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Chinese Chemical Letters 2023年第4期34卷 484-488页

作者： Shuguang Fu Xiaojun Yin yang tang Guohua Xie Chuluo yang Shenzhen Key Laboratory of New Information Display and Storage Materials College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Department of ChemistryWuhan UniversityWuhan 430072China

Self-doping cathode interfacial layers(CILs) with both favorable electron injection and transport characteristics meet the key requirement for realizing high-performance optoelectronic devices with simplified structures. Herein, four different polypyridinium salts with tunable backbones, side chains and counterions are elaborately designed to afford them desirable film-forming property, polarity, structural rigidity and self-doping feature. All-solution-processed red quantum dot light-emitting diodes(QLEDs) employing them as bifunctional CILs render remarkably improved device performances in contrast to the typical CIL material of poly[(9,9-bis(30-(N,N-dimethylamino)propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)](PFN).The maximum external quantum efficiency of 2.74% achieved in this work represents one of the best values among the all-solution-processed QLEDs with individual organic CILs.

关键词： Self-doping Cathode interfacial layer QLED Pyridinium salts All-solution-processable

Performance monitoring of non-gaussian chemical processes with modes-switching using globality-locality preserving projection

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Frontiers of Chemical Science and Engineering 2017年第3期11卷 429-439页

作者： Xin Peng yang tang Wenli Du Feng Qian Key Laboratory of Advanced Control and Optimization for Chemical Process Ministry of Education East China University of Science and Technology Shanghai 200237 China

In this paper, we propose a novel performance monitoring and fault detection method, which is based on modified structure analysis and globality and locality preserving （MSAGL） projection, for non-Gaussian processes with multiple operation conditions. By using locality preserving projection to analyze the embedding geometrical manifold and extracting the non-Gaussian features by independent component analysis, MSAGL preserves both the global and local structures of the data simultaneously. Furthermore, the tradeoff parameter of MSAGL is tuned adaptively in order to find the projection direction optimal for revealing the hidden structural information. The validity and effectiveness of this approach are illustrated by applying the proposed technique to the Tennessee Eastman process simulation under multiple operation conditions. The results demonstrate the advantages of the proposed method over conventional eigendecomposition-based monitoring methotis.

关键词： non-Gaussian processes subspace projection independent component analysis locality preserving projection finite mixture model

Mechanism of Huatan Sanjie Fang in improving goiter in Graves'disease mice based on the Hippo signaling pathway

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 289-295页

作者： Huimin Yuan Wenxin Ma Yifei Song Hang Wang Shuxin Yan Silan Hao Xiaoyun Zhu yang tang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China

Objective:To explore the mechanism of Huatan Sanjie Fang(HTSJ)in regulating goiter in Graves'disease(GD)mice by detecting key factors of the Hippo signaling pathway.Methods:A mouse model of GD was established by injecting Ad-TSHR289 adenovirus into the bilateral quadriceps femoris of female mice.Successful mouse models were then randomly divided into a model group,methimazole(MMI)group,and HTSJ group,and fed with deionized water,MMI(4.5 mg/kg per day),and HTSJ(35.10 g/kg per day),respectively,for 10 weeks.Histopathological changes of the thyroid gland were subsequently observed by hematoxylin-eosin staining.Radioimmunoassay was used to detect serum total thyroxine(T4)and thyrotrophin-receptor antibody(TRAb)levels.The relative expression of mRNA of Mst1,YAP,and TAZ were detected by quantitative real-time polymerase chain reaction,while the protein expression of Mst1,YAP,TAZ,pMst1,and pYAP were detected by western blot.Results:After 10 weeks of drug intervention,goiter and other pathological changes in the HTSJ group significantly improved compared with the model group,and the levels of serum T4 and TRAb significantly decreased(P=.002,P<.001,respectively).Decreased mRNA expression of Mst1,YAP,and TAZ,the key factors of the Hippo signaling transduction pathway,was also observed(P=.002,P=.022,P<.001,respectively).In contrast,protein expression of Mst1(P=.046),pMst1(P=.026),and p YAP(P=.004)increased,while protein expression of YAP and TAZ decreased(P=.041,P<.001,respectively).Conclusion:HTSJ can effectively improve goiter in GD mice through the Hippo signaling pathway.

