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Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1437-1452页

作者： Bin-Sheng Wang Chen-Li Zhang Xiang Cui qiang Li Lei yang zhi-Yun He Ze yang Miao-Miao Zeng Nong Cao Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Third Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastric cancer,characterized by a multifactorial etiology and high heterogeneity,continues to confound researchers in terms of its ***,a natural anticancer agent,exhibits therapeutic promise in gastric *** effects include promoting cell apoptosis,curtailing tumor angiogenesis,and enhancing sensitivity to radiation and *** noncoding RNAs(lncRNAs)have garnered significant attention as biomarkers for early screening,diagnosis,treatment,and drug response because of their remarkable specificity and *** investigations have revealed an association between aberrant lncRNA expression and early diagnosis,clinical staging,metastasis,drug sensitivity,and prognosis in gastric cancer.A profound understanding of the intricate mechanisms through which lncRNAs influence gastric cancer develop-ment can provide novel insights for precision treatment and tailored management of patients with gastric *** study aimed to unravel the potential of curcumin in suppressing the malignant behavior of gastric cancer cells by upregu-lating specific lncRNAs and modulating gastric cancer onset and *** To identify lncRNAs associated with curcumin treatment and investigate the role of lncRNA AC022424.2 in the effects of curcumin on gastric cancer cell apoptosis,proliferation,and ***,these findings were validated in clinical *** The study employed CCK-8 assays to assess the impact of curcumin on gastric cancer cell proliferation,flow cytometry to investigate its effects on apoptosis,and scratch and Transwell assays to evaluate its influence on the migration and invasion of BGC-823 and MGC-803 *** blotting was used to gauge changes in the protein expression levels of CDK6,CDK4,Bax,Bcl-2,caspase-3,P65,and the PI3K/Akt/mTOR pathway in gastric cancer cell lines after curcumin *** expression of lncRNAs before and after curcumin treatment was assessed using lncRNA seq

关键词： Gastric cancer Curcumin Long noncoding RNA AC022424.2 Apoptosis Akt/PI3K pathway Lymph metastasis

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Notably Accelerated Nano-Bainite Transformation via Increasing Undissolved Carbides Content on GCr15Si1Mo Bearing Steel

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 703-712页

作者： Yan-Hui Wang Hua-qiang Sun Wen-Jing Feng Lei-Jie Zhao Xiang Chen Qing-An Chen Hai-Tao Sun Jian-Jun Wang zhi-Nan yang Key Laboratory of Intelligent Industrial Equipment Technology of Hebei Province School of Mechanical and Equipment EngineeringHebei University of EngineeringHandan056038China Collaborative Innovation Center for Modern Equipment Manufacturing of Jinan New Area Hebei University of EngineeringHandan056038China School of Materials Science and Engineering Tsinghua UniversityBeijing100084China Avic Shang da Superalloys Company Limited Xingtai054800China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004China

In this study, a high-carbon nano-bainitic GCr15Si1Mo bearing steel was investigated. Specifically, the effects of content and size of undissolved carbides on the microstructure and transformation kinetics of nano-bainite were analyzed. The results demonstrated that after prolonged austempering at low temperatures, the mixed microstructure composed of nano-bainite (NB), undissolved carbides (UC), and retained austenite (RA) was obtained in GCr15SiMo steel. When the experimental steel was austenitized at 900 ℃, the undissolved carbides gradually dissolved until reaching a stable state with increasing holding time. Furthermore, at the same austempering temperature, despite different volume fractions of undissolved carbides in the substrate, the volume fractions of nano-bainite in the final microstructures remained essentially the same. Moreover, the higher the content of undissolved carbides in steel, the faster the transformation rate of nano-bainite and the shorter the total transformation time.

关键词： Nano-bainite Undissolved carbides Bainitic transformation kinetics Carbon concentration

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Synthesis and Crystal Structure of a Novel Monomeric Di butyltin Dicarboxylate: nBu 2Sn O 2CCH 2CH(4 ClC 6H 4)Ge(OCH 2CH 2) 3N 2·H 2O

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Chinese Journal of Structural Chemistry 1999年第2期18卷 9-13页

作者： SONG Xue Qing yang zhi qiang XIE Qing Lan (National Laboratory of Elemento Organic Chemistry, Nankai University, Tianjin, 300071)

nBu 2Sn O 2CCH 2CH(4 ClC 6H 4)Ge(OCH 2CH 2) 3N 2·H 2O( M r =1053.66) is an air stable compound which crystallizes in the monoclinic space group C2/c with a=21.182(5), b=12.174(3), c=17.108(4) , β=99.59(2)°, V=4350(3)  3, Z=4, F(000)=2104, μ =2.104 mm -1 . The refinement of structure with I≥3σ(I) for 1819 reflections converged at R =0.045. The coordination geometry around the Sn atom is best described as an askew pentagonal bipyramid, in which four carboxylate oxygen atoms ( Sn(1)-O(5), Sn(1)-O(5a)=2.099  and Sn(1)-O(4), Sn(1)-O(4a)=2.158 ) and an oxygen atom from an aqua ligand comprise the pentagonal plane, with two butyl groups occupying axial positions.

