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Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications

中华医学杂志(英文版) 2024年第10期137卷 1151-1159页

作者： Zhang Chunlan Qin Yun Wu Yu Xu Heng shu yang Department of Hematology West China Hospital Sichuan University Chengdu Sichuan China Department of Radiology West China Hospital Sichuan University Chengdu Sichuan China Department of Laboratory Medicine/Research Center of Clinical Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan China Department of Biotherapy State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu Sichuan China Institute of General Surgery West China Hospital Sichuan University Chengdu Sichuan China Department of General Surgery Gastric Cancer Center and Laboratory of Gastric Cancer West China Hospital Sichuan University Chengdu Sichuan China

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a well-established oncogenic long non-coding RNA, the higher expression of which is strongly correlated with cancer events such as tumorigenesis, progression, metastasis, drug resistance, and treatment outcome in solid cancers. Recently, a series of studies has highlighted its potential role in hematological malignancies in terms of these events. Similar to solid cancers,MALAT1 can regulate various target genes via sponging and epigenetic mechanisms, but the miRNAs sponged byMALAT1 differ from those identified in solid cancers. In this review, we systematically describe the role and underlying mechanisms ofMALAT1 in multiple types of hematological malignancies, including regulation of cell proliferation, metastasis, stress response, and glycolysis. Clinically,MALAT1 expression is related to poor treatment outcome and drug resistance, therefore exhibiting potential prognostic value in multiple myeloma, lymphoma, and leukemia. Finally, we discuss the evaluation ofMALAT1 as a novel therapeutic target against cancer in preclinical studies.

关键词： Long non-coding RNA MALAT1 Hematological malignancies Tumorigenesis Metastasis Drug resistance Prognostic biomarker

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Physiochemical and biological characteristics of fouling on landfill leachate treatment systems surface

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Journal of Environmental Sciences 2024年第1期135卷 59-71页

作者： Zhourui Gong shu yang Rui Zhang yangqing Wang Xiaoqing Wu Liyan Song School of resources and environmental engineering Anhui UniversityHefei 230601China Anhui Shengjin Lake Wetland Ecology National Long-term Scientific Research Base Dongzhi 247230China Key Laboratory of Three Gorges Reservoir Region’s Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China Xing Lu Huan Jing Co.LTD. Luzhou 646000China

Fouling of landfill leachate,a biofilm formation process on the surface of the collection system,migration pipeline and treatment system causes low efficiency of leachate transportation and treatment and increases cost for maintenance of those facilities.In addition,landfill leachate fouling might accumulate pathogens and antibiotic resistance genes(ARGs),posing threats to the environment.Characterization of the landfill leachate fouling and its associated environmental behavior is essential for the management of fouling.In this study,physicochemical and biological properties of landfill leachate fouling and the possible accumulation capacity of pathogens and ARGs were investigated in nitrification(aerobic condition)and denitrification(anaerobic condition)process during landfill leachate biological treatment,respectively.Results show that microbial(bacterial,archaeal,eukaryotic,and viral)community structure and function(carbon fixation,methanogenesis,nitrification and denitrification)differed in fouling under aerobic and anaerobic conditions,driven by the supplemental leachate water quality.Aerobic fouling had a higher abundance of nitrification and denitrification functional genes,while anaerobic fouling harbored a higher abundance of carbon fixation and methanogenesis genes.Both forms of leachate fouling had a higher abundance of pathogens and ARGs than the associated leachate,suggesting the accumulation capacity of fouling on biotic pollutants.Specifically,aerobic fouling harbored three orders of magnitude higher multidrug resistance genes mex D than its associated leachate.This finding provides fundamental knowledge on the biological properties of leachate fouling and suggests that leachate fouling might harbor significant pathogens and ARGs.

关键词： Landfill leachate fouling Biofilm Microbiome Carbon and nitrogen cycle Pathogens Antibiotic resistance genes

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Two-component dimers of ultracold atoms with center-of-mass-momentum dependent interactions

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Communications in Theoretical Physics 2024年第4期76卷 153-157页

作者： Yaru Liu shu yang Peng Zhang Department of Physics Renmin University of ChinaBeijing 100872China Graduate School of China Academy of Engineering Physics Beijing 100193China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China

