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Semi-template based,biomimetic-architectured,and mechanically robust ceramic nanofibrous aerogels for thermal insulation

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Nano Research 2022年第6期15卷 5581-5589页

作者： Lvye Dou yang si Jianyong Yu Bin Ding Innovation Center for Textile Science and Technology College of TextilesDonghua UniversityShanghai 200051China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Energy efficient buildings require novel thermal insulators accompanied by lightweight,mechanically robust,fire resistant,and low thermal *** fibrous aerogels have emerged as promising candidates,however it’s difficult for these materials to achieve exceptional mechanical and thermal insulation performance ***,we demonstrate a unique semi-template method to fabricate biomimetic-architectured silica/carbon dual-fibrous aerogel with robust mechanical ***,aerogels with honeycomb-like cellular and nanofiber/nanonet cell wall were constructed by freezedrying the homogeneous dispersion of siO_(2)nanofibers and cellulose nanofibers *** is worth noting that the biomimetic structure has been perfectly inherited even subjected to high-temperature *** a result,the excellent structural stability brought by the novel structure enables the aerogel to completely recover under large compression and buckling strain of 80%,and exhibit robust fatigue resistance over 200,000 *** importantly,the aerogels exhibit ultralow thermal conductivity(0.023 W·m^(−1)·K^(−1)),superior flame retardancy,together with excellent thermal insulation performance over a wide temperature ranging from−196 to 350°*** fabrication of such materials may provide new ideas for the development of next-generation thermal insulators for harsh conditions.

关键词： silica nanofiber carbon nanonet biomimetic-architectured aerogel mechanically robust thermal insulation

sirolimus treatment for neonate with blue rubber bleb nevus syndrome:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6929-6934页

作者： si-si yang Ming yang Xiao-Jie Yue Jin-Fa Tou Department of Neonatal Surgery The Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Burn and Plastic Surgery The Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Blue rubber bleb naevus syndrome(BRBNS)is a rare disease that usually presents with multiple venous malformations in the skin and gastrointestinal *** located in the gastrointestinal tract always result in chronic gastrointestinal bleeding and severe *** successful management of BRBNS with sirolimus had been reported in many institutions,due to its impact on signaling pathways of ***,the experience in treatment of neonates with BRBNS was *** SUMMARY A 38-day-old premature female infant born with multiple skin lesions,presented to our center complaining of severe anemia and *** examination demonstrated that hemoglobin was 5.3 g/dL and contrast-enhanced abdominal computed tomography showed multiple low-density space-occupying lesions in the right lobe of the *** was diagnosed as having BRBNS based on typical clinical and examination *** patient was treated by transfusions twice and hemostatic drugs but symptoms of anemia were difficult to alleviate.A review of BRBNS case reports found that patients had been successfully treated with *** the patient was treated with sirolimus at an average dose of 0.95 mg/m2/d with a target drug level of 10-15 ng/*** 28 mo of treatment,the lesion was reduced,hemoglobin returned to normal,and there were no adverse drug *** This case highlights the dosing regimen and plasma concentration in neonates,for the current common empiric dose is high.

关键词： Cutaneous hemangioma Vascular malformation sirolimus Rapamycin Blue rubber bleb nevus syndrome Case report

Trimmed and Winsorized Transformed Means Based on a Scaled Deviation

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Acta Mathematicae Applicatae sinica 2015年第2期31卷 475-492页

作者： si-yang WANG Heng-jian CUI School of Statistics and Mathematics Central University of Finance and Economics Department Statistics School of Mathematical Sciences Capital Normal University

This paper introduces the Tukey trimmed and Winsorized means for the transformed data based on a scaled deviation. The trimmed and Winsorized means and scale based on a scaled deviation are as special cases. Meanwhile, the trimmed and Winsorized skewness and kurtosis based on a scaled deviation are ***, some of their robust properties（influence function, breakdown points） and asymptotic properties（asymptotic representation and limiting distribution） are also obtained.

