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An integrated bioinformatics analysis and experimental study identified key biomarkers CD300A or CXCL1,pathways and immune infiltration in diabetic nephropathy mice

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BIOCELL 2022年第8期46卷 1989-2002页

作者： WEI LIANG QIANG LUO ZONGWEI ZHANG KEJU yang ankang yang QINGJIA CHI HUAN HU Division of Nephrology Renmin Hospital of Wuhan UniversityWuhanChina Nephrology and Urology Research Institute of Wuhan University WuhanChina The First College of Clinical Medical Science China Three Gorges UniversityYichangChina Department of Engineering Structure and Mechanics Wuhan University of TechnologyWuhanChina School of Life Science and Engineering Southwest Jiaotong UniversityChengdu610000China

Diabetic nephropathy(DN)is a common microvascular complication that easily leads to end-stage renal *** is important to explore the key biomarkers andmolecular mechanisms relevant to diabetic nephropathy(DN).We used highthroughput RNA sequencing to obtain the genes related to DN glomerular tissues and healthy glomerular tissues of *** we used LIMMA to analyze differentially expressed genes(DEGs)between DN and non-diabetic glomerular *** we performed KEGG,gene ontology functional(GO)enrichment,and gene set enrichment analysis to reveal the signaling pathway of the *** CIBERSORT algorithm based on support vector machine was used to determine the immune infiltration *** forest algorithm and Cytoscape obtained hub ***,we applied co-staining,immunohistochemical staining,RT-qPCR and western blotting to validate the protein and mRNA expression of both hub *** obtained 913 DEGs mainly related to inflammatory factors and *** results showed that differential genes were mainly enriched in IL-17 signaling pathway,lipid and atherosclerosis,rheumatoid arthritis,TNF signaling pathway,neutrophil extracellular trap formation,Staphylococcus aureus infection and other *** intersection of the random forest algorithm and Cytoscape revealed both hub genes of CD300A and *** have shown that the both key genes of CD300A and CXCL1 shown increased expression in glomerular podocytes,and are related to the inflammation of diabetic *** immunohistochemical staining and RT-qPCR further confirmed that the protein and mRNA expression level of CD300A or CXCL1 in glomeruli tissue in DN mice were *** expression levels of CD300A and CXCL1 increased significantly under HG(high glucose)stimulation,further confirming that diabetes can lead to increased levels of CD300A and CXCL1 at the cellular *** bioinformatics analysis,machine learning algorithms,and experimental research,CD300A and CXCL

关键词： Diabetic nephropathy Immune infiltration Machine learning Bioinformatics Biomarkers

Genetic algorithm-optimized backpropagation neural network establishes a diagnostic prediction model for diabetic nephropathy:Combined machine learning and experimental validation in mice

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BIOCELL 2023年第6期47卷 1253-1263页

作者： WEI LIANG ZONGWEI ZHANG KEJU yang HONGTU HU QIANG LUO ankang yang LI CHANG YUANYUAN ZENG Division of Nephrology Renmin Hospital of Wuhan UniversityWuhanChina Nephrology and Urology Research Institute of Wuhan University WuhanChina The First College of Clinical Medical Science Three Gorges UniversityYichangChina School of Life Science and Engineering Southwest Jiaotong UniversityChengduChina

Background:Diabetic nephropathy(DN)is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease *** biomarkers may allow early diagnosis and treatment of DN to reduce the prevalence and delay the development of *** biopsy is the gold standard for diagnosing DN;however,its invasive character is its primary *** machine learning approach provides a non-invasive and specific criterion for diagnosing DN,although traditional machine learning algorithms need to be improved to enhance diagnostic ***:We applied high-throughput RNA sequencing to obtain the genes related to DN tubular tissues and normal tubular tissues of *** machine learning algorithms,random forest,LASSO logistic regression,and principal component analysis were used to identify key genes(CES1G,CYP4A14,NDUFA4,ABCC4,ACE).Then,the genetic algorithm-optimized backpropagation neural network(GA-BPNN)was used to improve the DN diagnostic ***:The AUC value of the GA-BPNN model in the training dataset was 0.83,and the AUC value of the model in the validation dataset was 0.81,while the AUC values of the SVM model in the training dataset and external validation dataset were 0.756 and 0.650,***,this GA-BPNN gave better values than the traditional SVM *** diagnosis model may aim for personalized diagnosis and treatment of patients with *** staining further confirmed that the tissue and cell expression of NADH dehydrogenase(ubiquinone)1 alpha subcomplex,4-like 2(NDUFA4L2)in tubular tissue in DN mice were ***:The GA-BPNN model has better accuracy than the traditional SVM model and may provide an effective tool for diagnosing DN.

