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Development of a machine learning-based model for predicting risk of early postoperative recurrence of hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第43期29卷 5804-5817页

作者： Yu-Bo Zhang Gang yang yang bu Peng Lei Wei Zhang Dan-yang Zhang Department of Hepatobiliary Surgery General Hospital of Ningxia Medical UniversityYinchuan 750003Ningxia Hui Autonomous RegionChina Department of Hepatobiliary Surgery People's Hospital of Ningxia Hui Autonomous RegionYinchuan 750003Ningxia Hui Autonomous RegionChina

BACKGROUND Surgical resection is the primary treatment for hepatocellular carcinoma(HCC).However,studies indicate that nearly 70%of patients experience HCC recurrence within five years following hepatectomy.The earlier the recurrence,the worse the prognosis.Current studies on postoperative recurrence primarily rely on postoperative pathology and patient clinical data,which are lagging.Hence,developing a new pre-operative prediction model for postoperative recurrence is crucial for guiding individualized treatment of HCC patients and enhancing their prognosis.AIM To identify key variables in pre-operative clinical and imaging data using machine learning algorithms to construct multiple risk prediction models for early postoperative recurrence of HCC.METHODS The demographic and clinical data of 371 HCC patients were collected for this retrospective study.These data were randomly divided into training and test sets at a ratio of 8:2.The training set was analyzed,and key feature variables with predictive value for early HCC recurrence were selected to construct six different machine learning prediction models.Each model was evaluated,and the bestperforming model was selected for interpreting the importance of each variable.Finally,an online calculator based on the model was generated for daily clinical practice.RESULTS Following machine learning analysis,eight key feature variables(age,intratumoral arteries,alpha-fetoprotein,preoperative blood glucose,number of tumors,glucose-to-lymphocyte ratio,liver cirrhosis,and pre-operative platelets)were selected to construct six different prediction models.The XGBoost model outperformed other models,with the area under the receiver operating characteristic curve in the training,validation,and test datasets being 0.993(95%confidence interval:0.982-1.000),0.734(0.601-0.867),and 0.706(0.585-0.827),respectively.Calibration curve and decision curve analysis indicated that the XGBoost model also had good predictive performance and clinical application value.CONCLUSION The XGBoost mo

关键词： Machine learning Hepatocellular carcinoma Early recurrence Risk prediction models Imaging features Clinical features

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Comparison of prevention and treatment of portal vein thrombosis between proximal splenic vein ligation followed by postoperative transcatheter anticoagulant therapy and systemic anticoagulant therapy in patients with cirrhotic portal hypertension

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Portal Hypertension & Cirrhosis 2023年第3期2卷 136-143页

作者： yang bu Kejun Liu Mingguo Tian Baoding Li Liyun Wang Dong Jia Yong yang Junhao Liu Department of Hepatobiliary Surgery People's Hospital of Ningxia Hui Autonomous RegionYinchuanNingxiaChina Department of Hepatobiliary Surgery General Hospital of Ningxia Medical UniversityYinchuanNingxiaChina

Aims:Splenectomy combined with pericardial devascularization is one of the important methods to treat hypersplenism,gastrointestinal bleeding,and other complications caused by liver cirrhosis;however,it is accompanied by a high risk of portal vein thrombosis(PVT).This study aimed to explore the preventive and therapeutic effects of proximal splenic vein ligation(PSVL)with postoperative transcatheter anticoagulant therapy(TCAT)on PVT.Methods:This study retrospectively selected 143 patients with liver cirrhosis and portal hypertension,who received splenectomy combined with pericardial devascularization from June 30,2018 to June 30,2021.According to computed tomography photography,within 1 week before the operation,the patients were divided into a prevention group(without preoperative PVT,n=112)and a treatment group(preoperative PVT,n=31).Then,each group was subdivided based on the treatment and prevention measures into PSVL+TCAT(n=70)and systemic anticoagulant therapy(SAT)subgroups(n=73).The preventive and therapeutic effects of PSVL followed by TCAT on PVT were analyzed.Results:The operation time in the PSVL+TCAT subgroups was longer than that in the SAT subgroups(185±76 min vs.161±55 min;p0.50).There was no operative death,and all patients recovered uneventfully.In the prevention group,procedure-related complications occurred in two patients in the PSVL+TCAT subgroup(3.7%[2/54]),including one patient with slight pancreatitis and one patient with chylous leakage,owing to mobilization of the pancreas.The PVT incidence in the prevention group was significantly different between the two subgroups at postoperative 7th day,3rd month,and 6th month(PSVL+TCAT:0%,11.1%,and 5.6%vs.SAT:39.7%,31.0%,and 20.7%,respectively;all pbus regression rate at postoperative 7th day and disappearance rates at the 3rd month and the 6th month of the PSVL+TCAT subgroup were significantly high

