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COUPLING EFFECT OF SEEPAGE FLOW AND RIVER FLOW ON THE BANK FAILURE

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Journal of Hydrodynamics 2011年第6期23卷 834-840页

作者： NING Bo wu- Shi-qiang TAN Ye-fei XIE Xing-hua YAN Jun YAN Zhong-min GENG Yan-qiong College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China nanjing hydraulic research institute Nanjing 2100-29 China nanjing hydraulic research institute.nanjing 210029 China Lian Yungang Technical College Lian Yungang 222000 China

On the basis of the generalized physical model of the riverbank, the experiments were conducted to study the mechanisms of riverbank failure under the coupling effect of seepage flow and river flow. The experimental setup was specially designed, as well as test point location, parameters and procedures, and the main influencing factors were analyzed affecting riverbank failure based on the failure types, the variations of pore water pressure and soil displacement. The results indicated that the coupling effect has different influences on the bank failure in three aspects： the failure type, the process and the extent. In addition, the river flow played a more important role than the seepage flow in the coupling effect on the bank failure.

关键词： bank failure seepage flow river flow physical model test

Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing Wang Lin Guo Pan-Pan Ma Xiao-Long Ye ming-Lin Pan Bo Hang jian-hua Mao Antoine M Snijders Yi-Bing Lu Da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice

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Zoological research 2024年第5期45卷 1073-1087页

作者： Jing-Wei Ye Tanveer Abbas jian-Teng Zhou Jing Chen Meng-Lei yang Xiong-Heng huang huan Zhang Hui Ma Ao Ma Bo Xu Ghulam Murtaza Qing-hua Shi Bao-Lu Shi Division of Reproduction and Genetics First Affiliated Hospital of University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at MicroscaleSchool of Basic Medical SciencesDivision of Life Sciences and MedicineBiomedical Sciences and Health Laboratory of Anhui ProvinceInstitute of Health and MedicineHefei Comprehensive National Science CenterUniversity of Science and Technology of ChinaHefeiAnhui 230026China institute of Andrology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China

Infertility represents a significant health concern,with sperm quantity and quality being crucial determinants of male ***(OAT)is characterized by reduced sperm motility,lower sperm concentration,and morphological abnormalities in sperm heads and *** variants in several genes have been implicated in OAT,its genetic etiologies and pathogenetic mechanisms remain inadequately *** this study,we identified a homozygous nonsense mutation(c.916C>T,***306*)in the coiled-coil domain containing 146(CCDC146)gene in an infertile male patient with *** mutation resulted in the production of a truncated CCDC146 protein(amino acids 1-305),retaining only two out of five coiled-coil *** validate the pathogenicity of the CCDC146 mutation,we generated a mouse model(Ccdc146^(mut/mut))with a similar mutation to that of the ***,the Ccdc146mut/mut mice exhibited infertility,characterized by significantly reduced sperm counts,diminished motility,and multiple defects in sperm heads and ***,the levels of axonemal proteins,including DNAH17,DNAH1,and SPAG6,were significantly reduced in the sperm of Ccdc146^(mut/mut) ***,both human and mouse CCDC146 interacted with intraflagellar transport protein 20(IFT20),but this interaction was lost in the mutated versions,leading to the degradation of *** study identified a novel deleterious homozygous nonsense mutation in CCDC146 that causes male infertility,potentially by disrupting axonemal protein *** findings offer valuable insights for genetic counseling and understanding the mechanisms underlying CCDC146 mutant-associated infertility in human males.

关键词： Oligoasthenoteratozoospermia Human infertility Sperm flagellum CCDC146 Intraflagellar transport IFT20

Transmission of THz wave by liquid dielectric waveguide

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Science china(Technological Sciences) 2010年第6期53卷 1594-1597页

作者： ZHOU Lei,XU WeiWei,hua Tao,LU XueHui,CHEN jian,JIN BiaoBing,KANG Lin & wu PeiHeng research institute of Superconductor Electronics (RISE),nanjing University,nanjing 210093,china 1. research institute of Superconductor Electronics (RISE) Nanjing University Nanjing 210093 China

