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肝动脉灌注化疗联合瑞戈非尼治疗结直肠癌肝转移患者的临床研究

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中国临床药理学杂志 2024年第2期40卷 185-189页

作者：彭涛杨沔金梁斌沈雷斌宁波市医疗中心李惠利医院结直肠肛肠外科浙江宁波315000

目的观察肝动脉灌注化疗(HAIC)联合瑞戈非尼治疗结直肠癌肝转移的近远期效果。方法入选结直肠癌肝转移患者作为研究对象,按队列法分为试验组和对照组。对照组采用mFOLFOX6的HAIC化疗方案,试验组在对照组的基础上第1~21 d联合口服瑞戈非... 详细信息

目的观察肝动脉灌注化疗(HAIC)联合瑞戈非尼治疗结直肠癌肝转移的近远期效果。方法入选结直肠癌肝转移患者作为研究对象,按队列法分为试验组和对照组。对照组采用mFOLFOX6的HAIC化疗方案,试验组在对照组的基础上第1~21 d联合口服瑞戈非尼160 mg治疗,28 d为1个周期。治疗28 d后评价近期疗效,比较2组患者肿瘤标志物、肝功能、远期疗效、药物不良反应。结果试验组入组38例和对照组入组42例。试验组和对照组的客观缓解率分别为26.32%和9.52%,疾病控制率分别为71.05%和47.62%,治疗后,试验组和对照组的血清癌胚抗原水平分别为(10.06±2.33)和(14.67±3.50)μg·L^(-1),糖类抗原199水平分别为(41.39±10.25)和(62.19±15.38)kU·L^(-1),糖类抗原242水平分别为(8.67±2.12)和(13.04±3.17)kU·L^(-1),血清糖类抗原125水平分别为(36.52±9.18)和(45.22±9.01)kU·L^(-1),血清谷草转氨酶水平分别为(26.44±6.72)和(33.17±8.20)U·L^(-1),谷丙转氨酶水平分别为(22.98±5.78)和(30.89±7.62)U·L^(-1),中位无进展生存期分别为3.7和2.7个月,中位总生存期分别为11.7和9.4个月。试验组上述指标与对照组比较,在统计学上差异均有统计学意义(均P0.05)。结论HAIC联合瑞戈非尼治疗结直肠癌肝转移显著提高近期疗效,延长患者生存期,临床获益较好。

关键词：瑞戈非尼肝动脉灌注化疗结直肠癌肝转移疗效肿瘤标志物

中国资源型城市生态韧性的时空分异特征及驱动因素研究

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煤炭经济研究 2024年第1期44卷 66-78页

作者：李强谊杨冕广西师范大学经济管理学院广西桂林541006 武汉大学经济与管理学院湖北武汉430072

基于“抵抗—适应—恢复”的特性,构建2006—2020年资源型城市生态韧性指标体系,运用熵值法对资源型城市生态韧性进行定量测算并分析其时空特征。最后利用空间模型,深入探索影响资源型城市生态韧性的影响因素。结果表明:①采用Dagum基... 详细信息

基于“抵抗—适应—恢复”的特性,构建2006—2020年资源型城市生态韧性指标体系,运用熵值法对资源型城市生态韧性进行定量测算并分析其时空特征。最后利用空间模型,深入探索影响资源型城市生态韧性的影响因素。结果表明:①采用Dagum基尼系数发现,中国各区域资源型城市生态韧性水平皆呈下降趋势;除东部-东北部地区间呈微弱扩大趋势外,其他地区间差异整体上均呈波动下降趋势;区域间差异是资源型城市生态韧性差异的主要来源。②基于核密度估计显示,东部、中部、西部和东北地区的资源型城市生态韧性均处于上升态势。③空间计量模型表明,中国资源型城市生态韧性水平受到多重因素影响,包括产业结构、政府干预程度、人口密度、交通设施和对外开放水平等。研究结果可为提升资源型城市生态韧性水平提供科学参考。

关键词：资源型城市生态韧性地区差异溢出效应

吲哚丙酸通过促进调节性T细胞水平减轻硫代乙酰胺诱导的急性肝损伤

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现代实用医学 2024年第5期36卷 576-581页

作者：周波阮一朱宏达杨勇杨沔宁波市医疗中心李惠利医院宁波315040

目的探讨吲哚丙酸(IPA)减轻硫代乙酰胺(TAA)诱导急性肝损伤(ALI)的潜在机制,并分析调节性T细胞(Treg)在其中发挥的作用。方法将SPF级雄性C57BL/6小鼠按随机数表法分为对照组(注射0.9%氯化钠注射液)、TAA组(TAA 100 mg/kg腹腔注射)、IP... 详细信息

