 河南大学循证医学与临床转化研究院河南开封475000 贵州省人民医院医学影像科贵阳550002 武汉大学中南医院骨科武汉430071 武汉大学中南医院肝胆外科武汉430071 四川大学华西医院国家老年疾病临床医学研究中心成都610041 四川大学华西医院老年医学中心成都610041 武汉大学中南医院医学影像中心武汉430071 中国医学科学院/北京协和医学院检验学系北京协和医院检验科北京100730 瑞典隆德大学临床研究中心/斯科讷大学医院马尔默25002 武汉大学中南医院急救中心武汉403371 武汉大学中南医院过敏反应科武汉403371 武汉大学中南医院肿瘤放化疗科武汉403371 武汉大学人民医院重症医学科武汉430060 山东大学齐鲁医院急诊科与胸痛中心济南250002 湖北医药学院附属随州市中心医院呼吸与重症医学科湖北随州441300 湖南省怀化市第二人民医院药学部湖南怀化418000 安徽医科大学第二附属医院重症医学科合肥230601 郑州大学医院内科郑州450001 河南省人民医院呼吸与危重症医学科郑州450003 复旦大学附属儿科医院感染传染科上海201102 四川大学华西第二医院感染科成都610041 河南中医药大学第一附属医院心内科郑州450000 三峡大学人民医院/宜昌市第一人民医院心内科湖北宜昌443000 武汉大学中南医院儿科武汉430071 华中科技大学同济医学院附属同济医院药学部武汉430030 山东第一医科大学附属省立医院/山东省立医院药学部济南250021 南京中医药大学教育部针药结合重点实验室南京210023 四川大学华西医院华西期刊社成都610041 青岛大学附属烟台毓璜顶医院检验医学中心山东烟台264000 十堰市太和医院(湖北医药学院附属医院)医学影像中心湖北十堰442000 北京大学护理学院北京100191 开封市中心医院呼吸与危重症医学科河南开封475000 北京电力医院急诊科北京100073 中南大学湘雅二医院重症医学科长沙410008 武汉大学中南医院泌尿科武汉430071 武汉大学中南医院血液科武汉430071 河南大学医学院护理与健康学院河南开封475000 山西医科大学护理学院太原030001 首都医科大学北京佑安医院放射诊断科北京100069 武汉大学中南医院呼吸与危重症医学科武汉430071 麦克马斯特大学卫生研究方法证据及影响系安大略省哈密尔顿市L8S 4L8加拿大中国医疗保健国际交流促进会循证医学分会中国研究型医院学会

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)导致的新型冠状病毒肺炎(COVID-19)自暴发以来迅速在全球蔓延,造成数以千万人感染及数十万患者死亡。基于研究证据的临床实践指南是诊治COVID-19的有力武器。在疫情早期阶段,该团队制定并发布... 详细信息

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)导致的新型冠状病毒肺炎(COVID-19)自暴发以来迅速在全球蔓延,造成数以千万人感染及数十万患者死亡。基于研究证据的临床实践指南是诊治COVID-19的有力武器。在疫情早期阶段,该团队制定并发布了《新型冠状病毒(2019-nCoV)感染的肺炎诊疗快速建议指南(标准版)》。疫情暴发后大量相关临床研究陆续开展并发表,新的证据可能会改变以前的推荐意见,更新指南的时机已经成熟。因此,该团队成立了由临床专家和方法学家组成的工作组,通过咨询一线临床专家提出并确定了与COVID-19管理相关的29个临床问题。通过系统检索有关COVID-19预防及诊疗的直接证据,使用GRADE方法评估证据质量并制订推荐意见,最终形成34条建议,其中6条强推荐,14条弱推荐,3条弱不推荐,11条为基于共识的建议;共涵盖4个方面,分别为药物预防,诊断(包括临床表现、RT-PCR检测、呼吸道标本、IgM和IgG抗体检测、CT检查、胸部X线片及无症状感染的CT特征),治疗方法[包括洛匹那韦-利托那韦、阿比朵尔、法匹拉韦、干扰素、瑞德西韦、抗病毒药的组合、羟氯喹/氯喹、白介素-6抑制剂、白介素-1抑制剂、糖皮质激素、清肺排毒汤、连花清瘟胶囊/颗粒、康复者血浆、肺移植、有创或无创通气、体外膜肺氧合支持(ECMO)]以及出院管理(包括复阳患者管理及出院标准)。此外,还制订了针对推荐意见的指南实施工具流程图,以期有力支持医护人员对COVID-19患者的照护。