In a previous paper[Phys.Rev.A95,060701(R)(2017)],we demonstrated that a new type of two-body interaction,which depends on the center of mass(CoM)momentum,can be realized for ultracold atoms via laser-modulated magnetic Feshbach resonance(MFR).Further studies(e.g.L He et al,Phys.Rev.Lett.120,045302(2018))show that various interesting phenomena,such as Fulde–Ferrell superfluids,can be induced by scattering between ultracold atoms with this interaction.In this work we investigate the shallow bound states of two ultracold atoms with this type of interaction.We show that when the magnetic field B is below the MFR point B0,two shallow bound states can appear in this system.Namely,a'two-component dimer'or a dimer with pseudo-spin 1/2 can be formed by two atoms.Furthermore,the dispersion curve of the dimer may have either single or double minimums in the CoM momentum space.The latter case can be explained as a result from significant pseudo-spin-orbital coupling(SOC)effects.Our results show that the ultracold gases with CoM momentum dependent interaction may be a candidate for quantum simulations with ultracold two-component molecules,especially the molecule gases with SOC.

关键词： center-of-mass-momentum dependent interaction Raman-laser modulated MFR two-component dimer

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Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： yang Le Mei ZHENG Qi LIU Xiao Jia LI Xian Xian Veronica Lim CHEN Qi ZHAO Zhong Hua WANG shu yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,respectively.Dual-luciferase reporter gene assay was used to determine the target gene of miR-224-5p.The protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western blot.Flow cytometry was used to detect cell cycle and apoptosis.Cell proliferation was measured by CCK8 and EdU assay.Results The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC stage.CRC cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or paracrine.Moreover,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC tissues.Interestingly,ULK2 inhibited CRC cell proliferation in a p53-dependent manner.Furthermore,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC cells.Conclusion Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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Cutting Behavior of Cortical Bone in Different Bone Osteon Cutting Angles and Depths of Cut

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 80-91页

作者： Yuanqiang Luo Yinghui Ren yang shu Cong Mao Zhixiong Zhou Z.M.Bi College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High-performance Mechanical Equipment Changsha University of Science and TechnologyChangsha 410114China Department of Civil and Mechanical Engineering Purdue University Fort WayneFort WayneIN 46805USA

Cortical bone is semi-brittle and anisotropic,that brings a challenge to suppress vibration and avoid undesired fracture in precise cutting process in surgeries.In this paper,a novel analytical model is proposed to represent cortical bone cutting processes.The model is utilized to predict the chip formations,material removal behavior and cracks propagation under varying bone osteon cutting angles and depths.Series of orthogonal cutting experiments were conducted on cortical bone to investigate the impact of bone osteon cutting angle and depth of cut on cutting force,crack initialization and propagation.The observed chip morphology highly agreed with the prediction of chip formation based on the analytical model.The curly,serrated,grainy and powdery chips formed when the cutting angle was set as 0°,60°,90°,and 120°,respectively.Cortical bone were removed dominantly by shearing at a small depth of cut from 10 to 50μm,and by a mixture of pealing,shearing,fracture and crushing at a large depth of cut over 100μm at different bone osteon angles.Moreover,its fracture toughness was calculated based on measured cutting force.It is found that the fluctuation of cutting force is suppressed and the bone material becomes easy to remove,which attributes to lower fracture toughness at bone osteon cutting angle 0°.When the cutting direction develops a certain angle to bone osteon,the fracture toughness increases then the crack propagation is inhibited to some extent and the fluctuation of cutting force comparatively decreases.There is a theoretical and practical significance for tools design and operational parameters choice in surgeries.

关键词： Bone cutting surgery Orthogonal cutting models Anisotropic materials Chip formation Crack initialization and propagation Fracture toughness

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Einstein-Bumblebee引力理论中的Kerr-Sen-like黑洞玻色子隧穿辐射

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物理学报 2024年第4期73卷 60-68页

作者：谭霞杨树政齐鲁师范学院物理与电子工程学院济南250200 西华师范大学物理与天文学院南充637002

Lorentz-breaking理论不仅对弯曲时空背景有影响,而且对于在弯曲时空中的玻色子和费米子的动力学方程都有一定的修正.因此,我们需要在不同的黑洞时空中对玻色子和费米子的量子隧穿辐射进行适当的修正.从而得到经过Lorentz-breaking理论... 详细信息

