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Neoadjuvant sintilimab and apatinib combined with perioperative FLOT chemotherapy for locally advanced gastric cancer: A prospective, single-arm, phase II study

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中华医学杂志(英文版) 2024年第21期137卷 2615-2617页

作者： Zhou Huinian Long Bo Yu Zeyuan Zhu Junmin yang hanteng Luo Changjiang Zhang Wenjuan Dong Chi Guan Xiaoying Li Long Zhang Gengyuan Cao Hongtai Chen Shigong Zhou Linyan He Qichen Gan Shiying Jiang Xiangyan Gu Qianlin Wang Keshen Shi Wengui Qin Long Jiao Zuoyi Department of General Surgery Lanzhou University Second Hospital Lanzhou University Lanzhou Gansu China Department of Radiology Lanzhou University Second Hospital Lanzhou University Lanzhou Gansu China Department of Pathology Lanzhou University Second Hospital Lanzhou University Lanzhou Gansu China Department of Cuiying Biomedical Center Lanzhou University Second Hospital Lanzhou University Lanzhou Gansu China Biobank of Tumors from Plateau of Gansu Province Lanzhou University Second Hospital Lanzhou University Lanzhou Gansu China

For patients with locally advanced gastric cancer(LAGC), the effectiveness of perioperative chemotherapy can be significantly improved by adding programmed cell death protein 1(PD-1) inhibitors during the neoadjuvant phase. However, a substantial percentage of patients with a programmed death-ligand 1 combined positive score(PD-L1 CPS) <1 or microsatellite stable(MSS) status may still not experience benefits. The antiangiogenic agent apatinib can promote vascular normalization, which is indicated by the ratio of neural/glial antigen 2(NG2)-labeled pericytes to platelet endothelial cell adhesion molecule(CD31)-labeled endothelial cells, and work synergistically with PD-1 inhibitors to improve the efficacy of both chemotherapy and immunotherapy. However, the predictive value of the baseline NG2~+/CD31~+ ratio for immunotherapy has not yet been established. Based on the positive outcomes from our pilot study [Supplementary Table 1, http://***. com/CM9/C151], a phase II trial, which aimed to enhance treatment efficacy without increasing the risk of toxicity compared with previous studies involving FLOT chemotherapy alone, was conducted using the combination of triple perioperative FLOT chemotherapy with sintilimab and apatinib in patients with cT3/4 LAGC. Furthermore, we also examined the potential of the baseline NG2~+/CD31~+ ratio as a predictive marker for this intensified treatment regimen.

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan yang Han Jia Tuo Liu Yuzhen yang Jun yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

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Multiphysics simulation and optimization of the in-situ beneficiation process of ilmenite minerals from lunar regolith

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Science China Earth Sciences 2025年第1期68卷 195-207页

作者： Peng ZHANG Xin LIU Guanghui LIU Wei DAI Hanzhe yang Haibo ZHENG Zhi WANG Ran NIU Yifan BAI yang ZHANG Chengbao LIU Ge yang Junwei yang Guang ZHANG Technology and Engineering Center for Space Utilization Chinese Academy of Sciences Beijing Hegong Simulation Co. Ltd

The exploration and utilization of lunar resources have become the major objectives of future lunar exploration missions. The classified collection and processing of lunar minerals is the basic prerequisite for the in-situ exploration and utilization of lunar resources. In this study, we propose a scheme for in-situ separation of magnetic minerals from lunar soils using the dry magnetic separation method. The scheme can realize the purpose of separating magnetic minerals from lunar regolith by altering the motion trajectory of lunar regolith particles with different magnetic properties. Detailed modeling of the dry magnetic separation device is conducted, and the three-dimensional distribution of magnetic parameters is calculated and analyzed. Based on the characterization and analysis of the Chang E-5's samples, the morphologies and physical parameters of lunar regolith particles are modeled and simulated. A discrete element simulation of the motion process of lunar regolith particles under multi-physical field conditions is performed, and the influences of key parameters on the beneficiation performance of lunar magnetic minerals are investigated. Our results indicate that optimal separation and beneficiation of lunar regolith particles can be achieved under specific conditions of magnetic field strength and drum speed. Additionally, we analyze the effects of lunar weak gravity conditions and the charged nature of lunar particles on the beneficiation process, showing that these factors can obviously enhance the beneficiation process of lunar ilmenites. This study demonstrates the feasibility of using the dry magnetic separation method for the beneficiation of magnetic minerals from lunar regolith, providing a theoretical basis for the scientific tasks of collecting, processing, and utilizing lunar mineral resources.

