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HoLEP does not affect the overall sexual function of BPH patients： a prospective study

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Asian Journal of Andrology 2014年第6期16卷 873-877页

作者： Sung Hart Kim Hyung-Kook yang Hahn-ey Lee Jae-Seung Paick Seung-June Oh Department of Urology Prostate Cancer Center National Cancer Center Goyang Korea Department of Epidemiology and Statistics and Cancer Policy Branch of National Cancer Control Research Institute National Cancer Center Goyang Korea Department of Urology Seoul National University Hospital Seoul Korea.

We aimed to prospectively evaluate the influence of holmium laser enucleation of the prostate （HoLEP） on the overall postoperative sexual function of benign prostatic hyperplasia （BPH） patients with lower urinary tract symptoms （LUTS） and to explore the relationship between sexual function and LUTS. From January 2010 to December 2011, sixty sexually active consecutive patients with BPH who underwent HoLEP were prospectively enrolled in the study. All patients filled out the Male Sexual Health Questionnaire （MSHQ） for evaluation of their overall sexual function and the International Prostatic Symptom Score （IPSS） for pre- and post-operative 6 months evaluation of their voiding symptoms. The LUTS and sexual function changes were statistically analyzed. The preoperative and 6 months postoperative status of the patients was compared using uroflowmetry and IPSS questionnaires. The analysis revealed significant improvements following HoLEP. Among the sub-domains of the MSHQ, postoperative sexual function, including erection, ejaculation, sexual satisfaction, anxiety or sexual desire, did not significantly change after HoLEP （P 〉 0.05）, whereas satisfaction scores decreased slightly due to retrograde ejaculation in 38 patients （63.3%）. Sexual satisfaction improved significantly and was correlated with the improvements of all LUTS and the quality-of-life （QoL） domains in IPSS after surgery （QoL; relative risk [RR]： -0.293; total symptoms, RR： -0.411; P 〈 0.05）. The nocturia score was associated with the erectile function score （odds ratio 0.318, P = 0.029）. The change in ejaculatory scores did not show significant association with IPSS scores. HoLEP did not influence overall sexual function, including erectile function. In addition, sexual satisfaction improved in proportion with the improvement of LUTS.

关键词： benign prostatic hyperplasia ejaculation erectile dysfunction lasers prostatectomy sex disorders

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数智技术赋能农民精神生活共同富裕

西北农林科技大学学报(社会科学版) 2025年第2期25卷 80-88页

作者：杨逸隆张艳凤西安交通大学马克思主义学院内蒙古农业大学党委宣传部内蒙古农业大学水利与建筑工程学院

将数智技术有机嵌入农民精神生活的运行过程，不仅能够推动农民精神交往场域不断拓展，促进精神文化产品增量提质，更能有效加快精神资源流通速率，进而缩小城乡区域之间人民精神生活的差距，推动全民共享优质精神文化成果。从内在机理... 详细信息

将数智技术有机嵌入农民精神生活的运行过程，不仅能够推动农民精神交往场域不断拓展，促进精神文化产品增量提质，更能有效加快精神资源流通速率，进而缩小城乡区域之间人民精神生活的差距，推动全民共享优质精神文化成果。从内在机理看，数智技术提升了农民构筑精神家园的“主体性”,驱动农民汇聚向上向善的“正能量”,创造了农民精神文化交往“新模式”,助力农民精神生活运行的“全过程”。然而，数智技术所带来的“技术至上”思潮泛起、“技术鸿沟”加剧、“技术滥用”风险等也成为农民精神生活共同富裕的现实梗阻。未来，要处理好科技应用与人文关怀、供给提质与需求引导、内容丰富与形式创新、现实交往与虚拟交互“四对关系”,确保让数智技术为农民群众注入更丰富和优质的精神滋养，增强实现中国式农业现代化的精神力量。

关键词：数智技术精神生活共同富裕科技创新文化数字化

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Association between TNF-a and IL-1β genotypes vs Helicobacter pylori infection in Indonesia

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World Journal of Gastroenterology 2013年第46期19卷 8758-8763页