Lorentz-breaking理论不仅对弯曲时空背景有影响,而且对于在弯曲时空中的玻色子和费米子的动力学方程都有一定的修正.因此,我们需要在不同的黑洞时空中对玻色子和费米子的量子隧穿辐射进行适当的修正.从而得到经过Lorentz-breaking理论修正后的黑洞Hawking温度等物理量的新表达式及其物理意义.本文根据Einstein-Bumblebee引力理论中得到的Kerr-Sen-like(KSL)黑洞时空度规,在标量场作用量中引入aether-like场矢量修正项和弯曲时空中的d’Alembert算符并应用弯曲时空中的变分原理,研究了此时空度规中的Lorentz-breaking修正项及KSL时空中自旋为零的含有Lorentz-breaking修正项的玻色子动力学方程的新形式.通过正确选择与KSL时空度规相对应的aether-like场矢量,求解修正的玻色子动力学方程,得到了修正的量子隧穿率,并在此基础上研究了含有Lorentz-breaking修正项的此黑洞的Hawking温度和Bekenstein-Hawking熵.此外,还研究了Lorentz-breaking效应对玻色子正、负能级分布及其能级交错的最大值的影响,从而得出此黑洞时空中的量子非热辐射的条件.最后对所得到的一系列结果的物理意义进行了深入的讨论.

关键词： Lorentz-breaking Einstein-Bumblebee引力理论 Kerr-Sen-like黑洞 Bekenstein-Hawking熵

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BambooBase:A comprehensive database of bamboo omics and systematics

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Molecular Plant 2024年第5期17卷 682-685页

作者： Yun-Long Liu shu-yang Gao Guihua Jin Meng-Yuan Zhou Qijuan Gao Cen Guo Yi-Zhou yang Liang-Zhong Niu Enhua Xia Zhen-Hua Guo Peng-Fei Ma De-Zhu Li Germplasm Bank of Wild Species&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefeiAnhui 230036China School of Computer and Artificial Intelligence Hefei Normal UniversityHefeiAnhui 230061China Key Laboratory for Plant Diversity and Biogeography in East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

Dear Editor,Bamboos(Bambusoideae,Poaceae)are of significant economic and ecological importance,supporting billions of people and contributing to international trade(Wu et al.,2023).They play a crucial role in carbon fixation and support a multitude of other species including the giant panda(Clark et al.,2015).Since the release of the first draft genome of moso bamboo(Phyllostachys edulis)(Peng et al.,2013),there has been a notable increase in the sequencing,assembly,and annotation of diverse bamboo genomes(Guo et al.,2019;Zheng et al.,2022;Ma et al.,2024).An existing resource for bamboo genomics,BambooGDB(Zhao et al.,2014),provides information based on the individual draft reference genome of moso bamboo.What is needed,however,is a resource reinforcing multiple genome assemblies in Bambusoideae to enable researchers to unravel the evolutionary history of chromosomes and genes through cladespecific comparative genomic investigations.Here,we present BambooBase(https://***/),a newly developed web-based database designed to provide a seamless user experience for bamboo omics and systematics.

关键词： enable supporting Bamboo

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井下动水截流施工骨料堆积生长机制研究

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煤炭科学技术 2024年第5期52卷 209-221页

作者：苏培莉杨述刘锋西安科技大学建筑与土木工程学院陕西西安710054

灌注骨料形成阻水屏障实现截流降速是井下治水工程的关键所在。为定量描述骨料堆积生长的时空演化机理,提出了将骨料沉降堆积过程切分为具有一定厚度的片状颗粒层堆叠过程的分析计算方法,以及动水环境中骨料灌注后从沉降到堆积全过程关... 详细信息

灌注骨料形成阻水屏障实现截流降速是井下治水工程的关键所在。为定量描述骨料堆积生长的时空演化机理,提出了将骨料沉降堆积过程切分为具有一定厚度的片状颗粒层堆叠过程的分析计算方法,以及动水环境中骨料灌注后从沉降到堆积全过程关键参量(颗粒水平移距xd,动水休止角ψ,未接顶区流速U,骨料留存临界流速U_(cr))的理论计算公式,在此基础上构建了骨料堆积体生长预测模型。通过CFD-DEM双向耦合算法研究了骨料灌注期间流场分布演化特征和骨料堆积形态差异,并验证了预测模型合理性。研究表明:空间上,依据初始流速U_(s)是否超过骨料起动流速U_(c)或骨料留存临界流速U_(cr),可将截流初期骨料沉积主域的所在位置划分为3个区域,若沉积主域位于③区,则将其视为无效灌注;时间上,骨料堆积体生长过程可归结为3个阶段:高度快速增长阶段、高度长度同步生长阶段、仅水平向伸长阶段;初始流速决定了第1阶段的有无,而灌注条件(骨料粒径、灌注速度)主导着第1阶段所持续的时间;基于泥沙运动力学中推移质输沙率、起动流速等概念,得出了堵孔现象发生及骨料能否留存的临界判据;数值模拟试验结果表明,预测模型能够较好地刻画骨料灌注后的堆积生长规律,骨料堆积稳定后,理论计算值与模拟试验值相对误差小于10%。

