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Epidemiology of opportunistic invasive fungal infections in China： review of literature

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Chinese Medical Journal 2013年第2期126卷 361-368页

作者： LIAO Yong CHEN Min Thomas Hartmann yang rong-ya LIAO Wan-qing Department of Dermatology General Hospital of Beijing MilitaryCommand Beijing 100700 China Shanghai Key Laboratory of Molecular Medical Mycology Institute of Dermatology and Mycosis of Changzheng HospitalSecond Military Medical University Shanghai 200003 China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences Beijing I O0101 China

Objective To summarize the recent findings on the epidemiology of medically important, opportunistic invasive fungal infections （IFIs） in China and discuss the relevant social, economical reasons and medical factors. Data sources We performed a comprehensive search of both English and Chinese literatures of opportunistic IFIs from China up to April 2012. Study selection Relevant literatures involving researches and cases/case sedes were identified, retrieved and reviewed. Results The incidence of opportunistic IFIs in China was steadily increasing. The incidence and mortality of IFIs were different in patients with various underlying conditions/diseases, from 4.12% to 41.18% and 9.8% to 60.0%, respectively. Candida species, Aspergillus species and Cryptococcus neoformans species complex were the most frequent isolated pathogens. Other uncommon opportunistic IFIs were also been reported, including trichosporonosis, mucormycosis, hyalohyphomycosis （hyaline hyphomycetes） and phaeohyphomycosis （dematiaceous hyphomycetes）. Reports of Chinese patients differed from those of many other countries as there were a higher number of patients without identifiable underlying diseases/conditions. Conclusions Because of the rapid economic development, changing population structure and a growing number of immunocompromised hosts with risk factors, today opportunistic IFIs in China have a significant impact on public health, associated with high morbidity/mortality and higher care costs. Now information related to the epidemiology of opportunistic IFIs in China is still sparse, so we need more organized groups of clinical scientists performing related researches to help the clinicians to obtain more accurate epidemiological characteristics.

关键词： China, opportunistic fungal infection, Candida Aspergillus Cryptococcus

Environment surveillance of filamentous fungi in two tertiary care hospitals in China

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Chinese Medical Journal 2011年第13期124卷 1970-1975页

作者： HAO Zhen-feng AO Jun-hong HAO Fei yang rong-ya ZHU He ZHANG Jie Department of Dermatology General Hospital of Beijing MilitaryRegion of People's Liberation Army Beijing 100700 China Department of Dermatology Southwest Hospital Third MilitaryMedical University Chongqing 400038 China

Background Invasive fungal infections have constituted an increasingly important cause of morbidity and mortality in immunocompromised patients. In this study, a surveillance project was conducted in three different intensive care units of two large tertiary hospitals in China. Methods A one-year surveillance project was conducted in two tertiary hospitals which located in northern China and southwest China respectively. Air, surfaces and tap water were sampled twice a month in a central intensive care unit, a bone marrow transplant unit, a neurosurgery intensive care unit and a live transplant department. Environmental conditions such as humidity, temperature and events taking place, for example the present of the visitors, healthcare staff and cleaning crew were also recorded at the time of sampling. Results The air fungal load was 91.94 cfu/m3 and 71.02 cfu/m3 in the southwest China hospital and the northern China hospital respectively. The five most prevalent fungi collected from air and surfaces were Penicillium spp., Cladospcrium spp., Altemaria spp., Aspergillus spp. and Saccharomyces spp. in the southwest China hospital, meanwhile Penicillium spp., Fusarium spp., Aspergillus spp., Alternaria spp. and Cladospcrium spp. in the northern China hospital. The least contaminated department was intensive care units, and the heaviest contaminated department was neurosurgery intensive care unit. Seventy-three percent of all surfaces examined in the northern China hospital and eighty-six percent in the southwest China hospital yielded fungi. Fifty-four percent of water samples from the northern China hospital and forty-nine percent from the southwest China hospital yielded fungi. Conclusions These findings suggested that the fungus exist in the environment of the hospital including air, surface and water. Air and surface fungal load fluctuated over the year. Air fungal load was lower in winter and higher in summer and autumn, but seldom exceeded acceptable level. The h

关键词： fungi environmental surveillance nosocomial infection epidemiology

Breakthrough trichosporonosis in patients receiving echinocandins： case report and literature review

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Chinese Medical Journal 2012年第14期125卷 2632-2635页

作者： LIAO Yong Thomas Hartmann ZHENG Tao yang rong-ya AO Jun-hong WANG Wen-ling Department of Dermatology GeneralHospital of Beijing Military Command Beijing 100_700~ China Department of Intensive Care Unit GeneralHospital of Beijing Military Command Beijing 100700 China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences Beijing 100101 China

Trichosporon species now ranks as the second most common cause of disseminated yeast infections with a high mortality rate. Breakthrough trichosporonosis in patients receiving echinocandins therapy is being recognized recently. We present a case of breakthrough trichosporonosis with acute viral myocarditis while receiving caspofungin therapy. Trichosporon infection should be considered in patients, who have risk factors for invasive fungal infection and develop unexplained clinical manifestations of infection despite treatment with echinocandins.

