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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo ji jianhua Zhuang Yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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SHEAR-HORIZONTAL WAVES IN A ROTATED Y-CUT QUARTZ PLATE WITH AN ISOTROPIC ELASTIC LAYER OF FINITE THICKNESS

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Acta Mechanica Solida Sinica 2012年第1期25卷 82-89页

作者： Lei yang jianke Du ji Wang jiashi yang Piezoelectric Device Laboratory School of EngineeringNingbo University818 Fenghua RoadNingbo Zhejiang 315211China Department of Engineering Mechanics University of NebraskaLincolnNE 68588-0526USA

We study shear-horizontal （SH） waves in a rotated Y-cut quartz plate carrying an isotropic elastic layer of finite *** three-dimensional theories of anisotropic elasticity and isotropic elasticity are used for the quartz plate and the elastic layer,respectively.A transcen-dental frequency equation that determines the dispersion relations of the waves is *** dispersion relations are obtained and plotted by solving the frequency equation using *** dispersion relations are also obtained analytically for two special *** is for long waves whose wavelength is much larger than the plate *** other is for the case of a very thin elastic *** effects of the elastic layer on the dispersion relations are *** results obtained are fundamental and useful to acoustic wave sensors for measuring the mechanical and geometric properties of the elastic layer.

关键词： SH waves quartz plate elastic layer dispersion relation

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Healthy, natural, efficient and tunable lighting: four-package white LEDs for optimizing the circadian effect, color quality and vision performance

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Light(Science & Applications) 2014年第1期3卷 314-322页

作者： ji Hye Oh Su ji yang Young Rag Do Department of Chemistry Kookmin UniversitySeoul 136-702Korea

To date,most current reports on the development and optimization of artificial lighting sources have focused on the energy performance levels and limited color qualities of white light-emitting diodes(LEDs).However,these properties are insufficient in terms of representing all performance levels required when adjusting white LEDs for healthy and smart ***,we introduce essential and advanced figures of merit pertaining to circadian performance as well as vision performance and color *** compare all possible properties of commercialized artificial lighting,daylight and four-package white LEDs which consist of long-wavelength pass dichroic filter(LPDF)-capped,phosphor-converted red,amber and green LEDs(pc-LEDs)and a blue *** show that these tunable four-package white LEDs produce a tunable circadian effect for melatonin suppression/secretion,a high color quality for color perception/reproduction,high efficiency for energy savings and tunable figures of merit for the smart LED lighting market.

关键词： circadian effect color quality solid-state lighting vision performance white LED

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Optimal sensitivity perturbation analyses on persistent anomalous summer circulation in East Asia

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Chinese Science Bulletin 1997年第8期42卷 673-678页

作者： yang, Y ji, LR Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China

THE blocking high over Ural and Okhotsk Sea in mid- and high latitudes and the western Pa-cific subtropical high(SH)are the major components of the East Asian summer monsoon *** persistent anomalies may lead to severe... 详细信息

关键词： adjoint sensitivity analysis optimal sensitivity perturbation persistent anomaly East Asian summer monsoon.

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Hierarchical control of a class of uncertain linear systems

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Journal of Control and Decision 2016年第2期3卷 119-131页

作者： Kaihong yang Haibo ji Department of Automation University of Science and Technology of ChinaHefeiChina

Hierarchical control method which is based on a hierarchical architecture has been developed to be mainly aimed at large-scale complex *** order to analyse and control this kind of systems,we construct first an appropriate and low-dimensional abstract system,then synthesise and lift the control law from the obtained abstraction to the original *** far as the linear systems with uncertain terms are concerned,this paper studies the robust control problem of high-dimensional uncertain linear systems and derives the results by employing hierarchical ***,the LMI toolbox is allowed to be used for the computation of interface ***,our method framework is illustrated on a five-dimensional uncertain linear system.

关键词： hierarchical control abstraction robust control uncertain linear systems

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Simulation on effect of throat contraction ratio and strake stagger angle on flow field and aerodynamic performance of scrampressor

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航空动力学报 2017年第5期32卷 1183-1194页

作者： yang Ling ZHOng jing-jun HAN ji-ang Marine Engineering College Dalian Maritime University

The design methods of typical supersonic aircraft intakes and shock wave compression technology have been applied to ram-rotor,an attractive compression system.A ram-rotor is of a typical structure including the compression ramp,the throat and the subsonic diffuser;a scrampressor is similar to ram-rotor,the only difference is that scrampressor has no subsonic *** work was the continuation of the preparatory *** order to further study the effect of throat contraction ratio and strake stagger angle on the flow field and performance of a scrampressor,the flow field of a scrampressor with a three-dimensional flow path was numerically simulated with different throat contraction ratios and strake stagger *** results indicated that the optional aerodynamic performance of a scrampressor could be achieved with an adiabatic efficiency of 0.8413atotal pressure recovery coefficient of 0.8446,a total pressure ratio of 7.14 and a static pressure ratio of 5.17for a throat contraction ratio of 0.6 and a strake stagger angle of 12°.It was therefore concluded that an appropriate decrease in throat contraction ratio and an increase in strake stagger angle could help the comprehensive improvement of a scrampressor in performance.

