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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-xia yang Li-Ting Zhang xiao-Jun Liu Xue-Bin Peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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Optimal Secondary Control of Islanded AC Microgrids with Communication Time-delay Based on Multi-agent Deep Reinforcement Learning

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1301-1311页

作者： yang xia Yan Xu Yu Wang Suman Mondal Souvik Dasgupta Amit.K.Gupta the School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore Rolls-Royce@NTU Corporate Lab Nanyang Technological UniversitySingaporeand now is with the School of Electrical EngineeringChongqing University Rolls-Royce Singapore Pte.Ltd.Singapore Rolls-Royce Solutions GmbH Germany

In this paper,an optimal secondary control strategy is proposed for islanded AC microgrids considering communi-cation *** proposed method is designed based on the data-driven principle,which consists of an offine training phase and online application *** offline training,each control agent is formulated by a deep neural network(DNN)and trained based on a multi-agent deep reinforcement learning(MA-DRL)framework.A deep deterministic policy gradient(DDPG)algorithm is improved and applied to search for an optimal policy of the secondary control,where a global cost function is developed to evaluate the overall control *** addition,the communication time-delay is introduced in the system to enrich training scenarios,which aims to solve the time-delay problem in the secondary *** the online stage,each controller is deployed in a distributed way which only requires local and neighboring information for each *** on this,the well-trained controllers can provide optimal solutions under load variations,and communication time-delays for online *** case studies are conducted to validate the feasibility and stability of the proposed secondary *** Terms-Communication time-delay,global cost function,islanded AC microgrid,multi-agent deep reinforcement learning(MA-DRL),secondary control.

关键词： Communication time-delay global cost function islanded AC microgrid multi-agent deep reinforcement learning(MA-DRL) secondary control.

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Discriminative Histogram Intersection Metric Learning and Its Applications

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Journal of Computer Science & Technology 2017年第3期32卷 507-519页

作者： Peng-Yi Hao yang xia xiao-Xin Li Sei-ichiro Kamata Sheng-Yong Chen College of Computer Science and Technology Zhejiang University of Technology Hangzhou 310023 China Graduate School of Information Production and Systems Waseda University Kitakyushu 808-0135 Japan

In this paper, a novel method called discriminative histogram intersection metric learning （DHIML） is proposed for pair matching and classification. Specifically, we introduce a discrimination term for learning a metric from binary infor-mation such as same/not-same or similar/dissimilar, and then combine it with the classification error for the discrimination in classifier construction. Compared with conventional approaches, the proposed method has several advantages. 1） The histogram intersection strategy is adopted into metric learning to deal with the widely used histogram features effectively. 2） By introducing discriminative term and classification error term into metric learning, a more discriminative distance metric and a classifier can be learned together. 3） The objective function is robust to outliers and noises for both features and labels in the training. The performance of the proposed method is tested on four applications： face verification, face-track identification, face-track clustering, and image classification. Evaluations on the challenging restricted protocol of Labeled Faces in the Wild （LFW） benchmark, a dataset with more than 7000 face-tracks, and Caltech-101 dataset validate the robustness and discriminability of the proposed metric learning, compared with the recent state-of-the-art approaches.

关键词： metric learning pair matching image classification face verification

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An improved deep dilated convolutional neural network for seismic facies interpretation

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Petroleum Science 2024年第3期21卷 1569-1583页

作者： Na-xia yang Guo-Fa Li Ting-Hui Li Dong-Feng Zhao Wei-Wei Gu State Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationChina University of Petroleum(Beijing)Beijing 102249China Dagang Branch Research InstituteBGPTianjin300280China

With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural *** intelligent and automated methods significantly reduce manual labor,particularly in the laborious task of manually labeling seismic ***,the extensive demand for training data imposes limitations on their wider *** overcome this challenge,we adopt the UNet architecture as the foundational network structure for seismic facies classification,which has demonstrated effective segmentation results even with small-sample training ***,we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader *** seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies *** analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results,as evidenced by various evaluation metrics for image ***,the classification accuracy reaches an impressive 96%.Furthermore,the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method,which accurately defines the range of different seismic *** approach holds significant potential for analyzing geological patterns and extracting valuable depositional information.