关键词： Diabetic nephropathy Renal tubule Machine learning Diagnostic model Genetic algorithm

科技创新与新型城镇化耦合协调测度分析--以京津冀地区为例

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科技导报 2020年第15期38卷 111-120页

作者：曹琳剑杨安康天津城建大学经济与管理学院天津城镇化与新农村建设研究中心天津300384

构建了科技创新与新型城镇化耦合协调测度评价指标体系,采用熵值法确定了两系统评价指标的权重,综合应用耦合协调度模型和相对发展度模型,解析了2006—2017年京津冀地区科技创新与新型城镇化的耦合协调度。结果表明,京津冀地区科技创新... 详细信息

构建了科技创新与新型城镇化耦合协调测度评价指标体系,采用熵值法确定了两系统评价指标的权重,综合应用耦合协调度模型和相对发展度模型,解析了2006—2017年京津冀地区科技创新与新型城镇化的耦合协调度。结果表明,京津冀地区科技创新与新型城镇化综合发展指数、耦合协调度呈逐年增长态势;在时序上,北京两系统同步发展,天津、河北科技创新系统存在滞后;在空间上,各地区两系统耦合协调度存在差异,线性拟合显示,北京耦合协调态势良好,天津耦合协调趋同且潜力巨大,河北协同效应不明显;未来天津、河北两地区应重点考虑科技创新能力的提升。

关键词：科技创新新型城镇化耦合协调度

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布置真空绝热板的冷藏集装箱内温度分布

南京航空航天大学学报 2017年第1期49卷 29-33页

作者：郭志鹏阚安康杨帆陈超上海海事大学商船学院上海201306

为研究布置真空绝热板对冷藏集装箱内温度分布的影响,以20ft机械式冷藏集装箱为研究对象,建立箱内空气对流与换热的物理和数学模型。采用标准k-ε紊流模型,对稳态下的真空绝热板冷藏集装箱和聚氨酯冷藏集装箱内温度场分布情况进行模拟... 详细信息

为研究布置真空绝热板对冷藏集装箱内温度分布的影响,以20ft机械式冷藏集装箱为研究对象,建立箱内空气对流与换热的物理和数学模型。采用标准k-ε紊流模型,对稳态下的真空绝热板冷藏集装箱和聚氨酯冷藏集装箱内温度场分布情况进行模拟仿真。模拟结果表明:采用真空绝热板作为保温材料,冷藏集装箱箱内温度场分布状况明显优于聚氨酯冷藏集装箱,而且平均温度能够降低0.8K。最后,对20ft实体聚氨酯冷藏集装箱进行实验,仿真与实验结果能够较好吻合,验证了模型的准确性。

关键词：真空绝热板冷藏集装箱温度分布均匀性

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等离子体显示器屏板复合定位技术

东南大学学报（自然科学版） 2009年第4期39卷 758-762页

作者：张金龙刘阳杨安康刘京南内田敬久南京师范大学电气与自动化工程学院南京210042 东南大学自动化学院南京210096 爱知工业大学智能机械工学科

针对荫罩式等离子体显示器屏板定位的特点,研究了基于计算机视觉的图像定位和基于衍射光栅的莫尔定位2种方法.利用这2种定位方法建立了精密定位的复合控制系统,其中图像定位作为粗定位,光栅定位作为精定位.通过粗定位与精定位相结合的... 详细信息

针对荫罩式等离子体显示器屏板定位的特点,研究了基于计算机视觉的图像定位和基于衍射光栅的莫尔定位2种方法.利用这2种定位方法建立了精密定位的复合控制系统,其中图像定位作为粗定位,光栅定位作为精定位.通过粗定位与精定位相结合的两段式复合定位,可保证在较大的信号捕捉范围内,实现显示器屏板的高速高精度定位,有效地解决了定位精度、定位速度与信号捕捉范围三者之间的矛盾.实验结果表明,采用复合式精密定位可在50mm的工作行程内获得±1μm的屏板定位精度,这对荫罩式等离子体显示器的产业化具有重要的实用价值.