目的探讨吲哚丙酸(IPA)减轻硫代乙酰胺(TAA)诱导急性肝损伤(ALI)的潜在机制,并分析调节性T细胞(Treg)在其中发挥的作用。方法将SPF级雄性C57BL/6小鼠按随机数表法分为对照组(注射0.9%氯化钠注射液)、TAA组(TAA 100 mg/kg腹腔注射)、IPA组(TAA建模后IPA 20 mg/kg灌胃),每组10只。24 h后取小鼠血清和肝组织,ELISA法检测各组丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转氨酶(AST)、干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、IL-6、转化生长因子-β(TGF-β)及IL-10的水平,病理学鉴定肝损伤情况,免疫组织荧光检测肝内Treg水平。体外实验获取小鼠脾脏并分选幼稚T细胞(Na?veT)诱导Treg,培养过程加入IPA,ELISA检测处理后的TGF-β、IL-10及相对RNA表达水平。结果IPA能显著降低TAA诱导的ALI水平,IPA组ALT、AST及病理评分(Suzuki)明显低于TAA组,免疫荧光显示IPA组肝内表现更高的Treg水平(均P <0.05)。ELISA检测结果显示IPA组小鼠肝脏促炎因子IFN-γ、TNF-α、IL-1β、IL-6显著下降,抑炎因子TGF-β、IL-10水平明显上调(均P <0.05)。体外实验显示IPA能促进Treg分化并表达更高的叉状头转录因子3(Foxp3)水平,同时促进抑炎因子TGF-β、IL-10分泌及相应RNA表达。结论IPA通过促进Treg的分化及抑炎因子TGF-β、IL-10分泌,调节肝内免疫平衡,抑制肝内炎性反应进而减轻TAA诱导的ALI。

关键词：吲哚丙酸调节性T细胞硫代乙酰胺肝损伤

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21世纪以来我国景观设计的理论与实践探索

城市学报 2024年第1期 53-59页

作者：邱建杨勉江湘蓉程昕金凤西南交通大学建筑学院西南交通大学空间规划与工程设计研究中心四川旅游学院艺术学院西华大学建筑与土木工程学院

进入21世纪以来,我国的景观学者和设计师在借鉴西方理论的过程中,坚持守正创新,在继承中华传统园林精华基础上,探寻具有中国特色的景观设计之路,理论研究成果斐然,设计实践硕果累累,为人居环境改善做出重要贡献。文章通过对景观设计探... 详细信息

进入21世纪以来,我国的景观学者和设计师在借鉴西方理论的过程中,坚持守正创新,在继承中华传统园林精华基础上,探寻具有中国特色的景观设计之路,理论研究成果斐然,设计实践硕果累累,为人居环境改善做出重要贡献。文章通过对景观设计探索历程的回顾,梳理总结了从西方引入的理论成果,重点归纳提炼了扎根于本土文化的理论建构和设计创作成就,同时展望思考了新时代景观设计发展方向;是为刍荛之见,略述大端,希望有助于读者整体把握20多年来景观设计理论与实践的发展脉络,助力我国景观设计事业笃定前行。

关键词：景观设计理论建构设计实践本土文化

Beyond the Environmental Kuznets Curve:An Empirical Study Taking China's Poverty Alleviation Campaign as a Quasi-Experiment

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Social Sciences in China 2023年第1期44卷 98-128页

作者： yang mian Xie Zeyu Ye Chusheng Center for Economic Development Research Wuhan University Economics and Management School Wuhan University

Poverty-stricken areas in China have the dual task of alleviating poverty and safeguarding national ecological *** on statistical surveys and satellite remote sensing data,we construct a staggered difference-in-difference model to empirically analyze the dual impact of poverty alleviation on the economic development and eco-environment of povertystricken *** study also examines viable pathways for economic development in poor areas in the context of ecological *** results show that the poverty eradication campaign under the leadership of the Communist Party of China has significantly improved the rate of economic growth in poverty-stricken areas while also significantly improving the quality of the local *** analysis shows that ecological projects and ecological compensation make the greatest contribution to promoting the conversion of ecological resources into economic output in poverty-stricken ***'s successful experience in green poverty alleviation can not only provide important policy enlightenment for the nation's continuation of its comprehensive revitalization drive in rural areas,but also provide new options for other developing countries to achieve their green take-off.

