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Bivariate association analysis for quantitative traits using generalized estimation equation

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Journal of Genetics and Genomics 2009年第12期36卷 733-743页

作者： fang yang Zihui Tang Hongwen Deng Laboratory of Molecular and Statistical Genetics College of Life Sciences Hunan Normal University Changsha 410081 China Center of Systematic Biomedical Research Shanghai University of Science and Technology Shanghai 200093 China Departments of Orthopedic Surgery and Basic Medical Sciences University of Missouri-Kansas City Kansas City MO 64108 USA

Quantitative traits often underlie risk for complex diseases. Many studies collect multiple correlated quantitative phenotypes and perform univariate analyses on each of them respectively. However, this strategy may not be powerful and has limitations to detect plei- otropic genes that may underlie correlated quantitative traits. In addition, testing multiple traits individually will exacerbate perplexing problem of multiple testing. In this study, generalized estimating equation 2 （GEE2） is applied to association mapping of two correlated quantitative traits. We suppose that a quantitative trait locus is located in a chromosome region that exerts pleiotropic effects on multiple quantitative traits. In that region, multiple SNPs are genotyped. Genotypes of these SNPs and the two quantitative traits affected by a causal SNP were simulated under various parameter values： residual correlation coefficient between two traits, causal SNP heritability, minor allele frequency of the causal SNP, extent of linkage disequilibrium with the causal SNP, and the test sample size. By power ana- lytical analyses, it is showed that the bivariate method is generally more powerful than the univariate method. This method is robust and yields false-positive rates close to the pre-set nominal significance level. Our real data analyses attested to the usefulness of the method.

关键词： general estimating equation bivariate quantitative trait linkage disequilibrium

Effects of polar cortical cytoskeleton and unbalanced cortical surface tension on intercellular bridge thinning during cytokinesis

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Acta Mechanica Sinica 2011年第6期27卷 1081-1090页

作者： Li Wang Mei-Wen An Xiao-Na Li fang yang yang Liu Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of Technology 030024 Taiyuan China

To probe the contributions of polar cortical cytoskeleton and the surface tension of daughter cells to intercellular bridge thinning dynamics during cytokinesis,we applied cytochalasin D（CD） or colchicine（COLC） in a highly localized manner to polar regions of dividing normal rat kidney（NRK） *** observed cellular morphological changes and analyzed the intercellular bridge thinning trajectories of dividing cells with different polar cortical *** blebbistatin（BS） application was used to obtain cells losing active contractile force *** results show that locally released CD or colchicine at the polar region caused inhibition of cytokinesis before *** treatment at phases after ingression allowed completion of cytokinesis but dramatically influenced the trajectories of intercellular bridge *** single polar cortical actin induced transformation of the intercellular bridge thinning process,and polar cortical tension controlled deformation time of intercellular *** study provides a feasible framework to induce and analyze the effects of local changes in mechanical properties of cellular components on single cellular cytokinesis.

关键词： Cytokinesis Normal rat kidney epithelial cells Intercellular bridge Polar cortical cytoskeleton - Cortical surface tension

Finite Groups with Some Bounded Codegrees

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1778-1784页

作者： Dong fang yang Yu ZENG Heng LV School of Mathematics and Statistics Southwest UniversityChongqing400715P.R.China Department of Mathematics Changshu Institute of TechnologyChangshu215500P.R.China

For a characterχof a finite group G,the number cod(χ) := ∣G:ker(χ)∣/χ(1)is called the codegree ofχ.In this paper,we give a solvability criterion for a finite group G depending on the minimum of the ratioχ(1)^(... 详细信息

关键词： Finite group codegree degree simple group

Fault Detection for Networked Systems with Randomly Occurring Nonlinearities Via Switched System Approach

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Fault Detection for Networked Systems with Randomly Occurrin...

Non-Uniform APSK Optimization for BICM Systems

第25届中国控制与决策会议

作者： Xiongbo Wan Huajing fang fang yang College of Engineering Huazhong Agricultural University Department of Control Science and Engineering Huazhong University of Science and Technology

ISBN: (纸本)9781467355322

This paper addresses the fault detection （FD） problem for networked systems with with randomly occurring nonlinearities and incomplete measurements, including transmission time delays, packet dropouts, and signal quantizations which are described by a new switched system model. We aim to design a mode-dependent fault detection filter （FDF） such that, for all external disturbances, incomplete measurements, and the randomly occurring nonlinearities, the error between the residual and weighted fault is made as small as possible. The addressed FD problem is then converted into an auxiliary H∞ filtering problem of switched systems with time-varying delays. By applying Lyapunov-Krasovskii approach, a sufficient condition for the existence of the FDF is derived in terms of certain linear matrix inequalities （LMIs）. When these LMIs are feasible, the explicit expression of the desired FDF can also be characterized. A numerical example is exploited to show the effectiveness of the results obtained.

关键词： Fault detection networked systems time-varying delays packet dropouts randomly occurring nonlinearities

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Tsinghua Science and Technology 2015年第2期20卷 175-181页

作者： Keqian Yan Kewu Peng fang yang Jian Song Tsinghua National Laboratory for Information Science and Technology (TNList) Department of Electronic EngineeringTsinghua University

Traditional Amplitude Phase Shift Keying （APSK） consists of rings with points uniformly spaced. By giving up this uniform-spacing feature, we propose an APSK optimization method based on the uniform APSK with Gray labeling （Gray-APSK）. The aim of the optimization is to maximize the Generalized Mutual Information （GMI） of Bit-Interleaved Coded Modulation （BICM） for the targeted code rate and channel. We show that our optimized non-uniform APSK could offer further performance gain compared with the conventional uniform Gray-APSK and considerably outperforms the traditional quadrature amplitude modulation at the targeted SNR and channel.

