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索拉菲尼治疗肝癌肝移植术后肿瘤复发患者的疗效及安全性分析

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南方医科大学学报 2011年第9期31卷 1608-1610页

作者：李湘竑钟克波刘延杨定华周杰南方医科大学南方医院肝胆外科广东广州501515

目的探讨索拉菲尼治疗原发性肝细胞癌肝移植术后肿瘤复发患者的临床疗效和安全性。方法 10例肝移植术后肿瘤复发患者,确诊复发后即口服索拉菲尼400 mg,每日两次治疗（A组）;8例未接受索拉菲尼治疗的肝癌肝移植术后肿瘤复发患者（B组）;... 详细信息

目的探讨索拉菲尼治疗原发性肝细胞癌肝移植术后肿瘤复发患者的临床疗效和安全性。方法 10例肝移植术后肿瘤复发患者,确诊复发后即口服索拉菲尼400 mg,每日两次治疗（A组）;8例未接受索拉菲尼治疗的肝癌肝移植术后肿瘤复发患者（B组）;同期接受相同剂量的索拉菲尼治疗的肝癌患者25例（C组）。比较3组患者的带瘤生存时间、索拉菲尼的毒副作用及其他不良反应发生情况。结果 3组患者的带瘤生存时间分别为5~22个月（中位数10个月）、1~8个月（中位数4个月）和2~21个月（中位数4个月）,三组之间整体间差异有统计学意义（K-M法,以log-rank检验,P=0.045）。两组肝移植患者没有发生急性排斥反应,但服用索拉菲尼组有1例患者因上消化道出血而死亡,服用索拉菲尼的两组患者不良反应发生率差异无统计学意义（P〉0.05）。结论索拉菲尼能明显延长肝癌肝移植术后肿瘤复发患者的生存期,并不增加排斥反应发生率。

关键词：索拉菲尼肝细胞癌肝移植肿瘤复发

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富集型燃烧器的原理与应用

动力工程 2008年第1期28卷 45-49页

作者：杨定华吕俊复张海岳光溪徐秀清神华集团北京国华电力有限责任公司北京100025 清华大学热能工程系北京100084

在煤粉稳燃燃烧器的研制过程中，提出了一种新的煤粉燃烧器的着火稳燃机理：通过组织煤粉气流的浓淡分离及浓（小）股煤粉气流的急拐弯，让气粉分离；煤粉射入高温回流区，在这里滞止增浓，升温着火，形成小火焰，并点燃一次风煤粉火焰... 详细信息

在煤粉稳燃燃烧器的研制过程中，提出了一种新的煤粉燃烧器的着火稳燃机理：通过组织煤粉气流的浓淡分离及浓（小）股煤粉气流的急拐弯，让气粉分离；煤粉射入高温回流区，在这里滞止增浓，升温着火，形成小火焰，并点燃一次风煤粉火焰，即小火点大火的机理．以此为指导，成功地开发了富集型燃烧器及多重富集型燃烧器，并在100～200MW机组上得到广泛应用．此外，还介绍了在合山电厂中的实际应用情况．

关键词：能源与动力工程煤粉燃烧器浓淡燃烧稳燃点火机理应用

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600MW超临界燃褐煤机组的锅炉选型研究

锅炉技术 2014年第4期45卷 40-44页

作者：杨根盛李忠杨定华张大龙神华集团公司北京100011 清华大学热能工程系北京100084

对燃用内蒙古高水分褐煤的600MW超临界煤粉锅炉和600MW超临界循环流床(CFB)锅炉方案进行了技术经济性比较。研究表明,超临界CFB锅炉在总体性能指标、耗水指标、占地指标等方面均优于充分优化后的超临界煤粉锅炉方案。在建设投资和运行... 详细信息

对燃用内蒙古高水分褐煤的600MW超临界煤粉锅炉和600MW超临界循环流床(CFB)锅炉方案进行了技术经济性比较。研究表明,超临界CFB锅炉在总体性能指标、耗水指标、占地指标等方面均优于充分优化后的超临界煤粉锅炉方案。在建设投资和运行成本方面,超临界CFB锅炉也优于超临界煤粉锅炉。

关键词：褐煤超临界机组锅炉选型技术经济比较

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地区集聚背景下外资溢出效应的实证分析

云南财经大学学报（社会科学版） 2009年第6期24卷 24-25页

作者：袁满杨定华云南财经大学经济研究院云南昆明650221

外商直接投资的区域集中现象十分普遍,从我国来看,东部主要发达城市集中了大部分外资;而这些外资又大多集中于某些特定的产业。外资的这种集聚现象必然有其内在的规律,也必然对外资的溢出效应产生影响。我们就从地区集聚的角度考察外商... 详细信息

外商直接投资的区域集中现象十分普遍,从我国来看,东部主要发达城市集中了大部分外资;而这些外资又大多集中于某些特定的产业。外资的这种集聚现象必然有其内在的规律,也必然对外资的溢出效应产生影响。我们就从地区集聚的角度考察外商直接投资的溢出效应。

关键词：外商直接投资集聚溢出效应

Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： yang Shi Mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou huang hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

从危机中看金融改革与经济增长:金融与经济发展问题研究

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云南财经大学学报（社会科学版） 2010年第2期25卷 68-69页

作者：冯丹杨定华云南财经大学经济研究院云南昆明650221

我们分析了历次危机的产生和传导机制,并指出中国经济形势下的金融改革新任务。在资本流出流入日趋自由的情况下,政府比较适合选择独立的货币政策,以服务于物价稳定和经济增长的目标,并以灵活的汇率政策帮助实现经常项目收支平衡。

关键词：危机货币传导机制金融改革经济增长

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li Zhen Ma Jin-hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

TAZ和KLF5在肝细胞癌组织中的表达及其临床意义

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中国免疫学杂志 2015年第3期31卷 380-383页

作者：陈俊任杨定华孙艳花韩庆张敏杰南方医科大学广州510515 南方医科大学南方医院肝胆外科广州510515 深圳市第二人民医院病理科深圳518035 深圳市第二人民医院肝胆外科深圳518035

目的:检测TAZ和KLF5在肝细胞癌(HCC)及对应癌旁组织中的表达情况,分析两者的临床意义。方法:收集76例HCC及对应癌旁组织,运用免疫组化技术检测TAZ及KLF5的表达情况,分析两者与HCC临床病理特征之间的相关性。结果:TAZ及KLF5蛋白在HCC组... 详细信息

目的:检测TAZ和KLF5在肝细胞癌(HCC)及对应癌旁组织中的表达情况,分析两者的临床意义。方法:收集76例HCC及对应癌旁组织,运用免疫组化技术检测TAZ及KLF5的表达情况,分析两者与HCC临床病理特征之间的相关性。结果:TAZ及KLF5蛋白在HCC组织中的表达显著高于对应癌旁组织(P=0.001;P=0.035);TAZ及KLF5蛋白表达与肿瘤病理分级(P=0.007;P=0.047)和TNM分期(P=0.009;P=0.040)显著相关;HCC组织中TAZ与KLF5蛋白表达显著正相关(r=0.651,P=0.003)。结论:HCC组织中TAZ及KLF5过表达与恶性临床病理参数相关,且TAZ与KLF5蛋白表达正相关,提示TAZ可能通过抑制KLF5蛋白降解促进HCC进展。

关键词： TAZ KLF5 肝细胞癌肿瘤进展

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGhua SONG hua LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)