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Transarterial chemoembolization versus percutaneous microwave coagulation therapy for recurrent unresectable intrahepatic cholangiocarcinoma:Development of a prognostic nomogram

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 138-146页

作者： yang ge Seogsong Jeong Gui-Juan Luo Yi-Bin Ren Bao-Hua Zhang Yong-Jie Zhang Feng Shen Qing-Bao Cheng Cheng-Jun Sui Hong-yang Wang Qiang Xia Lei Chen School of Public Health Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438China National Center for Liver Cancer Shanghai 201805China Biliary Tract Department II Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Biliary Tract Department I Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Department of Special Medical Care&Liver Transplantation Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Department of Oncology Shanghai Cancer Center and Institutes of Biomedical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Background:Transarterial chemoembolization(TACE)and percutaneous microwave coagulation therapy(PMCT)are commonly used to treat intrahepatic recurrent liver ***,there is no informa-tion regarding their effectiveness in patients with recurrent intrahepatic cholangiocarcinoma(ICC)after ***:A total of 275 patients with localized recurrent ICC who received either TACE(n=183)or PMCT(n=92)were studied.A propensity score matching analysis was performed to compare prognostic impact of TACE and *** factors for TACE and PMCT were identified *** nomograms for each TACE and PMCT were developed using the Cox independent prognostic factors and were validated in independent patient groups by receiver operating characteristic curves and area under curve ***:Both TACE and PMCT provided curativeness in partial patients(5-year overall survival:21.4%and 6.1%,respectively),but TACE provided better survival benefit in both overall patients(hazard ratio[HR]=0.71;95%confidence interval[CI]:0.50–0.97;P=0.034)and propensity score matching analysis(HR=0.69;95%CI:0.47–0.98;P=0.041).Independent prognostic factors for TACE were tumor size>5 cm,poor differentiation,and major resection,whereas poor differentiation,hepatitis B virus infection,cholelithiasis,and lymph node metastasis were identified for *** predictive nomograms for TACE and PMCT were validated to be effective with area under curve values of 0.77 and 0.70,***:TACE provided better survival benefits compared to ***,there was a disparity in prognostic factors,suggesting evaluation of the two nomograms may be supportive in modality *** prospective validation studies are required for the results to be applied in clinical medicine.

关键词： Bile duct cancer Biliary malignancy Cholangiocarcinoma Locoregional therapy Nomogram

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考虑堆石料空间变异性的土石坝地震反应随机有限元分析

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岩土工程学报 2016年第10期38卷 1822-1832页

作者：杨鸽朱晟河海大学水文水资源与水利水电工程科学国家重点实验室江苏南京210098 国家能源局大坝安全监察中心浙江杭州311122 河海大学水工结构研究所江苏南京210098

探讨了一种将随机场模拟技术与有限元方法相结合的随机有限元法在土石坝地震反应分析中的应用途径。采用局部平均细分法模拟堆石料物理力学性质随机场,使得能够考虑堆石料的空间变异性。提出尽量利用建立材料物理性质与力学性质关系的... 详细信息

探讨了一种将随机场模拟技术与有限元方法相结合的随机有限元法在土石坝地震反应分析中的应用途径。采用局部平均细分法模拟堆石料物理力学性质随机场,使得能够考虑堆石料的空间变异性。提出尽量利用建立材料物理性质与力学性质关系的计算模型,以降低获取材料力学性质统计特性信息的成本。以一实际工程为例,采用该随机有限元法计算了堆石料的干密度、孔隙比、不均匀系数、平均粒径、Duncan–Chang E–B模型模量系数以及初始摩擦角具有不确定性时土石坝的随机地震响应及永久变形。结果表明:筑坝堆石料的不确定性会使大坝响应及永久变形发生一定程度的离散;忽略材料的不确定性可能导致低估大坝的地震反应;表征大坝地震反应的各性能指标并不一定都符合正态或对数正态分布。

关键词：土石坝地震反应堆石料空间变异性随机有限元法

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Numerical analysis of application for induction caving roof

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Journal of Central South University of Technology 2005年第Z1期12卷 146-149页

作者： HU Jian-hua ZHOU Ke-ping LI Xi-bing yang Nian-ge SU Jia-hong School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China

New method for handling roof of the base successive mining is proposed, which is induction caving in the roof. The key is that it is made certain to the station of the space-time in the induction caving roof, as the stress is released with the mining process. And applying the catastrophe theory, the influencing factors of induction caving roof are studied in the emptied areas, such as the mechanical property of the surrounding rock, the area of the gob,the scope and dimension of tensile stress. The results show that the key factor is the area of the gob to the method of the induction caving roof. Then according to the geology and the ore characteristic, the three dimension FEM mechanical model is built in Tongkeng Mine, the laws of the tensile stress are analyzed to the space and the time in the roof with the mining, then it is rational design to the mine step and time of the handing the roof.

