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Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression

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Genes & Diseases 2024年第5期11卷 456-469页

作者： Lixin Liang Tian Cai Xiaojia Li Jianhong An Sen Yu yang Zhang Fengjie Guo Fang Wei Jie he Keping Xie Tingting Jiang Center for Pancreatic Cancer Research South China University of Technology School of MedicineGuangzhouGuangdong 510006China Department of Laboratory Medicine The Sixth Affiliated Hospital and Nanhai People’s HospitalSouth China University of Technology School of MedicineFoshanGuangdong 528200China The Second Affiliated hospital and Guangzhou First People’s hospital South China University of Technology School of MedicineGuangzhouGuangdong 510006China

Transcriptional factor Forkhead box M1(FOXM1)plays an important role in pancreatic ductal adenocarcinoma(PDAC)development and *** molecular mechanisms underlying its dysregulation remain *** identified and functionally validated the microRNAs(miRNAs)that critically regulate FOXM1 expression in *** expression levels of miRNA-23a(miR-23a-3p and-5p)were altered in PDAC cell lines and their effects on FOXM1 signaling and cell proliferation and migration and tumorigenesis were examined in vitro and in vivo using mouse PDAC *** with non-tumor pancreatic tissues,PDAC tissues and cell lines exhibited significantly reduced levels of miR-23a *** miR-23a expression and concomitant increase in FOXM1 expression were also observed in acinar-toductal metaplasia and pancreatic intraepithelial neoplasia,the major premalignant lesions of *** expression of miR-23a reduced the expression of FOXM1 and suppressed cell proliferation and migration in PDAC cells,whereas the inhibitors of miR-23a did the *** or reduced levels of miR-23a increased the levels of FOXM1 expression,while increased expression of FOXM1 down-regulated miR-23a expression,suggesting that miR-23a and FOXM1 were mutual negative regulators of their expression in PDAC ***,the miR-23a/FOXM1 signaling axis is important in PDAC initiation and progression and could serve as an interventional or therapeutic target for patients with early or late stages of PDAC.

关键词： FOXM1 Gene expression Gene regulation MicroRNA Pancreatic cancer Targeted therapy

Deep learning-based inpainting of saturation artifacts in optical coherence tomography images

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Journal of Innovative Optical health Sciences 2024年第3期17卷 1-10页

作者： Muyun hu Zhuoqun Yuan Di yang Jingzhu Zhao Yanmei Liang Institute of Modern Optics Nankai UniversityTianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyTianjin 300350China Department of Thyroid and Neck Tumor Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Limited by the dynamic range of the detector,saturation artifacts usually occur in optical coherence tomography(OCT)imaging for high scattering *** available methods are difficult to remove saturation artifacts and restore texture completely in OCT *** proposed a deep learning-based inpainting method of saturation artifacts in this *** generation mechanism of saturation artifacts was analyzed,and experimental and simulated datasets were built based on the *** super-resolution generative adversarial networks were trained by the clear–saturated phantom image *** perfect reconstructed results of experimental zebrafish and thyroid OCT images proved its feasibility,strong generalization,and robustness.

关键词： Optical coherence tomography saturation artifacts deep learning image inpainting.

WOMEN PROVINGThEY CANhANDLE POWER Engineers with State Grid in Tianjin Are Defying Traditional Roles

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Women of China 2024年第9期 38-41页

作者： yang Cheng 无不详 State Grid Tianjin Electric Power Company

A woman-adorned in a heavy,custom-made,metal-shielding suit-is hard at work,dozens of meters above the *** of electricity flicker at her fingertips,and the crackling sound of current lingers in her *** up from the ground,the engineer,working on an electric tower,resembles a nimble dancer,gracefully navigating along the power lines connecting various *** is a typical workday for a live-line-maintenance engineer with State Grid Tianjin Electric Power *** North China's Tianjin Municipality,women engineers-many of whom born after 1990-are proving they are as capable and dedicated as their male counterparts.

