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Experimental investigation of bed-to-wall heat transfer in fluidized beds of a Geldart B sorbent particle under a full spectrum of fluidization regime

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PARTICUOLOGY 2024年第10期93卷 235-246页

作者： Xu, Chenhuan Zhang, Yongmin Wang, Liang Zhang, Yiming yang, tianlei Qiu, Feng Liu, Cenfan Jiang, Shuai Dong, Ke China Univ Petr State Key Lab Heavy Oil Proc Beijing 102249 Peoples R China Beijing DERUNCHEN Environm Protect Technol Co Ltd Beijing 100022 Peoples R China China Special Equipment Inspect & Res Inst Key Lab Special Equipment Safety & Energy Saving S Beijing 100029 Peoples R China

Fluidization technology has been used in CO 2 capture processes, the successful design and operation of the heat exchangers involved in this process require much information on the bed-to-wall heat transfer of the sorbent particles in fluidized states. In this study, the bed-to-wall heat transfer coefficient ( h ) of a solid amine sorbent was measured by a heat transfer probe in a large-scale circulating fluidized bed cold model unit, where full spectrum of fluidization regimes can be realized. The corresponding hydrodynamic signals were also studied by pressure sensors and optical fiber probes to further explain the newly discovered phenomenon. The results show that in a dense bed, due to the counterbalanced effect of time fraction of packet and packet renewal frequency, h of the Geldart B particle reaches a peak within the bubbling fluidized regime, and the radial distribution of h are opposite in bubbling and turbulent fluidized regimes. In a fast fluidization regime, gas convection becomes the dominant factor affecting h when the solids holdup is low enough. Correlations were provided or recommended to guide the design of heat exchangers in the fluidized bed CO 2 capture processes. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Bed-to-wall heat transfer Solid amine sorbent Geldart B particle Full spectrum of fluidization regime Correlation CONTINUOUS CO2 CAPTURE TEMPERATURE HYDRODYNAMICS TRANSITION TUBE INTEGRATION TRANSPORT

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池塘养殖凡纳滨对虾投喂膨化饲料和硬颗粒饲料的差异研究

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河北渔业 2024年第10期 14-19页

作者：杨全义杨天磊殷蕊宫春光河北农业大学海洋学院河北秦皇岛066003 河北省海洋与水产科学研究院河北秦皇岛066200

为更好地了解膨化饲料在池塘养殖凡纳滨对虾(Litopenaeus vannamei)中的应用效果,在天津宝坻选取位置临近、水源一致的6个淡水池塘进行膨化饲料与硬颗粒饲料的养殖对比试验,3个池塘投喂沉性膨化饲料,另外3个池塘投喂同一营养水平的硬颗... 详细信息

为更好地了解膨化饲料在池塘养殖凡纳滨对虾(Litopenaeus vannamei)中的应用效果,在天津宝坻选取位置临近、水源一致的6个淡水池塘进行膨化饲料与硬颗粒饲料的养殖对比试验,3个池塘投喂沉性膨化饲料,另外3个池塘投喂同一营养水平的硬颗粒饲料。虾苗初始体质量为(0.125±0.047)g,初始体长为(1.96±0.32)cm,放苗密度均为39万尾/hm 2,养殖90 d。从生长性能、养殖水体水质和养殖效益3个方面进行了比较。结果表明,膨化饲料组在养殖存活率、增重率、特定生长率和终末密度等方面略高于颗粒饲料组,饲料系数略低,但均无显著差异(P>0.05);养殖水体中氨氮、亚硝酸盐浓度显著低于颗粒饲料组(P<0.05)。此外,使用膨化饲料能够获得更高的产量和更高的养殖效益,且单位资金成本的回报更高。

关键词：凡纳滨对虾(Litopenaeus vannamei) 沉性膨化饲料硬颗粒饲料池塘养殖效益

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Single-domain antibodies as therapeutics for solid tumor treatment

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2854-2868页

作者： Mingkai Wang tianlei Ying Yanling Wu MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology School of Basic Medical SciencesDepartment of Pulmonary and Critical Care MedicineDepartment of Liver Surgery and TransplantationZhongshan HospitalFudan UniversityShanghai 200032China Shanghai Engineering Research Center for Synthetic Immunology Shanghai 200032China

Single-domain antibodies(sdAbs),initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs,have emerged as a promising alternative to conventional therapeutic *** sdAbs have many superior physicochemical and pharmacological properties,including small size,good solubility and thermostability,easier accessible epitopes,and strong tissue ***,the inherent challenges associated with the animal origin of sdAbs limit their clinical *** recent years,various innovative humanization technologies,including complementarity-determining region(CDR)grafting or complete engineering of fully human sdAbs,have been developed to mitigate potential immunogenicity issues and enhance their *** review provides a comprehensive exploration of sdAbs,emphasizing their distinctive features and the progress in humanization *** addition,we provide an overview of the recent progress in developing drugs and therapeutic strategies based on sdAbs and their potential in solid tumor treatment,such as sdAbedrug conjugates,multispecific sdAbs,sdAb-based delivery systems,and sdAb-based cell therapy.