关键词： hypertension portal prevention splenectomy venous thrombosis

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Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future

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Genes & Diseases 2020年第3期7卷 370-379页

作者： Xia Liao yang bu Qingan Jia Department of Nutrition First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Hepatobiliary Surgery General HospitalNingxia Medical UniversityYinchuan750001China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China

Liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide.Western medicine and therapies are the primary treatment strategies of hepatocellular carcinoma(HCC),but the general prognosis for HCC patients is still dismal.Under these circumstances,HCC prevention is particularly important.Traditional Chinese medicine(TCM)encompasses a wealth of documented therapeutic resources,and“preventative treatment”is the principle of TCM.In China,TCM has been used for HCC prevention for thousands of years,and has also been demonstrated to be effective for the treatment of HCC in modern China.However,the TCM theory for prevention and treatment of HCC is more widely accepted in China than abroad.In this review,we first summarize the herbs and ancient formulas with therapeutic effects on HCC.We also review the research status of TCM in modern medicine as well as the current obstacles in its development.Finally,we discuss the future of TCM in the context of precision and integrated medicine.After reviewing the literature,we believe that TCM,through ancient development,is an advanced method of cancer treatment with positive curative effects,despite its surrounding controversy.Furthermore,precise analyses and systematic research methods provides novel approaches to modernize TCM for the future.

关键词： Chinese herbal medicine Hepatocellular carcinoma Molecular mechanism Network pharmacology Traditional Chinese medicine

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Measuring Viscoelastic Properties of Living Cells

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Acta Mechanica Solida Sinica 2019年第5期32卷 599-610页

作者： yang bu Long Li Chendong yang Rui Li Jizeng Wang Key Laboratory of Mechanics on Disaster and Environment in Western China Ministry of EducationCollege of Civil Engineering and MechanicsLanzhou UniversityLanzhou 730000China

Precise measurement of mechanical properties of living cells is important in understanding their mechanics-biology relations.In this study,we adopted the atomic force microscope to measure the creep deformation and stress relaxation of six different human cell lines.We examined whether the measured creep and relaxation trajectories satisfy a verification relation derived based on the linear viscoelastic theory.We compared the traditional spring-dashpot and the newly developed power-law-type constitutive relations in fitting the experimental measurements.We found that the human normal liver(L02),hepatic cancer(HepG2),hepatic stellate(LX2)and gastric cancer(NCI-N87)cell lines are linear viscoelastic materials,and human normal gastric(GES-1)and gastric cancer(SGC7901)cell lines are nonlinear due to failing in satisfying the verification relation for linear viscoelastic theory.The three-parameter power-law-type const计utive relation can fit the experimentai measurements better than that of the five-parameter classical spring-dashpot.

关键词： Atomic force microscope Living cells Linear viscoelasticity Creep Relaxation

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经阴道三维超声检查在宫腔粘连诊断中的效能

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中国民康医学 2024年第5期36卷 120-122页

作者：卜杨郑州四六〇医院超声医学科河南郑州450000

目的:观察经阴道三维超声(3D-TVS)检查在宫腔粘连诊断中的效能。方法:选取2021年5月至2023年5月该院收治的83例疑似宫腔粘连患者进行前瞻性研究,所有患者均行经阴道二维超声(2D-TVS)、3D-TVS及宫腔镜检查,以宫腔镜检查为金标准,比较2D-... 详细信息

