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Multi-omics revealed the mechanism of feed efficiency in sheep by the combined action of the host and rumen microbiota

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ANIMAL NUTRITION 2024年第3期18卷 367-379页

作者： Zhou, Guangchen Li, Junda Liang, Xuhui yang, Bohua He, Ximeng Tang, Hongyu Guo, Hongran Liu, Gongwei Cui, Wenyuan Chen, Yulin yang, Yuxin Northwest A&F Univ Coll Anim Sci & Technol Key Lab Anim Genet Breeding & Reprod Shaanxi Prov Yangling 712100 Peoples R China

This study was conducted to investigate potential regulatory mechanisms of feed efficiency (FE) in sheep by linking rumen microbiota with its host by the multi-omics analysis. One hundred and ninety-eight hybrid female sheep (initial body weight = 30.88 +/- 4.57 kg; 4-month-old) were selected as candidate sheep. Each test sheep was fed in an individual pen for 60 days, and the residual feed intake (RFI) was calculated. The ten candidate sheep with the highest RFI were divided into the Low-FE group, and the ten with the lowest RFI were divided into the High-FE group, all selected for sample collection. The RFI, average daily gain and average daily feed intake were highly significantly different between the two experimental groups (P < 0.05). Compared with Low-FE group, the insulin-like growth factor-1 and very low-density lipoprotein in serum and the propionate in rumen significantly increased in High-FE group (P < 0.01), but the acetate:propionate ratio in rumen significantly decreased in High-FE group (P = 0.034). Metagenomics revealed Selenomonas ruminantium, Selenomonas sp. and Faecalibacterium prausnitzii were key bacteria, and increased abundance of the genes encoding the enzymes for cellulose degradation and production of propionate in High-FE group. The results of proteomics and section showed the rumen papilla length (P < 0.001) and expression of carbonic anhydrase and Na+/K+-ATPase were significantly higher in High-FE group (P < 0.05). On the other hand, the acetyl-CoA content significantly increased in the liver of High-FE group (P = 0.002). The relative expression levels of insulin-like growth factor-1 and apolipoprotein A4 genes were significantly up-regulated in the liver of High-FE group (P < 0.01), but relative expression level of monoacylglycerol O-acyltransferase 3 gene was significantly down-regulated (P = 0.037). These findings provide the mechanism by which the collaborative interaction between rumen microbiota fermentation and host uptake and me

关键词： Residual feed intake Sheep Microbial composition Rumen proteome Liver transcriptome Metabolite BUTYRATE-PRODUCING BACTERIA VOLATILE FATTY-ACIDS APOLIPOPROTEIN-A-IV DAIRY-COWS ALIGNMENT FIBER TRANSFERASE LACTATE ACETATE

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Flow and sound fields of scaled high-speed trains with different coach numbers running in long tunnel

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Railway Engineering Science 2024年第3期32卷 401-420页

作者： Qiliang Li Yuqing Sun Menghan Ouyang Zhigang yang School of Automotive Studies Tongji UniversityShanghai 201804China Shanghai Automotive Wind Tunnel Center Tongji UniversityShanghai 201804China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Segregated incompressible large eddy simulation and acoustic perturbation equations were used to obtain the flow field and sound field of 1:25 scale trains with three,six and eight coaches in a long tunnel,and the aerodynamic results were verified by wind tunnel test with the same scale two-coach train ***-averaged drag coefficients of the head coach of three trains are similar,but at the tail coach of the multi-group trains it is much larger than that of the three-coach *** eight-coach train presents the largest increment from the head coach to the tail coach in the standard deviation(STD)of aerodynamic force coefficients:0.0110 for drag coefficient(Cd),0.0198 for lift coefficient(Cl)and 0.0371 for side coef-ficient(Cs).Total sound pressure level at the bottom of multi-group trains presents a significant streamwise increase,which is different from the three-coach *** walls affect the acoustic distribution at the bottom,only after the coach number reaches a certain value,and the streamwise increase in the sound pressure fluctuation of multi-group trains is strengthened by coach *** transform of the turbulent and sound pressures presents that coach number has little influence on the peak frequencies,but increases the sound pressure level values at the tail bogie ***,different from the turbulent pressure,the first two sound pressure proper orthogonal decomposition(POD)modes in the bogie cavities contain 90%of the total energy,and the spatial distributions indicate that the acoustic distributions in the head and tail bogies are not related to coach number.

