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Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies

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Signal Transduction and Targeted Therapy 2020年第1期5卷 235-248页

作者： Miaoqin Chen Shiman Hu Yiling Li Ting Ting Jiang hongchuan Jin Lifeng Feng Laboratory of Cancer Biology Key lab of Biotherapy in Zhejiang ProvinceCancer Institute of Zhejiang UniversitySir Run Run Shaw hospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310016China Department of Radiation Oncology Sir Run Run Shaw HospitalMedical School of Zhejiang UniversityHangzhou 310016China

Cancer immunotherapy especially immune checkpoint inhibition has achieved unprecedented successes in cancer ***,there are many patients who failed to benefit from these therapies,highlighting the need for new combinations to increase the clinical efficacy of immune checkpoint *** this review,we summarized the latest discoveries on the combination of nucleic acid-sensing immunity and immune checkpoint inhibitors in cancer *** the critical role of nuclear acid-mediated immunity in maintaining the activation of T cell function,it seems that harnessing the nuclear acidmediated immunity opens up new strategies to enhance the effect of immune checkpoint inhibitors for tumor control.

关键词： immunity cancer therapies

A NEW ROPER-SUFFRIDGE EXTENSION OPERATOR ON BOUNDED COMPLETE REINHARDT DOMAINS

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Acta Mathematica Scientia 2014年第6期34卷 1835-1844页

作者：刘浩夏红川 Institute of Contemporary Mathematics Henan University School of Mathematical Science Xiamen University

In this paper, we construct a new Roper-Suffridge extension operator Φn^r,β1,,βn（f）（z） = F（z） = （（rf（z1/r）/z1）^β1z1,（rf（z1/r）/z1）^β2z2,...,（rf（z1/r）/z1）^βnzn）＇,where f is a normalized locally biholomorphic function on the unit disc D, r = sup{｜z1｜： z =（z1, ···, zn） ∈Ω}, β1∈ [0, 1], 0 ≤βk≤β1, k = 2, ···, n, then we prove it can preserve the property of spirallikeness of type β, almost starlikeness of order α and starlikeness of orderα on bounded complete Reinhardt domain Ω, respectively.

关键词： Roper-Suffridge operator biholomorphic mappings bounded complete Reinhardt domains

Influences of Sputtering Angles and Annealing Temperatures on the Magnetic and Magnetostrictive Performances of TbFe Films

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Journal of Materials Science & Technology 2005年第3期21卷 315-318页

作者： hongchuan JIANG, Wanli ZHANG, Wenxu ZHANG, Shiqing yang and Huaiwu ZHANG College of Microelectronics and Solid State Electronics, University of Electronic Science and Technology of China, Chengdu 610054, China College of Microelectronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China

To increase the low-field magnetostriction of TbFe films, the influences of sputtering angles and annealing temperatures on its magnetic and magnetostrictive performances were systematically investigated. With the change in sputtering angles from 90° to 15°, the in-plane magnetization of TbFe films, at 1600 kA·m-1 external field, is strongly increased. An enhancement in the in-plane magnetostrictive coefficient of the films at 40 kA·m-1 is also observed. A detection of magnetic domains by MFM (magnetic force microscopy) indicates that the easy magnetization direction shifts gradually from perpendicular to parallel to the film plane with decreasing sputtering angles. Annealing can enhance the magnetization and magnetostriction of the TbFe films. However, at too high annealing temperature, both the magnetization and magnetostriction of the TbFe films were suppressed to some extent.

关键词： TbFe films Oblique sputtering Annealing Magnetization Magnetostriction

Coupling between Particle Shape and Long-Range Interaction in the High-Density Regime

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Chinese Physics Letters 2020年第8期37卷 63-67页

作者： Can-can Zhou hongchuan Shen Hua Tong Ning Xu Peng Tan State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China CAS Key Laboratory of Soft Matter Chemistry Hefei National Laboratory for Physical Sciences at the Microscaleand Department of PhysicsUniversity of Science and Technology of ChinaHefei 230026China Department of Fundamental Engineering Institute of Industrial ScienceUniversity of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

We experimentally probe the coupling between particle shape and long-range interaction,using long-range interacting *** two typical space-filling polygons,square and triangle,we find two types of coupling modes that predominantly control the structure ***,the rotational ordering of squares brings a lattice deformation that produces a hexagonal-to-rhombic transition in the high density regime,whereas the alignment of triangles introduces a large geometric frustration that causes an order-to-disorder ***,the two coupling modes lead to small and large“internal roughness”of the two systems,and thus predominantly control their structure *** study thus provides a physical picture to the coupling between long-range interaction effect and short-range shape effect in the high-density regime unexplored before.