目的:观察经阴道三维超声(3D-TVS)检查在宫腔粘连诊断中的效能。方法:选取2021年5月至2023年5月该院收治的83例疑似宫腔粘连患者进行前瞻性研究,所有患者均行经阴道二维超声(2D-TVS)、3D-TVS及宫腔镜检查,以宫腔镜检查为金标准,比较2D-TVS、3D-TVS检查在宫腔粘连诊断中的效能,以及不同程度宫腔粘连患者3D-TVS定量参数[子宫内膜容积(EV)、血流指数(FI)、血管指数(VI)、血管血流综合指数(VFI)]水平。结果:宫腔镜检查结果显示,83例疑似宫腔粘连患者阳性76例,阴性7例,其中轻度33例、中度28例、重度15例;2D-TV检查结果显示阳性65例,阴性18例,3D-TVS检查结果显示阳性70例,阴性13例;3D-TVS检查诊断宫腔粘连的准确度高于2D-TVS检查,差异有统计学意义(P中度>重度,差异均有统计学意义(P<0.05)。结论:3D-TVS检查在宫腔粘连诊断中的效能高于2D-TVS检查。

关键词：经阴道三维超声检查宫腔粘连定量参数诊断效能

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Depletion of MRPL35 inhibits gastric carcinoma cell proliferation by regulating downstream signaling proteins

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World Journal of Gastroenterology 2021年第16期27卷 1785-1804页

作者： Ling Yuan Jia-Xin Li Yi yang Yan Chen Ting-Ting Ma Shuang Liang yang bu Lei Yu Yi Nan Pharmacy College of Ningxia Medical University Yinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Hui Ethnic Medicine Modernization of Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Oncology and Endocrinology Yinchuan Hospital of Traditional Chinese Medicine Affiliated to Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Hepatobiliary Surgery General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Infectious Diseases The Fourth Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Gastric carcinoma(GC)is a digestive system disease with high morbidity and mortality.However,early clinical detection is difficult,and the therapeutic effect for advanced disease is not satisfactory.Thus,finding new tumor markers and therapeutic targets conducive to the treatment of GC is imperative.MRPL35 is a member of the large subunit family of mitochondrial ribosomal protein.MRPL35 shows the characteristic of oncogene in colorectal cancer and esophageal cancer,which promotes the exploration of the correlation between MRPL35 and GC.We proposed that the expression of MRPL35 might be critical in GC.AIM To study the effect of MRPL35 knockdown on GC cell proliferation.METHODS The expression of MRPL35 in GC was evaluated based on data from the publictumor database UALCAN(www.***.path.***.edu).The effect of theexpression of MRPL35 on the prognosis was evaluated with KMplot(***).The expression of MRPL35 was assessed on the tissuemicroarray by immunohistochemistry and the level of MRPL35 mRNA in 25 pairsof clinical GC tissues and matched adjacent tissues was detected by quantitativereverse transcription-polymerase chain reaction.Celigo cell count assay,colonyformation assay,and flow cytometry were used to assess the role of MRPL35 inGC cell proliferation and apoptosis in vitro.Additionally,tumor formationexperiment in BALB/c nude mice was utilized to determine the effect of MRPL35on GC cell proliferation.After knockdown of MRPL35,related proteins wereidentified by isobaric tags for relative and absolute quantification analysis,andthe expression of related proteins was detected by Western blot.RESULTSThe expression of MRPL35 was up-regulated in GC(P=1.77×10^(-4)).The Kaplan-Meier plots of the overall survival indicated that high expression of MRPL35 wasassociated with a poor survival in GC.Compared with adjacent tissues,theexpression of MRPL35 in GC tissues was increased,which was related to age(P=0.03),lymph node metastasis(P=0.007),and pathological tumor-node-metastasisstage(P=0.024).Knockdown of MRPL3

关键词： Gastric carcinoma MRPL35 Apoptosis Proliferation Tissue microarray Isobaric tags for relative and absolute quantification

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应用驱动宽带Mesh与广电5G混合专网解决方案

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电信工程技术与标准化 2024年第6期37卷 57-62页