关键词： trichosporonosis caspofungin echinocandins

Pathogenicity of Trichosporon asahii in a murine model of disseminated trichosporonosis

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Chinese Medical Journal 2008年第24期121卷 2557-2560页

作者： yang rong-ya WANG Wen-ling AO Jun-hong HAO Zhen-feng ZHANG Jie WANG Cong-min Department of Dermatology General Hospital of Beijing Military Region of PLA Beijing 100700 China

Background In recent years, superficial and deep mycoses caused by trichosporon were occasionally reported. In 2001, we reported the first case of disseminated trichosporonosis caused by Trichosporon asahfi （T. asahii） in China. In this study, the pathogenicity of T. asahii was investigated in a murine model of disseminated trichosporonosis. Methods Seventy-five mice were randomly divided into 7 groups. Each group was inoculated with T. asahii, through intradermal, gastrointestinal tract or intravenous injection. The mice in the experimental groups were given an intraperitoneal injection of cyclophosphamide （CY） to induce granulocytopenia. Mice in the therapeutic group were given both liposomal amphotericin B and fluconazole. The main viscera of the mice were examined by means of tissue culture and pathologic sections. Results In the two intravenous inoculation groups, T. asahfi was isolated from at least one organ in 10 of the 12 granulocytopenic mice and 2 of the 14 immunocompetent mice. Two of the 7 mice in the granulocytopenia group presented with lesions in the inoculation position, but none of the 30 mice in the granulocytopenia and the control group which were inoculated intradermally or through the gastrointestinal tract had viscera infection. In the therapeutic group, the ratio of consequently dead mice, the number of involved viscera, and the incidence of systemic infection were significantly less than the untreated group. Acute purulent inflammation and granulomatous inflammation were the main pathological changes in the course of the infection. Arthrospores and filaments were found in the focus. Conclusions T. asahii is an opportunistic pathogen that causes cutaneous and visceral infections in immunologically impaired hosts. An immunocompetent host was to be infected by the invading T. asahii. Several organs, namely the liver, lungs, kidneys, spleen and heart, were predisposed. The therapy of combining liposomal amphotericin B with fluconazole can preven

关键词： trichosporonosis Trichosporon asahii pathogenicity

转化生长因子-β、内皮素-1及血管紧张素Ⅱ与硬皮病纤维化关系研究进展

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临床皮肤科杂志 2011年第3期40卷 184-186页

作者：宋克敏杨蓉娅北京军区总医院皮肤病诊治中心北京100700

硬皮病的发病机制比较复杂,认为主要与免疫失常相关。研究证实许多细胞因子在其纤维化发病过程中发挥重要作用,目前研究较多的有转化生长因子(TGF)-β、内皮素(ET)-1及血管紧张素(Ang)Ⅱ等。该文综述了上述细胞因子在硬皮病纤维化过程... 详细信息

硬皮病的发病机制比较复杂,认为主要与免疫失常相关。研究证实许多细胞因子在其纤维化发病过程中发挥重要作用,目前研究较多的有转化生长因子(TGF)-β、内皮素(ET)-1及血管紧张素(Ang)Ⅱ等。该文综述了上述细胞因子在硬皮病纤维化过程中的作用及相互作用。

关键词：纤维化转化生长因子-β 内皮素-1 血管紧张素Ⅱ

巢式PCR扩增诊断播散性毛孢子菌病的动物实验研究

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第三军医大学学报 2006年第14期28卷 1506-1508页

作者：杨蓉娅赵逊郝飞第三军医大学西南医院皮肤科重庆400038

目的探讨应用PCR技术诊断播散性毛孢子菌病的可行性。方法建立动物模型后,于接种3、7、14 d分别采集小鼠眶静脉血和肝脏组织标本,进行真菌培养和巢式PCR扩增。结果小鼠静脉接种3、7、14 d后血清培养的阳性率分别为0、20%、0,而巢式PCR... 详细信息