The absorption and dispersion of several non-polar organic solvents from 0.2 to 2.5 THz are measured with the method of time-domain *** on the result,we believe that liquid paraffin might be a proper choice for liquid... 详细信息

关键词： THz liquid dielectric waveguide

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao jiang Xiao-ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei Wang Qi Liu yang Ren Xun-Li Wang Xiao-Ya Cui Xiao-yang Wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao Jia-ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui huang Ling-Kun Zhang Yi-Ping Lu Xu-Bo Li huai-Jun Lin Yan Ma Wei-ming yang Zhi-hua Shen Hai-Yan He Yong-Gang Sun Yong-jiang huang De-Zhuang Wang Qing-Feng Liu Fei-yang Wang Hui Liu Hong-Hui wu Li-Qiang Wang yang Lu Nan Wang Tian-Li Wang Wei-Bing Liao Yi-Han Wang Yuan wu Yu-Zhen Yin Jie Pan Yi Zhang Qing Wang jian-yang Zhang Tao yang Yasir Sohail Jin-Yu Zhang hua Ji Qiang Li Wei-Di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo wu School of Materials Science and Engineering Nanjing University of Science and Technology jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

EFFECTS OF ENTRAINED AIR MANNER ON CAVITATION DAMAGE

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Journal of Hydrodynamics 2011年第3期23卷 333-338页

作者： wu jian-hua LUO Chao College of Water Conservancy and Hydropwer Engineering Hohai University Nanjing 210098 China

Early in 1953 the experiments by Peterka proved that air entrainment has effects on decreasing cavitation damage. This technology has been widely used in the release works of high dams since the inception of air entrainment in the Grand Goulee Dam in 1960. Behavior, mechanism and application of air entrainment for cavitation damage control have been investigated for over half century. However, severe cavitation damage happened due to complex mechanism of air entrainment. The effects of air entrainment are related to many factors, including geometric parameters, hydraulic parameters and entrained air manners. In the present work an experimental set-up for air entrainment was specially designed, the behavior of reducing cavitation damage was experimentally investigated in the three aspects of entrained air pressure, air tube aera and air tube number. The results show that magnitude of reduction of cavitation damage is closely related to the entrained air tube number as well as entrained air pressure, air tube aera, and that the effect through three air tubes is larger than that through single air tube although the entrained air tubes have the same sum of tube aera, that is, 1 ＋ 1 ＋ 1 〉 3. Therefore, it is important to design an effective manner of air entrainment.

关键词： air entrainment air pressure air tube area cavitation damage entrained air manner

Land use and river-lake connectivity: Biodiversity determinants of lake ecosystems

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Environmental Science and Ecotechnology 2024年第5期21卷 329-340页

作者： Huiyu Xie Yu Ma Xiaowei Jin Shiqi Jia Xu Zhao Xianfu Zhao Yongjiu Cai jian Xu Fengchang wu John P.Giesy State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China College of Water Sciences Beijing Normal UniversityBeijing100875China china National Environmental Monitoring Centre Beijing100012China Key Laboratory of Ecological Impacts of hydraulic-Projects and Restoration of Aquatic Ecosystem of Ministry of Water Resources Institute of HydroecologyMinistry of Water Resources and Chinese Academy of SciencesWuhan430079China nanjing institute of Geography and Limnology Chinese Academy of SciencesNanjing210008China Department of Integrative Biology Michigan State UniversityEast LansingMI48895USA Department of Veterinary Biomedical Sciences and Toxicology Centre University of SaskatchewanSaskatoonSaskatchewanS7N 5B3Canada Toxicology Centre and Department of Veterinary Biomedical Sciences University of Saskatchewan44 Campus DriveSaskatoonSKS7N 5B3SaskatoonSKCanada