作者：罗新军王楚锋许步扬中通服咨询设计研究院有限公司南京210019 深圳市天威视讯股份有限公司深圳518036

面对海域、空域、河流、偏远山区和矿区等复杂场景的立体专网通信覆盖需求,存在建设成本高、可靠性低、传输链路困难等诸多瓶颈与挑战,需要构建更加合理、灵活和韧性强的混合专网系统以应对。本文分析了广电700 MHz频段5G网络的优势特点... 详细信息

面对海域、空域、河流、偏远山区和矿区等复杂场景的立体专网通信覆盖需求,存在建设成本高、可靠性低、传输链路困难等诸多瓶颈与挑战,需要构建更加合理、灵活和韧性强的混合专网系统以应对。本文分析了广电700 MHz频段5G网络的优势特点,研究了宽带Mesh无线自组网的特性,建设应用驱动下的宽带Mesh无线自组网与广电5G的混合专网系统,构建基于混合专网系统与MEC边缘计算的智慧管理平台,为智联、物联等多种行业应用提供整体解决方案。

关键词： 5G MIMO Mesh 混合专网智慧管理平台

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一种基于残差网络改进的牙齿颜色分类模型

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软件工程 2024年第3期27卷 52-57页

作者：刘博文步扬邹多宏李建郎上海理工大学光电信息与计算机工程学院上海200093 中国科学院上海光学精密机械研究所上海201899 上海交通大学医学院附属第九人民医院上海200011

针对传统牙齿比色方法准确率低和效率低等问题,提出一种基于残差网络改进的牙齿颜色分类模型。该模型通过融合多层卷积结果以及引入压缩与激励注意力机制模块的方式,使网络能学习到更多的图像颜色特征。基于典型牙齿所建数据集进行颜色... 详细信息

针对传统牙齿比色方法准确率低和效率低等问题,提出一种基于残差网络改进的牙齿颜色分类模型。该模型通过融合多层卷积结果以及引入压缩与激励注意力机制模块的方式,使网络能学习到更多的图像颜色特征。基于典型牙齿所建数据集进行颜色分类实验,在该数据集上对文中模型与GoogleNet、MobileNet-V1、ResNet-34和ResNet-50等模型进行颜色分类预测结果比较。实验结果表明,文中模型优于传统模型,预测分类准确度达到91.16%,有效提高了牙齿颜色分类准确率和效率。

关键词：牙齿比色颜色分类深度学习 ResNet-18网络

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超声引导下经皮热消融与腔镜手术治疗甲状腺结节对甲状腺功能的影响及安全性比较

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临床医学工程 2024年第1期31卷 19-20页

作者：张华丽卜杨赵洁郑州四六〇医院超声医学科河南郑州450007

目的探讨超声引导下经皮热消融与腔镜手术治疗甲状腺结节对甲状腺功能的影响及安全性。方法选择2020年4月至2023年4月我院收治的60例甲状腺结节患者随机分为对照组(腔镜手术)与观察组(超声引导下经皮热消融术)。比较两组的手术效果、甲... 详细信息

目的探讨超声引导下经皮热消融与腔镜手术治疗甲状腺结节对甲状腺功能的影响及安全性。方法选择2020年4月至2023年4月我院收治的60例甲状腺结节患者随机分为对照组(腔镜手术)与观察组(超声引导下经皮热消融术)。比较两组的手术效果、甲状腺功能、术后并发症发生率。结果两组的治疗总有效率比较差异无统计学意义(P>0.05)。术后3个月,观察组TSH高于对照组,FT3、FT4低于对照组(P<0.05)。观察组术后并发症发生率为0.00%,低于对照组的13.33%(P<0.05)。结论超声引导下经皮热消融与腔镜手术治疗甲状腺结节均能取得较好的手术效果,但前者对患者甲状腺功能改善程度更加显著,安全性更高。

关键词：超声引导下经皮热消融术腔镜手术甲状腺结节甲状腺功能安全性

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Endoscopic Ruler for varix size measurement:A multicenter pilot study

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世界胃肠内镜杂志:英文版(电子版) 2023年第9期15卷 564-573页