关键词： Bit-Interleaved Coded Modulation (BICM) non-uniform Amplitude Phase Shift Keying (APSK) mutual information geometrical shaping

Monitoring impact of mefenacet treatment on soil microbial communities by PCR-DGGE fingerprinting and conventional testing procedures

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Journal of Environmental Sciences 2006年第2期18卷 373-378页

作者： YE yang-fang MIN Hang LU Zhen-mei College of Life Science and Biotechnology Ningbo University Ningbo 315211 China College of Life Science Zhejiang University Hangzhou 310029 China

The effect of acetanilide herbicide mefenacet on soil microbial communities was studied using paddy soil samples with different short-term treatments. The culturable bacteria （plate counts）, dehydrogenase activity and changes in community structure （denaturing gradient gel electrophoresis （DGGE） analysis） were used for biological community assessments. Mefenacet was a significant stimulus to cultural aerobic bacteria and dehydrogenase activity while Sphingobacterium multivorum Y1, a bacterium efficiently degrading the mefenacet, only induced the increasing colony-forming unit （CFU） of bacteria but little effect on dehydrogenase activity during the whole experiment. The degree of similarity between the 16S rDNA profiles of the communities was quantified by numerically analyzing the DGGE band patterns. Similarity dendrograms showed that the microbial community structures of the mefenacet-treated and non-treated soils were not significantly different. But supplement of S. multivorum Y1 could increase the diversity of the microbial community in the mefenacet-polluted paddy soil. This work is a new attempt to apply the S. multivorum Y1 for remediation of the mefenacet-polluted environments.

关键词： denaturing gradient gel electrophoresis(DGGE) soil microbial diversity mefenacet dehydrogenase

Internet intelligent remote sensing scientific experimental satellite LuoJia3-01

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Geo-Spatial Information Science 2023年第3期26卷 257-261页

作者： Deren Li Mi Wang fang yang Rongfan Dai State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina School of Cyber Science and Engineering Wuhan UniversityWuhanChina DFH Satellite Co LtdBeijingChina

With the development of new technologies such as 5G/6G,cloud computing,the Internet of Things,and artificial intelligence,humanity has entered the era of the interconnection of *** traditional remote sensing satellite data acquisition,processing,and application models have been unable to meet the popular and real-time application *** order to meet the service needs of the geospatial information industry in the era of the Internet of Things,it has become an inevitable trend to move from isolated remote sensing satellites to space-based information networks.

关键词： Internet artificial service

production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis

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World Journal of Gastroenterology 2018年第36期24卷 4132-4151页

作者： fang yang Guo-Xun Chen School of Laboratory Medicine Hubei University of Chinese Medicine Department of Nutrition University of Tennessee at Knoxville

Lysophosphatidic acid(LPA), a glycerophospholipid, consists of a glycerol backbone connected to a phosphate head group and an acyl chain linked to sn-1 or sn-2 position. In the circulation, LPA is in submillimolar range and mainly derived from hydrolysis of lysophosphatidylcholine, a process mediated by lysophospholipase D activity in proteins such as autotaxin(ATX). Intracellular and extracellular LPAs act as bioactive lipid mediators with diverse functions in almost every mammalian cell type. The binding of LPA to its receptors LPA1-6 activates multiple cellular processes such as migration, proliferation and survival. The production of LPA and activation of LPA receptor signaling pathways in the events of physiology and pathophysiology have attracted the interest of researchers. Results from studies using transgenic and gene knockout animals with alterations of ATX and LPA receptors genes, have revealed the roles of LPA signaling pathways in metabolic active tissues and organs. The present review was aimed to summarize recent progresses in the studies of extracellular and intracellular LPA production pathways. This includes the functional, structural and biochemical properties of ATX and LPA receptors. The potential roles of LPA production and LPA receptor signaling pathways in obesity, insulin resistance and liver fibrosis are also discussed.

关键词： Autotaxin Lysophosphatidic acid receptors Obesity Lysophosphatidic acid Insulin resistance Liver fibrosis

Magnetic properties of sputtered anisotropic Pr–Fe–B thin films with different structures and antiferromagnetic materials

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Rare Metals 2016年第12期35卷 926-929页

作者： fang yang Wei Liu Zhi-Dong Zhang Shenyang National Laboratory for Materials Science Institute of Metal Research and International Centre for Materials PhysicsChinese Academy of Sciences Superconducting Materials Research Center Northwest Institute for Nonferrous Metal Research

Anisotropic Pr-Fe-B films with soft-magnetic layer （Fe） and/or antiferromagnetic layer （Mn, FeMn or MnO） were prepared by direct-current （DC） magnetron sputtering on Si （100） substrates heated at 650℃. The influence of four types＇ different structures on the magnetic properties of Pr-Fe-B films was investigated. The phase and magnetic properties were characterized by means of X-ray diffraction （XRD） and superconducting quantum interference device （SQUID）. Addition of anti-ferromagnetic layer enhances both the coercivity and the remanence ratios of Pr-Fe-B films with suitable structures. The interface number increases and the antiferromagnetic-ferromagnetic exchange interaction is likely to become stronger, which affect the improvement of magnetic properties. To further understand the influence of structures with soft-magnetic Fe layer and/or antifer- romagnetic FeMn layer on the magnetic properties of Pr-Fe-B hard-magnetic films, the thickness of Pr-Fe-B layer was designed to decrease from 600 to 50 nm. The improvement of magnetic properties becomes obvious in Mo（50 nm）/Pr-Fe-B（25 nm）Mo（2 nm）FeMn（20 nm）Mo （2 nm）Pr-Fe-B（25 nm）/Mo（50 rim） film.

关键词： Magnetic materials Thin films Coercivity Hysteresis loop Sputtering