关键词： trimmed and Winsorized transformed means influence function skewness kurtosis

Preparation of hollow B–siO2@TiO2 composites and their photocatalytic performances for degradation of ammonia-nitrogen and green algae in aqueous solution

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2535-2543页

作者： Qin Zhou Hengbo Yin Aili Wang yang si Faculty of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China

Hollow B–siO2@TiO2 composites were prepared by the wet chemical deposition method starting from TiCl4 and hollow B–siO2 ***2 layers composed of anatase TiO2 nanoparticles were coated on the surfaces of the hollow B–siO2 microspheres probably through the formation of Ti—O—si and Ti—O—B bonds.A great number of—OH groups were also present at the TiO2 coating *** presence of Ti—O—si bonds and Ti—O—B bonds resulted in the formation of defects in the TiO2 coating layers,which decreased the band gap of the TiO2 coating layers to ca.3.0 eV and endowed the TiO2 coating layers with visible light absorption *** buoyancy hollow B–siO2@TiO2 composites exhibited high photocatalytic activities for the degradation of ammonia-nitrogen and green *** conversion of ammonia-nitrogen reached 65%when the degradation of ammonia-nitrogen(43 mg·L-1 at pH value of 8)was catalyzed by the B–siO2@TiO2(100:10)composite under the simulated solar light irradiation at 35°C for 660 *** green algae(5 mg·L-1)were almost completely degraded over the B–siO@TiO2(100:20)photocatalyst under the visible light irradiation at 35°C for 510 min.

关键词： B–siO2@TiO 2composites Photocatalysis Ammonia-nitrogen Green algae

Machine learning applications for electroencephalograph signals in epilepsy:a quick review

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Acta Epileptologica 2020年第1期2卷 32-38页

作者： yang si Department of neurology Sichuan Academy of Medical Science and Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731China

Machine learning(ML)is a fundamental concept in the field of state-of-the-art artificial intelligence(AI).Over the past two decades,it has evolved rapidly and been employed wildly in many *** medicine the widespread usage of ML has been observed in recent *** present review examines various ML approaches for electroencephalograph(EEG)signal procession in epilepsy research,highlighting applications in the aspect of automated seizure detection,prediction and *** present review also presents advantage,challenge and future direction of ML techniques in the analysis of EEG signals in epilepsy.

关键词： Machine learning Electroencephalograph Epilepsy Seizure

An immunological storm for cancer therapy: 2018 Nobel Prize in Physiology or Medicine

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Science Bulletin 2018年第24期63卷 1608-1610页

作者： si-yang Liu Yi-Long Wu Guangdong General Hospital School of MedicineSouth China University of Technology

Immunotherapy with checkpoint inhibitors (CPIs)is a new approach to cancer therapy that harnesses and enhances the innate abilities of the immune system to recognize and fight *** has become a breakthrough in the history of cancer treatment and is of epoch-making significance [1 ]. In the past century,Nobel Prize has been awarded to the advances in immunology for 15 *** year,it won for the 16th *** *** from the University of Texas MD Anderson Cancer Center and Japanese immunologist Tasuku Honjo were awarded the 2018 Nobel Prize in Physiology or Medicine,for their great contributions to the discovery of the CTLA-4 and PD-1 and the development of promising cancer therapy by inhibition of negative immune *** research shows how different strategies to inhibit the brakes on the immune system can be used in the treatment of cancer,which became a landmark in the history of cancer therapy.

关键词： Immunotherapy checkpoint inhibitors cancer

Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity

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Chinese Journal of Natural Medicines 2018年第5期16卷 347-353页

作者： ZHANG Wei WU Chun-Zhen FAN si-yang Department of Traditional Chinese Medicine Shanghai Institute of Pharmaceutical Industry Innovation Center of Traditional Chinese Medicine China State Institute of Pharmaceutical Industry sinopharm Health Industry Research Co. Ltd.

Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named(-) ethyl 1, 4-di-O-caffeoylquinate(1) and(-) methyl 1, 4-di-O-caffeoylquinate(2), together with 35 known compounds(3-37). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1(IC_(50) 11.94 μmol·L^(-1)) and 2(IC_(50) 15.04 μmol·L^(-1)) showed a good inhibitory activity. The current results supported the medical use of the plant.