关键词： transition. coupling polygon

Effects of micro-oxygenation on the aroma of Cabernet Sauvignon wine from Ningxia,China

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International Journal of Agricultural and Biological Engineering 2022年第4期15卷 251-263页

作者： Zhong Zhang Qingchen Zhang Huiqing Wang hongchuan Xia Lijun Sun Junxiang Zhang School of Life Sciences Ningxia UniversityYinchuan 750021China College of Pharmacy University of FloridaGainesville FL32610USA School of Agriculture Ningxia UniversityYinchuan 750021China School of Food and Wine Ningxia UniversityYinchuan 750021China China Wine Industry Technology Institute Yinchuan 750021China

Micro-oxygenation (MOX) is an effective post-harvest technique for the flavor improvement of grape wine. This study investigated the effect of MOX on the aroma quality of Ningxia wine for the first time. Three sub-region Cabernet Sauvignon dry red wines were treated with different levels of oxygen before or after malolactic fermentation. The wine aroma was analyzed through gas chromatography-mass spectrometry (GC-MS) and quantitative descriptive analysis (QDA) after six months of aging. The data obtained demonstrated that the dose and timing of oxygen addition were key factors influencing the effectiveness of MOX. The most noticeable modifications in wine aroma compounds were generated by an oxygen dosage of 30 (mL/L)/month added before malolactic fermentation. Predominantly, the concentrations of 2-phenylethanol, benzaldehyde, diacetyl, and 2,3-pentanedione showed an increased pattern upon MOX treatments. The sensory analysis revealed that MOX improved the aroma quality of wine by decreasing green and animal odors, meanwhile enhancing the olfactory intensities of dried fruits, flowers, and nuts. This work confirmed that MOX was suitable for aroma modification of Cabernet Sauvignon dry red wine from Ningxia and established a preliminary MOX procedure that can serve as a reference for future applications.

关键词： grape wine micro-oxygenation volatile organic compounds aroma profiles Ningxia

Characteristics of the Deep Crustal Structure of the Greenland–Iceland–Faroe Ridge in the North Atlantic

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Acta Geologica Sinica(English Edition) 2024年第S1期98卷 87-89页

作者： ZHANG Chunguan LI Fengyuan ZHANG Qiang ZHANG Guoli HU hongchuan YIN Rui School of Earth Sciences and Engineering Xi’an Shiyou UniversityXi’an 710065China Shaanxi Key Laboratory of Petroleum Accumulation Geology Xi’an Shiyou UniversityXi’an 710065China Institute of Geophysical and Geochemical Exploration CAGSLangfangHebei 065000China Tianjin Center China Geological SurveyTianjin 300170China

The Greenland–Iceland–Faroe Ridge,located between the central eastern part of Greenland and the northwestern edge of Europe,spans across the North *** the core component of the Greenland–Iceland–Faroe Ridge,the Iceland is an alkaline basalt area,which belongs to the periodic submarine magmatism and submarine volcano eruption resulting from mantle plume upwelling(Jiang et al.,2020).For the oceanic plateaus,the characteristics of the Iceland are closest to the continental crust,so the Iceland is considered the most suitable for simulating the earliest continental crust on the Earth(Reimink et al.,2014).