关键词： Flow and sound fields Scaled high-speed trains Different coach numbers long tunnel Proper orthogonal decomposition

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多民族小区域社会共同性的形成——以贵州榕江县“宰牙四寨”为例

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湖北民族大学学报（哲学社会科学版） 2024年第2期42卷 32-42页

作者：杨正文龙宁东西南民族大学民族学与社会学学院西南民族大学

铸牢中华民族共同体意识,需要从各民族的交往交流交融历史实践中去认知和理解共同拥有的文化认同基础,进而才能引导新时代民族工作主线的具体实践。本文聚焦于贵州榕江县郎洞镇的宰牙四寨小区域社会,梳理自清代雍正年间国家“开辟”建... 详细信息

铸牢中华民族共同体意识,需要从各民族的交往交流交融历史实践中去认知和理解共同拥有的文化认同基础,进而才能引导新时代民族工作主线的具体实践。本文聚焦于贵州榕江县郎洞镇的宰牙四寨小区域社会,梳理自清代雍正年间国家“开辟”建制治理下,重构了村寨人群地理空间,使之步入苗、侗、汉等多民族共居互动的社会结构过程。在几百年的历史发展中,一方面是各民族面临相同的自然与社会生境,形成了共同的社会诉求和生活方式,一些被认为对共同生活与社会秩序稳定有保障的族性社会文化规则,被接纳重构为地缘性规则;另一方面是国家制度、文化理念、通用文字及现代民族平等政策等先后植入,与地方社会文化传统互动,生成新的整合机制,进一步强化了超越单一民族的小区域共同体凝聚。该个案的意义在于透析出具有共同性的“文化中国”是由若干类似超越族性的小区域共同体及其文化共遵共享连缀而成的。

关键词：多民族共居小区域社会协作与竞争宰牙四寨

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Unraveling the enigma:A comprehensive review of solid pseudopapillary tumor of the pancreas

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 614-629页

作者： Ye-Cheng Xu De-Liang Fu Feng yang Department of Pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalFudan UniversityShanghai 200040China

Solid pseudopapillary tumor of the pancreas(SPTP)is a rare neoplasm predom-inantly observed in young ***,CTNNB1 mutations,β-catenin nuclear accumulation,and subsequent Wnt-signaling pathway activation are the leading molecular *** preoperative diagnosis often relies on imaging techniques and endoscopic *** resection remains the mainstay *** models,such as the Fudan Prognostic Index,show promise as predictive tools for assessing the prognosis of *** three types of metachronous liver metastasis can be beneficial in tailoring individu-alized treatment and follow-up *** advancements,challenges persist in understanding its etiology,establishing standardized treatments for unresectable or metastatic diseases,and developing a widely recognized grading *** comprehensive review aims to elucidate the enigma by consolidating current knowledge on the epidemiology,clinical presentation,pathology,molecular characteristics,diagnostic methods,treatment options,and prognostic factors.

关键词： Pancreas Solid pseudopapillary tumor β-catenin Endoscopic ultrasound Surgery Recurrence Liver metastasis Prognostic prediction

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Detection Algorithm of Laboratory Personnel Irregularities Based on Improved YOLOv7

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Computers, Materials & Continua 2024年第2期78卷 2741-2765页

作者： Yongliang yang Linghua Xu Maolin Luo Xiao Wang Min Cao School of Electrical Engineering Guizhou UniversityGuiyang550025China

Due to the complex environment of the university laboratory,personnel flow intensive,personnel irregular behavior is easy to cause security *** using mainstream detection algorithms suffers from low detection accuracy and slow ***,the current management of personnel behavior mainly relies on institutional constraints,education and training,on-site supervision,etc.,which is time-consuming and *** the above situation,this paper proposes an improved You Only Look Once version 7(YOLOv7)to achieve the purpose of quickly detecting irregular behaviors of laboratory personnel while ensuring high detection ***,to better capture the shape features of the target,deformable convolutional networks(DCN)is used in the backbone part of the model to replace the traditional convolution to improve the detection accuracy and ***,to enhance the extraction of important features and suppress useless features,this paper proposes a new convolutional block attention module_efficient channel attention(CBAM_E)for embedding the neck network to improve the model’s ability to extract features from complex ***,to reduce the influence of angle factor and bounding box regression accuracy,this paper proposes a newα-SCYLLA intersection over union(α-SIoU)instead of the complete intersection over union(CIoU),which improves the regression accuracy while increasing the convergence *** experiments on public and homemade datasets show that the improved algorithm outperforms the original algorithm in all evaluation indexes,with an increase of 2.92%in the precision rate,4.14%in the recall rate,0.0356 in the weighted harmonic mean,3.60%in the mAP@0.5 value,and a reduction in the number of parameters and *** with the mainstream algorithm,the improved algorithm has higher detection accuracy,faster convergence speed,and better actual recognition effect,indicating the effectiveness of the improved algorithm in this p