目的探讨应用PCR技术诊断播散性毛孢子菌病的可行性。方法建立动物模型后,于接种3、7、14 d分别采集小鼠眶静脉血和肝脏组织标本,进行真菌培养和巢式PCR扩增。结果小鼠静脉接种3、7、14 d后血清培养的阳性率分别为0、20%、0,而巢式PCR的阳性率分别为80%、90%、88.9%;在上述时相点,肝脏组织真菌培养阳性率分别为50%、40%、22.2%,而巢式PCR的阳性率分别为90%、90%、88.9%。血清和肝脏组织真菌培养阳性率与巢式PCR阳性率差异均具有统计学意义(P<0.05,P<0.01)。结论巢式PCR扩增***特异性DNA片段,可作为播散性毛孢子菌病的一种特异、灵敏、快捷的早期诊断手段。

关键词：播散性毛孢子菌病诊断

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战略性新兴产业企业治理金融支持动力源分析

软科学 2017年第10期31卷 47-51页

作者：杨荣海李亚波南京财经大学金融学院南京210023 复旦大学管理学院上海200433

运用2009Q1~2015Q1的季度数据,结合面板VAR模型,采用GMM方法对战略性新兴产业从企业治理角度展开了金融支持动力源分析,得到了以下两方面结论:一方面,直接金融支持与间接金融支持短期内对新兴产业上市公司企业治理带来的冲击难以界定,... 详细信息

运用2009Q1~2015Q1的季度数据,结合面板VAR模型,采用GMM方法对战略性新兴产业从企业治理角度展开了金融支持动力源分析,得到了以下两方面结论:一方面,直接金融支持与间接金融支持短期内对新兴产业上市公司企业治理带来的冲击难以界定,存在一定程度拉动作用;但是,从长期角度来看,这一冲击呈现出稳步递增现象。另一方面,间接金融对新兴产业企业成长带来的冲击高于直接金融,而直接金融支持冲击带来的影响在稳健增加。

关键词：战略性新兴产业企业成长金融支持面板VAR

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变态反应性接触性皮炎中郎格罕细胞的研究

中华皮肤科杂志 1990年第4期23卷 219-221页

作者：杨蓉娅徐鸿声北京军区总医院皮肤科第三军医大学皮肤科

我们用ATP酶染色、抗HLA-DR和抗Te两种单克隆抗体的酶标亲和素一生物素化抗体染色以及透射电镜观察了21例变态反应性接触性皮炎(ACD)患者皮损中的郎格罕细胞(LC).结果表皮内LC密度明显减低,细胞分布不均,树枝状胞夹减少、变短或消失.真... 详细信息

我们用ATP酶染色、抗HLA-DR和抗Te两种单克隆抗体的酶标亲和素一生物素化抗体染色以及透射电镜观察了21例变态反应性接触性皮炎(ACD)患者皮损中的郎格罕细胞(LC).结果表皮内LC密度明显减低,细胞分布不均,树枝状胞夹减少、变短或消失.真皮内见较正常皮肤墩多的T6 + 细胞.电镜下表皮LC有明显损伤迹象.表皮中层的LC内见明显增多的郎格罕细胞颗粒(LG).真皮内未见带有LG的细胞,但见淋巴样细胞与组织细胞样细胞的并列接触.观察提示LC可能做为一种抗原撼带及释放细胞并充当致敏淋巴细胞的靶细胞在ACD免疫病理中起着关键的作用.

关键词：接触性皮炎变态反应性郎格罕细胞

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朱红毛斑蛾生物学和防治措施初探

青海农林科技 2018年第2期 87-90页

作者：杨亚蓉龙海市森林植物防治检疫站福建龙海363100

朱红毛斑蛾(Phauda flammans Walker)是榕属植物的重要食叶害虫。本研究通过野外跟踪调查,对朱红毛斑蛾生物学特性和发生动态进行了研究,并对其防控措施进行简述。结果表明,朱红毛斑蛾在福建龙海一年发生2-3代,以第2代预蛹期幼虫或蛹及... 详细信息

朱红毛斑蛾(Phauda flammans Walker)是榕属植物的重要食叶害虫。本研究通过野外跟踪调查,对朱红毛斑蛾生物学特性和发生动态进行了研究,并对其防控措施进行简述。结果表明,朱红毛斑蛾在福建龙海一年发生2-3代,以第2代预蛹期幼虫或蛹及第3代低龄幼虫在榕树根系与地表形成的夹角处和草丛中越冬。根据朱红毛斑蛾生物学特性,提出在防治上可采取缠绕稻草防治,清除落叶杂草,天敌防治,以及白僵菌防治等措施。

关键词：朱红毛斑蛾榕树发生规律防治措施