关键词： Seismic facies interpretation Dilated convolution Spatial pyramid pooling Internal feature maps Compound loss function

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Screening for a^(177)Lu-labeled CA19–9 monoclonal antibody via PET imaging for colorectal cancer therapy

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Chinese Chemical Letters 2022年第7期33卷 3502-3506页

作者： Jing Wang Liangang Zhuo Peng Zhao Wei Liao Hongyuan Wei Yuchuan yang Shuming Peng xia yang Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China NHC Key Laboratory of Nuclear Technology Mediccal Trasnformation(Mianyang Central Hospital) Mianyang 621900China Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province Mianyang 621999China Department of Nuclear Medicine The Affiliated Hospital Southwest of Medical UniversityLuzhou 646000China

Carbohydrate antigen 19–9(CA19–9)with multi epitopes relatively high expresses on colorectal cancer(CRC)cells,making it an attractive target for developing radioimmunotherapy(RIT)for *** lutetium-177(^(177)Lu)labeled monoclonal antibodies(mA bs)can selectively bind the corresponding antigens and release targeted cytotoxic radiation,which could induce cell apoptosis and reduce the drug-induced ***,a series of CA19–9 m Abs were labeled with zirconium-89(^(89)Zr),and one with high tumor uptake was screened via PET imaging,which has potential application for the diagnosis of *** the screened m Ab(C003)labeled with^(177)Lu was utilized for CA19–9 targeted RIT,which presents a significant suppression effect on the growth of colo205 xenografts than immunotherapy ***,the side effects of ^(177)Lu-DOTA-C003 are limited according to the results of in vivo ***89Zr-DFO-C003for CRC immune-PET imaging and ^(177)Lu-DOTA-C003 for RIT against CRC exhibit good potential in clinical applications.

关键词： Lutetium-177 CA19–9 Monoclonal antibody Colorectal cancer Radioimmunotherapy

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Quinclorac Resistance in Echinochloa crus-galli from China

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Rice science 2019年第5期26卷 300-308页

作者： PENG Qiong HAN Heping yang xia BAI Lianyang YU Qin Stephen BPOWLES Hunan Agricultural Biotechnology Research Institute Hunan Academy of Agricultural SciencesChangsha 410125China Collaborative Innovation Center for Field Weeds Control Hunan University of HumanitiesScience and TechnologyLoudi 417000China Australian Herbicide Resistance Initiative School of Agriculture and EnvironmentUniversity of Western AustraliaWA 6009Australia Jiangsu Academy of Agricultural Sciences Nanjing 210014China

Echinochloa crus-galli is a major weed in rice fields in China,and quinclorac has been long used for its ***-reliance of quinclorac has resulted in quinclorac resistance in *** resistant(R)***-galli populations from Hunan,China were confirmed to be at least 78-fold more resistant to quinclorac than the susceptible(S)*** difference in foliar uptake of 14C-labelled quinclorac was detected between the R and S ***,a higher level of 14C translocation and a lower level of quinclorac metabolism were found in the R *** and induced expression levels ofβ-cyanoalanine synthase(β-CAS)gene andβ-CAS activity were not significantly different between the R and S ***,the induction expression of 1-aminocyclopropane-1-carboxylic acid oxidase(ACO1)gene by quinclorac treatment was evident in the S plants but not in the R *** resistance in the two resistant ***-galli populations was not likely to be related to foliar uptake,translocation or metabolism of quinclorac,nor to cyanide detoxification viaβ-***,target-site based quinclorac signal reception and transduction and regulation of the ethylene synthesis pathway should be the focus for further research.