关键词： University laboratory personnel behavior YOLOv7 deformable convolutional networks attention module intersection over union

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Experimental study on the sandstone abrasiveness via mineral composition and microstructure analysis

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PETROLEUM 2024年第3期10卷 440-445页

作者： Shi, Xiangchao Tang, yang Chen, Shuai Gao, Leiyu Wang, Yuming Southwest Petr Univ State Key Lab Oil & Gas Reservoir Geol & Exploitat Chengdu 610500 Peoples R China

Rock abrasiveness is an important factor affecting the tool's lifetime and efficiency in breaking a rock. Characterizing rock abrasiveness helps in the design, optimization, and mean-life prediction of tools. Xray diffraction, cast thin section analysis, and CERCHAR abrasiveness tests were performed on 18 different sandstones to characterize rock abrasiveness and explore new methods for characterization. The relationship between the mineral composition and microstructure of sandstone and abrasiveness was investigated. The results show that different structural maturities have varying effects on abrasiveness. In addition, the higher the structural maturity, the more the abrasiveness. Furthermore, in sandstones of the same structural maturity, the abrasiveness increases with equivalent quartz content (EQC). The texture coefficient (TC) and CERCHAR abrasiveness index (CAI) of sandstones with the same structural maturity showed a good linear relationship. Moreover, the correlation coefficients considering the combined parameters are above 0.85. Therefore, obtaining the microstructure and mineral composition of sandstone can effectively characterize rock abrasiveness. It also provides a new method for predicting the abrasiveness of the rock in the well. (c) 2023 Southwest Petroleum University. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http:// ***/licenses/by-nc-nd/4.0/).

关键词： Abrasiveness Microstructure Mineral compositions Structural maturity Equivalent quartz content Sandstone CERCHAR ABRASIVITY INDEX GEOMECHANICAL PROPERTIES ROCK STRENGTH CAI DRILLABILITY PREDICTION TEXTURE DRILL WEAR

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细菌发酵生产蓝色素提取条件的优化

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中国食品添加剂 2014年第9期25卷 96-100页

作者：左勇江鹏叶碧霞王小龙傅彬杨小龙郑惠四川理工学院生物工程学院自贡643000

本文主要研究细菌(T2013)发酵生产蓝色素的提取条件。首先对蓝色素提取的主要单因素(浸提剂种类、浓度、浸提温度、浸提时间等)进行研究;在单因素实验基础上进行正交试验优化提取条件。结果表明:温度对该色素提取有显著影响,以80%的乙... 详细信息

本文主要研究细菌(T2013)发酵生产蓝色素的提取条件。首先对蓝色素提取的主要单因素(浸提剂种类、浓度、浸提温度、浸提时间等)进行研究;在单因素实验基础上进行正交试验优化提取条件。结果表明:温度对该色素提取有显著影响,以80%的乙醇为浸提剂,在浸提时间为150min、浸提温度为60℃、固液比为1∶50的条件下,提取效果最佳。

关键词：细菌蓝色素提取正交试验

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Identification of TNFRSF1A as a novel regulator of carfilzomib resistance in multiple myeloma

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Oncology Research 2024年第2期32卷 325-337页

作者： JIE ZHAO XUANTAO yang HAIXI ZHANG XUEZHONG GU Department of Hematology The First People’s Hospital of Yunnan ProvinceYunnan Province Clinical Research Center for Hematologic DiseaseYunnan Province Clinical Center for Hematologic DiseaseKunming650032China Department of Pathology The First People’s Hospital of Yunnan ProvinceKunming650032China

Multiple myeloma(MM)is a hematological tumor with high mortality and recurrence *** is a new-generation proteasome inhibitor that is used as the first-line therapy for ***,the development of drug resistance is a pervasive obstacle to treating ***,elucidating the drug resistance mechanisms is conducive to the formulation of novel therapeutic *** elucidate the mechanisms of carfilzomib resistance,we retrieved the GSE78069 microarray dataset containing carfilzomib-resistant LP-1 MM cells and parental MM *** gene expression analyses revealed major alterations in the major histocompatibility complex(MHC)and cell adhesion *** upregulation of the tumor necrosis factor(TNF)receptor superfamily member 1A(TNFRSF1A)gene was accompanied by the downregulation of MHC genes and cell adhesion ***,to investigate the roles of these genes,we established a carfilzomib-resistant cell model and observed that carfilzomib resistance induced TNFRSF1A overexpression and TNFRSF1A silencing reversed carfilzomib resistance and reactivated the expression of cell adhesion ***,TNFRSF1A silencing suppressed the tumorigenesis of MM cells in immunocompetent mice,indicating that TNFRSF1A may lead to carfilzomib resistance by dampening antitumor ***,our results indicated that TNFRSF1A overexpression conferred carfilzomib resistance in MM cells and suppressed the expression of MHC genes and cell adhesion *** suppression of MHC genes and cell adhesion molecules may impair the interaction between immune cells and cancer cells to impair antitumor *** studies are warranted to further investigate the signaling pathway underlying the regulatory role of TNFRSF1A in MM cells.

