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Effect of Acupuncture on Endometrial Blood Flow in Women Undergoing in vitro Fertilization Embryo Transfer: A Single Blind, Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第1期30卷 10-17页

作者： DONG Hao-xu Wu Xiao ZHOU Qin HUANG Dong-mei ZHANG Ming-min HUANG Guang-ying yang wei Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhan(430030)China Department of Obstetrics and Gynecoiogy Tongji HospitalHuazhong University of Science and TechnologyWuhan(430030)China Institute of Integrated Traditional Chinese and Western Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhan(430030)China Department of Reproductive Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhan(430030)China

Objective: To evaluate the effect of manual acupuncture on endometrial blood flow parameters by three-dimensional(3D) power Doppler ultrasound in women undergoing in vitro fertilization embryo transfer(IVF-ET). Methods: Seventy patients undergoing IVF-ET were equally randomized into traditional or sham acupuncture treatment group for totally 4 days(from the day of oocyte aspiration to the day of embryo transfer) of treatment by random envelope method at the Reproductive Medicine Center and Outpatient Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology from January 2013 to December 2015. Patients in the traditional acupuncture group accepted traditional acupuncture methods with manual acupuncture, and Zhongji(CV3), Qihai(CV 6), Sanyinjiao(SP6), Taichong(LR 3), Tianshu(ST 25), Guilai(ST 29) and Zusanli(ST 36) were chosen. Patients at the sham acupuncture group accepted shallow acupuncture methods at 4 non-meridian points at each shoulder and upper arm. Outcome measures included endometrial ultrasonic indices such as vascularization index(VI), flow index(FI) and vascularization flow index(VFI), endometrial thickness and volume, subendometrial VI(sVI), subendometrial FI(sFI), subendometrial VFI(sVFI), implantation rate, clinical pregnancy rate, abortion rate, live birth rate and number of live births. Results: Finally, 34 patients in the traditional acupuncture group and 35 in the sham acupuncture group completed this trial. VI, FI and VFI of the traditional acupuncture group were significantly higher than those in the sham acupuncture group(P0.05). Conclusions: Manual acupuncture performed after oocyte aspiration and before transplantation improved the endometrial blood flow parametersVI, RI and VFI in women

关键词： acupuncture endometrial blood flow endometrial receptivity in vitro fertilization randomized controlled trial

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Advances in ice avalanches on the Tibetan Plateau

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Journal of Mountain Science 2024年第6期21卷 1814-1829页

作者： TANG Minggao LI Guang ZHAO Huanle XU Qiang WU Guangjian yang wei GUO Daojing State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Environment and Civil Engineering Chengdu University of TechnologyChengdu 610059China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China

As some of the greatest natural disasters in the cryosphere,ice avalanches(IAs)seriously threaten lives and cause catastrophic damage to the resource environment,but a comprehensive overview of the state of knowledge on IAs remains lacking.We summarized 63 IAs on the Tibetan Plateau(TP)since the 20th century,of which,over 20 IAs occurred after the 21st century.The distributions of IAs are mainly concentrated in the southeastern and northwestern TP,and the occurrence time of IAs is mostly concentrated from July to September.We highlight recent advances in mechanical properties and genetic mechanisms of IAs and emphasize that temperature,rainfall,and seismicity are the inducing factors.The failure modes of IAs are summarized into 6 categories by examples:slip pulling type,slip toppling type,slip breaking type,water level collapse type,cave roof collapse type,and wedge failure type.Finally,we deliver recommendations concerning the risk assessment and prediction of IAs.The results provide important scientific value for addressing climate change and resisting glacier-related hazards.

关键词： Ice avalanche Global warming Genetic mechanism Risk assessment Tibetan Plateau

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Optimization of nursing interventions for postoperative mental status recovery in patients with cerebral hemorrhage

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World Journal of Psychiatry 2024年第3期14卷 434-444页

作者： Jin-Li Tang wei-wei yang Xiao-yang yang Neurosurgery Ward 2 Affiliated hospital of Nantong UniversityNantong 226100Jiangsu ProvinceChina Department of Anesthesiology and Surgery The Affiliated Hospital of Nantong UniversityNantong 226100Jiangsu ProvinceChina Department of Neurosurgery Suzhou Kowloon HospitalSchool of MedicineShanghai Jiao Tong UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Hypertensive cerebral hemorrhage(HCH),the most common chronic diseases,has become a topic of global public health discussions.AIM To investigate the role of rehabilitative nursing interventions in optimizing the postoperative mental status recovery phase and to provide clinical value for future rehabilitation of patients with HCH.METHODS This randomized controlled study included 120 patients with cerebral HCH who were contained to our neurosurgery department between May 2021–May 2023 as the participants.The participants have randomly sampled and grouped into the observation and control groups.The observation group received the rehabilitation nursing model,whereas the control group have given conventional nursing.The conscious state of the patients was assessed at 7,14,21,and 30 d postoperatively.After one month of care,sleep quality,anxiety,and depression were compared between the two groups.Patient and family satisfaction were assessed using a nursing care model.RESULTS The results showed that the state of consciousness scores of the patients in both groups significantly increased(P<0.05)after surgical treatment.From the 14th day onwards,differences in the state of consciousness scores between the two groups of patients began to appear(P<0.05).After one month of care,the sleep quality,anxiety state,and depression state of patients were significantly better in the observation group than in the control group(P<0.05).Satisfaction with nursing care was higher in the observation group than in the control group(P<0.05).CONCLUSION The rehabilitation nursing model has a more complete system compared to conventional nursing,which can effectively improve the postoperative quality of life of patients with cerebral hemorrhage and improve the efficiency of mental state recovery;however,further analysis and research are needed to provide more scientific evidence.