关键词： handling roof induction caving catastrophe finite element method

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Molecular Design and Property Prediction of High Density 4-Nitro-5-(5-nitro-1,2,4-triazol-3-yl)-2H-1,2,3-triazolate Derivatives as the Potential High Energy Explosives

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Chinese Journal of Structural Chemistry 2022年第2期41卷 123-131,I0011页

作者： yang Jing PANG Yu LI Min-Xian yang ge-Fei JIA Jing-Xian MENG Xiang-Jun LIU Li-Hua yang Xiao-Chun GAO Xiao-Zhen Department of Chemistry Tangshan Normal CollegeTangshan 063000China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China yangquan Municipal Key Laboratory of Quantum Manipulation Shanxi Institute of TechnologyYangquan 045000China

To search for potential energetic materials with large energy density and acceptable thermodynamics and kinetics stability,twelve derivatives of 4-nitro-5-(5-nitro-1,2,4-triazol-3-yl)-2H-1,2,3-triazolate(named A~L)are designed and analyzed by using density functional theory(DFT)calculations at the B3LYP/6-311G**level of *** molecular heats of formation(HOF),electronic structures,impact sensitivity(H_(50)),oxygen balance(OB)and density(ρ)are investigated by isodesmic reaction method and physicochemical ***,the detonation velocity(D)and detonation pressure(P)are calculated to study the detonation performance by Kamlet-Jacobs(K-J)*** results show that new molecule J(H_(50)=36.9 cm,ρ=1.90g/cm^(3),Q=1912.46 cal/g,P=37.82 GPa,D=9.22 km/s,OB=0.00),compound A(H_(50)=27.9 cm,ρ=1.93 g/cm^(3),Q=1612.93 cal/g,P=38.90 GPa,D=9.19 km/s)and compound H(H_(50)=37.3 cm,ρ=1.97 g/cm^(3),Q=1505.06cal/g,P=37.20 GPa,D=9.01 km/s)present promising effects that are far better RDX and HMX as the high energy density *** calculations can provide useful information for the molecular synthesis of novel high energy density materials.

关键词： 4-nitro-5-(5-nitro-1,2,4-triazol-3-yl)-2H-1,2,3-triazolate energetic materials density functional theory explosive

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Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui yang Chunhui Li Guoguo Ye Chenguang Shen Huiping Shi Liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu Abid Hussain Tian Zhang Haiyin yang Jun yang Yuhua Weng Xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu ge yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

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基于扩张式主从自适应陷波滤波器与动态频率跟踪的永磁同步电机无传感器控制

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电工技术学报 2023年第14期38卷 3824-3835页

作者：葛扬宋卫章杨洋西安理工大学电气工程学院西安710061

磁链观测法是永磁同步电机在中高速区域一种有效的无传感器控制方案。但是由于逆变器非线性、初始位置误差、电流测量偏置等因素,磁链估计结果将不可避免地含有斜坡信号、直流偏置和各次谐波等多种干扰信号。这些干扰信号的存在将降低... 详细信息

磁链观测法是永磁同步电机在中高速区域一种有效的无传感器控制方案。但是由于逆变器非线性、初始位置误差、电流测量偏置等因素,磁链估计结果将不可避免地含有斜坡信号、直流偏置和各次谐波等多种干扰信号。这些干扰信号的存在将降低无传感器控制的稳态精度,增加转速波动,严重时甚至使系统失稳。针对这一问题,提出了基于扩张式主从自适应陷波滤波器(EMAF)的磁链观测方案。利用不同干扰信号的特性,EMAF可同时跟踪磁链观测中的多种干扰信号;通过对积分对象中的直流偏差进行反馈补偿,EMAF可消除积分环节产生的斜坡信号。进一步地,给出了EMAF的参数整定图解法,将多参数整定问题转换为单参数整定。另外,为了提高频率跟踪环节的动态性能,提出一种考虑电机运动方程的动态频率跟踪算法。相比锁相环或锁频环,该算法在频率变化时可减小频率跟踪误差,避免频率突变引起的暂态振荡。不同条件下的实验结果验证了所提方法的有效性。

关键词：永磁同步电机(PMSM) 无传感器控制扩张式主从自适应陷波滤波器参数整定频率跟踪

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面向人体运动视觉跟踪的多线索融合算法

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计算机辅助设计与图形学学报 2009年第10期21卷 1495-1499页

作者：杨戈刘宏北京大学深圳研究生院集成微系统科学工程与应用重点实验室深圳518055 北京大学机器感知与智能教育部重点实验室北京100871

为了跟踪人体的运动轨迹,结合人体运动图像的颜色特征、预测目标位置特征和运动连续性特征,提出一种面向视觉跟踪的多线索融合算法.该算法采用连续自适应均值漂移技术,其中,颜色特征采用色调和饱和度特征、红色信道特征、绿色信道特征... 详细信息

为了跟踪人体的运动轨迹,结合人体运动图像的颜色特征、预测目标位置特征和运动连续性特征,提出一种面向视觉跟踪的多线索融合算法.该算法采用连续自适应均值漂移技术,其中,颜色特征采用色调和饱和度特征、红色信道特征、绿色信道特征以及蓝色信道特征,对于遮挡和位姿的改变实现了较好的鲁棒性;预测目标位置特征利用帧差技术实现;运动连续性特征根据帧间连续性完成.实验结果表明,文中算法比单一线索的算法更加鲁棒,取得了比协作均值漂移跟踪算法更好的跟踪效果,并可以处理目标被部分遮挡、目标环境的颜色饱和度较低等情况.

