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中西医结合视角下《伤寒论》“六经病篇”提要

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中国中医急症 2024年第4期33卷 713-716,720页

作者：陈腾飞汤阳刘清泉首都医科大学附属北京中医医院北京100010 北京中医药大学北京100027

“六经病篇”构成了《伤寒论》之主体内容,笔者结合ICU中西医结合救治重症感染性疾病、新发突发传染病等的临床经验体会,认为“六经病篇”是多种感染性疾病诊疗经验之整合。太阳病篇论述了各类外感病初期发汗法及禁忌证,以及发汗后基础... 详细信息

“六经病篇”构成了《伤寒论》之主体内容,笔者结合ICU中西医结合救治重症感染性疾病、新发突发传染病等的临床经验体会,认为“六经病篇”是多种感染性疾病诊疗经验之整合。太阳病篇论述了各类外感病初期发汗法及禁忌证,以及发汗后基础病种加重等变证之应对;阳明病篇论述了外感病中“发热、汗出、恶热”为主之病症,并详论了下法之应用时机、力度、禁忌等,旁及阳明中寒病、谷疸病等;少阳病篇之意义在于后世医家之发挥和推广;太阴病篇主要叙述了具有自限性的急性胃肠炎;少阴病篇主要论述了表现为中医“寒邪直中”和“伏气温病”之重症感染,亦涉及了较多之“下利”;厥阴病篇论述了表现为“热深厥深”之感染性休克,亦涉及病情危重之“下利”。

关键词：六经病重症感染中西医结合《伤寒论》

Bioinspired nanomaterials for the treatment of bacterial infections

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Nano Research 2024年第2期17卷 691-714页

作者： Xiaojing Ma Wenjing tang Rong yang Robert F.Smith School of Chemical&Biomolecular Engineering Cornell UniversityIthacaNY 14853USA

Infectious diseases pose a serious threat to global health.Although immunizations can control most viral infections,bacterial infections,particularly those caused by drug-resistant strains,continue to cause high rates of illness and death.Unfortunately,the creation of new antibiotics has come to a grinding halt in the last ten years.In response to this crisis,nanotechnology has emerged as a hopeful solution to tackle drug resistance and enhance treatment results.A large variety of biomimetic nanomaterials,termed nanozymes,have demonstrated strong antimicrobial efficacy.While the inherent toxicity of nanomaterials is a concern,recent studies have harnessed the stimuli-responsiveness of nanomaterials to enable local and/or targeted delivery to reduce the treatment side effects.Indeed,the physicochemical versatility of nanomaterials affords many degrees of freedom that enable rational design of smart or autonomous therapeutics,which cannot be achieved using conventional antibiotics.The design straddles the fields of catalysis,nanoscience,microbiology,and translational medicine.To provide an overview of this interdisciplinary landscape,this review is organized based on composition into lipid,metal,metal oxide,and non-metallic nanomaterials.Liposomes as a delivery vehicle enhance bioavailability and reduce toxicity.Metal-and metal oxide-based nanomaterials inhibit bacterial growth by mimicking natural enzymatic activities such as peroxidase(POD)and oxidase.Furthermore,carbon-,polymer-,and cell membrane-based nanomaterials are combined into a discussion on non-metallic materials.At the end of this review,potentially fruitful directions for future bioinspired nanomaterials in infectious disease treatment are included.

关键词： bioinspired nanomaterial bacteria infectious disease antimicrobial liposome nanozyme

A missense variant of MASP2 is associated with increased risk of radiation pneumonitis in lung cancer patients treated with radiation therapy

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Oncology and Translational Medicine 2020年第5期6卷 193-199页

作者： yang tang Li yang Wan Qin Minxiao Yi Bo Liu Xianglin Yuan Department of Oncology Tongji HospitalHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology Tongji HospitalHuazhong University of Science and TechnologyWuhan 430030China

Objective In this study,mannan-binding lectin-associated serine protease 2(MASP2)gene variant was evaluated to assess the risk of radiation pneumonitis(RP)in patients with pulmonary malignancies.Methods A total of 169 lung cancer patients with radiotherapy were included in our prospective study(NCT02490319)and genotyped using the Sanger sequencing method.Multivariate Cox hazards analysis and multiple testing were applied to estimate the hazard ratio(HR)and 95%confidence intervals(CIs)of all factors possibly associated with RP risk.Results Patients with mean lung disease≥15 Gy and V20≥24%had higher risk of RP≥grade 2 compared with their counterparts(HR=1.888,95%CI:1.186-3.004,P=0.007;HR=2.126,95%CI:1.338-3.378,P=0.001,respectively).Importantly,CC+CA genotype of MASP2:rs12711521 was strongly associated with an increased occurrence of RP≥grade 2(HR=1.949,95%CI:1.278-2.971,P=0.002).Conclusion MASP2:rs12711521 was found to be significantly associated with RP≥grade 2 in our cohort and may thus be one of the important predictors of severe RP before radiotherapy,if further validated in larger population.