作者： Yi-Fei Huang Sheng-Juan Hu yang bu Yi-Ling Li Yan-Hong Deng Jian-Ping Hu Shao-Qi yang Qian Shen Mark McAlindon Rui-Chun Shi Xiao-Qin Li Tie-Ying Song Hai-Long Qi Tai-Wei Jiao Meng-Yuan Liu Fang He Jun Zhu Bin Ma Xiao-Bin Yu Jian-yang Guo Yue-Hua Yu Hai-Jiang Yong Wen-Tun Yao Ting Ye Hua Wang Wen-Fu Dong Jian-Guo Liu Qiang Wei Jing Tian Xiao-Guo Li Xavier Dray Xiao-Long Qi Institute of Portal Hypertension The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology People's Hospital of Ningxia Hui Autonomous RegionNingxia Medical University Affiliated People's Hospital of Autonomous RegionYinchuan 750000Ningxia Hui Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Gastroenterology Yinchuan First People's HospitalYinchuan 750000Ningxia Hui Autonomous RegionChina Department of Gastroenterology Ningxia Medical University General HospitalYinchuan 750000Ningxia Hui Autonomous RegionChina Department of Gastroenterology Yinchuan Second People's HospitalYinchuan 750000Ningxia Hui Autonomous RegionChina Academic Department of Gastroenterology and Hepatology Sheffield Teaching Hospitals NHS TrustAL 35660SheffieldUnited Kingdom Department of Gastroenterology Wuzhong People's HospitalWuzhong 751100Ningxia Hui Autonomous RegionChina Department of Gastroenterology The Fifth People's Hospital of Ningxia Hui Autonomous RegionShizuishan 753000Ningxia Hui Autonomous RegionChina Department of Second Gastroenterology The Sixth People’s Hospital of ShenyangShenyang 110000Liaoning ProvinceChina Department of Gastroenterology Shizuishan Second People's HospitalShizuishan 753000Ningxia Hui Autonomous RegionChina Department of Gastroenterology Zhongwei People's HospitalZhongwei 755000Ningxia Hui Autonomous RegionChina Department of Hepato-Gastroenterology ETISENSEACNRSSorbonne Université&APHPHôpital Saint AntoineUniversitéParis-SeineUniversitéde Cergy-PontoiseParis 75012SélectionnerFrance Center of Portal Hypertension Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND We invented Endoscopic Ruler,a new endoscopic device to measure the size of varices in patients with cirrhosis and portal hypertension.AIM To assess the feasibility and safety of Endoscopic Ruler,and evaluate the agreement on identifying large oesophageal varices(OV)between Endoscopic Ruler and the endoscopists,as well as the interobserver agreement on diagnosing large OV using Endoscopic Ruler.METHODS We prospectively and consecutively enrolled patients with cirrhosis from 11 hospitals,all of whom got esophagogastroduodenoscopy(EGD)with Endoscopic Ruler.The primary study outcome was a successful measurement of the size of varices using Endoscopic Ruler.The secondary outcomes included adverse events,operation time,the agreement of identifying large OV between the objective measurement of Endoscopic Ruler and the empirical reading of endoscopists,together with the interobserver agreement on diagnosing large OV by Endoscopic Ruler.RESULTS From November 2020 to April 2022,a total of 120 eligible patients with cirrhosis were recruited and all of them underwent EGD examinations with Endoscopic Ruler successfully without any adverse event.The median operation time of Endoscopic Ruler was 3.00 min[interquartile range(IQR):3.00 min].The kappa value between Endoscopic Ruler and the endoscopists while detecting large OV was 0.52,demonstrating a moderate agreement.The kappa value for diagnosing large OV using Endoscopic Ruler among the six independent observers was 0.77,demonstrating a substantial agreement.CONCLUSION The data demonstrates that Endoscopic Ruler is feasible and safe for measuring the size of varices in patients with cirrhosis and portal hypertension.Endoscopic Ruler is potential to promote the clinical practice of the two-grade classification system of OV.

关键词： Oesophageal varices Cirrhosis Portal hypertension Esophagogastroduodenoscopy Endoscopic ruler

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