关键词： Single-domain antibody Nanobody Humanization Fully human singledomain antibody Solid tumor

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Performance and Application of Double-layered Microcapsule Corrosion Inhibitors

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 845-853页

作者：余海燕 WANG Yingxiang WANG Ruizhi HU Lintong WANG tianlei School of Materials Science and Engineering Tianjin Chengjian UniversityTianjin 300384China Tianjin Key Laboratory of Building Green Functional Materials Tianjin Chengjian UniversityTianjin 300384China

Double-layered microcapsule corrosion inhibitors were developed by sodium monofluorophosphate as the core material,polymethyl methacrylate as the inner wall material,and polyvinyl alcohol as the outer wall material combining the solvent evaporation method and spray drying *** protection by the outer capsule wall was used to prolong the service life of the corrosion *** dispersion,encapsulation,thermal stability of microcapsules,and the degradation rate of capsule wall in concrete pore solution were analyzed by ultra-deep field microscopy,scanning electron microscopy,thermal analyzer,and sodium ion release rate *** microcapsules were incorporated into mortar samples containing steel reinforcement,and the effects of double-layered microcapsule corrosion inhibitors on the performance of the cement matrix and the actual corrosion-inhibiting effect were *** experimental results show that the double-layered microcapsules have a moderate particle size and uniform distribution,and the capsules were completely *** microcapsules as a whole have good thermal stability below 230 ℃.The monolayer membrane structure microcapsules completely broke within 1 day in the simulated concrete pore solution,and the double-layer membrane structure prolonged the service life of the microcapsules to 80 days in the simulated concrete pore solution before the core material was completely *** mortar samples containing steel reinforcement incorporated with the double-layered microcapsule corrosion inhibitors still maintained a higher corrosion potential than the monolayer microcapsule corrosion inhibitors control group at 60 *** incorporation of double-layered microcapsules into the cement matrix has no significant adverse effect on the setting time and early strength.

关键词： corrosion inhibitors microcapsule double-layer structure potentiodynamic polarization curve

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Effect of Iron on the Stability of Rhodochrosite at the Topmost Lower Mantle Conditions

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Journal of Earth Science 2024年第2期35卷 504-513页

作者： tianlei Zhai Fei Qin Shengxuan Huang Shan Qin Yu Gong Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing100871China School of Earth Sciences and Resources China University of GeosciencesBeijing100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China

Carbonates are viewed as the principal oxidized carbon carriers during subduction,and thus the stability of subducted carbonates has significant implications for the deep carbon *** we investigate the high pressure-temperature behaviors of rhodochrosite in the presence of iron up to∼34 GPa by in-situ X-ray diffraction and ex-situ Raman *** relatively low temperature below∼1500 K,MnCO_(3)breaks down into MnO and CO_(2).Upon heating to∼1800 K,however,the MnCO_(3)-Fe^(0)reactions occur with the formation of Mn_(3)O_(4),Fe^(O)and reduced carbon.A'three-stage'reaction mechanism is proposed to understand the kinetics of the carbon-iron-manganese redox *** results suggest that Fe^(0)can serve as a reductant to greatly affect the stability of rhodochrosite,which implies that the effect of Fe-metal should be seriously considered for the high pressure-temperature behaviors of other predominant carbonates at Earth's mantle conditions,particularly at depths greater than∼250 km.

关键词： deep carbon cycle rhodochrosite reduced mantle diamond formation high pressure tectonics geochemistry

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The Four Most Basic Elements In Machine Cognition

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Data Intelligence 2024年第2期6卷 297-319页

作者： Deyi Li Jialun Yin tianlei Zhang Wei Han Hong Bao Chinese Association for Artificial Intelligence Beijing 100101China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Trunk Beijing 100101China AIForceTech Beijing 100101China College of Robotics Beijing Union UniversityBeijing 100101China