关键词：煤矿突水骨料灌注临界流速沉积主域固–液两相流

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铁精矿内配某生物质高温高压热解及其还原行为研究

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中南大学学报（自然科学版） 2024年第3期55卷 860-870页

作者：黄柱成李屹鑫舒阳中南大学资源加工与生物工程学院湖南长沙410083

以生物质为还原剂,在温度为1 040℃、压力为30 kPa下对铁精矿内配生物质热解气化及其还原行为进行研究。研究结果表明:初期热解产生了酚类等大分子碳氢氧化合物液相,并与铁精矿形成了焦油包裹体,显著迟滞了生物质挥发分的释放;外配水和... 详细信息

以生物质为还原剂,在温度为1 040℃、压力为30 kPa下对铁精矿内配生物质热解气化及其还原行为进行研究。研究结果表明:初期热解产生了酚类等大分子碳氢氧化合物液相,并与铁精矿形成了焦油包裹体,显著迟滞了生物质挥发分的释放;外配水和铁精矿中的晶格氧促进了大分子碳氢氧化合物逐步氧化为酮类、酸类化合物,并最终转化为CO和H_(2)等还原性气体;铁精矿还原生成了铁晶须,部分形成了碳铁化合物,实现了铁氧化物的高效快速还原,入炉50 min时,金属化率达96.72%。

关键词：生物质高温高压热解直接还原

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Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking

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World Journal of Clinical Cases 2024年第18期12卷 3505-3514页

作者： shu-yang Zhang Song-Xue Guo Lei-Lei Chen Jia-Yan Zhu Ming-Sheng Hou Jia-Ke Lu Xue-Xiang Shen Department of General Surgery Shaoxing Hospital of Traditional Chinese MedicineShaoxing 312000Zhejiang ProvinceChina Department of Plastic Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Hand and Plastic Surgery The first People’s Hospital of Linping DistrictHangzhou 311013Zhejiang ProvinceChina Department of Pathology Shaoxing Hospital of Traditional Chinese MedicineShaoxing 312000Zhejiang ProvinceChina Department of Traumatology Yuyao Hospital of Traditional Chinese MedicineNingbo 315400Zhejiang ProvinceChina

BACKGROUND Hypertrophic scar(HTS)is dermal fibroproliferative disorder,which may cause physiological and psychological problems.Currently,the potential mechanism of WuFuYin(WFY)in the treatment of HTS remained to be elucidated.AIM To explore the potential mechanism of WFY in treating HTS.METHODS Active components and corresponding targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.HTSrelated genes were obtained from the GeneCards,DisGeNET,and National Center for Biotechnology Information.The function of targets was analyzed by performing Gene Ontology and Kyoto Encyclopaedia of Genes and Genome(KEGG)enrichment analysis.A protein+IBM-protein interaction(PPI)network was developed using STRING database and Cytoscape.To confirm the high affinity between compounds and targets,molecular docking was performed.RESULTS A total of 65 core genes,which were both related to compounds and HTS,were selected from multiple databases.PPI analysis showed that CKD2,ABCC1,MMP2,MMP9,glycogen synthase kinase 3 beta(GSK3B),PRARG,MMP3,and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma(PIK3CG)were the hub targets and MOL004941,MOL004935,MOL004866,MOL004993,and MOL004989 were the key compounds of WFY against HTS.The results of KEGG enrichment analysis demonstrated that the function of most genes were enriched in the PI3K-Akt pathway.Moreover,by performing molecular docking,we confirmed that GSK3B and 8-prenylated eriodictyol shared the highest affinity.CONCLUSION The current findings showed that the GSK3B and cyclin dependent kinase 2 were the potential targets and MOL004941,MOL004989,and MOL004993 were the main compounds of WFY in HTS treatment.

关键词： WuFuYin Hypertrophic scar Network pharmacology Molecular docking Enrichment analysis

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