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Efficient synthesis of 5,6-dihydrothieno[3′,2′:4,5]-thieno[2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane

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Chinese Chemical Letters 2009年第9期20卷 1055-1058页

作者： Yu Lu Chen Yi bo nie Ming Wu Ding Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Central China Normal University Wuhan 430079 China Department of Biology Xianning Vocational and Technical College Xianning 437100 China

5,6-Dihydrothieno[3＇,2＇：4,5]thieno[2,3-d]pyrimidin-4（3H）-ones 6 were synthesized in yields of 71-87% by a consecutive method, which includes aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various amines, phenols or alcohols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate. 2009 Ming Wu Ding. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： 5,6-Dihydrothieno[3r,2':4,5]thieno[2,3-d]pyrimidin-4(3//)-one Iminophosphorane Aza-Wittig reaction Carbodiimide Isocyanate

Effects of dietary phosphorous supplementation on laying performance,egg quality,bone health and immune responses of laying hens challenged with Escherichia coli lipopolysaccharide

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Journal of Animal Science and Biotechnology 2018年第4期9卷 980-990页

作者： Wei nie bo Wang Jing Gao Yuming Guo Zhong Wang State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Department of Animal Science Washington State University

Background: Phosphorus is an essential nutrient to maintain poultry health and performance. The objective of this study was to evaluate the effect of dietary phosphorus levels on egg production, egg quality, bone health, immune responses of laying hens challenged with Escherichia coli ***: Three hundred laying hens at 28 wk were randomly divided into 2 dietary treatments with 10 replicates of 15 birds. The wheat-soybean based diets contained either 0.12% or 0.4% non-phytate phosphorus(NPP). At 32 wk of age, all the birds of each dietary treatment were injected into the abdomen with 1.5 mg/kg body weight(BW) of either LPS or saline once a day at 24-h intervals for continuous 9 d. The performance of laying hens was evaluated for 9 d. The eggs after the fifth injection were collected to value the egg quality. Three hours after the first injection, blood was collected to measure serum metabolite and immune response associated *** hours after the fifth injection, the hens were euthanized to obtain tibia, cecal tonsils and ***: Compared with saline-injected hens, LPS-injected hens had lower feed intake and egg production(P < 0.05).Eggshell thickness, strength, albumin height and Haugh unit were significantly increased in LPS-injected hens compared with saline-injected hens(P < 0.05). Furthermore, laying hens challenged with LPS had lower villious height/crypt depth ration than those received saline. Serum calcium, phosphorus and SOD activities significantly decreased in the LPS-injected hens compared with the control(P < 0.05). LPS up-regulated expression of IL-1β, IL-6 and IL-10 in cecum, and serum concentration of MDA, IL-1β and IL-6(P < 0.05), whereas 0.40% dietary non-phytate phosphorus supplementation significantly increased(P < 0.05) villi height/crypt depth ratio, decreased(P < 0.05) serum MDA and IFN-γ concentration compared with the 0.12% non-phytate phosphorus ***: In summary, this study demonstrates t

关键词： Egg quality Immune response Laying hens Lipopolysaccharide Phosphorus

MYH7B variants cause hypertrophic cardiomyopathy by activating the Ca MK-signaling pathway

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Science China(Life Sciences) 2020年第9期63卷 1347-1362页

作者： Peng Chen Zongzhe Li Jiali nie Hong Wang bo Yu Zheng Wen yang Sun Xiaolu Shi Li Jin Dao-Wen Wang Division of Cardiology Departments of Internal Medicine and Genetic Diagnosis CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiological Disorders Wuhan 430030China Collaborative Innovation Center for Genetics and Development School of Life SciencesFudan UniversityShanghai 200438China Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China

Hypertrophic cardiomyopathy(HCM) is a common genetic disease, predominantly caused by mutations in cardiac sarcomere genes;however, whether MYH7 B causes HCM is not known. In this study, 549 unrelated patients with HCM and 500 healthycontrols were screened using targeted sequencing and whole exome sequencing together. We observed seven variants in MYH7 B causing HCM in 8/549 patients, which accounted for 1.46% of HCM cases. Of these seven variants, three likely pathogenic variants in MYH7 B co-segregating with 5 HCM patients were identified in three HCM pedigrees without other HCM-associated variants. Myh7 b knockout rats were generated and cardiac functions were detected by Millar pressure-volume catheterization and echocardiography. Spontaneous HCM phenotypes, cellular disarray and cardiac fibrosis were observed in both Myh7 b^+/–/Myh7 b^–/–rats. Transcriptome sequencing showed that calcium is the key mediator of cardiac hypertrophy in Myh7 b knockout. Subsequent analysis confirmed over-activation of Ca MK-signaling pathway in cardiomyocytes of Myh7 b^–/–***, MYH7 B expression in human and rat hearts was identified and micro RNA-208 a and micro RNA-499 levels are unchanged in HCM patients and Myh7 b^+/–/Myh7 b^–/–rats. This study is the first to identify MYH7 B variants as cause of HCM,which account for 1.46% of pathogenesisin HCM patients. Activation of Ca MK-signaling pathway may be involved in its pathophysiology.

