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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： yang-Zheng lan Zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Optothermal dynamics in whispering-gallery microresonators

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Light(Science & Applications) 2020年第1期9卷 1760-1774页

作者： Xuefeng Jiang lan yang Department of Electrical and System Engineering Washington University in St.LouisSt.LouisMO 63130USA

Optical whispering-gallery-mode microresonators with ultrahigh quality factors and small mode volumes have played an important role in modern *** have been demonstrated as a diverse platform for a wide range of applications in photonics,such as nonlinear optics,optomechanics,quantum optics,and information *** behaviors induced by power build-up in the resonators or environmental perturbations are ubiquitous in high-quality-factor whispering-gallery-mode resonators and have played an important role in their operation for various *** this review,we discuss the mechanisms of laser-field-induced thermal nonlinear effects,including thermal bistability and thermal *** the help of the thermal bistability effect,optothermal spectroscopy and optical nonreciprocity have been *** tuning the temperature of the environment,the resonant mode frequency will shift,which can also be used for thermal sensing/tuning *** thermal locking technique and thermal imaging mechanisms are discussed ***,we review some techniques employed to achieve thermal stability in a high-quality-factor resonator system.

关键词： oscillation optics nonlinear

Projecting the potential distribution and analyzing the bioclimatic factors of four Rhododendron *** species under climate warming

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Journal of Forestry Research 2023年第6期34卷 1707-1721页

作者： lan yang Huie Li College of Agriculture Guizhou UniversityGuiyang 550025People’s Republic of China

Tsutsusi is one of the eight subgenera of the Rhododendron *** Tsutsusi species,***,***,***,and ***,have high ornamental and medicinal values,resulting in an increasing market *** species thrive in cool and humid environments and are widely distributed in Europe and *** global climate warming will affect the distribution of these valuable resources remains ***,this study analyzed the climatic suitability of these species for the first time on the basis of 1552 geographical distribution points and 19 bioclimatic factors using the maximum entropy *** results show that a suitable distribution area for all four species would decrease under climate *** main bioclimatic factors affecting their distribution are the mean temperature of the coldest quarter for ***,the mean diurnal range for ***,and precipitation of the warmest quarter for *** and *** addition,the contribution of the temperature-related bioclimatic factors to the distribution of *** and *** is higher than that of the associated precipitation-related climatic factors;in contrast,the contribution of precipitation-related bioclimatic factors to the distribution of *** and *** is higher than that of the temperature-related climatic *** results provide references for the introduction,conservation,sustainable development,and utilization of these four species in the future,and may also provide information with regards to other Rhododendron species.

关键词： Rhododendron simisii Rhododendron indicum Rhododendron schlippenbachii Rhododendron oldhamii Climate change Future distribution

Optical whispering-gallery mode barcodes for high-precision and wide-range temperature measurements

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Light(Science & Applications) 2021年第2期10卷 278-288页

作者： Jie Liao lan yang Department of Electrical&Systems Engineering Washington University in St.LouisMO 63130 St.LouisUSA Department of Physics Washington University in St.LouisMO 63130 St.LouisUSA

Temperature is one of the most fundamental physical properties to characterize various physical,chemical,and biological *** a slight change in temperature could have an impact on the status or dynamics of a ***,there is a great need for high-precision and large-dynamic-range temperature *** temperature sensors encounter difficulties in high-precision thermal sensing on the submicron ***,optical whispering-gallery mode(WGM)sensors have shown promise for many sensing applications,such as thermal sensing,magnetic detection,and ***,despite their superior sensitivity,the conventional sensing method for WGM resonators relies on tracking the changes in a single mode,which limits the dynamic range constrained by the laser source that has to be fine-tuned in a timely manner to follow the selected mode during the ***,we cannot derive the actual temperature from the spectrum directly but rather derive a relative temperature ***,we demonstrate an optical WGM barcode technique involving simultaneous monitoring of the patterns of multiple modes that can provide a direct temperature readout from the *** measurement relies on the patterns of multiple modes in the WGM spectrum instead of the changes of a particular *** can provide us with more information than the single-mode spectrum,such as the precise measurement of actual *** the high sensitivity of WGMs and eliminating the need to monitor particular modes,this work lays the foundation for developing a high-performance temperature sensor with not only superior sensitivity but also a broad dynamic range.