Lake ecosystems confront escalating challenges to their stability and resilience,most intuitively leading to biodiversity loss,necessitating effective preservation strategies to safeguard aquatic ***,the complexity of ecological processes governing lake biodiversity under multi-stressor interactions remains an ongoing concern,primarily due to insufficient long-term bioindicator data,particularly concerning macroinvertebrate *** we utilize a unique,continuous,and in situ biomonitoring dataset spanning from 2011 to 2019 to investigate the spatio-temporal variation of macroinvertebrate *** assess the impact of four crucial environmental parameters on Lake Dongting and Lake Taihu,i.e.,water quality,hydrology,climate change,and land *** two systems are representative of lakes with yangtze-connected and disconnected subtropical floodplains in *** find an alarming trend of declining taxonomic and functional diversities among macroinvertebrate communities despite improvements in water *** contributing factors to this decline include persistent anthropogenic pressures,particularly alterations in human land use around the lakes,including intensified nutrient loads and reduced habitat ***,river-lake connectivity is pivotal in shaping differential responses to multiple *** results highlight a strong correlation between biodiversity alterations and land use within a 2e5 km radius and 0.05e2.5 km from the shorelines of Lakes Dongting and Taihu,*** findings highlight the importance of implementing land buffer zones with specific spatial scales to enhance taxonomic and functional diversity,securing essential ecosystem services and enhancing the resilience of crucial lake ecosystems.

关键词： Taxonomic richness Functional diversity Biotic homogenization River-lake connectivity Multiple stressors

Hollow Multishelled Structure: Synthesis Chemistry and Application

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Chemical research in Chinese Universities 2024年第3期40卷 346-393页

作者： MAO Dan WANG Chao LI Wei ZHOU Liang LIU jian ZHENG Zjian ZHAO Yong CAO An-min WANG Shutao huaNG Jiaxing HUO Fengwei CHEN Hongyu MAI Liqiang YU Ranbo WANG Lianzhou LU Yunfeng YU Chengzhong yang Qihua yang Zhenzhong ZENG hua Chun ZHAO Hujun TANG Zhiyong ZHAO Dongyuan WANG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChineseAcademy of SciencesBeijing 100190P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBejing 100190P.R.China School of Fashion and Textiles The Hong Kong Polytechnic UniversityHong Kong SARP.R.China Department of Chemistry Fudan UniversityShanghai 200433P.R.China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070P.R.China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China School of Chemistry Beihang UniversityBejing 100191P.R.China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190P.R.China School of Engineering Westlake UniversityHangzhou 310024P.R.China School of Flexible Electronics(Future Technologies) Nanjing Tech UniversityNanjing 211816P.R.China School of Science Westlake UniversityHangzhou 310024P.R.China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070P.R.China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083P.R.China School of Chemical Engineering and Australian institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072Australia College of Life Science and Technology Bejing University of Chemical TechnologyBejing 100029P.R.China School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200241P.R.China College of Life Sciences Zhejiang Normal UniversityJinhua 321004P.R.China Department of Chemical Engineering Tsinghua UniversityBeijing 100

Hollow multishelled structure(HoMS),a promising and complex multifunctional structural system,features at least two shells that are separated by internal *** unique structure endows it with numerous advantages including low density,high loading capacity,large specific surface area,facilitated mass transport,and multiple spatial confinement *** the past twenty years,benefiting from the booming development of synthesis methods,various HoMS materials have been prepared and show promising applications in diverse areas.

关键词： Hollow multishelled structure Synthesis chemistry Energy storage Catalysis Electromagnetic wave absorption Drug delivery Sensor

hydraulic CHARACTERISTICS OF PARTIAL OPENING OF THE WORKING GATE FOR A DISCHARGE TUNNEL

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Journal of Hydrodynamics 2007年第4期19卷 488-493页

作者： wu jian-hua FENG Shu-rong wu Wei-wei RUAN Shi-ping College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China china Hydro Mid-South Design and research institute Changsha 410014 China

The partial opening of the working gate for a discharge tunnel is used more and more widely in the various conditions, such as releasing discharge to meet the needs of the various stages under construction, or of the operations at low reservoir levels. In this article the hydraulic characteristics were investigated of the partial opening of the working gate based on the physical model experiments of the discharge tunnel for the Longtan Hydropower Project, including the discharge coefficient, the surface profile of the free flow section, the bottom pressure distribution of the tunnel with an aerator, the cavity length just from the ramp, and the wall pressure of the curve section of the outlet. Some new issues were discussed and the properties were presented of the partial opening of the gate.

关键词： partial opening hydraulic characteristics working gate discharge tunnel