关键词：荫罩式等离子显示器精密定位计算机视觉莫尔信号复合控制

An adaptive generation method for free curve trajectory based on NURBS

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Journal of Southeast University(English Edition) 2014年第3期30卷 296-301页

作者：朱昊刘京南杨安康汪木兰东南大学自动化学院南京210096 南京工程学院先进数控技术江苏省重点实验室南京211167

To realize the high precision and real-time interpolation of the NURBS （non-uniform rational B-spline） curve, a kinetic model based on the modified sigmoid function is proposed. The constraints of maximum feed rate, chord error, curvature radius and interpolator cycle are discussed. This kinetic model reduces the cubic polynomial S-shape model and the trigonometry function S-shape model from 15 sections into 3 sections under the precondition of jerk, acceleration and feedrate continuity. Then an optimized Adams algorithm using the difference quotient to replace the derivative is presented to calculate the interpolator cycle parameters. The higher-order derivation in the Taylor expansion algorithm can be avoided by this algorithm. Finally, the simplified design is analyzed by reducing the times of computing the low-degree zero-value B-spline basis function and the simplified De Boor-Cox recursive algorithm is proposed. The simulation analysis indicates that by these algorithms, the feed rate is effectively controlled according to tool path. The calculated amount is decreased and the calculated speed is increased while the machining precision is ensured. The experimental results show that the target parameter can be correctly calculated and these algorithms can be applied to actual systems.

关键词： free curve NURBS (non-uniform rational B-spline) sigmoid function Adams algorithm

基于分数次幂多项式的NURBS曲线快速插补方法研究

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中国机械工程 2013年第23期24卷 3159-3163页

作者：朱昊刘京南杨安康汪木兰东南大学南京210096 南京工程学院先进数控技术江苏省重点实验室南京211167

为减小NURBS曲线插补过程中对机床产生的柔性冲击,针对目前常用的S型速度控制策略中加加速度不连续以及速度变化相对缓慢的问题,在满足加加速度最大值限制的前提下,提出了一种基于分数次幂多项式的速度控制方法。结合加工路径曲率变化... 详细信息

为减小NURBS曲线插补过程中对机床产生的柔性冲击,针对目前常用的S型速度控制策略中加加速度不连续以及速度变化相对缓慢的问题,在满足加加速度最大值限制的前提下,提出了一种基于分数次幂多项式的速度控制方法。结合加工路径曲率变化设计了前瞻算法计算加减速位移,自适应确定减速点。仿真结果表明,该方法可以快速提高进给速度,实现加加速度的平滑过渡。

关键词： NURBS曲线曲线插补加减速控制加加速度

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开放型物理实验刷卡管理系统的建设

实验技术与管理 2009年第12期26卷 88-90页

作者：孙贵宁杨安康熊宏齐东南大学物理实验中心

东南大学物理实验中心在网络信息化教学平台的建设方面做了很多工作，近年来又根据教学需要，以原有网络平台为基础研发了基于以太网（Ethernet）的开放型物理实验刷卡管理系统。这是一个自动化管理系统．它实现了学生物理实验的系统管... 详细信息

东南大学物理实验中心在网络信息化教学平台的建设方面做了很多工作，近年来又根据教学需要，以原有网络平台为基础研发了基于以太网（Ethernet）的开放型物理实验刷卡管理系统。这是一个自动化管理系统．它实现了学生物理实验的系统管理和过程管理，做到了预约选课、身份验证、电源管理、考勤记录及统计分析的全部自动化操作。

关键词：开放型实验信息化管理刷卡网络信息平台

Fast estimation of fundamental matrix based on stripe constraints

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Journal of Southeast University(English Edition) 2008年第4期24卷 473-477页

作者：杨安康刘京南内田敬久内田悦行东南大学自动化学院南京210096 爱知工业大学情报通讯工学科

In order to improve the performance of estimating the fundamental matrix, a key problem arising in stereo vision, a novel method based on stripe constraints is presented. In contrast to traditional methods based on algebraic least-square algorithms, the proposed approach aims to minimize a cost function that is derived from the minimum radius of the Hough transform. In a structured-light system with a particular stripe code pattern, there are linear constraints that the points with the same code are on the same surface. Using the Hough transform, the pixels with the same code map to the Hough space, and the radius of the intersections can be defined as the evaluation function in the optimization progress. The global optimum solution of the fundamental matrix can be estimated using a Levenberg- Marquardt optimization iterative process based on the Hough transform radius. Results illustrate the validity of this algorithm, and prove that this method can obtain good performance with high efficiency.

关键词： fundamental matrix structured-light stripe code pattern stereo vision