关键词： diorganotin dicarboxylate crystal structure synthesis.

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全尾砂胶凝材料配比正交试验及其充填体强度模型

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中国有色金属学报 2021年第8期31卷 2269-2278页

作者：吴凡高谦杨志强北京科技大学土木与资源工程学院北京100083 金川集团股份有限公司金昌737100

为了确定超深铁矿胶结充填体强度模型,进行全尾砂胶凝材料配比的充填体强度正交试验,研究水泥熟料、脱硫石膏和工业芒硝对充填体强度性能的影响,并建立充填体强度预测模型。结果表明:充填体强度随水泥熟料添加量的增大而减小,随脱硫石... 详细信息

为了确定超深铁矿胶结充填体强度模型,进行全尾砂胶凝材料配比的充填体强度正交试验,研究水泥熟料、脱硫石膏和工业芒硝对充填体强度性能的影响,并建立充填体强度预测模型。结果表明:充填体强度随水泥熟料添加量的增大而减小,随脱硫石膏和芒硝添加量的增大而增大。全尾砂胶凝材料最优配方:水泥熟料9%、脱硫石膏4%、芒硝1%。考虑井下作业时间,建立了养护龄期与其强度的双曲线函数关系,揭示随龄期增长强度先增加后趋于稳定的规律,为此提出极限抗压强度p_1和修正参数p_2的概念;采用1st Opt软件,极限抗压强度及修正参数与熟料添加量、石膏添加量及芒硝添加量呈多元非线性关系;综合胶凝材料添加量和养护龄期,建立充填体强度模型。模型预测误差小于6%,满足工程预测精度,可应用于全尾砂胶凝材料开发与强度预测。

关键词：胶凝材料正交试验数据可视化配比优化强度模型

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从“苗”到“苗族”——论近代民族集团形成的“他者性”问题

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西南民族大学学报（人文社会科学版） 2010年第6期31卷 1-7页

作者：杨志强日本东京大学日本学术振兴会贵州大学人类学研究所

苗族在中国素以历史悠久、苦难深重的民族而闻名。然而,事实上这一印象是进入近代以后才形成的。本文通过实证研究,对中国苗族最初作为近代民族集团诞生的历史过程进行了回顾与分析,具体探讨了在前近代时期,曾经是南方是非汉系族群泛称... 详细信息

苗族在中国素以历史悠久、苦难深重的民族而闻名。然而,事实上这一印象是进入近代以后才形成的。本文通过实证研究,对中国苗族最初作为近代民族集团诞生的历史过程进行了回顾与分析,具体探讨了在前近代时期,曾经是南方是非汉系族群泛称的"苗",在20世纪初叶兴起的中国民族主义思潮中,是如何作为近代民族集团的"苗族",首先在汉文化这一"他者"的语境中被建构起来的过程,并在此基础上对影响民族集团形成的"他者性"等问题进行了初步的理论探讨。

关键词：苗苗族华夷之辨非苗化现象他者性

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“国家化”视野下的中国西南地域与民族社会--以“古苗疆走廊”为中心

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广西民族大学学报（哲学社会科学版） 2014年第3期36卷 2-9页

作者：杨志强日本学术振兴会(JSPS) 贵州大学人类学研究所中国民族学人类学研究会

通过"古苗疆走廊"形成过程的追溯,初步探讨了国家力量、汉族移民及文化对西南边疆地区及各民族社会带来的冲击;认为明清时代西南边疆地区所经历的剧烈的社会变迁,其主要特点就是王朝权力依托"国家走廊"自上而下地开展"国家化"整合过程,... 详细信息

通过"古苗疆走廊"形成过程的追溯,初步探讨了国家力量、汉族移民及文化对西南边疆地区及各民族社会带来的冲击;认为明清时代西南边疆地区所经历的剧烈的社会变迁,其主要特点就是王朝权力依托"国家走廊"自上而下地开展"国家化"整合过程,其地域及族群文化多样性的形成与宏大的"国家叙事"间有着内在因果关联;进而对前近代时期的"国家化"等内涵进行了若干理论梳理与探讨。

关键词：古苗疆走廊国家化内地化汉族移民华夷之辩

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Charge regulation by ferromagnetic metal/LiF spin-polarized interface for high-performance Li metal anodes

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Rare Metals 2024年第3期43卷 995-1005页

作者： Ming-yang Feng Shuang Zhou Yi-Fang Zhang Ya-Ping Wang Chun-Yan Fu Jian-Wen Li Yuan-Lang Wan zhi-Jia Zhang Yong Jiang An-qiang Pan State Key Laboratory of Powder Metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the Li metal anode(LMA)play a crucial role in its overall *** various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be ***,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/LiF heterogeneous films(T^(M)-LiF-CC)as the substrate for LMA,which exhibit superior electrochemical *** ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-LiF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/LiF *** and LiF play individual roles in redistributing electrons and Li^(+)to promote homogeneous Li *** nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while LiF,with low surface diffusion barriers,ensures fast transportation of Li^(+).The Co-LiF-CC@Li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the N/P ratios are low(3.3 or even 1.7).

