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Clinical outcomes of people living with human immunodeficiency virus(HIV)with diffuse large B-cell lymphoma(DLBCL)in Shanghai,China

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Chinese Medical Journal 2020年第23期133卷 2796-2802页

作者： Jian-Jun Sun Li Liu Jiang-Rong Wang Yin-Zhong Shen tang-Kai Qi Zhen-Yan Wang yang tang Wei Song Jun Chen Ren-Fang Zhang Department of Infection and Immunity Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China

Background:Numerous studies have focused on lymphoma among patients infected with human immunodeficiency virus(HIV).However,little is known about the treatment options and survival rate of lymphoma in the Chinese people living with HIV(PLHIV).Our study aimed to investigate the prognosis and compare outcome of dose-adjusted etoposide,prednisone,vincristine,cyclophosphamide,doxorubicin,and rituximab(DA-EPOCH-R)with standard cyclophosphamide,doxorubicin,vincristine,prednisone and rituximab(R-CHOP)as front line therapy for PLHIV with diffuse large B-cell lymphoma(DLBCL)receiving modern combined antiretroviral therapy(cART).Methods:A retrospective analysis evaluating PLHIV with DLBCL was performed in Shanghai Public Health Clinical Center from July 2012 to September 2019.The demographic and clinical data were collected,and overall survival(OS)and progression-free survival(PFS)analyses of patients receiving R-CHOP or DA-EPOCH-R therapy were performed by Kaplan-Meier analysis.Additionally,a Cox multiple regression model was constructed to identify related factors for OS.Results:A total of 54 eligible patients were included in the final analysis with a median follow-up of 14 months(interquartile range[IQR]:8-29 months).The proportion of high international prognostic index(IPI)patients was much larger in the DA-EPOCH-R group(n=29)than that in the R-CHOP group(n=25).The CD4 cell counts and HIV RNA levels were not significantly different between the two groups.The 2-year OS for all patients was 73%.However,OS was not significantly different between the two groups,with a 2-year OS rate of 78%for the DA-EPOCH-R group and 66%for the R-CHOP group.Only an IPI greater than 3 was associated with a decrease in OS,with a hazard ratio of 5.0.The occurrence of grade 3 and 4 adverse events of chemotherapy was not significantly different between the two groups.Conclusions:Outcomes of R-CHOP therapy do not differ from those of DA-EPOCH-R therapy.No HIV-related factors were found to be associated with the OS of PLHIV in the modern cART er

关键词： Diffuse large B-cell lymphoma HIV infection Overall survival Progression free survival

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Eff ect of Cementation on Calcium Carbonate Precipitation of Loose Sand Resulting from Microbial Treatment

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Transactions of Tianjin University 2017年第6期23卷 547-554页

作者： yang tang Jijian Lian Guobin Xu Yue Yan Hongyin Xu State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin University Tianjin 300072China

Microbe-induced calcite precipitation is a sustainable improvement technique for sandy soil, which can alter the properties of sand via microbial activity. In this study, we investigated the loose-sand-consolidation eff ect by controlling the injection velocity, bacterial and cementingsolution concentrations, and hold times. The results demonstrate that, as the cyclic batch increases, the utilization rate of the bacterial fl uid increases and both the optical density(OD_(600)) of the bacteria and urease activity decrease. Moreover, it was determined that a 3-h hold time for a 0.5 mol/L cementing solution with a cementing fl uid velocity of 2 mL/min has the greatest bonding eff ect. The fi nal strength of the loose sand with an increase in calcium carbonate content was further discussed.

关键词： Microbe-induced calcite precipitation Consolidation effect Urease CO2 volume evaluation method Loose sand

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Risk factors affecting the mortality of HIVinfected patients with pulmonary tuberculosis in the cART era:a retrospective cohort study in China

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Infectious Diseases of Poverty 2018年第1期7卷 255-263页

作者： Yong-Jia Ji Pei-Pei Liang Jia-Yin Shen Jian-Jun Sun Jun-yang yang Jun Chen tang-Kai Qi Zhen-Yan Wang Wei Song yang tang Li Liu Ren-Fang Zhang Yin-Zhong Shen Hong-Zhou Lu Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityNo.2901 Cao Lang RdJinshan DistrictShanghai 201508China Department of Infectious Disease Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Internal Medicine Shanghai Medical CollegeFudan UniversityShanghai 200032China