关键词： MYH7B hypertrophic cardiomyopathy whole exome sequencing transcriptome sequencing Ca MK-signaling pathway

Lithiophilic montmorillonite as a robust substrate toward high-stable lithium metal anodes

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Rare Metals 2023年第7期42卷 2157-2165页

作者： Meng Wang Ying Li Sheng-yang Li Xin-Xin Jia bo nie Hong-Tao Sun Ya-Ya Wang Jian Zhu State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan Key Laboratory of Two-Dimensional MaterialsEngineering Research Center of Advanced CatalysisMinistry of EducationHunan UniversityChangsha410082China The Harold&Inge Marcus Department of Industrial and Manufacturing Engineering The Pennsylvania State UniversityState CollegePA16802USA Materials Research Institute(MRI) The Pennsylvania State UniversityState CollegePA16802USA

Lithium metal is considered a desirable anode for the nextgeneration high-energy-density rechargeable energy storage ***,poor lifespan and safety issues caused by unexpected dendrites growth have prevented the commerc... 详细信息

关键词： lithium anode high

Recent Research on the Deformation Behavior of Particle Reinforced Magnesium Matrix Composite: A Review

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Acta Metallurgica Sinica(English Letters) 2019年第4期32卷 413-425页

作者： Kun-Kun Deng Cui-Ju Wang Kai-bo nie Xiao-Jun Wang Shanxi Key Laboratory of Advanced Magnesium-Based Materials College of Materials Science and Engineering Taiyuan University of Technology School of Materials Science and Engineering Harbin Institute of Technology

Particle reinforced magnesium matrix composite(PMMC) possesses the merits of high specific strength, high specific modulus, better dimensional stability, good wear resistance and lower production cost, which is thought as a promising material in the field of aerospace, automobile, electronic communication, etc. To eliminate the casting defect, the PMMC is usually experienced hot deformation process. The present paper mainly focuses on the deformation behavior of PMMCs. First, the development of PMMCs based on particle size is introduced. Then, the hot deformation technology and deformation mechanism of PMMCs at elevated temperature are given and analyzed, respectively. After reviewing the dynamic recrystallization and texture of PMMCs, its future development is suggested based on the current research progress.

关键词： Magnesium matrix composite Particle Hot deformation Deformation mechanism Recrystallization

Attention-based encoder-decoder model for answer selection in question answering

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Frontiers of Information Technology & Electronic Engineering 2017年第4期18卷 535-544页

作者： Yuan-ping nie Yi HAN Jiu-ming HUANG bo JIAO Ai-ping LI College of Computer National University of Defense Technology Changsha 410073 China Institute of Information Engineering Chinese Academy of Sciences Beijing 100093 China Luoyang Electronic Equipment Test Center Luoyang 471003 China

One of the key challenges for question answering is to bridge the lexical gap between questions and answers because there may not be any matching word between them. Machine translation models have been shown to boost the performance of solving the lexical gap problem between question-answer pairs. In this paper, we introduce an attention-based deep learning model to address the answer selection task for question answering. The proposed model employs a bidirectional long short-term memory （LSTM） encoder-decoder, which has been demonstrated to be effective on machine translation tasks to bridge the lexical gap between questions and answers. Our model also uses a step attention mechanism which allows the question to focus on a certain part of the candidate answer. Finally, we evaluate our model using a benchmark dataset and the results show that our approach outperforms the existing approaches. Integrating our model significantly improves the performance of our question answering system in the TREC 2015 LiveQA task.