关键词： Echinochloa crus-galli quinclorac resistance quinclorac metabolism β-cyanoalanine synthase 1-aminocyclopropane-1-carboxylic acid synthase 1-aminocyclopropane-1-carboxylic acid oxidase rice

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Targeting of circulating hepatocellular carcinoma cells to prevent postoperative recurrence and metastasis

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World Journal of Gastroenterology 2014年第1期20卷 142-147页

作者： Yu Zhang Zhi-Long Shi xia yang Zheng-Feng Yin EMolecular Oncology Laboratory Eastern Hepatobiliary Surgery Hospital

Currently,the main treatment for hepatocellular carcinoma(HCC)involves the surgical removal of tumors or liver ***,these treatments are often not completely curative,as they are associated with a risk for postoperative recurrence and *** tumor cells(CTCs)are increasingly recognized as the main source for recurrence and metastasis after radical hepatectomies are *** studies have demonstrated the association between the presence of either pre-or postoperative CTCs and an increased risk for HCC *** improve the therapeutic outcome of HCC,a personalized,comprehensive and multidisciplinary approach should be considered,involving the application of appropriate diagnostic and therapeutic measures targeting HCC CTCs in different stages throughout the course of *** article proposes some HCC CTC-based strategies for the treatment of HCC,including the monitoring of HCC CTCs before,during and after radical hepatectomy,therapeutic targeting of HCC CTCs,prevention of the generation and colonization of CTCs,as well as the use of CTC indexes for the selection of indications,prediction of prognoses,and planning of individualized therapeutic *** and technological development of therapies targeting CTCs,as well as their translation into clinical practice,will help to effectively reduce postoperative recurrence and metastasis,and significantly prolong the survival of HCC patients.

关键词： Hepatocellular carcinoma Circulating tumor cells Recurrence and metastasis Surgical treatment Individualized treatment

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Observational evidence for the evolution of nuclear metallicity and star formation rate with the merger stage

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Research in Astronomy and Astrophysics 2016年第7期16卷 113-124页

作者： Rui Guo Cai-Na Hao xiao-yang xia Peng Wei Xin Guo National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China University of Chinese Academy of Sciences Beijing 100049China Tianjin Astrophysics Center Tianjin Normal UniversityTianjin 300387China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China

We investigate the evolution of nuclear gas-phase oxygen abundance and star formation rate（SFR） of local far-infrared selected star-forming galaxies along the merger sequence, as traced by their optical morphologies. The sample was drawn from a cross-correlation analysis of the IRAS Point Source Catalog Redshift Survey and 1 Jy ultraluminous infrared galaxy sample with the Sloan Digital Sky Survey Data Release 7 database. The investigation is done by comparing our sample to a control sample matched in the normalized redshift distribution in two diagnostics, which are the nuclear gas-phase metallicity *** mass and the nuclear SFR vs. stellar mass diagrams. Galaxies with different morphological types show different mass-metallicity relations（MZRs）. Compared to the MZR defined by the control sample,isolated spirals have comparable metallicities with the control sample at a given stellar mass. Spirals in pairs and interacting galaxies with projected separations of rp 〉 20 kpc show a mild metallicity dilution of0.02–0.03 dex. Interacting galaxies with rp 〈 20 kpc, pre-mergers and advanced mergers are underabundant by～0.06,～0.05 and～0.04 dex, respectively. This shows an evolutionary trend that the metallicity is increasingly depressed as the merging proceeds and it is diluted most dramatically when two galaxies are closely interacting. Afterwards, the interstellar medium（ISM） is enriched when the galaxies *** is the first time that such ISM enrichment at the final coalescence stage has been observed, which demonstrates the importance of supernova explosions in affecting the nuclear metallicity. Moreover, the central SFR enhancement relative to the control sample evolves simultaneously with the nuclear gas-phase oxygen abundance. Our results support the predictions from numerical simulations.