关键词： Graves'disease Huatan Sanjie Fang Goiter Hippo signaling pathway Organ size Graves'disease model methimazole YAP

Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes

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Molecular Plant 2022年第2期15卷 308-321页

作者： Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin yang tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhou 510405China College of Agriculture Heilongjiang Bayi Agricultural UniversityDaqing 163000China Department of Agriculture Northeast Agricultural UniversityHarbin 150000China Soybean Research Institute National Engineering Research Center for SoybeanJilin Academy of Agricultural SciencesChangchun 130033China National Center for Soybean Improvement National Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural UniversityNanjing 210095China The Innovative Academy of Seed Design Key Laboratory of Soybean Molecular Design BreedingNortheast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081China

Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication.

关键词： soybean wild natural selection artificially selection latitude adaptation flowering time

Antiretroviral therapy-naïve people living with HIV tend to have more severe symptoms of COVID-19

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Chinese Medical Journal 2023年第22期136卷 2753-2755页

作者： Jinfeng Sun Rui Jiang Yueming Shao Jingjing Hu Zhihang Zheng Luling Wu Li Liu Junyang yang Yinzhong Shen Renfang Zhang tangkai Qi Jianjun Sun Zhenyan Wang yang tang Wei Song Shuibao Xu Bihe Zhao Jun Chen Department of Infection and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China

To the Editor:Coronavirus disease 2019(COVID-19),instigated by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has manifested as a formidable global pandemic,precipitating significant economic implications and leading to extensive mortalities.Simultaneously,the acquired immune deficiency syndrome(AIDS)epidemic caused by the human immunodeficiency virus(HIV)persists as a salient global health exigency.Cumulatively by the termination of 2022,AIDS-related pathologies accounted for approximately 40.4 million fatalities,with an extant global HIV population of roughly 39 million people living with HIV(PLWH),as a potentially immunocompromised population,have received limited attention in the realm of COVID-19 research.

关键词： acute termination living

Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis

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Signal Transduction and Targeted Therapy 2022年第3期7卷 869-880页

作者： Yu Jin Yalin Kang Minghuan Wang Bili Wu Beibei Su Han Yin yang tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei Wang Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 Hubei ProvinceChina Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 Hubei ProvinceChina Institute of Experimental Immunology University Clinic of Rheinische Friedrich-Wilhelms-UniversityBonnGermany

Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mech... 详细信息

关键词： metastasis JAK2 NSCLC STAT3

Arabidopsis NF-YCs Mediate the Light-Controlled Hypocotyl Elongation via Modulating Histone Acetylation

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Molecular Plant 2017年第2期10卷 260-273页

作者： yang tang Xuncheng Liu Xu Liu Yuge Li Keqiang Wu Xingliang Hou Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement & Guangdong Provincial Key Laboratory of Applied Botany South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China University of the Chinese Academy of Sciences Beijing 100049 China Institute of Plant Biology College of Ufe Science National Taiwan University Taipei 106 Taiwan These authors contributed equally to this article.

Light is a crucial environmental signal that promotes photomorphogenesis, the developmental process with a series of light-dependent alterations for plants to adapt various external challenges. Chromatin modification has been proposed to be involved in such light-mediated growth, but the underlying mecha- nism is still elusive. In this study, we identified four Arabidopsis thaliana Nuclear Factor-YC homologs, NF- YCl, NF-YC3, NF-YC4, and NF-YC9 （NF-YCs）, which function redundantly as repressors of light-controlled hypocotyl elongation via histone deacetylation. Obvious etiolation phenotypes are observed in NF-YCs loss-of-function mutant seedlings grown under light conditions, including significant elongated hypocotyls and fewer opened cotyledons. We found that NF-YCs interact with histone deacetylase HDA15 in the light, co-target the promoters of a set of hypocotyl elongation-related genes, and modulate the levels of histone H4 acetylation on the associated chromatins, thus repressing gene expression. In contrast, NF-YC-HDA15 complex is dismissed from the target genes in the dark, resulting in increased level of H4 acetylation and consequent etiolated growth. Further analyses revealed that transcriptional repression activity of NF-YCs on the light-controlled hypocotyl elongation partially depends on the deacetylation activity of HDA15, and loss of HDA15 function could rescue the short-hypocotyl phenotype of NF-YCs overexpression plants. Taken together, our results indicate that NF-YCl, NF-YC3, NF-YC4, and NF-YC9 function as tran- scriptional co-repressors by interacting with HDA15 to inhibit hypocotyl elongation in photomorphogen- esis during the early seedling stage. Our findings highlight that NF-YCs can modulate plant development in response to environmental cues via epigenetic regulation.

