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The ubiquitin codes in cellular stress responses

Protein & Cell 2024年第3期15卷 157-190页

作者： Xiangpeng Sheng Zhixiong Xia hanting yang Ronggui Hu Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China State Key Laboratory of Animal Disease Control Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China Department of Neurology State Key Laboratory of Medical NeurobiologyInstitute for Translational Brain ResearchMOE Frontiers Center for Brain ScienceZhongshan HospitalFudan UniversityShanghai 200032China

Ubiquitination/ubiquitylation,one of the most fundamental post-translational modifications,regulates almost every critical cellular process in *** evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses,from exogenous factors to cellular reactions,causing a dazzling variety of functional *** forms of ubiquitin sig-nals generated by ubiquitylation events in specific milieus,known as ubiquitin codes,constitute an intrinsic part of myriad cellular stress *** ubiquitination events,leading to proteolytic turnover of the substrates or just switch in functionality,initiate,regulate,or supervise multiple cellular stress-associated responses,supporting adaptation,homeostasis recovery,and survival of the stressed *** this review,we attempted to summarize the crucial roles of ubiquitination in response to different environmental and intracellular stresses,while discussing how stresses modulate the ubiquitin *** review also updates the most recent advances in understanding ubiquitination machinery as well as different stress responses and discusses some important questions that may warrant future investigation.

关键词： ubiquitin E3 ligase environmental stresses intercellular stresses stress response homeostasis

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Structural form selection of the high-rise buildingwith the improved BP neural network

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High Technology Letters 2020年第1期26卷 92-97页

作者： Zhao Guangzhe yang hanting Tu Bing Zhou Meiling Zhou Chengle School of Electrical and Information Engineering Beijing University of Civil Engineeringand ArchitectureBeijing 100044P.R.China College of Information and Communication Engineering Hunan Institute of Science and TechnologyYueyang 414000P.R.China

As civil engineering technology development,the structural form selection is more and more critical in design of high-rise ***,structural form selection involves expertise knowledge and changes with the environment which makes the task *** approach utilizing improved back propagation(BP)neural network optimized by the Levenberg-Marquardt(L-M)algorithm is proposed to extract the main controlling factors of structural form ***,an intelligent expert system with artificial neural network is constructed to design high-rise buildings structure *** experiment tests the model in 15 well-known architecture samples and get the prediction accuracy of 93.33%.The results show that the method is feasible and can help designers select the appropriate structural form.

关键词： back propagation(BP)neural network high-rise building structural form selection Levenberg-Marquardt(L-M)algorithm

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DNA bridging of FOXP3 ladder-like multimer: Unveiling a novel transcriptional regulation paradigm

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The Innovation 2024年第3期5卷 15-16页

作者： Ying Lu Lanfang Li hanting yang Bin Li Zuoyun Wang Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Shanghai Xuhui Central Hospital and School of Basic Medical SciencesFudan UniversityShanghai 200032China Institute for Translational Brain Research State Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceDepartment of NeurologyZhongshan HospitalFudan UniversityShanghai 200032China Center for Immune-Related Diseases at Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of MedicineShanghai 200025China

In the latest issue of Nature,Zhang et *** a novel ladder-like structure of FOXP3-DNA interaction involving FOXP3 multimerization and remote DNA bridging through a combination of biochemistry,structural biology,cell biology,and bioinformatics analyses.1 In this commentary,we highlight their key findings and provide our insights into the research paradigm for further exploration of a novel transcriptional regulation mode as well as a therapeutic strategy from the structural aspects of the FOXP3 complex(Figure 1).

关键词： FOXP3 bridging

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Thermodynamics of voltage-gated ion channels

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Biophysics Reports 2018年第6期4卷 300-319页

作者： Xuejun C.Zhang hanting yang Zhenfeng Liu Fei Sun National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences College of Life Science University of Chinese Academy of Sciences

Ion channels are essential for cellular signaling. Voltage-gated ion channels(VGICs) are the largest and most extensively studied superfamily of ion channels. They possess modular structural features such as voltage-sensing domains that encircle and form mechanical connections with the pore-forming domains. Such features are intimately related to their function in sensing and responding to changes in the membrane potential. In the present work, we discuss the thermodynamic mechanisms of the VGIC superfamily, including the two-state gating mechanism, sliding-rocking mechanism of the voltage sensor, subunit cooperation, lipid-infiltration mechanism of inactivation, and the relationship with their structural features.