关键词： Gnaphalium affine Compositae Caffeoylquinate Flavonoid Xanthine oxidase inhibition

Efficacy and cost-effectiveness of antiviral regimens for entecavir-resistant hepatitis B:A systematic review and network meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 507-514页

作者： si-si yang Cheng-Wei Cai Xue-Qing Ma Jia Xu Cheng-Bo Yu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Neurosurgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Kidney Disease Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Chronic hepatitis B(CHB)patients who had exposed to lamivudine(LAM)and telbivudine(LdT)had high risk of developing entecavir(ETV)-resistance after long-term *** aimed to conduct a systematic review and a network meta-analysis on the efficacy and cost-effectiveness on antiviral regimens in CHB patients with *** sources:We searched PubMed,EMBASE and Web of Science for studies on nucleos(t)ide analogues(NAs)treatment[including tenofovir disoproxil fumarate(TDF)-based rescue therapies,adefovir(ADV)-based rescue therapies and double-dose ETV therapy]in CHB patients with *** network meta-analysis was conducted for 1-year complete virological response(CVR)and biological response(BR)rates using GeMTC and ADDIS.A cost-effective analysis was conducted to select an economic and effective treatment regimen based on the 1-year CVR ***:A total of 6 studies were finally included in this *** antiviral efficacy was *** network meta-analysis,the 1-year CVR rate in ETV-TDF[odds ratio(OR)=22.30;95%confidence interval(CI):2.78-241.93],LAM-TDF(OR=70.67;95%CI:5.16-1307.45)and TDF(OR=16.90;95%CI:2.28-186.30)groups were significantly higher than that in the ETV double-dose group;the 1-year CVR rate in the LAM-TDF group(OR=14.82;95%CI:1.03-220.31)was significantly higher than that in the LAM/LdTADV *** 1-year BR rate of ETV-TDF(OR=28.68;95%CI:1.70-1505.08)and TDF(OR=21.79;95%CI:1.43-1070.09)therapies were significantly higher than that of ETV double-dose *** therapies had the highest possibility to achieve the CVR and BR at 1 year,in which LAM-TDF combined therapy was the most effective *** ratio of cost/effectiveness for 1-year treatment was 8526,17649,20651 Yuan in the TDF group,TDF-ETV group,and ETV-ADV group,***:TDF-based combined therapies such as ETV-TDF and LAM-TDF therapies were the first-line treatment if financial condition is allowed.

关键词： Chronic hepatitis B Drug resistance Entecavir Anitviral therapy

Soil erosion differences in paired grassland and forestland catchments on the Chinese Loess Plateau

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Journal of Mountain Science 2023年第5期20卷 1336-1348页

作者： yang si-qi LUO Da HAN Hao JIN Zhao Interdisciplinary Research Center of Earth Science Frontier State Key Laboratory of Earth Surface Processes and Resource EcologyBeijing Normal UniversityBeijing 100875China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China College of Geology Engineering and Geomatics Chang'an UniversityXi'an 710054China National Observation and Research Station of Earth Critical Zone on the Loess Plateau of Shaanxi Xi’an 710061China

In this study,two adjacent gauged catchments on the Chinese Loess Plateau were selected,in which one catchment was afforested and one was restored with natural vegetation in *** distributions of soil erosion rates were estimated between 2010 and 2020 with a high spatial resolution of 2 m in the paired catchments based on the Revised Universal Soil Loss Equation model(RUSLE)and Geographic Information Systems(GIS).The results showed that the simulated soil erosion rates in 2010-2020 averaged 12.58 and 8.56 t ha^(-1)a^(-1)for the grassland and forestland catchment,***,areas with high soil erosion rates(>80t ha^(-1)a^(-1))were mainly distributed in the topography with steep slope gradients(>45°).Comparisons between simulated soil erosion rates and observed annual sediment loads indicated that the simulation results of the grassland catchment were lower than the observed values,while it was reversed in the forestland *** conclude that the RUSLE model cannot simulate the gravity erosion induced by extreme rainfall *** the forestland catchment,insufficient streamflow and dense vegetation coverage are crucial factors resulting in hindering the movement of sediments.

关键词： Catchment comparison Soil erosion RUSLE model Vegetation effect Topography effect Spatial analysis