关键词： connecting Tianjin engineer

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重要林木樟科植物全基因组测序研究进展

植物学报 2024年第2期59卷 302-318页

作者：杨智杨永南京林业大学南方现代林业协同创新中心南京210037 南京林业大学生物与环境学院南京210037 南京林业大学国家林业和草原局亚热带森林生物多样性保护重点实验室南京210037

近年来,随着测序技术的革新、测序成本的降低和生物信息学软件的开发,植物全基因组研究蓬勃发展。樟科(Lauraceae)隶属被子植物木兰类,泛热带分布,物种多样性高,其中很多物种具有重要的经济和生态价值,目前已发表包括8个物种的13个基因... 详细信息

近年来,随着测序技术的革新、测序成本的降低和生物信息学软件的开发,植物全基因组研究蓬勃发展。樟科(Lauraceae)隶属被子植物木兰类,泛热带分布,物种多样性高,其中很多物种具有重要的经济和生态价值,目前已发表包括8个物种的13个基因组。该文从樟科全基因组研究现状、基因组特征、起源和进化以及功能基因和基因家族4个方面进行综述,着重介绍基于组学数据的木兰类及樟科的系统发生、樟科经历的多倍化事件以及与樟科花器官进化和代谢产物相关的基因鉴定。结合研究现状展望了樟科基因组研究的发展方向,建议通过增加测序基因组分支的代表性并关注具有特殊价值的物种,及研究物种特异性功能基因以加深对该家族基因功能和进化的理解。

关键词：樟科演化核基因组功能基因系统发生

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基于分数阶小波变换的电力系统谐波检测方法

中国电机工程学报 2024年第3期44卷 872-879,I0002页

作者：窦嘉炜杨小煜杨晓忠华北电力大学数理学院北京市昌平区102206 中国电力科学研究院有限公司北京市海淀区100192

针对稳态和暂态谐波检测易受噪声干扰的问题,提出一种基于分数阶小波变换(fractional wavelet transform,FRWT)的电力系统谐波检测方法。首先,通过快速傅里叶变换(fast Fourier transform,FFT)检测出各频谱的频率,根据频率确定分解层数... 详细信息

针对稳态和暂态谐波检测易受噪声干扰的问题,提出一种基于分数阶小波变换(fractional wavelet transform,FRWT)的电力系统谐波检测方法。首先,通过快速傅里叶变换(fast Fourier transform,FFT)检测出各频谱的频率,根据频率确定分解层数;其次,利用FRWT对信号进行分解和重构,实现基波与各次谐波分量的分离;最后,对各次谐波分量进行hilbert变换(hilbert transform,hT),获取各次谐波分量的频率和幅值检测结果以及暂态扰动的起止时刻。对多种谐波信号的仿真试验结果表明,FRWT方法可以有效实现对含噪信号中稳态和暂态谐波的检测,即使信噪比较低也能保证各项结果的检测精度,证明FRWT方法是检测谐波的一种有效新方法。

关键词：分数阶小波变换小波变换 hilbert变换谐波检测仿真试验

Analysis of debris flow control effect and hazard assessment in Xinqiao Gully,Wenchuan M_(s)8.0 earthquake area based on numerical simulation

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China Geology 2024年第2期7卷 248-263页

作者： Chang yang Yong-bo Tie Xian-zheng Zhang Yan-feng Zhang Zhi-jie Ning Zong-liang Li Chinese Academy of Geological Sciences Beijing 100037China Chengdu Center of China Geological Survey China Geological SurveyChengdu 610081China Technology innovation center for risk prevention and mitigation of geohazard Ministry of Natural ResourcesChengdu 611734China Observation and Research Station of Chengdu Geological hazards Ministry of Natural ResourcesChengdu 610000China

Xinqiao Gully is located in the area of the 2008 Wenchuan M_(s)8.0 earthquake in Sichuan province,*** on the investigation of the 2023"6-26"Xinqiao Gully debris flow event,this study assessed the effectiveness of the debris flow control project and evaluated the debris flow *** field investigation and numerical simulation methods,the indicators of flow intensity reduction rate and storage capacity fullness were proposed to quantify the effectiveness of the engineering measures in the debris flow *** simulation results show that the debris flow control project reduced the flow intensity by41.05%to 64.61%.The storage capacity of the dam decreases gradually from upstream to the mouth of the gully,thus effectively intercepting and controlling the debris *** evaluating the debris flow of different recurrence intervals,further measures are recommended for managing debris flow events.