The widespread use of ChatGPT has normalized the dialogue Turing *** meet this challenge,China's major national development strategy suggests that for a new generation of artificial intelligence,it is first necessary to answer the big questions raised by Turing in 1950 from the perspective of cognitive physics:Can machines think?How do machines think?How do machines cognize?Whether it is carbon-based human cognition or silicon-based machine cognition,it is an interaction between complex constructs composed of the four most basic elements:matter,energy,structure,and *** humans and machines depend on negative entropy for living,and time is the cornerstone of *** and time are parasitic on matter and energy in physical space,forming hard-structured *** soft-structured ware in cognitive space is mind,which is parasitic on the hard-structured ware or other existing soft-structured ware,and constitutes a rich hierarchy of multi-scale feelings,concepts,information,and ***"abstraction"from the symbolic school of artificial intelligence,"association"from the connectionist school,and"interaction"from the behaviorist school,the core of cognition is established on the shoulders of such scientific giants such as Schrodinger,Turing and *** and hard-structured ware *** machine can comprise heterogeneous hard-structured ware,such as field programmable gate arrays(FPGAs),data processing units(DPUs),central processing units(CPUs),graphics processing units(GPUs),tensor processing units(TPUs),and *** can also be implanted with the"Baby Cognitive Nucleus"which is hard-structured ware genetically inherited and naturally evolved to form the embodied *** the hard-structured ware is parasitized by rich,multi-scale soft-structured *** regulating matter and energy through soft-structured ware,machines produce orderly events,form coordinated and orderly thinking *** heterogeneous sensors configur

关键词： Cognitive physical science Negentropy Soft-structured ware Baby cognitive nucleus Intense thinking Embodied turing test

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Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function

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National Science Review 2024年第2期11卷 145-154页

作者： Farong Ye Cheng Li Feng-Liang Liu Xinliang Liu Peng Xu Rong-Hua Luo Wenping Song Yong-Tang Zheng tianlei Ying Biao Yu Ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–function relationships. Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice. Furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the N-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein

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Effects of Nitrogen-Regulating Gene AreA on Growth,Pathogenicity,and Fumonisin Synthesis of Fusarium proliferatum

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Rice science 2024年第1期31卷 10-13,I0013-I0017页

作者： SUN Lei CHEN Xu ZHOU Qianya ZHANG tianlei YU Qian LIU Lianmeng HUANG Shiwen WANG Ling Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province College of Biological and Food EngineeringHuaihua UniversityHuaihua 418000China State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China

Rice spikelet rot disease not only threatens rice yields but also poses risks to humans and animals due to the production of the category 2B carcinogen fumonisins by the pathogen Fusarium ***(N)metabolism is known to have a significant influence on fungal growth and the synthesis of secondary *** is a global N regulatory gene belonging to the GATA transcription factor *** this study,we observed that theΔAreA mutant exhibited a notable reduction in growth rate and conidium *** experiments revealed thatΔAreA had almost lost its ability to infect rice spikelets.

关键词： metabolism Fusarium Growth

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Vibration properties of Paulownia wood for Ruan sound quality using machine learning methods

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Journal of Forestry Research 2024年第5期35卷 216-222页

作者： yang yang College of Art and Design Harbin UniversityHarbin 150076People’s Republic of China College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin 150040People’s Republic of China

As an important material for manufacturing resonant components of musical instruments,Paulownia has an important influence on the sound quality of *** this paper,a model for evaluating the sound quality of Ruan based on the vibration characteristics of wood is developed using machine learning ***,the selection of materials for Ruan manufacturing relies primarily on manually weighing,observing,striking,and listening by the instrument *** in scientific theory have hindered the quality of the finished *** this study,nine Ruans were manufactured,and a prediction model of Ruan sound quality was proposed based on the raw material information of *** of a total of 180 data sets,145 and 45 sets were chosen for training and validation,*** this paper,typical correlation analysis was used to determine the correlation between two single indicators in two adjacent pairwise combinations of the measured objects in each stage of the production process in *** vibra-tion characteristics of the wood were tested,and a model for predicting the evaluation of Ruan’s acoustic qualities was developed by measuring the vibration characteristics of the resonating plate *** acoustic quality of the Ruan sound board wood was evaluated and predicted using machine learning model generalized regression neural *** results show that the prediction of Ruan sound quality can be achieved using Matlab simulation based on the vibration characteristics of the soundboard *** the model-predicted values were compared with the tradi-tional predicted results,it was found that the generalized regression neural network had good performance,achieving an accuracy of 93.8%which was highly consistent with the experimental *** was concluded that the model can accurately predict the acoustic quality of the Ruan based on the vibration performance of the soundboards.

关键词： Sound quality Wood vibration performance Paulownia wood Machine learning methods

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Overview of radar detection methods for low altitude targets in marine environments

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Journal of Systems Engineering and Electronics 2024年第1期35卷 1-13页

作者： yang Yong yang Boyu School of Electronic Science National University of Defense TechnologyChangsha 410073China

In this paper,a comprehensive overview of radar detection methods for low-altitude targets in maritime environments is presented,focusing on the challenges posed by sea clutter and multipath *** performance of the radar detection methods under sea clutter,multipath,and combined conditions is categorized and summarized,and future research directions are outlined to enhance radar detection performance for low-altitude targets in maritime environments.

关键词： radar sea clutter multipath scattering detection low altitude target

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