关键词：多线索融合视觉跟踪连续自适应均值漂移遮挡处理

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一个具有保底投资收益的投资连接寿险定价模型

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系统工程理论与实践 2005年第11期25卷 51-54,91页

作者：杨舸田澎上海交通大学安泰管理学院上海200052

针对某些投资连接寿险产品既存在最低死亡赔付又存在最低投资回报的情形,提出了一个具有保底投资收益的投资连接寿险产品(即具有双重担保收益)的定价模型,并给出了数值算例.研究结果表明,这类产品在定价时可以看作由一个具有保底收益的... 详细信息

针对某些投资连接寿险产品既存在最低死亡赔付又存在最低投资回报的情形,提出了一个具有保底投资收益的投资连接寿险产品(即具有双重担保收益)的定价模型,并给出了数值算例.研究结果表明,这类产品在定价时可以看作由一个具有保底收益的投资基金与一个基于死亡赔付的欧式熊市价差期权组合(EBSOP)构成,该期权组合的价值通常不容忽视;当最低死亡赔付额小于保底投资收益时,欧式熊市价差期权组合为虚值,保单可视为一个可提前执行的有保底收益的投资基金.

关键词：投资连接寿险定价模型保底投资收益组合期权

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Study on Classification of Personality-Based Brand Archetype from the Perspective of Internet

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China Communications 2014年第7期11卷 153-160页

作者： CHEN Fei YUE Xin yang Xuecheng ge Tingting School of Economics and Management Beijing University of Posts and Telecommunications Beijing 100876 China

Due to the rapid development,Internet has become the main field for brand *** this circumstance,the image of the brand is always consistent with the consumers' ***,this study uses the method of text mining of search engine to explore the categories of brand archetype based on Brand Personality Theory from the perspective of *** results find that 12 brand archetypes,including caregiver,sage,hero,innocent,dominator,creator,vitality,explorer,stylish woman,lover,cooperator,and vogue gentleman,have a high degree *** study uses case study to verify the reasonability and effectiveness of the classification standard.

关键词： brand archetype brandpersonality brand positioning SE text mining

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Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population

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Chinese Journal of Cancer 2011年第10期30卷 721-730页

作者： Chang-Hu Zhou Jian-Ye Wang Su-Yan Cao Xiao-Hong Shi Yao-Guang Zhang Ming Liu Xin wang Jin Huang Yi-ge yang Dong Wei Ze yang The Fifth School of Clinical Medicine Peking Uniersity Beijing 100730 P. R. China Department of Urology Beijing Hospital Ministry of Health Beijing 100730 P. R. China Beijing Institute of geriatrics Beijing Hospital Ministry of Health Beijing 100730 P. R. China.

In European populations,7 single nucleotide polymorphisms(SNPs) on chromosome 17q,3 SNPs on 17q12,and 4 SNPs on 17q24.3 were recently identified to be closely related to the risk of prostate cancer by a genome-wide association *** Japanese populations,the correlation between 2 SNPs on 17q and the risk of prostate cancer and tumor aggressiveness was also confirmed by a large-scale ***,whether 17q is associated with prostate cancer and its clinical manifestations in Chinese populations is still ***,we conducted a case-control study in a northern Chinese population and tested 2 SNPs,rs4430796 and rs1859962,on 17q in 124 prostate cancer patients and 111 controls using polymerase chain reaction-high resolution melting curve(PCR-HRM) combined with *** analyzed the association of the 2 SNPs with the risk of prostate cancer as well as patients' lifestyles,onset ages,Gleason scores,PSA levels,and pathologic *** found a significant difference in the G allele of SNP rs1859962(P = 0.035,OR = 1.51,95% CI = 1.03-2.21) but not in the rs4430796 genotype frequency or allele frequency distribution between prostate cancer patients and the controls(P > 0.05).Neither of the SNPs was significantly associated with the onset age,Gleason score,PSA level,pathologic stage,or other clinical indicators of patients with prostate cancer(P > 0.05).Our results show that polymorphism of the G allele of SNP rs1859962 is associated with the risk of prostate cancer in a Chinese population.

关键词：单核苷酸多态性前列腺癌中国人群中国人口染色体风险等位基因频率 SNPs

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