作者： yang Zhao Jing-Wen Wang Tsutomu Tanaka Akihiro Hosono Ryosuke Ando Shinkan Tokudome Soeripto FX Ediati Triningsih Tegu Triono Suwignyo Sumoharjo ey Wenny Astuti Achwan Stephanus Gunawan Yu-Min Li Department of Cancer Center Second Hospital of Lanzhou University Department of Public Health Nagoya City University Graduate School of Medical Sciences Bell Research Center for Reproductive Health and Cancer Medical Corporation Kishokai Department of Nephro-urology Nagoya City University Graduate School of Medical Sciences Department of Nutritional Epidemiology National Institute of Health and Nutrition Department of Anatomic Pathology Gadjah Mada University Faculty of MedicineDaerah Istimewa Yogyakarta Department of Biomedical Research Unit General Hospital of West Nusa Tenggara Province First Department of General Surgery Second Hospital of Lanzhou University Gansu Provincial Key Laboratory of Digestive System Tumors

AIM:To investigate the correlation between the Helicobacter pylori(***)infection and host genetic background of healthy populations in ***:In March 2007,epidemiological studies were undertaken on the general population of a city in Indonesia(Mataram,Lombok).The participants included 107 men and 187 women,whose ages ranged from6 to 74 years old,with an average age of 34.0(±14.4)(±SD).The *** of subject by UBT method determination,and through the polymerase chain reaction with confronting two-pair primers(PCR-CTPP)method parsing the single nucleotide polymorphism of interleukin(IL)-8,IL-4,IL-1β,CD14,tumor necrosis factor(TNF-a)and tyrosine-protein phosphates non-receptor type 11(PTPN11)*** experimental data were analyzed by the statistical software ***:The *** infection rates in the healthy Indonesian population studied were 8.4%for men and12.8%for women;no obvious differences were noted for *** infection rates by sex or *** genotypes of IL-4,TC and CC genotypes of TNF-a,and GA genotypes of PTPN11,were higher in *** CC and TC genotype of TNF-a T-1031C loci featured higher expressions in the healthy Indonesian population Indonesia studied of(OR=1.99;95%CI:0.67-5.89)and(OR=1.66;95%CI:0.73-3.76),respectively.C allele of IL-1βT-31C gene locus was at a higher risk(OR=1.11;95%CI:0.70-1.73)of *** infection,but no statistical significance was found in our ***:We reveal that the association between the TNF-a and IL-1βgenotypes may be the susceptibility of *** in the studied population.

关键词： Helicobacter pylori Tumor necrosis factor Interleukin-1β Infection Allele

肺结节中西医结合恶性风险预测模型的建立与验证

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中国实验方剂学杂志 2025年第2期31卷 129-139页

作者：杨倩肖晶旻陈远彬吴蕾中医证候全国重点实验室广州中医药大学第二临床医学院广州510120

目的:基于临床数据探索肺结节恶性风险的危险因素,构建肺结节中西医结合恶性风险预测模型并使用列线图将预测结果可视化。方法:基于横断面调查研究设计,纳入2023年4月至2024年1月于广东省中医院呼吸与心胸外科住院的肺结节患者,按7∶3... 详细信息

目的:基于临床数据探索肺结节恶性风险的危险因素,构建肺结节中西医结合恶性风险预测模型并使用列线图将预测结果可视化。方法:基于横断面调查研究设计,纳入2023年4月至2024年1月于广东省中医院呼吸与心胸外科住院的肺结节患者,按7∶3随机将数据集分成训练集和验证集。在训练集中,通过单因素Logistic回归分析及最小绝对值压缩选样模型(LASSO)回归分析选择预测因素,经Logistic回归方法建模,对西医及中西医结合预测模型的区分度、校准度及临床决策曲线等性能进行比较,筛选出最优模型,并使用列线图对模型进行可视化呈现。结果:本研究共纳入366例患者,划分为训练集(258例)及验证集(108例),可纳入年龄、嗜食肥甘厚腻、环境或职业暴露史、气虚质、阳虚质、结节密度及结节直径等7个预测因素。采用Logistic回归构建模型,仅以年龄、环境或职业暴露史、结节密度及结节直径为预测因素建立的西医模型定义为model1,而在以上基础上增加嗜食肥甘厚腻、气虚质和阳虚质为预测因素建立的中西医结合模型定义为model2,model2在训练集及验证集中具有更好的预测效能,其训练集准确率为0.740,精确率为0.825,召回率为0.829,F1分数为0.827,曲线下面积(AUC)为0.865[95%置信区间(95%CI)0.815~0.915],布里尔评分为0.122;验证集准确率为0.731,精确率为0.776,召回率为0.831,F1分数为0.803,AUC为0.852(95%CI 0.776~0.927),布里尔评分为0.149,校准曲线及决策曲线分析显示该模型在预测中具有较好的一致性与临床效用性。构建方程为肺结节恶性概率p=ey/(1+ey),其中Y=-4.187+0.022×(年龄)+1.079×(环境或职业暴露史)+0.718×(嗜食肥甘厚腻)+1.403×(气虚质)+0.732×(阳虚质)+0.349×(纯磨玻璃密度结节)+1.304×(部分实性密度结节)+0.148×(结节直径),并采用直观的列线图进行展示。结论:该研究开发了一个肺结节恶性风险的综合评估模型,结合了中医和西医的因素,将中医元素嵌入预测模型可以多维度评估结节恶变的相关危险因素,具有良好的诊断效能,为早期识别肺癌提供一定的参考价值。