关键词： Question answering Answer selection Attention Deep learning

Wetting behaviors of methanol,ethanol,and propanol on hydroxylated SiO2 substrate

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Nuclear Science and Techniques 2018年第2期29卷 26-31页

作者： Xue-Chuan nie bo Zhou Chun-Lei Wang Hai-Ping Fang Division of Interfacial Water and Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Electronic Engineering Chengdu Technological UniversityChengdu 611730China

Water molecules could form a liquid droplet on the water monolayer on a specific solid surface, which has been referred to as ‘‘ordered water monolayer that does not completely wet water'' at room temperature. In contrast to the water molecules, the family of alcohol molecules has the same OH polar head and various lengths of their hydrophobic nonpolar tail; the length of the hydrophobic tail can affect the hydrophobic effect. In this study, using molecular dynamics simulations, we investigated the wetting behaviors of methanol, ethanol, and propanol molecules adsorbed on a SiO_2 surface. The results showed that the methanol, ethanol, and propanol molecules could form an ordered monolayer on the SiO_2 surface and a droplet on top of this monolayer, with different contact angles. The differences in the contact angles were attributed to the differences in the interactions between the alcohol monolayer and droplet.

关键词： Wetting behavior Alcohol SiO2 Molecular dynamics simulation

聚丙烯腈/聚砜双尺度纳米纤维膜的制备、表征及空气过滤应用

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中原工学院学报 2024年第1期35卷 41-49页

作者：韩鹏举于博聂高伟陈彦斐郑海敏杨明慧中原工学院纺织服装产业研究院河南郑州450007

通过模块化静电纺丝技术,制备了一种由掺杂氟化聚氨酯(FPU)的聚丙烯腈(PAN)纳米纤维与聚砜(PSF)纳米纤维组成的双尺度复合纳米纤维膜空气过滤材料,并对其性能进行了表征。该复合膜平均孔径仅有1.35μm,孔隙率达到94.4%,对PM0.3的过滤效... 详细信息

通过模块化静电纺丝技术,制备了一种由掺杂氟化聚氨酯(FPU)的聚丙烯腈(PAN)纳米纤维与聚砜(PSF)纳米纤维组成的双尺度复合纳米纤维膜空气过滤材料,并对其性能进行了表征。该复合膜平均孔径仅有1.35μm,孔隙率达到94.4%,对PM0.3的过滤效率达到99.90%,压降仅有68 Pa,品质因子高达0.101 Pa^(-1),实现了高效低阻。此外,聚丙烯腈纤维膜在氟化聚氨酯掺杂量达到18 wt%时,纤维直径为70±5 nm,水接触角高达153°。通过在COMSOL multiphysics 6.1软件上建立空气流场来模拟纤维膜的滤效和压降,进一步证明了该纤维膜具有优异的高效低阻性能。将双尺度纳米纤维膜与纺粘无纺布进行超声复合后,经打折、封边制备成品过滤器,并将其与商用过滤器进行了对比,在5 min内PM_(2.5)浓度仍保持在18μg·m^(-3),过滤性能明显优于商用过滤器。可为构建高效低阻的纳米纤维空气滤材提供一种思路。

关键词：静电纺丝双尺度纳米纤维膜聚丙烯腈聚砜空气过滤

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Toward broad optimal output bandwidth dielectric elastomer actuators

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Science China(Technological Sciences) 2022年第5期65卷 1137-1148页

作者： CAO ChongJing CHEN LiJin LI bo CHEN GuiMin nie ZeDong WANG Lei GAO Xing Research Centre for Medical Robotics and Minimally Invasive Surgical Devices Shenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen518055China Shaanxi Key Laboratory of Intelligent Robots School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an710049China

Dielectric elastomer actuators(DEAs)are one of the most promising soft actuation technologies owing to their relatively high power density and electromechanical efficiency enabled by a resonant actuation ***,existing DEA designs suffer from a very narrow optimal output bandwidth close to resonance and poor output control capability due to their fixed geometrical *** condition greatly limits their applications in programmable actuation and broad-bandwidth ***,this work developed a novel resonance tunable DEA(RTDEA)design for broad-optimal-output actuation bandwidths that is enabled by an integration of a stiffness and voltage control *** design features a broad resonant frequency adjustment from 84 to 126 Hz and independent tunings of its resonant amplitude and *** studies were conducted to illustrate the fundamental principles behind the resonance tuning strategy,and optimization was performed to maximize the tuning ***,a resonance tuning control strategy is proposed to achieve accurate adjustments of the RTDEA’s resonance based on the stiffness and voltage control *** resonance tunable soft actuators are envisioned to greatly expand DEAs’applications in,for instance,soft robotic locomotion,human–robot communication,and active vibrational control with demands of broad actuation bandwidths and high output performance.

关键词： dielectric elastomer actuators soft robotics soft actuators resonance tuning resonant actuation