关键词： Lunar regolith In-situ resource utilization Magnetic separation Classified sampling

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SMC4在信号通路及其在肿瘤疾病中作用的研究进展

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现代肿瘤医学 2023年第18期31卷 3524-3528页

作者：蔡伟文俞泽元杨含腾禹艳梅焦作义兰州大学第二临床医学院甘肃兰州730000 兰州大学第二医院普通外科甘肃兰州730000

SMC家族不仅参与了DNA的复制、修复过程以及染色体的聚集和分离过程,还与一系列疾病的发生和发展相关。而SMC4作为SMC家族的一员,既具有上述功能,又参与调控了TGF-β/Smad、JAK2/Stat3、PI3K/Akt和NF-κB等通路,同时它还在血液、呼吸、... 详细信息

SMC家族不仅参与了DNA的复制、修复过程以及染色体的聚集和分离过程,还与一系列疾病的发生和发展相关。而SMC4作为SMC家族的一员,既具有上述功能,又参与调控了TGF-β/Smad、JAK2/Stat3、PI3K/Akt和NF-κB等通路,同时它还在血液、呼吸、消化、生殖等系统肿瘤疾病中起着重要的作用。因此,本文就SMC4在信号通路及在肿瘤疾病中的作用进行综述。

关键词： SMC4 信号通路肿瘤疾病

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全腹腔镜全胃切除术消化道重建方式研究进展

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西北国防医学杂志 2019年第5期40卷 327-330页

作者：杜恒锐王振江杨含腾兰州大学第二医院普外一科甘肃兰州730030

全腹腔镜全胃切除术(totally laparoscopic total gastrectomy,TLTG)在治疗可切除胃癌方面发挥着重要作用,但全腹腔镜下消化道的重建仍是手术的难点和重点,不同的重建方式其疗效差异显著。本研究针对全腹腔镜全胃切除术消化道重建方式... 详细信息

全腹腔镜全胃切除术(totally laparoscopic total gastrectomy,TLTG)在治疗可切除胃癌方面发挥着重要作用,但全腹腔镜下消化道的重建仍是手术的难点和重点,不同的重建方式其疗效差异显著。本研究针对全腹腔镜全胃切除术消化道重建方式的选择作一综述,以期更好地指导和应用于临床实践。

关键词：全腹腔镜全胃切除术消化道重建

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B细胞急性淋巴瘤9L蛋白在结肠癌中的表达和临床意义及其与预后的关系

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上海医学 2022年第1期45卷 33-38页

作者：陈丑彦杨含腾潘宏波定西市人民医院普外中心甘肃定西743000 兰州大学第二医院普外一科

目的探讨B细胞急性淋巴瘤9L(BCL9L)蛋白在结肠癌中的表达和临床意义及其对患者术后预后的影响。方法选取2012年1月—2014年1月行手术治疗的68例结肠癌患者。对患者结肠癌组织和癌旁正常组织标本行免疫组织化学染色、蛋白质印迹法检测BC... 详细信息