关键词：肺结节中西医结合预测模型危险因素列线图

SEC1A and SEC6 synergistically regulate pollen tube polar growth

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Journal of Integrative Plant Biology 2023年第7期65卷 1717-1733页

作者： Tingting Fan Yuemin Fan yang yang Dong Qian Yue Niu Lizhe An Yun Xiang MOE Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 730000China

Pollen tube polar growth is a key physiological activity for angiosperms to complete double fertilization, which is highly dependent on the transport of polar substances mediated by secretory *** exocyst and Sec1/Munc18(SM) proteins are involved in the regulation of the tethering and fusion of vesicles and plasma membranes, but the molecular mechanism by which they regulate pollen tube polar growth is still unclear. In this study, we found that loss of function of SEC1A, a member of the SM protein family in Arabidopsis thaliana, resulted in reducing pollen tube growth and a significant increase in pollen tube width. SEC1A was diffusely distributed in the pollen tube cytoplasm, and was more concentrated at the tip of the pollen tube. Through coimmunoprecipitation-mass spectrometry screening,protein interaction analysis and in vivo microscopy,we found that SEC1A interacted with the exocyst subunit SEC6, and they mutually affected the distribution and secretion rate at the tip of the pollen tube. Meanwhile, the functional loss of SEC1A and SEC6 significantly affected the distribution of the SNARE(soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex member SYP125 at the tip of the pollen tube, and led to the disorder of pollen tube cell wall components. Genetic analysis revealed that the pollen tube-related phenotype of the sec1a sec6 double mutant was significantly enhanced compared with their respective single mutants. Therefore, we speculated that SEC1A and SEC6 cooperatively regulate the fusion of secretory vesicles and plasma membranes in pollen tubes, thereby affecting the length and the width of pollen tubes.

关键词： pollen tube SEC1A SEC6 SYP125 vesicle secretory

Retraction Note to:Light hydrocarbon geochemistry:insight into oils/condensates families and inferred source rocks of the Woodford-Mississippian tight oil play in North-Central Oklahoma,USA

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Petroleum Science 2020年第6期17卷 1795-1795页

作者： Ting Wang Dong-Lin Zhang Xiao-Yong yang Jing-Qian Xu Coff ey Matthew You-Jun Tang Key Laboratory of Exploration Technologies for Oil and Gas Resources(yangtze University) Ministry of EducationWuhan 430100HubeiChina School of Geology and Geophysics University of OklahomaNormanOK 73019USA Devon Energy Corporation Oklahoma CityOK 73102USA

Retraction Note to:Petroleum Science(2020)17:582-597https://***/10.1007/s12182-020-00441-1The authors have retracted their article(Wang et al.2020)because of significant textual overlap with previously published works... 详细信息

关键词： geochemistry source rocks

Gene therapy for neurodegenerative disorders:advances, insights and prospects

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1347-1359页

作者： Wei Chen yang Hu Dianwen Ju Department of Biological Medicines Fudan University School of Pharmacy Shanghai 201203 China Department of Ophthalmology Stanford University School of Medicine Palo Alto CA 94304 USA

Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of neurodegenerative disorders, including Alzheimer’s disease(AD), Parkinson’s disease(PD) and Huntington’s disease(HD). Some early clinical trials have failed to achieve satisfactory therapeutic effects. Efforts to enhance effectiveness are now concentrating on three major fields: identification of new vectors,novel therapeutic targets, and reliable of delivery routes for transgenes. These approaches are being assessed closely in preclinical and clinical trials, which may ultimately provide powerful treatments for patients. Here, we discuss advances and challenges of gene therapy for neurodegenerative disorders,highlighting promising technologies, targets, and future prospects.