关键词： Lithium metal anode Interfacial charge Ferromagnetic metal Lithium fluoride Spin polarization

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Design and synthesis of polyoxovanadate-based framework for efficient dye degradation

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Tungsten 2024年第2期6卷 447-453页

作者： Qing Lan Su-Juan Jin Zheng Wang Xu-yang Li Yan Xiong Zhuo-Cheng Wang Shan-Shan Liu zhi-Ming Zhang qiang Zhao Engineering Technology Research Center of Henan Province for Solar Catalysis School of Chemical and Pharmaceutical EngineeringNanyang Normal UniversityNanyang 473061China Institute of New Energy Materials&Low Carbon Technology Tianjin University of TechnologyTianjin 300384China

A new polyoxovanadate-based framework material[Cu(en)_(2)]_(4)V_(18)O_(42)(H_(2)O)·6H_(2)O(1)was designed and synthesized by hydrothermal reaction of NaVO_(3),Cu(NO_(3))_(2)·6H_(2)O and 1,2-diaminoethane(en)via carefully adjusting the pH value of the reaction *** structure of the title compound has been determined by single-crystal X-ray diff raction analysis,thermogravimetric analysis,infrared spectra and elemental *** structural analysis demonstrate the three-dimensional(3D)framework structure of compound 1,which was composed of the[V_(18)O_(42)(H_(2)O)]_(8)−({V_(18)O_(42)(H_(2)O)})anions linked by the Cu^(2+)*** 1 represents the fi rst 3D framework based on{V_(18)O_(42)(H_(2)O)}polyoxoanions and copper ***-driven degradation of residual organic pollutants in industrial wastewater is still a major problem for human *** experiments reveal that compound 1 possesses of excellent photocatalytic activity for the degradation of methylene blue and rhodamine B.

关键词： Polyoxovanadate Framework Polyoxovanadate-based framework Photocatalytic Organic pollutants

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Growth hormone improves insulin resistance in visceral adipose tissue after duodenal-jejunal bypass by regulating adiponectin secretion

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World Journal of Diabetes 2024年第6期15卷 1340-1352页

作者： Zi-Tian Liu Guang-Wei yang Xiang Zhao Shuo-Hui Dong yang Jiao Zheng Ge Ao Yu Xi-qiang Zhang Xin-Zhen Xu zhi-qiang Cheng Xiang Zhang Ke-Xin Wang Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Shandong University of Qilu Hospital(Qingdao)Qingdao 266000Shandong ProvinceChina

BACKGROUND The mechanism of improvement of type 2 diabetes after duodenal-jejunal bypass(DJB)surgery is not *** To study the morphological and functional changes in adipose tissue after DJB and explore the potential mechanisms contributing to postoperative insulin sensitivity improvement of adipose tissue in a diabetic male rat *** DJB and sham surgery was performed in a-high-fat-diet/streptozotocin-induced diabetic rat *** adipose tissue was weighed and observed under *** inguinal fat to represent subcutaneous adipose tissue(SAT)and mesangial fat to represent visceral adipose ***-sequencing was utilized to evaluate gene expression alterations *** hematoxylin and eosin staining,reverse transcription-quantitative polymerase chain reaction,western blot,and enzyme-linked immunosorbent assay were used to study the *** resistance was evaluated by *** After DJB,whole body blood glucose metabolism and insulin sensitivity in adipose tissue *** cell volume in both visceral adipose tissue(VAT)and SAT *** to SAT,VAT showed more significantly functional alterations after DJB and KEGG analysis indicated growth hormone(GH)pathway and downstream adiponectin secretion were involved in metabolic *** circulating GH and adiponectin levels and GH receptor and adiponectin levels in VAT *** experiment showed that GH stimulated adiponectin secretion and improve insulin *** GH improves insulin resistance in VAT in male diabetic rats after receiving DJB,possibly by increasing adiponectin secretion.

关键词： Growth hormone Insulin resistance Bariatric surgery Adipose tissue Adiponectin

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台湾作家钟理和与鲁迅比较研究

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内蒙古大学学报（哲学社会科学版） 2009年第1期41卷 28-32页

作者：杨志强华东师范大学文学院上海200241

钟理和《故乡》系列四篇小说独立成章,却又有密切的联系,构成光复后台湾的社会写实画。其风景的冷峻、晦暗与鲁迅《故乡》有着惊人的相似,笔下的形象都是受到时代局限的与主人公有较为密切关系的悲剧式人物。他们身上有最为淳朴的一面,... 详细信息

钟理和《故乡》系列四篇小说独立成章,却又有密切的联系,构成光复后台湾的社会写实画。其风景的冷峻、晦暗与鲁迅《故乡》有着惊人的相似,笔下的形象都是受到时代局限的与主人公有较为密切关系的悲剧式人物。他们身上有最为淳朴的一面,也有在世事沧桑下拘泥、古怪的一面。两个故乡互文性的最核心部分,在于钟理和与鲁迅在精神上的相通性。

关键词：钟理和鲁迅《故乡》互文性

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