关键词： Ion channel Inactivation Voltage sensor Membrane potential Gating mechanism Sliding-rocking model

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Genome-wide pan-GPCR cell libraries accelerate drug discovery

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4296-4311页

作者： hanting yang Yongfu Wang Wei Liu Taiping He Jiayu Liao Zhongzhi Qian Jinghao Zhao Zhaotong Cong Dan Sun Zhixiang Liu Can Wang Lingping Zhu Shilin Chen School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China School of Basic Medical Science Chengdu University of Traditional Chinese MedicineChengdu 611137China Department of Bioengineering University of CaliforniaRiversideCA 92521USA The Huaxi-Cal Research Center for Predictive Intervention Medicine West China HospitalSichuan UniversityChengdu 610041China Chinese Pharmacopoeia Commission Beijing 100061China

G protein-coupled receptors(GPCRs)are pivotal in mediating diverse physiological and pathological processes,rendering them promising targets for drug *** account for about 40%of FDA-approved drugs,representing the most successful drug ***,only approximately 15%of the 800 human GPCRs are targeted by market drugs,leaving numerous opportunities for drug discovery among the remaining *** expression systems play crucial roles in the GPCR drug discovery field,including novel target identification,structural and functional characterization,potential ligand screening,signal pathway elucidation,and drug safety ***,we discuss the principles,applications,and limitations of widely used cell expression systems in GPCR-targeted drug discovery,GPCR function investigation,signal pathway characterization,and pharmacological property *** also propose three strategies for constructing genome-wide pan-GPCR cell libraries,which will provide a powerful platform for GPCR ligand screening,and facilitate the study of GPCR mechanisms and drug safety evaluation,ultimately accelerating the process of GPCR-targeted drug discovery.

关键词： G-protein coupled receptors Genome-wide pan-GPCR Transgenic cell library High-throughput screening Drug discovery

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Pore architecture and gating mechanism of TRIC channels

Pore architecture and gating mechanism of TRIC channels

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中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）

作者： hanting yang Miaohui Hu Jianli Guo Xiaomin Ou Tanxi Cai Zhenfeng Liu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics Institute of BiophysicsChinese Academy of Sciences

Release of Ca from sarcoplasma/endoplasma reticulum(SR/ER)is a key step during the intracellular Ca-handling processes,and underlies various fundamental cellular *** Intracellular Cation(TRIC)channels provide counteracting ionic flux so as to support the release of Ca from SR/ER lumen through ryanodine receptor(RyR)or inositol triphosphate

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疫情防控常态下唐山市旅游业高质量发展对策

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河北能源职业技术学院学报 2021年第2期21卷 24-26,31页

作者：杨涵婷浙江海洋大学浙江舟山316022

新冠疫情给世界各领域都带来不利影响,对于旅游业而言,巨大的冲击不言而喻。唐山的旅游业也未能幸免,各项指标下滑明显。当前,疫情防控已进入常态化。文章分析了疫情对旅游业的影响和原因,提出创新宣传模式、加大政策扶持、开展预约旅... 详细信息

新冠疫情给世界各领域都带来不利影响,对于旅游业而言,巨大的冲击不言而喻。唐山的旅游业也未能幸免,各项指标下滑明显。当前,疫情防控已进入常态化。文章分析了疫情对旅游业的影响和原因,提出创新宣传模式、加大政策扶持、开展预约旅游、实施人才强游等对策,促进唐山旅游业高质量发展。

关键词：疫情防控旅游业高质量发展对策

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青岛纺织工业遗产的时空演变与整体特征分析

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青岛理工大学学报 2023年第4期44卷 119-126,135页