关键词：新型冠状病毒肺炎 2019新型冠状病毒感染性疾病临床实践指南循证医学

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新型冠状病毒肺炎药物预防、诊断、治疗与出院管理临床指南计划书

引用

医学新知 2020年第3期30卷 209-226页

作者：靳英辉李宏军詹庆元彭志勇袁玉峰蔡林尹训涛岳冀蓉杨启文纪建光夏剑李一荣周福祥高亚东余追徐峰张笑春涂明利谭力铭任学群杨旻陈芳张晓菊曾玫朱渝刘新灿杨简赵东赤丁玉峰侯宁汪付兵陈昊张永刚李玮陈文施月仙杨秀芝王学军钟燕军邓通高锦萍余绍福范曼如薛竑飏余临心李柄辉李路遥马琳璐任相颖王娜翁鸿赵明娟訾豪黄笛罗丽莎黄桥王云云曾宪涛程真顺姚晓梅王行环武汉大学中南医院循证与转化医学中心武汉430071 武汉大学循证与转化医学中心武汉430071 首都医科大学附属北京佑安医院影像中心北京100069 中日友好医院国家呼吸系统疾病临床研究中心北京100029 中日医院呼吸与危重症医学科北京100029 武汉雷神山医院武汉430200 武汉大学中南医院重症医学科武汉430071 贵州省人民医院医学影像科贵阳550002 四川大学华西医院国家老年疾病临床医学研究中心成都610041 四川大学华西医院老年医学中心成都610041 中国医学科学院/北京协和医学院检验学系·北京协和医院检验科北京100730 瑞典隆德大学临床研究中心·斯科讷大学医院瑞典马尔默25002 武汉大学中南医院急救中心武汉430071 武汉大学中南医院医学检验科武汉430071 武汉大学中南医院肿瘤放化疗科武汉430071 武汉大学中南医院过敏反应科武汉430071 武汉大学人民医院重症医学科武汉430060 山东大学齐鲁医院急诊科与胸痛中心济南250002 武汉大学中南医院医学影像中心武汉430071 湖北医药学院附属随州市中心医院呼吸与重症医学科湖北随州441300 湖南省怀化市第二人民医院药学部湖南怀化418000 河南大学循证医学与临床转化研究院河南开封475000 安徽医科大学第二附属医院重症医学科合肥230601 郑州大学医院内科郑州450001 河南省人民医院呼吸与危重症医学科郑州450003 复旦大学附属儿科医院感染传染科上海201102 四川大学华西第二医院感染儿科成都610041 河南中医学院第一附属医院心脏中心郑州450000 三峡大学人民医院·宜昌市第一人民医院心内科湖北宜昌443000 武汉大学中南医院儿科武汉430071 华中科技大学同济医学院附属同济医院药学部武汉430030 山东第一医科大学附属省立医院·山东省立医院药学部济南250021 南京中医药大学教育部针药结合重点实验室南京210023 四川大学华西医院华西期刊社成都610041 青岛大学附属烟台毓璜顶医院检验医学中心山东烟台264000 十堰市太和医院(湖北医药学院附属医院)医学影像中心湖北十堰442000 北京大学护理学院北京100191 开封市中心医院呼吸与危重症医学科河南开封475000 北京电力医院急诊科北京100073 中南大学湘雅二医院重症医学科长沙410008 山西医科大学护理学院太原030001 河南大学医学院护理与健康学院河南开封475000 武汉大学中南医院呼吸与危重症医学科武汉430071 麦克马斯特大学卫生研究方法证据及影响系加拿大安大略省哈密尔顿市L8S 4L8

本计划书为《新型冠状病毒(2019-nCoV)感染的肺炎诊疗快速建议指南(标准版)》更新版的研究方案。计划书涵盖指南制定方法学、指南的目标用户、指南的目标人群、利益冲突调查与声明、临床问题和结局指标的遴选与确定、证据的检索、合成... 详细信息

本计划书为《新型冠状病毒(2019-nCoV)感染的肺炎诊疗快速建议指南(标准版)》更新版的研究方案。计划书涵盖指南制定方法学、指南的目标用户、指南的目标人群、利益冲突调查与声明、临床问题和结局指标的遴选与确定、证据的检索、合成与评价、证据与推荐意见分级标准、推荐意见的形成、指南的更新,并附录指南临床问题清单、文献检索策略及利益冲突调查表。

关键词：新型冠状病毒新型冠状病毒肺炎药物预防诊断治疗出院管理临床实践指南

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