Background:Tuberculosis infection still places a great burden on HIV-infected individuals in China and other developing countries.Knowledge of the survival of HIV-infected patients with pulmonary tuberculosis(PTB)would provide important insights for the clinical management of this population,which remains to be well described in current China.Methods:HIV-infected patients with PTB admitted to Shanghai Public Health Clinical Center from January 2011 to December 2015 were retrospectively enrolled.In this cohort,the survival prognosis was estimated by the Kaplan-Meier method,while univariate and multivariate Cox proportional hazards models were used to determine the risk factors affecting mortality.Results:After reviewing 4914 admitted patients with HIV infection,359 PTB cases were identified.At the time of PTB diagnosis,the patients’median CD4+T cell count was 51/mm3(IQR:23-116),and 27.30%of patients(98/359)were on combination antiretroviral therapy(cART).For the 333 cases included in the survival analysis,the overall mortality was 15.92%(53/333)during a median 27-month follow-up.The risk factors,including age older than 60 years(HR:3.18;95%CI:1.66-6.10),complication with bacterial pneumonia(HR:2.64;95%CI:1.30-5.35),diagnosis delay(HR:2.60;95%CI:1.42-4.78),CD4+T cell count less than 50/mm3(HR:2.38;95%CI:1.27-4.43)and pulmonary atelectasis(HR:2.20;95%CI:1.05-4.60),might independently contribute to poor survival.Among patients without cART before anti-TB treatment,the later initiation of cART(more than 8 weeks after starting anti-TB treatment)was found to increase the mortality rate(OR:4.33;95%CI:1.22-15.36),while the initiation of cART within 4-8 weeks after starting anti-TB treatment was associated with the fewest deaths(0/14).Conclusions:The subjects in this study conducted in the cART era were still characterized by depressed immunological competence and low rates of cART administration,revealing possible intervention targets for preventing TB reactivation in HIV-infected individuals under current circumstances.F

关键词： HIV infections Acquired immunodeficiency syndrome Pulmonary tuberculosis Survival analysis

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Clinical features and treatment outcomes of human immunodeficiency virus-associated cryptococcal meningitis:a 2-year retrospective analysis

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Chinese Medical Journal 2020年第23期133卷 2787-2795页

作者： Wei Song Yin-Zhong Shen Zhen-Yan Wang tang-Kai Qi Li Liu Ren-Fang Zhang Jiang-Rong Wang yang tang Jun Chen Jian-Jun Sun Hong-Zhou Lu Department of Infection and Immunity Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China

Background:Cryptococcal meningitis(CM)is one of the most common opportunistic infections caused by Cryptococcus neoformans in human immunodeficiency virus(HIV)-infected patients,and is complicated with significant morbidity and mortality.This study retrospectively analyzed the clinical features,characteristics,treatment,and outcomes of first-diagnosed HIV-associated CM after 2-years of follow-up.Methods:Data from all patients(n=101)of HIV-associated CM hospitalized in Shanghai Public Health Clinical Center from September 2013 to December 2016 were collected and analyzed using logistic regression to identify clinical and microbiological factors associated with mortality.Results:Of the 101 patients,86/99(86.9%)of patients had CD4 count<50 cells/mm^3,57/101(56.4%)were diagnosed at≥14 days from the onset to diagnosis,42/99(42.4%)had normal cerebrospinal fluid(CSF)cell counts and biochemical examination,30/101(29.7%)had concomitant Pneumocystis(carinii)jiroveci pneumonia(PCP)on admission and 37/92(40.2%)were complicated with cryptococcal pneumonia,50/74(67.6%)had abnormalities shown on intracranial imaging,amongst whom 24/50(48.0%)had more than one lesion.The median time to negative CSF Indian ink staining was 8.50 months(interquartile range,3.25-12.00 months).Patients who initiated antiretroviral therapy(ART)before admission had a shorter time to negative CSF Indian ink compared with ART-naïve patients(7 vs.12 months,χ^2=15.53,P<0.001).All-cause mortality at 2 weeks,8 weeks,and 2 years was 10.1%(10/99),18.9%(18/95),and 20.7%(19/92),respectively.Coinfection with PCP on admission(adjusted odds ratio[AOR],3.933;95%confidence interval[CI],1.166-13.269,P=0.027)and altered mental status(AOR,9.574;95%CI,2.548-35.974,P=0.001)were associated with higher mortality at 8 weeks.Conclusion:This study described the clinical features and outcomes of first diagnosed HIV-associated CM with 2-year follow-up data.Altered mental status and coinfection with PCP predicted mortality in HIV-associated CM.