关键词： poverty alleviation ecological protection economic development Staggered DID

Carbon emission trading system and stock price crash risk of heavily polluting listed companies in China:based on analyst coverage mechanism

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Financial Innovation 2023年第1期9卷 1877-1906页

作者： Zeyu Xie mian yang Fei Xu School of Economics and Management Wuhan UniversityWuhanChina School of Economics and Management Anhui Normal UniversityWuhuChina

This study reveals the inconsistencies between the negative externalities of carbon emissions and the recognition condition of accounting ***,the study identifies that heavily polluting enterprises in China have severe off-balance sheet carbon reduction risks before implementing the carbon emission trading system(CETS).Through the staggered difference-in-difference(DID)model and the propen-sity score matching-DID model,the impact of CETS on reducing the risk of stock price crashes is examined using data from China’s A-share heavily polluting listed companies from 2007 to *** results of this study are as follows:(1)CETS can significantly reduce the risk of stock price crashes for heavily polluting companies in the pilot ***,CETS reduces the skewness(negative conditional skewness)and down-to-up volatility of the firm-specific weekly returns by 8.7%and 7.6%,respectively.(2)Heterogeneity analysis further shows that the impacts of CETS on the risk of stock price crashes are more significant for heavily polluting enterprises with the bear market condition,short-sighted management,and intensive air pollution.(3)Mechanism tests show that CETS can reduce analysts’coverage of heavy polluters,reducing the risk of stock price *** study reveals the role of CETS from the stock price crash risk perspective and helps to clarify the relationship between climatic risk and corporate financial risk.

关键词： Carbon emission trading system Stock price crash risk Off-balance sheet carbon reduction risks Analyst coverage

Heterogeneous impacts of GVCs participation on CO_(2) intensity:Evidence from developed and developing countries/regions

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Advances in Climate Change Research 2022年第2期13卷 187-195页

作者： Zhi-Da JIN Hong-Bo DUAN Jin-Chao WANG mian yang Yu-Huan GUO Xiao-Dong CUI Center for Economic Development Research Wuhan UniversityWuhan430072China School of Economics and Management University of Chinese Academy of SciencesBeijing100190China Economics and Management School Wuhan UniversityWuhan430072China

The deepening of global value chains(GVCs)has made remarkable impacts on the environmental outcomes of all countries/*** are the differences in environmental burden undertaken by countries/regions at different stages of economic development are a question worthy *** study compares the impacts of GVCs participation degree on CO_(2) intensity between developed and developing countries/*** panel data of 19 manufacturing industries in 43 countries/regions over the period of 2000-2014,it is discovered that the deeper participation in GVCs of developed countries/regions significantly reduces their CO_(2) intensity,while the more participation in GVCs of developing countries/regions significantly increases their CO_(2) ***,the quantile regression results reveal that the reduction of CO_(2) intensity is increasing for industries with higher initial CO_(2) intensity for developed countries/regions,whereas for developing countries/regions,only industries with initial low CO_(2) intensity experience significant increases in CO_(2) *** further analyzed the effect of GVCs participation degree on CO_(2) intensity for high-tech and low-tech industries and discovered that the effect is only significant in low-tech *** findings provide empirical evidence for the pollution haven hypothesis and offer enlightenment to formulate future trade and environmental policies.

关键词： Global value chains participation CO_(2)intensity Pollution haven hypothesis Manufacturing industries

Dysfunction of synaptic endocytic trafficking in Parkinson's disease

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Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin Yi Ng mian Cao Programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Physiology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease *** will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

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区域梯次有序碳达峰下我国省际碳转移研究

系统工程理论与实践 2023年第7期43卷 2102-2121页

作者：杨冕谢泽宇徐飞武汉大学经济与管理学院武汉430072 安徽师范大学经济管理学院芜湖241000

推进各地区梯次有序碳达峰是实施“双碳”战略的必然选择,但同时也可能会加剧区域间的碳转移问题.本文基于我国多区域投入产出表,系统分析并直观呈现2017年省际碳转移的网络特征;在此基础上,通过构建地方政府策略性达峰模型分析发现,在... 详细信息

推进各地区梯次有序碳达峰是实施“双碳”战略的必然选择,但同时也可能会加剧区域间的碳转移问题.本文基于我国多区域投入产出表,系统分析并直观呈现2017年省际碳转移的网络特征;在此基础上,通过构建地方政府策略性达峰模型分析发现,在各地区梯次有序碳达峰的制度安排下,为掌握碳达峰主动权以获得更大晋升优势,发达省份存在通过省际贸易的方式向欠发达省份进一步转移碳排放的内生动力,而落后省份出于促进当地经济发展的考虑会竞相承接来自发达地区的碳转移.这一博弈均衡不可避免地导致落后地区承担更沉重的减排压力,从而造成区域间减排责任的不平等问题.为有效遏制各地区梯次有序碳达峰下的策略性碳转移,本文秉持全国一盘棋理念,基于省际产业关联关系,分别从碳转出端和碳转入端两个视角,在省份-行业层面系统识别驱动省际碳转移的关键领域,从而为优化各地区梯次有序碳达峰方案提供科学的决策参考.

关键词：碳达峰投入产出分析省际贸易隐含碳排放国内国际双循环