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Enantioselective hydrolysis of naproxen ethyl ester catalyzed by polyclonal antibodies

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Chinese Science Bulletin 1997年第9期42卷 741-744页

作者： Hu, YJ yang, bh Zhao, H Wu, YL Ji, YY Ye, M State Key Laboratory of Bicorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China Shanghai Institute of Cell Biology Chinese Academy of Sciences Shanghai China

BASED on the hypothesis of Pauling on enzyme action that free energy difference between theground and transition state is reduced by the specific binding of active center of enzyme to theintermediate,a large number of... 详细信息

关键词： enantioselectivity hydrolysis of naproxen ethyl ester polyclonal antibody catalytic antibody.

Evolutionary Multi/Many-Objective Optimisation via Bilevel Decomposition

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1973-1986页

作者： Shouyong Jiang Jinglei Guo Yong Wang Shengxiang yang School of Automation Central South UniversityChangsha 410083China Department of Computing Science University of AberdeenAberdeen AB243FXUK School of Computer Science Central China Normal UniversityWuhan 430079China School of Computer Science and Informatics De Montfort UniversityLeicester LE19BHUK

Decomposition of a complex multi-objective optimisation problem(MOP)to multiple simple subMOPs,known as M2M for short,is an effective approach to multi-objective ***,M2M facilitates little communication/collaboration between subMOPs,which limits its use in complex optimisation *** paper extends the M2M framework to develop a unified algorithm for both multi-objective and manyobjective *** bilevel decomposition,an MOP is divided into multiple subMOPs at upper level,each of which is further divided into a number of single-objective subproblems at lower *** subMOPs are allowed to share some subproblems so that the knowledge gained from solving one subMOP can be transferred to another,and eventually to all the *** bilevel decomposition is readily combined with some new mating selection and population update strategies,leading to a high-performance algorithm that competes effectively against a number of state-of-the-arts studied in this paper for both multiand many-objective *** analysis and component analysis have been also carried out to further justify the proposed algorithm.

关键词： Bilevel decomposition evolutionary algorithm many-objective optimisation multi-objective optimisation

Multiparameter Numerical Investigation of Two Types of Moving Interactions Between the Deep-Sea Mining Vehicle Track Plate and Seabed Soil:Digging and Rotating Motions

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China Ocean Engineering 2024年第3期38卷 408-423页

作者： SUN Peng-fei LYU Hai-ning yang Jian-min XU Zhi-yong State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Yazhou Bay Institute of Deepsea SCI-TECH Shanghai Jiao Tong UniversitySanya 572024China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China

To ensure the safe performance of deep-sea mining vehicles(DSMVs),it is necessary to study the mechanical characteristics of the interaction between the seabed soil and the track *** rotation and digging motions of the track plate are important links in the contact between the driving mechanism of the DSMV and seabed *** this study,a numerical simulation is conducted using the coupled Eulerian–Lagrangian(CEL)large deformation numerical method to investigate the interaction between the track plate of the DSMV and the seabed soil under two working conditions:rotating condition and digging ***,a soil numerical model is established based on the elastoplastic mechanical characterization using the basic physical and mechanical properties of the seabed soil obtained by in situ ***,the soil disturbance mechanism and the dynamic mechanical response of the track plate under rotating and digging conditions are obtained through the analysis of the sensitivity of the motion parameters,the grouser structure,the layered soil features and the soil *** results indicate that the above parameters remarkably influence the interaction between the DSMV and the seabed ***,it is important to consider the rotating and digging motion of the DSMV in practical engineering to develop a detailed optimization design of the track plate.

关键词： deep-sea mining vehicle rotating motion digging motion track plate-seabed soil interaction CEL numerical method

Mechanism of Primary Frequency Regulation for Battery Hybridization in Hydropower Plant

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 2127-2137页

作者： Yiwen Liao Weijia yang Zhecheng Wang Yifan Huang C.Y.Chung State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Battery hybridization in hydropower plants is a hydropower flexibility enhancement technology innovation that can potentially expand hydropower’s contributions to the grid,but its fundamental characteristics and influencing mechanisms are still *** this paper,primary frequency regulation(PFR)performance and the mechanism of this new technology are studied.A battery hybridized hydropower plant(bh-HPP)model,based on a field-measured-data-based hydropower plant(HPP)model and a verified battery simplified model,is *** of system stability and dynamics is undertaken for three different battery control strategies by root locus and participation factor *** to conventional HPPs,analysis results theoretically reveal bh-HPP can not only accelerate system regulation rapidity but also effectively enlarge HPP stability region during PFR *** domain simulation verifies the results and further shows synthetic control has better performance among introduced ***,initial design ranges of control parameters considering battery capacity and a renewable energy source scenario case are also *** work could provide theoretical support for flexibility enhancement solutions for hydropower systems.

关键词： Battery hybridization dynamic response hydropower plant primary frequency regulation stability

Borohydride Ammoniate Solid Electrolyte Design for All-Solid-State Mg Batteries

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Energy & Environmental Materials 2024年第1期7卷 100-106页

作者： Yuepeng Pang Zhengfang Nie Fen Xu Lixian Sun Junhe yang Dalin Sun Fang Fang Shiyou Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Guangxi Key Laboratory of Information Materials&Guangxi Collaborative Innovation Centre of Structure and Property for New Energy and Materials Guilin University of Electronic TechnologyGuilin 541004China Department of Materials Science Fudan UniversityShanghai 200433China