关键词： Landslide Debris flow hazard assessment Numerical simulation OpenLISEM Prevention and control project Wenchuan M_(s)8.0 earthquake Xinqiao Gully Sichuan province Geological hazards survey engineering

The Preliminary Study on Screening and Application of Phthalic Acid-Degrading Bacteria

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Advances in Microbiology 2024年第4期14卷 226-239页

作者： honghao Zhang Lin yang Rubing Xu Yuxiao Sun Yong yang Yanyan Li College of Life Sciences Hubei University Wuhan China hubei Academy of Tobacco Science Wuhan China Xuan217 en Branch Company of Enshi Tobacco Corporation Enshi China

Phthalic acid is a main pollutant, which is also an important reason for the continuous cropping effect of tobacco. In order to degrade the phthalic acid accumulated in the environment and relieve the obstacle effect of tobacco continuous cropping caused by the accumulation of phthalic acid in the soil. In this study, phthalate degrading bacteria B3 is screened from continuous cropping tobacco soil. The results of biochemical identification and 16sDNA comparison show that the homology between degrading bacterium B3 and Enterobacter sp. is 99%. At the same time, the growth of Enterobacter hormaechei subsp. B3 and the degradation of phthalic acid under different environmental conditions are studied. The results show that the environment with a temperature of 30˚C, Ph of 7, and inoculation amount of not less than 1.2%, which is the optimal growth conditions for Enterobacter sp. B3. In an environment with a concentration of phthalic acid not exceeding 500 mg/L, Enterobacter sp. B3 has a better effect on phthalic acid degradation, and the degradation rate can reach 77% in 7 d. The results of indoor potting experiments on tobacco show that the degradation rate of phthalic acid by Enterobacter B3 in the soil is about 45%, which can reduce the inhibitory effect of phthalic acid on the growth of tobacco seedlings. This study enriches the microbial resources for degrading phthalic acid and provides a theoretical basis for alleviating tobacco continuous cropping obstacles.

关键词： Phthalic Acid Degrading Bacteria Rhizosphere Soil

highly crystalline,highly stable n-type ultrathin crystalline films enabled by solution blending strategy toward organic single-crystal electronics

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Chinese Chemical Letters 2024年第1期35卷 321-325页

作者： yang Liu Shuyu Li Yihan Zhang Xiaoting Zhu Fangxu yang Fei Jiao Wenping hu Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

The development of n-type semiconductor is still far behind that of p-type semiconductor on account of the challenges in enhancing carrier mobility and environmental ***,by blending with the polymers,n-type ultrathin crystalline thin film was successfully prepared by the method of meniscus-guided ***,the n-type crystalline films exhibit ultrathin thickness as low as 5 nm and excellent mobility of 1.58 cm^(2) V^(-1) s^(-1),which is outstanding in currently reported organic n-type ***,the PS layer provides a high-quality interface with ultralow defect which has strong resistance to external interference with excellent long-term stability,paving the way for the application of n-type transistors in logic circuits.

关键词： n-type organic field effect transistors Ultrathin film high-performance Composites

Dark Matter Search in Dwarf Irregular Galaxies with Ten Years of Data from the Ice Cube Neutrino Observatory

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Research in Astronomy and Astrophysics 2024年第3期24卷 75-82页

作者： Yi-Fei Lü Ben-yang Zhu Rong-Lan Li Xue-Kang Guo Tian-Ci Liu Yong-Bo huang Yun-Feng Liang Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi University Nanning 530004China

Dwarf irregular galaxies(dIrrs),as rotationally supported systems,have more reliable J-factor measurements than dwarf spheroidal galaxies and have received attention as targets for dark matter detection in recent *** this paper,we use 10 yr of IceCube muon-track data and an unbinned maximum-likelihood-ratio method to search for neutrino signals beyond the background from the directions of seven dIrrs,aiming to detect neutrinos produced by heavy annihilation dark *** do not detect any significant *** on such null results,we calculate the upper limits on the velocity-averaged annihilation cross section for 1 TeV–10 PeV dark *** limits,although weaker than the strictest constraints in the literature in this mass range,are also a good complement to the existing results considering the more reliable J-factor measurements of dIrrs.

关键词： (cosmology) dark matter-cosmology theory-galaxies dwarf