关键词： scrampressor flow field aerodynamic performance throat contraction ratio strake stagger angle

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Improvement in mechanical properties in AlN-h-BN composites with high thermal conductivity

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Journal of Advanced Ceramics 2021年第6期10卷 1317-1325页

作者： Zetan LIU Shiqiang ZHAO Tian yang ji ZHOU State Key Laboratory of New Ceramics&Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

It is possible to improve the machinability of aluminum nitride-hexagonal boron nitride(AlN-h-BN)ceramics while maintaining high strength and high thermal *** composite ceramics with 0-30 wt%BN as secondary phase were prepared by hot pressed sintering,using yttrium oxide(Y_(2)O_(3))as sintering *** phase composition,density,microstructure,mechanical properties,thermal conductivity,and dielectric properties were *** sintering additives were favorable to purify the grain boundaries and improve densification,reacting with oxide impurities on the surface of raw material powder *** optimum BN content improved the flexural strength and fracture toughness of composite ceramics with 475 MPa and 4.86 MPa·m^(1/2),*** increasing the amount of BN,the thermal conductivity and hardness of composites gradually decreased,but the minimum value of thermal conductivity was still 85.6 W·m^(-1)·K^(-1) The relative dielectric constant and dielectric loss tangent of the samples ranged from 6.8 to 8.3 and from 2.4×10^(3) to 6.4×10^(3),respectively,in 22-26 GHz.

关键词： aluminum nitride(AIN) boron nitride(BN) mechanical properties thermal conductivity

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Time-Domain Nonlinear Wave-Current Interaction with A Steep Wave Riser Considering Internal Flow Effect

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China Ocean Engineering 2021年第3期35卷 410-421页

作者： TAng Lian-yang CHEng Yong ji Chun-yan School of naval architecture and ocean engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Nippon Kaiji Kyokai(China)Co. LtdShanghai 200336China

The nonlinear dynamic response induced by the wave-current interaction on a deepwater steep wave riser(SWR)is numerically investigated based on a three-dimensional(3 D)time-domain finite element method(FEM).The governing equation considering internal flow is established in the global coordinate *** whole SWR consists of three segments:the decline segment,buoyancy segment and hang-off segment,in which the buoyancy segment is wrapped by several buoyancy modules in the middle section,leading to the arch bend and sag bend.A Newmark-β iterative scheme is adopted for the accurate analysis to solve the governing equation and update the dynamic response at each time *** proposed method is verified through the published results for the dynamic response of steel catenary riser(SCR)and static configuration of steel lazy wave riser(SLWR).Simulations are executed to study the influence of wave height,current velocity/direction,internal flow density/velocity and top-end pressure on the tension,configuration and bending moment of the *** results indicate that the influence of the current on the configuration and mechanical behavior of the SWR is greater than that of the wave,especially in the middle *** increasing current velocity,the suspending height of the middle section drops,meanwhile,its bending moment decreases accordingly,but the tension increases *** a fixed external load,the increasing internal flow density induces the amplification of the tension at the hang-off segment and the mitigation at the decline segment,while the opposite trend occurs at the bending moment.

关键词： steep wave riser(SWR) nonlinear dynamic response wave-current interaction time-domain finite element method(FEM)

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Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li Zhuoran yang Ziming Yan Huibin Shi Zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

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Full blended blade and endwall design of a compressor cascade

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Chinese Journal of Aeronautics 2021年第11期34卷 79-93页

作者： Tongtong MEng Guang yang Ling ZHOU Lucheng ji School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Poly Technologies Inc. Beijing 100010China Institute for Aero Engine Tsinghua UniversityBeijing 100084China

In the current state-of-the-art,high-loss flow in the endwall significantly influences compressor ***,the control of endwall corner separation in compressor blade rows is important to *** on the previous research of the Blended Blade and End Wall(BBEW)technique,which can significantly reduce corner separation,in combination with a nonaxisymmetric endwall,the full-BBEW technique is proposed in this study to further reduce the separation in endwall *** principle of the unchanged axial passage area is considered to derive the geometric method for this *** models are further classified based on different geometric characteristics of this technique:the BBEW model,Inclining-Only End Wall(IOEW)model,and full-BBEW *** most effective design of each model is then found by performing several optimizations at the design point and related numerical investigations over the entire operational *** with the prototype,the total pressure loss coefficient decreases by 7%–9%in the optimized full-BBEW at the design ***,the aerodynamic blockage coefficient over the entire operational range decreases more than the other models,which shows its positive effect for *** approach has a larger decrease at negative incidence angles where the intersection of the boundary layer plays an important role in corner *** analysis shows that the blended blade profile enlarges the dihedral angle and creates a span-wise pressure gradient to move low momentum fluid towards the ***,the inclining hub geometry accelerates the accumulated flow in the corner downstream by increasing the pressure ***,though losses in the mainstream grow,especially for large incidences,the full-BBEW technique effectively reduces the separation in corners.

关键词： Aerodynamics Blended Blade and End Wall(BBEW) Corner separation Endwall profiling Flow control Turbomachinery

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