关键词： Clinical features Cryptococcal meningitis HIV Intracranial lesions Mortality

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自然资源问责审计对水污染治理效率的影响研究

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重庆理工大学学报（社会科学） 2024年第5期38卷 112-125页

作者：李学峰唐洋黄小龙南华大学经济管理与法学学院湖南衡阳421001

作为一项重大的改革措施,领导干部自然资源资产离任审计(简称“自然资源问责审计”)在推进环境保护、资源节约方面具有重要作用。基于2005—2017年我国271个城市的面板数据,使用双重差分模型考察自然资源问责审计与水污染治理效率之间... 详细信息

作为一项重大的改革措施,领导干部自然资源资产离任审计(简称“自然资源问责审计”)在推进环境保护、资源节约方面具有重要作用。基于2005—2017年我国271个城市的面板数据,使用双重差分模型考察自然资源问责审计与水污染治理效率之间的关系。研究表明:自然资源问责审计的实施显著提高了水污染治理效率,经过一系列稳健性检验,结果依然成立。进一步研究发现,中央环保督察是自然资源问责审计提高试点城市水污染治理效率的调节机制。在南方地区与水污染治理效率较低的地区,自然资源问责审计发挥的作用更加显著,且与动态面板数据估计方法的结果与之吻合。因此,加强自然资源问责审计结果运用、强化地方官员水污染治理主体责任意识、实施动态的差异化政策,有助于推动我国水污染防治。

关键词：自然资源问责审计水污染治理效率双重差分模型中央环保督察环境保护

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Regio- and （E）-Stereoselective Triborylation of Propargylic Carbonates

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Chinese Journal of Chemistry 2017年第8期35卷 1251-1262页

作者： Zheng yang Tao Cao Yulin Han Weilong Lin Qi Liu yang tang Yizhan Zhai Minqiang Jia Wanli Zhang Tonghao Zhu Shengming Ma State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China University of Chinese Academy of Sciences Beijing 100049 China Department of Chemistry Fudan University 220 Handan Lu Shanghai 200433 China

An efficient synthesis of （E）-alken-1,2,3-triboronates form readily available propargylic carbonates is described. The reaction enjoys excellent regio- and E-selectivity and many synthetically useful functional groups can be tolerated. Based on mechanistic studies, a two-step mechanism via 1,2-allenyl boronate intermediate is proposed.

关键词： palladium copper propargylic carbonate triborylation

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Efficacy of autologous bone marrow mononuclear cell transplantation therapy in patients with refractory diabetic peripheral neuropathy

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Chinese Medical Journal 2019年第1期132卷 11-16页

作者： Hong Mao Wei Wei Xiu-Li Fu Jing-Jian Dong Xiao-Yu Lyu Ting Jia yang tang Shi Zhao Department of Endocrinology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014China Department of Economics Nanyang Technological UniversitySingapore 637332Singapore

Background:Owing to the multifactorial nature of the pathogenesis of diabetic peripheral neuropathy (DPN),conventional drug therapies have not been effective.The application of stem cells transplantation may be useful for the treatment of DPN.This study was designed to assess the safety and therapeutic effects of autologous bone marrow mononuclear cells (BMMNCs) transplantation on the treatment of refractory DPN.Methods:One hundred and sixty-eight patients with refractory DPN were recruited and enrolled in the study.They received intramuscular injection of BMMNCs and followed at 1,3,6,12,18,24,and 36 months after the transplantation.Clinical data,Toronto Clinical Scoring System (TCSS),and nerve conduction studies (NCSs) were compared before and after the transplantation.Results:The signs and symptoms of neuropathy were significantly improved after BMMNCs transplantation.The values of the TCSS scores at 1 month (9.68 ± 2.49 vs.12.55 ± 2.19,P<0.001) and 3 months (8.47 ± 2.39 vs.12.55 ± 2.19,P<0.001) after the treatment reduced significantly compared with the baseline value.This decrement remained persistent until the end of the study.The conduction velocity and action potential and sensory nerves were significantly improved after transplantation (3 and 12 months after the treatment vs.the baseline:motor nerve conduction velocity,40.24 ± 2.80 and 41.00 ± 2.22 m/s vs.38.21 ± 2.28 m/s,P<0.001;sensory nerve conduction velocity,36.96 ± 2.26 and 39.15 ± 2.61 m/s vs.40.41 ± 2.22 m/s,P<0.001;compound muscle action potential,4.67 ± 1.05 and 5.50 ± 1.20 μV vs.5.68 ± 1.08 μV,P<0.001;sensory nerve action potential,4.29 ± 0.99 and 5.14 ± 1.26 μV vs.5.41 ± 1.14 μV,P<0.001).No adverse event associated with the treatment was observed during the follow-up period.Conclusions:Autologous transplantation of BMMNCs may be an effective and promising therapeutic strategy for the treatment of refractory DPN.