目的探讨B细胞急性淋巴瘤9L(BCL9L)蛋白在结肠癌中的表达和临床意义及其对患者术后预后的影响。方法选取2012年1月—2014年1月行手术治疗的68例结肠癌患者。对患者结肠癌组织和癌旁正常组织标本行免疫组织化学染色、蛋白质印迹法检测BCL9L蛋白表达、实时荧光定量(qRT)-PCR检测BCL 9 L mRNA。采用多因素Cox回归分析影响结肠癌手术预后的因素,Kaplan-Meier法绘制生存曲线,Spearman检验分析BCL9L蛋白与肿瘤复发转移的相关性。结果结肠癌组织BCL9L蛋白表达评分显著低于癌旁正常组织(P<0.001)。与BCL9L蛋白高表达患者相比,低表达患者的淋巴结转移、TNM分期为晚期(Ⅲ或Ⅳ期),以及切缘肿瘤细胞阳性比例更高(P值均<0.05)。患者术后随访8~59个月(中位随访时间38个月),36例肿瘤无复发,32例复发;复发的患者中30例死亡。多因素Cox回归分析显示,淋巴结转移、临床分期为晚期、切缘肿瘤细胞阳性和BCL9L蛋白低表达均是结肠癌术后患者3年总体生存率的独立危险因素(P值均<0.05)。术后3年总体复发率和生存率分别为52.94%和55.88%,而BCL9L蛋白低表达和高表达结肠癌患者术后3年的生存率分别为38.10%和84.62%。生存曲线显示,BCL9L蛋白高表达的结肠癌患者总体生存率显著高于低表达患者(log rank P=0.0058)。Spearman相关性分析结果显示,BCL9L蛋白低表达与结肠癌术后肿瘤复发和死亡明显相关(r=0.862、0.640,P值均<0.05)。结论BCL9L蛋白在结肠癌中的表达水平与术后肿瘤复发相关,可作为结肠癌患者肿瘤复发与转移的预测指标。

关键词： BCL9L蛋白结肠肿瘤预后复发转移

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Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： WEN yang BIN TANG DAN XU WENXIU yang Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

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Reconstructing forest and grassland cover changes in China over the past millennium

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Science China Earth Sciences 2025年第1期68卷 94-110页

作者： Fanneng HE Fan yang Yafei WANG Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Key Research Institute of Yellow River Civilization and Sustainable Development Henan University University of Chinese Academy of Sciences

Historical forest and grassland cover changes not only are critical indicators for quantifying ecological and environmental change processes but also serve as fundamental data for long-term climate change simulations and terrestrial ecosystem carbon emission assessments. However, because of limitations in historical data, quantitative estimations and spatially gridded reconstructions of these changes remain challenging, necessitating further methodological exploration. This study focused on China's present-day land area over the past millennium, objectively capturing the characteristics and drivers of forest and grassland cover changes. On this basis, using the forest transition theory and the space-for-time substitution method, we depicted the historical deforestation process as an inverted “S” curve and developed a model to reconstruct historical forest area changes based on the functional relationship between the forest area and population size dynamics. Subsequently, a gridded forest allocation model was established on the basis of deforestation tendencies. For the grassland cover, we implemented regionspecific methods, such as the cropland area deduction method and the habitat constraint method, to quantitatively reconstruct historical changes. Consequently, we obtained provincial forest and grassland area changes over the past millennium and mapped 10-km-resolution gridded data of forest and grassland cover. The results indicated the following.(1) The methods developed using population data as a proxy objectively reproduced the spatiotemporal evolution of forest and grassland cover in China over the past millennium. These feasible methods offer a novel pathway for the quantitative reconstruction of historical forest and grassland cover changes.(2) The data indicated that China's forest area generally decreased over the past millennium, characterized by a “decrease-then-increase” pattern. The forest area experienced three distinct phases: a slow decline(AD 1000

关键词： Land use and land cover change Forest Grassland Quantitative reconstruction Gridded reconstruction China historical period

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Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya LI Feng WANG Tao DUAN Kaijie yang Bin yang Chunmei WANG Xin TIAN Qi LU Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green Wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FWVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FWVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt: Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing HAO Jin-Hui yang Guang ZHU State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Resource and Environmental Engineering Hefei University of Technology

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB), adjacent to the North China Craton(NCC) to the south. This region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun region. The volcanic-sedimentary rocks were previously assigned an early Carboniferous age, but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma, which were intruded by a granite with an age of 242 Ma. This indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma) and correspond to the Qingfengshan and Liujiagou formations. Moreover, two volcanic rock samples have high εHf(t) values(+1.6 to +16.1) and relatively young two-stage Hf model ages(1095–327 Ma), indicating their sources associated with the CAOB. The age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that, during the middle Permian to Middle Triassic, the sedimentary provenance in the Kulun region was mainly the CAOB. However, by the Early Jurassic, the provenance changed to the NCC(i.e., the Inner Mongolia Paleo-uplift, IMPU). This result, combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e., Xingshikou, Xiaoyingzi,and Xiaohekou formations), indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic, with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun region. Based on the Late Triassic alkaline igneous belt(235–215 Ma) in the IMPU, we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift

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