关键词： mode high spectrum

Photonics Research Interview with Professor Marlan Scully

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Photonics Research 2022年第1期10卷 256-260页

作者： lan yang Department of Electrical and Systems Engineering Washington University in St.LouisSt.LouisMissouri 63130USA

Professor Marlan Scully discusses his career in quantum optics with the Editor-in-Chief of Photonics Research,*** yang.

关键词： optics Photonics quantum

Flutter and gust response analysis of a wing model including geometric nonlinearities based on a modified structural ROM

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Chinese Journal of Aeronautics 2020年第1期33卷 48-63页

作者： Chao AN Chao yang Changchuan XIE lan yang School of Aeronautic Science and Engineering Beihang UniversityBeijing 100083China

In this paper,a framework is established for nonlinear flutter and gust response analyses based on an efficient Reduced Order Model(ROM).The proposed method can be used to solve the aeroelastic response problems of wings containing geometric nonlinearities.A structural modeling approach presented herein describes the stiffness nonlinearities with a modal *** orthogonal spanwise modes describe the foreshortening effects of the *** linearization of the ROM under nonlinear equilibrium states is applied to a nonlinear flutter analysis,and the fully nonlinear ROM coupled with the non-planar Unsteady Vortex Lattice Method(UVLM)is applied to gust response ***,extended Precise Integration Method(PIM)ensures accuracy of the dynamic equation *** demonstrate applicability and accuracy of the method presented,a wind tunnel test is conducted and good agreements between theoretical and test results of nonlinear flutter speed and gust response deflection are *** method described in this paper is suitable for predicting the nonlinear flutter speed and calculating the gust responses of a large-aspect-ratio wing in time ***,the results derived highlight the effects of geometric nonlinearities obviously.

关键词： Aeroelasticity Flutter Geometric nonlinearity Reduced order models Response analysis Structural model

Photonics Research Interview with Professor Yidong Huang

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Photonics Research 2024年第11期12卷 2521-2523页

作者： lan yang Editor-in-Chief Photonics Research Washington University in St.Louis

This interview article features Professor Yidong Huang, a pioneering scientist and exceptional community leader in optoelectronics, whose contributions extend beyond academia into entrepreneurship and leadership. As part of a new series launched by Photonics Research, this interview aims to highlight the journeys and achievements of prominent women in optics and photonics.

关键词： Laser communications Photonic crystals Photonics Real time imaging Reflection Surface plasmon polaritons

Photonics Research 10th anniversary:editorial

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Photonics Research 2023年第5期11卷 I0002-I0003页

作者： lan yang Research Washington University in St.Louis

As the editor-in-chief of Photonics Research,I am honored to serve in this role as we celebrate our 10th *** its launch in 2013,the journal has been dedicated to publishing and promoting high-quality research work in the field of optics and *** goal is to ensure that every paper accepted for publication is not only technically correct,but also adds new and important results to the field.

关键词： journal anniversary editor

Role of Y_(4)Al_(2)O_(9)in High Temperature Oxidation Resistance of NiCoCrAlY-ZrO_(2)·Y_(2)O_(3)Coatings

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Journal of Materials Science & Technology 2007年第4期23卷 568-570页

作者： Shuqin yang Xiaohua lan Ningkang HUANG Key Laboratory of Radiation Physics and Technology of Education Ministry of China Institute of Nuclear Science and Technology Sichuan University Chengdu 610064 China

NiCoCrAlY-ZrO2·Y2O3 coatings were deposited on the substrates by using a technology of combining electron,atom and ion beams （three beams）. Isothermal oxidation for these samples was performed at 1100℃ for 100-300 h. The results show that a thermally grown oxide （TGO） layer was formed between NiCoCrAlY layer and oxidation. The TGO contains α-Al2O3 and Y4Al2O9 etc. oxides. The intensity ratio of α-Al2O3/Y4Al2O9 was monotonously decreased with increasing oxidation time based on XRD （X-ray diffraction） analysis. The Y4Al2O9 phase plays the most important role in high temperature oxidation resistance at 1100℃. The related mechanism was also discussed.

关键词： NiCoCrAlY-ZrO2·Y2O3 coatings XRD Al2Y4O9