关键词： crustal thickness deep fault Moho surface gravity anomaly Greenland-Iceland-Faroe Ridge

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含铁介孔氧化硅材料的研究进展

石油化工 2006年第11期35卷 1017-1024页

作者：辛洪川杨启华中国科学研究院大连化学物理研究所催化基础国家重点实验室辽宁大连116023

综述了含铁介孔氧化硅材料的合成及其应用研究的最新进展,从合成方法(直接合成法和后合成法)、铁物种的表征(酸性表征、氧化还原表征、配位状态表征)及催化性能(用于酸催化反应、选择氧化反应、环境催化反应等)等方面评述了含铁介孔氧... 详细信息

综述了含铁介孔氧化硅材料的合成及其应用研究的最新进展,从合成方法(直接合成法和后合成法)、铁物种的表征(酸性表征、氧化还原表征、配位状态表征)及催化性能(用于酸催化反应、选择氧化反应、环境催化反应等)等方面评述了含铁介孔氧化硅材料的研究概况。

关键词：铁铁氧化物介孔氧化硅分子筛结构表征催化

Stress corrosion cracking of L360NS pipeline steel in sulfur environment

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Petroleum 2017年第3期3卷 377-383页

作者： Zhou Fan Xiaogang Hu Jianyi Liu hongchuan Li Jinwen Fu School of Materials Science and Engineering Southwest Petroleum UniversitySichuan 610500China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversitySichuan 610500China SINOPEC Pipeline Transportation and Storage Company Nanjing 210000China

Slow strain rate test(SSRT)and tensile fracture observation are applied to study the stress corrosion cracking(SCC)of L360NS pipeline steel.5.0 wt.%sodium chloride solution containing elemental sulfur and 0.5 wt.%glacial acetic acid solution containing elemental sulfur are *** results show that brittle fracture mainly occurs on the samples in high sulfur *** the sulfur suspension solution,the SCC sensitivity of L360NS pipeline steel increases along elemental sulfur *** sulfur melting cladding condition,obvious corrosion can be observed with a large amount of corrosion pits appearing on the gauge section of the *** corrosion products are Fe1txS,black easily detached,and *** sulfur suspension and sulfur melting cladding conditions,stress oriented hydrogen induced cracking(SOHIC)is the main cracking,which is caused by the joint effect of SCC and hydrogen induced cracking(HIC).

关键词： Sour gas field Elemental sulfur SSRT SCC

Multi-center investigation of breast reconstruction after mastectomy from Chinese Society of Breast Surgery:A survey based on 31 tertiary hospitals(CSBrS-004)

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Chinese Journal of Cancer Research 2021年第1期33卷 33-41页

作者： Feng Xu Chuqi Lei Heng Cao Jun Liu Jie Li hongchuan Jiang Chinese Society of Breast Surgery Department of Breast Surgery Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China 不详

Objective:Multi-center data on the current status and trends of breast reconstruction after mastectomy in China are ***,we conducted a cross-sectional survey to investigate the current clinical practice pattern of postmastectomy breast reconstruction among Chinese female patients with breast ***:A standardized questionnaire used to collect information on breast reconstruction among females diagnosed with breast cancer was distributed by 31 members of the Chinese Society of Breast Surgery between January 1,2018 and December 31,*** was collected on tumor characteristics,treatment,mesh application,nipple-areola complex(NAC)preservation,postoperative complications,bilateral reconstruction,patient satisfaction and local *** overall rate of breast reconstruction was assessed,and the characteristics were compared across patient groups with different reconstruction ***:A total of 1,554 patients underwent breast reconstruction after total mastectomy,with a reconstruction rate of 9.6%.Among them,1,190 were implant-based,and 262 underwent autologous reconstructions,while 102 cases underwent a combination of *** who underwent implant-based reconstruction were younger than those who received autologous reconstruction(40.1±4.6 vs.45.0±5.9,P=0.004).Compared to patients with autologous reconstruction,mesh application(25.5%vs.6.5%),NAC preservation(51.8%vs.40.5%)and reconstruction failure(1.8%vs.0)were more frequently reported among those with implant-based *** was no significant difference in general satisfaction across three reconstruction approaches,though patients with autologous reconstruction reported the highest aesthetic satisfaction among the three groups(P=0.044).Conclusions:Implant-based breast reconstruction remains the dominant choice among patients,while autologous reconstruction was associated with higher aesthetic *** multi-center investigation based on the findings o

关键词： Breast cancer mastectomy breast reconstruction questionnaire survey patient satisfaction