关键词： radiation pneumonitis lung cancer mannan-binding lectin-associated serine protease 2(MASP2) Single Nucleotide Polymorphisms(SNP)

BaTiO_(3)-based ceramics with high energy storage density

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Rare Metals 2023年第4期42卷 1261-1273页

作者： yang Li Ming-yang tang Zhong-Gang Zhang Qi Li Jing-Lei Li Zhuo Xu Gang Liu Fei Li Electronic Materials Research Lab Key Lab of Education Ministry and State Key Laboratory for Mechanical Behavior of MaterialsSchool of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an710049China Laboratory of Micro/Nano Systems for Aerospace Ministry of EducationNorthwestern Polytechnical UniversityXi’an710072China School of Materials and Energy Southwest UniversityChongqing400715China

BaTiO_(3)ceramics are difficult to withstand high electric fields,so the energy storage density is relatively low,inhabiting their applications for miniaturized and lightweight power electronic devices.To address this issue,we added Sr_(0.7)Bi_(0.2)TiO_(3)(SBT)into BaTiO_(3)(BT)to destroy the long-range ferroelectric domains.Ca^(2+)was introduced into BT-SBT in the form of CaTiO_(3)(CT),which has the effect of inhibiting the movement of A-site defects to reduce dielectric loss and refining the grains to increase the breakdown field strength.In addition,we have increased the density and grain uniformity of ceramics by repeated rolling of the green samples through the viscous polymer processing(VPP),to further increase the breakdown electric field.The BT-SBT-CT ceramics exhibit the high recoverable energy storage density of 4.0 J·cm^(-3)under electric field of 480 kV·cm^(-1).Its recoverable energy storage density varies by less than 8%in the temperature range of 30-150℃,indicating good temperature stability of the energy storage performance.In this work,the energy storage performance of barium titanate-based ceramics was greatly improved by transforming ferroelectrics into relaxor ferroelectrics and VPP method,which can bring new inspiration for the research of energy storage ceramics.

关键词： Barium titanate Energy storage Viscous polymer processing(VPP)

Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula

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Journal of Traditional Chinese Medical Sciences 2021年第4期8卷 309-316页

作者： Jingang Liu Yan Sun Huimin Yuan Yuda Li Jing Feng Yushan Gao yang tang Shujing Zhang Hang Wang Fengjie Zheng School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD.

关键词： Atopic dermatitis Mahuang Lianqiao Chixiaodou decoction Correspondence between pattern and formula elements Skin barrier

Functional characterization of Bmcap in uric acid metabolism in the silkworm

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Insect Science 2024年第1期31卷 147-156页

作者： Linmeng tang Dehong yang Zhiwei Liu Yaohui Wang Xu yang Yujia Liu Dongbin Chen Zheng tang Yongping Huang Key Laboratory of Insect Developmental and Evolutionary Biology Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghaiChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina Central Research Institute Shanghai Pharmaceuticals Holding Co.Ltd.ShanghaiChina Departments of Neonatology International Peace Maternity and Child Health Hospital of China Welfare InstitutionSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

After a millennium of domestication,numerous silkworm mutants have emerged that exhibit transparent epidermis,which is caused by abnormally low levels of uric acid.We identified the Bombyx mori gene Bmcap(BMSK0003832)as the homolog of cappuccino,a subunit of the biogenesis of lysosome-related organelles complex-1(BLOC-1)that has been extensively characterized in human,mouse,and insect species,by analyzing the amino acid sequences of putative purine metabolism genes.Using the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9 system,we disrupted Bmcap,resulting in decreased uric acid levels in the silkworm epidermis and a translucent skin phenotype.In the Bmcap mutant,the purine metabolism,nitrogen metabolism,pyrimidine metabolism,and membrane system were altered compared to the wild type.Biogenesis of lysosome-related organelle complex genes play a role in the pigmentation and biogenesis of lysosome-related organelles(LROs)in platelets,melanocytes,and megakaryocytes.LROs exhibit unique morphologies and functions in various tissues and cells.Investigation of the Bmcap mutant will enhance our understanding of the uric acid metabolic pathway in silkworms,and this mutant offers a valuable silkworm model for LRO studies.