关键词： galaxies abundances galaxies evolution galaxies interactions galaxies starburst galaxies star formation infrared galaxies

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Dehydroxylation action on surface of TiO_2 films restrained by nitrogen carrier gas during atomic layer deposition process

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Rare Metals 2014年第5期33卷 583-586页

作者： Zhi-Peng Rao Bang-Wu Liu Chao-Bo Li yang xia Jun Wan Key Laboratory of Microelectronic Devices and Integration Technology Institute of Microelectronics Chinese Academy of Sciences Jiaxing Research and Commercialization Center for Microelectronics Equipment Zhejiang Institute of Advanced Technology Chinese Academy of Sciences Jiaxing Kemin Electronic Equipment & Technologies Co. LtdZhejiang Institute of Advanced Technology Chinese Academy of Sciences

A strong influence of nitrogen gas on the content of surface hydroxyl groups of TiO2 films by atomic layer deposition（ALD） was investigated by X-ray photoelectron spectroscopy（XPS）, contact angle measuring system, and UV–Vis spectrophotometer. XPS spectra of O 1s indicate that the content of surface hydroxyl groups is varied when using N2 as carrier gas. The results of water contact angles and optical reflection spectra show that the content variation of surface hydroxyl groups influences the wetting properties and optical reflectivity of TiO2 films. A surface reaction model is suggested to explain the ALD reaction process using N2 as carrier gas.

关键词： Atomic layer deposition TiO2 N2 Surface hydroxyl groups XPS Reaction model

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Boosting the Photocatalytic Activity of WO3 by Highly Dispersed CoWO4 or CuWO4

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China Petroleum Processing & Petrochemical Technology 2019年第4期21卷 9-20页

作者： He Fang Kang Mingliang Song Chundong yang xia Zhang Jing School of Chemistry and Materials Science Liaoning Shihua University

WO3 photocatalyst decorated with highly dispersed CoWO4 or CuWO4 nanoparticles(CoWO4/WO3 or CuWO4/WO3) was successfully synthesized using an in-situ impregnation method followed by solid-state reaction. The structure, morphology, photophysical property, and photocatalytic degradation mechanism of the CoWO4/WO3 or CuWO4/WO3 samples were investigated by XRD, SEM, TEM, EDS, HR-TEM, UV-vis DRS, SPV, and active trapping techniques. The XRD, SEM, and TEM results have revealed that CoWO4 or CuWO4 are highly dispersed on the WO3 surface, when the loading amount of CoWO4 or CuWO4 is small. However, obvious agglomeration is observed for the CoWO4 or CuWO4 particles, when the loading amount of CoWO4 or CuWO4 was increased. The visible-light photocatalytic degradation of RhB shows that all CoWO4/WO3 or CuWO4/WO3 samples exhibit superior photocatalytic performance as compared to pure WO3. This is mainly attributed to the formation of type II heterojunction between WO3 and CoWO4 or CuWO4, which can promote the photogenerated electrons and holes separation and transfer. Moreover, it is found that 0.2% CoWO4/WO3 or 0.2% CuWO4/WO3, in which MWO4 nanoparticles are uniformly dispersed on the surface of WO3, can achieve the most excellent photocatalytic activity among CoWO4/WO3 or CuWO4/WO3 samples, respectively. As compared with WO3, an enhancement about 9.1 times or 6.8 times in photocatalytic activity is observed on 0.2% CoWO4/WO3 or 0.2% CuWO4/WO3, respectively. Furthermore, the active species trapping experiment demonstrates that ·OH, h+, and ·O-2 generated during the photocatalytic process are all the reactive species in photocatalytic degradation of Rhodamine B(RhB) on CoWO4/WO3 or CuWO4/WO3. This study presents a strategy to design superior photocatalyst for organic compound degradation.

关键词： WO3 CoWO4 CuWO4 heterojunction photocatalytic degradation

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