关键词： Cerebral hemorrhage Nursing interventions Mental status Optimization Rehabilitation nursing model Quality of life

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High-sensitivity formaldehyde gas sensor based on Ce-doped urchin-like SnO_(2) nanowires derived from calcination of Sn-MOFs

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Frontiers of Materials Science 2024年第1期18卷 29-43页

作者： wei Xiao wei yang Shantang Liu Hubei Key Lab of Novel Reactor&Green Chemical Technology School of Chemistry and Environmental EngineeringWuhan Institute of TechnologyWuhan 430073China Hubei Key Laboratory of Wudang Local Chinese Medicine Research Department of ChemistrySchool of Pharmaceutical SciencesHubei University of MedicineShiyan 442000China

Metal-organic frameworks(MOFs)have attracted widespread attention due to their regular structures,multiple material centers,and various ligands.They are always considered as one kind of ideal templates for developing highly sensitive and selective gas sensors.In this study,the advantages of MOFs with the high specific surface area(71.9891 m^(2)·g^(-1))and uniform morphology were fully utilized,and urchin-like SnO_(2) nanowires were obtained by the hydrothermal method followed by the calcination using Sn-MOFs consisting of the ligand of C_(9)H_(6)O_(6)(H_(3)BTC)and Sn/Ce center ions as sacrificial templates.This unique urchin-like nanowire structure facilitated gas diffusion and adsorption,resulting in superior gas sensitivity.A series of Ce-doped SnO_(2) nanowires with different doping ratios were synthesized,and their gas sensing properties towards formaldehyde were studied.The resulted Ce-SnO_(2) was revealed to have high sensitivity(201.2 at 250℃),rapid response(4 s),long-term stability,and good repeatability for formaldehyde sensing,and the gas sensing mechanism of Ce-SnO_(2) exposed to formaldehyde was also systematically discussed.

关键词： Ce-SnO_(2) SnO_(2) gas sensor formaldehyde Sn-MOF

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Evaluation of UAV spraying quality based on 1D-CNN model and wireless multi-sensors system

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Information Processing in Agriculture 2024年第1期11卷 65-79页

作者： Ziyuan Hao Minzan Li wei yang Xinze Li Key Laboratory of Smart Agriculture Systems Ministry of EducationChina Agricultural UniversityBeijing 100083PR China

The droplet deposition is a key index to evaluate the quality of unmanned aerial vehicle(UAV)spraying.The detection of the droplet deposition is time-consuming and costly,therefore,it is difficult to achieve large-scale and rapid acquisition in the field.To solve the above problems,a droplet deposition acquisition system(DDAS)was developed.It was composed of the multiple sensors,processing units,remote server database and Android-based software.A droplet deposition prediction model based on field experimental data was established by using a one-dimensional convolutional neural network(1D-CNN)algorithm,and the effects of different inputs on the prediction ability of the model were analyzed.The results showed that adding temperature and humidity data to the inputs can achieve higher prediction accuracy than only using UAV spraying operation parameters and wind speed data as the inputs to the model.In addition,the prediction accuracy of the 1D-CNN model was the highest when compared with other models such as back propagation neural network,multiple correlation vector machine,and multiple linear regression.The 1D-CNN model was embedded into the DDAS,and the evaluation experiments were carried out in the field.The correlation analysis was conducted between two datasets of the droplet deposition obtained by the DDAS and water sensitive paper(WSP),respectively.The R2 was 0.924,and the RMSE was 0.026μL/cm2.It is proved that the droplet deposition values obtained by the DDAS and WSP have high consistency,and the DDAS developed can provide an auxiliary solution for the intelligent evaluation of UAV spraying quality.

关键词： UAV Spraying quality Droplet deposition 1D-CNN model Sensor

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Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus

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Acta Pharmaceutica Sinica B 2024年第2期14卷 437-454页