关键词： BLOC-1 subunit Bombyx mori cappuccino translucent mutation uric acid

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基于UKF算法的电动汽车车速坡度估计

内燃机与配件 2024年第5期 12-14页

作者：华仲让唐阳山徐莉辽宁工业大学辽宁锦州121001

精准的车辆车速与道路坡度,是实现车辆驱动防滑控制系统研究的关键,本文考虑到转弯工况,建立转向与道路坡度耦合的混合工况模型,运用UKF算法进行车速坡度联合估计,该算法融合了运动学与动力学两种方式,并且基于MATLAB/Simulink与Carsim... 详细信息

精准的车辆车速与道路坡度,是实现车辆驱动防滑控制系统研究的关键,本文考虑到转弯工况,建立转向与道路坡度耦合的混合工况模型,运用UKF算法进行车速坡度联合估计,该算法融合了运动学与动力学两种方式,并且基于MATLAB/Simulink与Carsim搭建联合仿真平台,对所设计的混合工况车速和坡度的估计器与控制策略进行了仿真验证,比传统估计方法精度更高,响应速度以及鲁棒性更好。

关键词：混合工况 UKF算法车速坡度联合估计联合仿真

代综方对肥胖小鼠白色脂肪组织糖原代谢的影响

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中国中医药信息杂志 2024年第2期31卷 90-96页

作者：张莉唯刘喜明付守强冯慧汤阳徐婧朱晓云中国中医科学院广安门医院北京100053 北京中医药大学北京100029 南京中医药大学江苏南京210023

目的观察代综方对肥胖小鼠脂肪组织糖原代谢的影响,探讨其激活白色脂肪组织棕色化的调控机制。方法采用高脂饲料喂养C57BL/6J小鼠建立肥胖模型,将成模小鼠分为模型组、二甲双胍组(0.15 g/kg)和代综方低(0.20 g/kg)、高(0.40 g/kg)剂量组... 详细信息

目的观察代综方对肥胖小鼠脂肪组织糖原代谢的影响,探讨其激活白色脂肪组织棕色化的调控机制。方法采用高脂饲料喂养C57BL/6J小鼠建立肥胖模型,将成模小鼠分为模型组、二甲双胍组(0.15 g/kg)和代综方低(0.20 g/kg)、高(0.40 g/kg)剂量组,另取常规维持饲料喂养的小鼠作为正常组,每组12只,各给药组分别予相应药物灌胃,连续6周。测量小鼠体质量及空腹血糖,检测血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量,取肩胛棕色脂肪组织及腹股沟、肾周、附睾白色脂肪组织,分别测定脂肪组织质量并计算体脂系数,HE染色观察脂肪组织形态变化,PAS染色观察脂肪组织糖原分布,免疫组化染色检测腹股沟白色脂肪组织糖原合成酶2(Gys2)、蛋白磷酸酶1调节亚基3c(Ppp1r3c)、糖原合酶激酶(GSK)-3β表达。结果与正常组比较,模型组小鼠各时点体质量和空腹血糖均显著升高(P<0.05,P<0.01),血清TC、HDL-C含量显著升高(P<0.01);腹股沟、肾周、附睾白色脂肪组织质量及体脂系数显著升高(P<0.01),腹股沟白色脂肪组织细胞肥大、呈大空泡样,糖原积累较少,Gys2、Ppp1r3c表达显著降低(P<0.01)。与模型组比较,代综方高剂量组小鼠给药4、6周体质量和空腹血糖均显著降低(P<0.05,P<0.01),血清TG、TC、HDL-C、LDL-C含量均显著降低(P<0.01);肾周、附睾白色脂肪组织质量及体脂系数显著降低(P<0.05,P<0.01),腹股沟白色脂肪组织质量显著降低(P<0.05),腹股沟白色脂肪组织可见多处形态不规则的小空泡,周围伴有细胞核聚集,糖原积累增加,Gys2、Ppp1r3c阳性表达显著升高(P<0.01)。各组小鼠腹股沟白色脂肪组织GSK-3β表达差异无统计学意义。结论代综方可通过上调Ppp1r3c表达提高Gys2活性,促进糖原合成,诱导脂肪组织棕色化,增加脂肪产热,改善肥胖及相关糖脂代谢紊乱。

关键词：肥胖代综方脂肪组织糖原合成小鼠

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基于模糊变换的多模型速度结果融合

内燃机与配件 2024年第6期 125-127页

作者：朱娜唐阳山甘恬张康辽宁工业大学汽车与交通工程学院辽宁锦州121001 辽宁正大司法鉴定中心辽宁营口115000

在不确定分析基础上,为融合多源模型事故再现速度结果,本文提出一种基于模糊变换的多模型结果融合方法。首先对多模型事故再现速度结果离散化,采用K-means聚类获得聚类结果,以各聚类区间数据极值作子区间;根据熵值法得到各模型的信度,... 详细信息

在不确定分析基础上,为融合多源模型事故再现速度结果,本文提出一种基于模糊变换的多模型结果融合方法。首先对多模型事故再现速度结果离散化,采用K-means聚类获得聚类结果,以各聚类区间数据极值作子区间;根据熵值法得到各模型的信度,用最小信息熵原理将D-S证据理论融合得到的各专家对模型的打分融入到熵值法模型信度中去,对其进行修正;最后以模型信度为权重集与评判矩阵作模糊变换进行综合评判,得最终融合结果。并通过一真实事故案例进行实际应用。

关键词：多模型事故速度结果熵值法 D-S证据理论最小信息熵模糊变换