作者：路宁杨瀚霆青岛理工大学建筑与城乡规划学院青岛266033

纺织工业是构成青岛城市文脉的关键要素,是其工业文明起源与蝶变的重要见证,对纺织工业的保护与传承是延续青岛工业文脉的内在需要。以青岛纺织工业遗产的时空演变和整体特征解析为根本出发点,通过对现存遗产信息的提取,建立数据库,进... 详细信息

纺织工业是构成青岛城市文脉的关键要素,是其工业文明起源与蝶变的重要见证,对纺织工业的保护与传承是延续青岛工业文脉的内在需要。以青岛纺织工业遗产的时空演变和整体特征解析为根本出发点,通过对现存遗产信息的提取,建立数据库,进而对青岛纺织工业遗产的时空演化过程、空间分布及整体特征进行研究,并对未来研究作出展望。结果表明:青岛纺织工业遗产构成要素具有物质文化、精神文化、制度文化等多维度属性,可按其类型划分为三级结构层次;其时空演化整体上具有线性遗产特征,呈局部聚集但整体不均匀分布的状态;具有鲜明的文化符号性、工业标志性和可被感知场所等特征,是一种维系地域文化认同的重要的文化旅游资源。

关键词：纺织工业遗产时空演变整体特征分析青岛

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谈唐山市区现存震前欧式古旧建筑及保护

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工业技术与职业教育 2015年第3期13卷 72-75页

作者：杨东益杨涵婷刘建娣杨学益唐山工业职业技术学院河北唐山063020 唐山第五十四中学河北唐山063000 中共唐山市路北区委农村工作委员会河北唐山063000

1976年唐山大地震后,几乎市区各类建筑瞬间被夷为平地。近年来,建设文化唐山的呼声鹊起,笔者认为,那些承载历史的古旧建筑在挖掘唐山历史文化工作中举足轻重。本文介绍了唐山市区现存近百年的欧式古建筑,分析了保护方面存在的问题,提出... 详细信息

1976年唐山大地震后,几乎市区各类建筑瞬间被夷为平地。近年来,建设文化唐山的呼声鹊起,笔者认为,那些承载历史的古旧建筑在挖掘唐山历史文化工作中举足轻重。本文介绍了唐山市区现存近百年的欧式古建筑,分析了保护方面存在的问题,提出了保护措施。

关键词：唐山欧式古建筑保护

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海上高密度聚乙烯输水管道关键技术分析

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石油机械 2016年第4期44卷 62-65页

作者：胡知辉杨涵婷唐彪中国石油集团海洋工程有限公司工程设计院

目前高密度聚乙烯（HDPE）输水管道设计和施工尚无统一的规范标准。为此,对HDPE输水管道的配重块、热熔焊接、内熔珠环切除和海上施工等关键技术进行分析,同时针对HDPE管材的粘弹性力学特性,采用ABAQUS有限元软件对HDPE输水管道的安装... 详细信息

目前高密度聚乙烯（HDPE）输水管道设计和施工尚无统一的规范标准。为此,对HDPE输水管道的配重块、热熔焊接、内熔珠环切除和海上施工等关键技术进行分析,同时针对HDPE管材的粘弹性力学特性,采用ABAQUS有限元软件对HDPE输水管道的安装过程进行模拟计算。分析结果表明,配重块可保证管道安装及在位稳定性,一般按45%～80%的空管率确定单位长度管道上的配重块质量,配重块间距为1～2 m可以限制管道变形;热熔焊接一般参照丹麦DS/INF 70标准,热熔焊接过程中产生的熔珠环会阻碍清管器通过,增加输水阻力,使管道内滋生微生物,因此应切除内熔珠环;国内主要采用专用铺管船安装HDPE输水管道,宜采用增加托管架长度,减小张紧器张力的方法进行铺设,以保证HDPE管道的施工质量和安全。研究结果可为相关海上HDPE输水管道工程设计提供参考。

关键词： HDPE输水管道配重块热熔焊接内熔珠环切除专用铺管船

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