关键词： disorders degenerative Huntington

KIF5B-mediated internalization of FMDV promotes virus infection

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Virologica Sinica 2024年第3期39卷 378-389页

作者： Wei Zhang Fan yang yang yang Weijun Cao Wenhua Shao Jiali Wang Mengyao Huang Zhitong Chen Xiaoyi Zhao Weiwei Li Zixiang Zhu Haixue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Gansu Province Research Center for Basic Disciplines of Pathogen Biology Lanzhou 730046China

Foot-and-mouth disease(FMD)is a highly contagious and economically important disease,which is caused by the FMD virus(FMDV).Although the cell receptor for FMDV has been identified,the specific mechanism of FMDV internalization after infection remains *** this study,we found that kinesin family member 5B(KIF5B)plays a vital role during FMDV ***,we confirmed the interaction between KIF5B and FMDV structural protein VP1 by co-immunoprecipitation(Co-IP)and co-localization in FMDV-infected *** particular,the stalk[amino acids(aa)413–678]domain of KIF5B was indispensable for KIF5B-VP1 ***,overexpression of KIF5B dramatically enhanced FMDV replication;consistently,knockdown or knockout of KIF5B suppressed FMDV ***,we also demonstrated that KIF5B promotes the internalization of FMDV via regulating clathrin ***5B also promotes the transmission of viral particles to early and late endosomes during the early stages of *** conclusion,our results demonstrate that KIF5B promotes the internalization of FMDV via regulating clathrin uncoating and intracellular *** study may provide a new therapeutic target for developing FMDV antiviral drugs.

关键词： FMDV VP1 protein KIF5B Endosome Clathrin

Sorption and desorption of pymetrozine on six Chinese soils

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Frontiers of Environmental Science & Engineering 2016年第1期10卷 1-10页

作者： Mingxing GAO Yingying LI Hong yang Yucheng GU Jiangsu Key Laboratory of Pesticide Science College of Sciences Nanjing Agricultural University Nanjing 210095 China Syngenta Nantong Crop Protection Co. Ltd. Nantong Economic & Technological Development Area Nantong 226009 China Syngenta Jealott's Hill International Research Centre Bracknell Berkshire RG42 6EY UK

Pymetrozine is a selective insecticide with a unique chemical structure and mode to control hemipteran and homopteran. While pymetrozine has brought great benefits to crop production by killing insects, its residues in soil may have a detrimental effect on environment. Therefore, it is of great importance to investigate its behaviors in soil. In this study, the sorption and desorption of pymetrozine on six Chinese soils were investigated using a batch equilibrium approach to understand its mobile behavior in the soils. Both sorption and desorption isotherms ofpymetrozine were in good agreement with the Freundlich model. The sorption coefficient KF varied between 3.37 and 58.32 mL. g-1 and the sorption isotherms were nonlinear, with 1/n ranging from 0.57 to 0.91. A regression equation was proposed to predict the solption of pymetrozine on six different soil samples： log KF = 4.3708 - 4.5709 × log （pH in 0.01mol·L-1 CaC12）＋ 0.4700 × log OC% ＋ 0.0057 × sand （%）＋ 0.0022 × CEC（clay）, with R2 = 0.9982. The organic carbon content of soil positively affected the sorption ofpymetrozine, but soil pH had a negative effect on the sorption. Additionally, effects of CaC12 concentration, soil to solution ratio and pesticide form were investigated. The sorption was promoted with an increase in soil to solution ratio and a decrease in CaC12 concentration. The possible variation of the five formulated products of pymetrozine was also investigated.

关键词： pymetrozine sorption desorption soil