关键词： photomorphogenesis hypocotyl elongation NF-YC histone deactylation

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人体工频电场受特高压输电线的影响研究

铁道建筑技术 2024年第3期 27-29,95页

作者：唐阳中铁建电气化局集团南方工程有限公司湖北武汉430000

在我国电力系统领域中,对特高压输电系统的研究越来越重视。输电线周围区域的工频电场强度受输送的电压幅值影响,当幅值较大时,其产生的强电场会对人体产生危害。文中使用三维仿真软件建立输电线和人体仿真模型,对人体周围区域的工频电... 详细信息

在我国电力系统领域中,对特高压输电系统的研究越来越重视。输电线周围区域的工频电场强度受输送的电压幅值影响,当幅值较大时,其产生的强电场会对人体产生危害。文中使用三维仿真软件建立输电线和人体仿真模型,对人体周围区域的工频电场强度和电流密度分布进行模拟仿真,分析其受输电线的影响规律;并依据相关限值标准,结合仿真得到的输电线路电场分布云图,提出了输电线路下的安全区域。

关键词：特高压输电工频电场人体电流密度电场分布

郑渝高铁工程接触网动态检测中发现的问题及整改措施(上)

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铁道技术监督 2024年第4期52卷 52-55,65页

作者：唐阳中铁建电气化局集团南方工程有限公司湖北武汉430073

针对郑渝高铁郑州—万州段联调联试过程中发现的接触网问题,介绍接触网动态评价方法,分析问题成因,提出相应整改措施。经验收发现:通过实施整改措施,消除了接触网接触线高度、拉出值、相邻定位点高差、同一跨内相邻吊弦点高差等动态缺陷... 详细信息

针对郑渝高铁郑州—万州段联调联试过程中发现的接触网问题,介绍接触网动态评价方法,分析问题成因,提出相应整改措施。经验收发现:通过实施整改措施,消除了接触网接触线高度、拉出值、相邻定位点高差、同一跨内相邻吊弦点高差等动态缺陷,改善了接触线硬点及燃弧缺陷,接触网动态参数符合Q/CR 841—2021《接触网动态检测评价方法》要求。整改措施不仅可用于指导既有线接触网缺陷整治工作,还可为接触网设计施工提供参考。

关键词：郑渝高铁接触网联调联试整改措施

健康中国视域下高校公共体育教学模式优化路径研究

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当代体育科技 2024年第5期14卷 58-61,66页

作者：唐杨西南林业大学体育学院云南昆明650223

高等院校的公共体育课程在推动健康中国战略、落实健康教育理念、促进学生身心健康等方面具有重要的地位和作用。随着新时代的发展和社会需求的变化,高校公共体育课程教学模式面临着一系列挑战。该文旨在从健康中国的视域出发,对高校公... 详细信息

高等院校的公共体育课程在推动健康中国战略、落实健康教育理念、促进学生身心健康等方面具有重要的地位和作用。随着新时代的发展和社会需求的变化,高校公共体育课程教学模式面临着一系列挑战。该文旨在从健康中国的视域出发,对高校公共体育教学模式进行研究,并提出相关建议,以期提高高校公共体育课教学效果和质量,满足学生的健康发展需求。

关键词：健康公共体育高等教育体育教学