Searching for novel solid electrolytes is of great importance and challenge for all-solid-state Mg *** this work,we develop an amorphous Mg borohydride ammoniate,Mg(bh_(4))_(2)·2NH_(3),as a solid Mg electrolyte that prepared by a NH_(3)redistribution between 3D framework-γ-Mg(bh_(4))_(2)and Mg(bh_(4))_(2)·6NH_(3).Amorphous Mg(bh_(4))_(2)·2NH_(3)exhibits a high Mg-ion conductivity of 5×10^(-4)S cm^(-1)at 75℃,which is attributed to the fast migration of abundant Mg vacancies according to the theoretical ***,amorphous Mg(bh_(4))_(2)·2NH_(3)shows an apparent electrochemical stability window of 0-1.4 V with the help of in-situ formed interphases,which can prevent further side reactions without hindering the Mg-ion *** on the above superiorities,amorphous Mg(bh_(4))_(2)·2NH_(3)enables the stable cycling of all-solid-state Mg cells,as the critical current density reaches 3.2 mA cm^(-2)for Mg symmetrical cells and the reversible specific capacity reaches 141 mAh g^(-1)with a coulombic efficiency of 91.7%(first cycle)for Mg||TiS_(2)cells.

关键词： all-solid-state Mg batteries amorphization Mg borohydride ammoniate Mg vacancy migration solid electrolyte

Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

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Current Medical Science 2024年第2期44卷 309-327页

作者： Xiao-jun WANG Jia-ping CHEN Xin-wei QIAO Wang-yang MENG yang-wei WANG Yun-chong MENG Rong ZHAO Wei LIN Yong-de LIAO Han XIAO Pei-yuan MEI Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival *** suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and ***,a comprehensive analysis of their role in LUSC is *** study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of ***:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO ***,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in *** core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for *** specimens were examined by immunohistochemical analysis to confirm the diagnostic value in ***,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was ***:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2bh,FLRT3,CHEK2,and ALPL)for ***10 showed a significant positive correlation with immune cell infiltration and immune checkpoint ***:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

Coercivity mechanism of high-performance anisotropic heterostructure SmCo_(5)magnets

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Journal of Rare Earths 2024年第10期42卷 1882-1888页

作者： Yuan Teng Yuqing Li Weiqiang Liu Xiaochang Xu Zhanjia Wang Jianjun yang Dongtao Zhang Hongguo Zhang Qingmei Lu Qiong Wu Weixing Xia Ming Yue Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing100124China School of Mechanical and Electrical Engineering Henan Institute of Science and TechnologyXinxiang453000China School of Mechanical Engineering Anyang Institute of TechnologyAnyang455000China Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China

Due to its large magnetocrystalline anisotropy field and high Curie temperature,SmCo-based magnets are irreplaceable in high-temperature applications,The hot-deformed SmCo-based magnets are especially attractive for their excellent corrosion resistance,making them more suitable for harsh ***,it is still challenging for hot-deformed SmCo-based magnets to obtain high magnetization and high coercivity ***,it is necessary to analyze the relationship between its microstructure and magnetic properties and explore its magnetic hardening mechanism to guide the further improvement of magnetic *** this paper,the anisotropic heterostructure SmCo_(5)magnet was prepared by combining large height-reduction and introducing a nano-grained Smrich *** c-axis texture,(bh)m of 16.1 MGOe,and H_(ci)of 9.6 kOe were obtained via the heterostructure with SmCo_(5)micron-grain and Sm-rich nano-scale *** magnetic domain observation and technical magnetization analysis demonstrate that the coe rcivity mechanism is dominated by *** results also show that the smooth and Sm-rich precipitated grain boundary provides weak pinning *** provides a reference for the development of high-pe rformance nanocrystalline SmCo_(5)magnets.

关键词： Permanent magnet Heterostructure Rare earths Coercivity mechanism Hot-deformed SmCo magnet

Structural engineering of Fe single-atom oxygen reduction catalyst with high site density and improved mass transfer

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Journal of Energy Chemistry 2024年第11期 634-644页

作者： Jiawen Wu Yuanzhi Zhu An Cai Xiaobin Fan Wenchao Peng yang Li School of Chemical Engineering and Technology Tianjin University Faculty of Chemical Engineering Yunnan Provincial Key Laboratory of Energy Saving in Phosphorus Chemical Engineering and New Phosphorus MaterialsKunming University of Science and Technology Institute of Shaoxing Tianjin University

Fe-N-C catalysts are widely considered as promising non-precious-metal candidates for electrocatalytic oxygen reduction reaction（ORR）,Yet despite their high catalytic activity through rational modulation,challenges remain in their low site density and unsatisfactory mass transfer ***,we present a structural engineering approach employing a soft-template coating strategy to fabricate a hollow and hierarchically porous N-doped carbon framework anchored with atomically dispersed Fe sites（FeNCh） as an efficient ORR *** combination of hierarchical porosity and high exterior surface area is proven crucial for exposing more active sites,which gives rise to a remarkable ORR performance with a half-wave potential of 0.902 V in 0.1 m KOH and 0.814 V in 0.1 m HClO4,significantly outperforming its counterpart with solid structure and dominance of micropores（FeNC-s）.The mass transfer property is revealed by in-situ electrochemical impedance spectroscopy（EIS） *** distribution of relaxation time（DRT） analysis is further introduced to deconvolve the kinetic and mass transport processes,which demonstrates an alleviated mass transport resistance for FeNC-h,validating the effectiveness of structural *** work not only provides an effective structural engineering approach but also contributes to the comprehensive mass transfer evaluation on advanced electrocatalyst for energy conversion applications.

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FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma

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World Journal of Gastroenterology 2000年第2期6卷 223-227页

作者： Sun bh Zhao XP Wang BJ yang DL Hao LJ Tongji Med Univ Tongji Hosp Dept Clin Immunol Wuhan 430030 Hubei Province Peoples R China

AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with *** FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD *** positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver *** Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to *** cell apoptosis in HCC isassociated with FADD expres

关键词： FADD TRADD apoptosis carcinoma hepatocellular liver neoplasms