作者： Jiamei Le Yilong Chen wei yang Ligong Chen Jianping Ye Shanghai Key Laboratory of Molecular Imaging Zhoupu HospitalShanghai University of Medicine and Health SciencesShanghai 201318China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450007China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Solute carriers(SLCs) constitute the largest superfamily of membrane transporter proteins.These transporters, present in various SLC families, play a vital role in energy metabolism by facilitating the transport of diverse substances, including glucose, fatty acids, amino acids, nucleotides, and ions.They actively participate in the regulation of glucose metabolism at various steps, such as glucose uptake(e.g., SLC2A4/GLUT4), glucose reabsorption(e.g., SLC5A2/SGLT2), thermogenesis(e.g., SLC25A7/UCP-1), and ATP production(e.g., SLC25A4/ANT1 and SLC25A5/ANT2). The activities of these transporters contribute to the pathogenesis of type 2 diabetes mellitus(T2DM). Notably, SLC5A2 has emerged as a valid drug target for T2DM due to its role in renal glucose reabsorption, leading to groundbreaking advancements in diabetes drug discovery. Alongside SLC5A2, multiple families of SLC transporters involved in the regulation of glucose homeostasis hold potential applications for T2DM therapy. SLCs also impact drug metabolism of diabetic medicines through gene polymorphisms, such as rosiglitazone(SLCO1B1/OATP1B1) and metformin(SLC22A1-3/OCT1-3 and SLC47A1, 2/MATE1, 2). By consolidating insights into the biological activities and clinical relevance of SLC transporters in T2DM, this review offers a comprehensive update on their roles in controlling glucose metabolism as potential drug targets.

关键词： Solute carriers(SLCs) Energ ymetabolism ATP production Type 2 diabetes mellitus(T2DM) Glucose homeostasis Polymorphisms

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On traceable iterated line graph and hamiltonian path index

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 239-252页

作者： NIU Zhao-hong XIONG Li-ming yang wei-hua School of Mathematical Sciences Shanxi UniversityTaiyuan 030006China School of Mathematics and Statistics Beijing Key Laboratory on MCAACIBeijing Institute of TechnologyBeijing 100081China Department of Mathematics Taiyuan University of TechnologyTaiyuan 030024China

Xiong and Liu[21]gave a characterization of the graphs G for which the n-iterated line graph L^(n)(G)is hamiltonian,for n≥2.In this paper,we study the existence of a hamiltonian path in L^(n)(G),and give a characterization of G for which L^(n)(G)has a hamiltonian path.As applications,we use this characterization to give several upper bounds on the hamiltonian path index of a graph.

关键词： iterated line graph traceable hamiltonian index hamiltonian path index

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Mitochondrial dysfunction in type 2 diabetes:A neglected path to skeletal muscle atrophy

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World Journal of Orthopedics 2024年第2期15卷 101-104页

作者： Jian-Jun Wu Hui-Min Xian Da-wei yang Fan yang Department of Cardiology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Orthopedic Surgery The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 30000China

Over the course of several decades,robust research has firmly established the significance of mitochondrial pathology as a central contributor to the onset of skeletal muscle atrophy in individuals with diabetes.However,the specific intricacies governing this process remain elusive.Extensive evidence highlights that individuals with diabetes regularly confront the severe consequences of skeletal muscle degradation.Deciphering the sophisticated mechanisms at the core of this pathology requires a thorough and meticulous exploration into the nuanced factors intricately associated with mitochondrial dysfunction.

关键词： Mfn-2 Oxidative stress Mitochondria metabolism Skeletal muscle atrophy Diabetes

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Formation and properties of a Zr-based amorphous coating by laser cladding

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Rare Metals 2024年第4期43卷 1809-1814页

作者： Ning Zhang Ying Liu wei yang Shu-Jie Pang Key Laboratory of Aerospace Materials and Performance (Ministry of Education) School of Materials Science and EngineeringBeihang University

(Zr0.53Al0.1Ni0.05Cu0.3Ti0.02)99Y1（at%） coating with amorphous layer of about 180 μm thick was prepared on a steel substrate by using laser cladding method.The coating is compact and shows good metallurgical bonding with substrate.The microstructure,microhardness and corrosion behavior along the depth from the coating surface to the substrate were investigated.It is found that a gradient structure consisted of amorphous surface layer,amorphous-crystalline transitional layer and substrate is formed after the laser cladding.The microhardness and corrosion behavior exhibit variation with the microstructural evolution at different depths from the coating surface.The microhardness and corrosion resistance in 3.5 wt%NaCl solution of the amorphous surface layer are comparable to those of the as-cast Zr-based BMG with the same composition,and higher than those of the steel substrate.

关键词： Laser cladding Amorphous coating Microstructure Hardness Corrosion resistance

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Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

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Current Medical Science 2024年第2期44卷 309-327页

作者： Xiao-jun WANG Jia-ping CHEN Xin-wei QIAO Wang-yang MENG yang-wei WANG Yun-chong MENG Rong ZHAO wei LIN Yong-de LIAO Han XIAO Pei-yuan MEI Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thoracic Surgery Shandong Provincial Hospital Afiliated to Shandong First Medical UniversityJinan 250021China

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival rate.Evidence suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and progression.However,a comprehensive analysis of their role in LUSC is lacking.Our study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of LUSC.Methods:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO databases.Concurrently,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in LUSC.The core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for LUSC.Clinical specimens were examined by immunohistochemical analysis to confirm the diagnostic value in LUSC.Furthermore,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was explored.Results:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for LUSC.GDF10 showed a significant positive correlation with immune cell infiltration and immune checkpoint expression.Conclusion:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

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