关键词： Bone marrow mononuclear cells diabetic peripheral neuropathy autologous transplantation Toronto clinical scoring system nerve conduction

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Ni掺杂Ba_(0.5)Sr_(0.5)(Co_(0.8)Fe_(0.2))_(1−x)Ni_(x)O_(3−δ)质子陶瓷燃料电池阴极的制备及电化学性能研究

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陶瓷学报 2024年第3期45卷 475-482页

作者：绳阳周晓亮刘立敏何非凡唐阳蒋星洲西南石油大学化学化工学院四川成都610000

通过镍掺杂策略改善了传统混合离子—电子导电氧化物Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3−δ)(BSCF)在质子陶瓷燃料电池(PCFCs)中的电化学性能。采用溶胶—凝胶法成功制备了Ba_(0.5)Sr_(0.5)(Co_(0.8)Fe_(0.2))_(1−x)Ni_(x)O_(3−δ)系列材料,并研究了Ba_(0.5)Sr_(0.5)(Co_(0.8)Fe_(0.2))_(0.9)Ni_(0.1)O_(3−δ)(BSCFN10)阴极与电解质BaZr_(0.1)Ce_(0.7)Y_(0.2)O_(3−δ)(BZCY)之间的化学相容性和稳定性。通过构建对称电池评估电极的催化活性,结果表明BSCFN10阴极比BSCF具有更优越的催化活性。在700℃下含有3%水蒸气的氢气氛围内,相较于未掺杂的BSCF,BSCFN10阴极的峰值功率密度从380 mW·cm^(-2)提升到503 mW·cm^(-2),极化阻抗从0.21Ω·cm^(2)降低到0.12Ω·cm^(2)。此外,BSCFN10电极在电流密度为0.4 A·cm^(-2)下表现出良好的工作稳定性。实验表明BSCFN10阴极在PCFCs中具有良好的应用性能。

关键词： PCFCs BSCF阴极,过渡金属镍掺杂

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Spatial distribution of soil moisture,salinity and organic matter in Manas River watershed,Xinjiang,China

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Journal of Arid Land 2012年第4期4卷 441-449页

作者： Jilili ABUDUWAILI yang tang Mireban ABULIMITI DongWei LIU Long MA State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geography Chinese Academy of Sci-ences Urumqi 830011 China College of Resources and Environmental Science Xinjiang University Urumqi 830011 China Inner Mongolia University Hohhot 010021 China

With the classical statistical and geostatistical methods, the study of the spatial distribution and its in- fluence factors of soil water, salinity and organic matter was carried out for 0-70 cm soil layers in Manas River watershed. The results showed that the soil moisture data from all soil layers exhibited a normal distribution, with average values of 14.08%-21.55%. Geostatistical analysis revealed that the content of soil moisture had a moder- ate spatial autocorrelation with the ratios of nugget/sill ranging from 0.500 to 0.718, which implies that the spatial pattern of soil moisture is influenced by the combined effects of structural factors and random factors. Remarkable spatial distributions with stripped and mottled features were found for soil moisture in all different soil layers. The landform and crop planting had a relatively big influence on the spatial distribution of soil moisture; total soil salinity was high in east but low in west, and non-salinized soil and lightly salinized soil appeared at the northwest and southwest of the study area. Under the effect of reservoir leakage, the heavily salinized soils are widely distributed in the middle of the study area. The areas of the non-salinized and lightly salinized soils decreased gradually with soil depth increment, which is contrary to the case for saline soils that reached a maximum of 245.67 km2 at the layer of 50-70 cm. The types of soil salinization in Manas River watershed were classified into four classes： the sulfate, chloride-sulfate, sulfate-chloride and chloride. The sulfate salinized soil is most widely distributed in the surface layer. The areas of chloride-sulfate, sulfate-chloride, and chloride salinized soils increased gradually along with the increment of soil depth; the variation range of the average values of soil organic matter content was be- tween 7.48%-11.33%. The ratios of nugget/sill reduced gradually from 0.698 to 0.299 with soil depth increment, which shows that the content of soil organic matter has a moderate spatial

关键词： soil water and salt organic matter spatial distribution Manas River watershed

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注册制改革效果研究文献综述--基于定价效率视角

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商业观察 2024年第8期10卷 109-112页

作者：唐洋曹冠群天津商业大学会计学院天津300134

全面推行注册制对深化资本市场改革有着深远意义,其在定价效率上的改革效果至关重要。文章基于定价效率视角,总结注册制改革内容特征及各板块差异性内容,按照科创板、创业板以及多板块研究划分文献,并分别立足于一级市场和二级市场梳理... 详细信息

全面推行注册制对深化资本市场改革有着深远意义,其在定价效率上的改革效果至关重要。文章基于定价效率视角,总结注册制改革内容特征及各板块差异性内容,按照科创板、创业板以及多板块研究划分文献,并分别立足于一级市场和二级市场梳理分析注册制改革对定价效率的影响和作用机制,在归纳总结研究结论的基础上进一步提出可能的研究内容。

关键词：注册制定价效率改革效果文献综述

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