关键词： Multiple myeloma Carfilzomib Drug resistance Major histocompatibility complex TNFRSF1A

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Microstructure and texture evolution of Cu–Cr–Co–Ti alloys during the two-stage cryorolling

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Rare Metals 2024年第9期43卷 4535-4547页

作者： Jia-Jun Zhang long-Jian Li Zhi-Feng Liu Zong-Ning Chen En-Yu Guo Hui-Jun Kang Ren-Geng Li Tong-Min Wang Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and EngineeringDalian University of Technology Center of Hyper-Gravity Experimental and Interdisciplinary Research Zhejiang University Ningbo Institute of Dalian University of Technology！Ningbo315000 China Key Laboratory for Light-Weight Materials Nanjing Tech University

This study entailed an investigation of the mechanical properties, microstructural and texture orientation evolutions of CuDCrDCoDTi alloys prepared via twostage cryorolling and intermediate aging treatment. To this end, X-ray diffraction and electron backscatter diffraction were employed. The results indicate that the two-stage cryorolling and intermediate aging treatments led to the development of profuse twin bundles and significantly enhanced the mechanical properties. The initial cryorolling led to coplanar slip and developed a strong Y({111} ) orientation, accelerating the formation of Goss({011} ) orientation and a Brass-type *** intermediate aging treatment relieved the restriction on dislocation slip and reoriented the grains toward the Copper({112} ) and Z({111} ) *** Z orientation, with a relatively high volume fraction,dominated the macrotexture. Secondary cryorolling intensified twinning and shear banding, transforming the Copper-type shear bands into Brass-type shear bands with rhomboidal prism morphology. The areas inside the Brasstype shear bands exhibited a Y orientation, and the areas outside the shear bands exhibited a stable Brass-type texture. The evident decrease in the weighted Schmid factors demonstrated that the two-stage cryorolling and intermediate aging treatment can modify the texture evolution and aid the design of high-performance Cu alloys.

关键词： Copper alloys Electron backscatter diffraction Macrotexture evolution Schmid factor Two-stage cryorolling

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Predictability of the 7·20 extreme rainstorm in Zhengzhou in stochastic kinetic-energy backscatter ensembles

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Science China Earth Sciences 2024年第7期67卷 2226-2241页

作者： Min yang Peilong YU Lifeng ZHANG Xiaobing PAN Quanjia ZHONG Yunying LI College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory of High Impact Weather(Special) China Meteorological AdministrationChangsha 410073China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjing 210044China Department of Ocean Science Hong Kong University of Science and TechnologyHong Kong 999077China

The scale-dependent predictability of the devastating 7·20 extreme rainstorm in Zhengzhou,China in 2021 was investigated via ensemble experiments,which were perturbed on different scales using the stochastic kinetic-energy backscatter(SKEB)scheme in the WRF model,with the innermost domain having a 3-km grid *** daily rainfall(RAIN24h)and the cloudburst during 1600-1700 LST(RAIN1h)were *** demonstrated that with larger perturbation scales,the ensemble spread for the rainfall maximum widens and rainfall forecasts become closer to the *** ensembles with mesoscale or convective-scale perturbations,RAIN1h loses predictability at scales smaller than 20 km and RAIN24h is predictable for all *** in ensembles with synoptic-scale perturbations,the largest scale of predictability loss extends to 60 km for both RAIN1h and ***,the average positional error in forecasting the heaviest rainfall for RAIN24h(RAIN1h)was 400 km(50-60)*** southerly low-level jet near Zhengzhou was assumed to be directly responsible for the forecast uncertainty of *** rapid intensification in low-level cyclonic vorticity,mid-level divergence,and upward motion concomitant with the jet dynamically facilitated the *** analysis of the divergent,rotational and vertical kinetic spectra and the corresponding error spectra showed that the error kinetic energy at smaller scales grows faster than that at larger scales and saturates more quickly in all ***-scale perturbations not only boost larger-scale error growth but are also conducive to error growth at all scales through a downscale cascade,which indicates that improving the accuracy of larger-scale flow forecast may discernibly contributes to the forecast of cloudburst intensity and position.

关键词： Stochastic kinetic-energy backscatter(SKEB) Extreme rainfall Ensemble forecast Predictability

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