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TCMATHF:a bioinformatics platform to predict pharmacological action of drug and dynamic molecular changes against from myocardial infarction to heart failure

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中国药理学与毒理学杂志 2023年第S1期37卷 26-27页

作者： XI Yujie TANG Xuan GUO Feifei yang hongjun Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China China Academy of Chinese Medical Sciences Beijing 100700China

OBJECTIVE To investigate the characteristics and regulations of medication in different stages of disease by constructing a dynamic disease network and a cellular feature network spanning from myocardial infarction to heart *** Based on transcrip⁃tome and single-cell sequencing data from a mouse model of left anterior descending coro⁃nary artery ligation,a dynamic early-middle-late network and cellular feature network were con⁃structed by integrating differential gene expres⁃sion trends and biological *** robust⁃ness of the perturbation effect of traditional Chi⁃nese medicine(TCM)on the disease network was calculated based on multi-target TCM,and we acquired the foundational data by analyzing the results of *** predictive plat⁃form was scrutinized and assessed with regards to the functional attributes of FDA approveddrugs and compound prescriptions,in order to determine the primary stages of intervention and the drug patterns actions in the progression of heart *** In this study,we devel⁃oped a prediction and analysis platform for assessing the efficacy of drugs using a networkbased *** accuracy of the system was validated by FDA *** was found that blood-activating drugs,heat-clearing drugs,and phlegm-expelling drugs exhibited favorable intervention effects during the early to middle stages of the disease by investigating the effects of single herbs and TCM prescriptions on disease ***,phlegm-expelling drugs,spirit-nourishing drugs,and diuretic showed better intervention effects during the mid⁃dle to late *** findings were consis⁃tent with the clinical use of *** of the clustering heatmap results of TCM prescriptions revealed that the formulas aimed at qi stagnation and blood stasis had a strong effect in early stage,while the formulas for qi and yin deficiency and cardiorenal yang deficiency had a strong effect in the middle to late ***,analys

关键词： myocardial infarction heart failure dynamic network single cell drug perturbation

Protective effects of Yindanxinnaotong capsule in a rat model of myocardial ischemia/reperfusion injury

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Journal of Traditional Chinese Medicine 2014年第6期34卷 699-709页

作者： Wandan Wang Lan Wang hongjun yang Jianlu Wang Xiaojie Yin Haiyu Xu Long Cheng Rixin Liang Pharmacology and Pharmacokinetics Laboratory Institute of Chinese MaterialMedical China Academy of Chinese Medical Sciences Institute of Medical Plant Development Chinese Academy of Medical Sciences

OBJECTIVE: To investigate the effects of Yindanxinnaotong capsule(YDXNTC) and main components compatibility and ratios on myocardium against ischemia/reperfusion injury and the effect's underlying ***: Myocardial ischemia/reperfusion injury(MIRI) was induced by ischemia for 30 min and reperfusion for 30 min. Electrocardiogram data and coronary flow were recorded, and superoxide dismutase(SOD), malondialdehyde(MDA), lactate dehydrogenase, creatine kinase-MB, cardiac troponin T and I(cT nT, cT n I) and interleukin-1β, interleukin-8,interleukin-18(IL-1β, IL-8, IL-18) in myocardium were measured. Hypoxia/reoxygenation and hydrogen peroxide(H2O2) injury were induced by hypoxia for 3 h/reoxygenation for 2 h, and 100 μM H2O2 for 1 h, respectively, in vitro rat myocardial cells(H9c2). Cell viability, SOD, MDA, cT nT and inflamma-tory factors(IL-1β, IL-8 and IL-18) were determined,and Toll-like receptor 4(TLR-4) expression was measured by western ***: In the isolated heart experiment, elevated heart function, coronary flow and SOD levels,and decreased MDA levels and inflammatory factors were noted in the YDXNTC, main components and main components compatibility groups. Ventricular tachycardia/ventricular fibrillation occurrence decreased in the ginkgo biloba extract(GBE),and GBE and salvia miltiorrhiza ethanol extract compatibility(SM-E, GSEC) groups. Lactic dehydrogenase levels decreased in the YDXNTC and aqueous extract of salvia miltiorrhiza(SM-H) groups. Creatine kinase-MB decreased with GBE, SM-E, SM-H and GSEC treatment, and cT n I and cT nT levels decreased with GSEC. In the in vitro cell study,YDXNTC and main components ratios improved cell viability and SOD levels, and suppressed MDA,cT nT and inflammatory factors. TLR-4 expression was ***: YDXNTC and main components compatibility showed protective effects on MIRI in this rat model and in vitro study. Regulating the Toll-like receptor signaling pathway may affect the

关键词： Myocardial ischemia Reperfusion Components compatibility Yindanxinnaotong cap-sule

Humus-Rich Compost Increases Lettuce Growth, Nutrient Uptake, Mycorrhizal Colonisation, and Soil Fertility

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Pedosphere 2019年第2期29卷 170-179页

作者： Zakaria M.SOLAIMAN hongjun yang Deb ARCHDEACON Orna TIPPETT Michaela TIBI Andrew S.WHITELEY SoilsWest UWA School of Agriculture and Environment and the UWA Institute of Agriculture Faculty of Science The University of Western Australia College of Resources and Environment Southwest University C-Wise

Sandy soils, typical of Australia's west, either have little or no habitat protection for microbes including arbuscular mycorrhizal(AM) fungi, which are essential for nutrient cycling. To minimize this problem, the application of organic matter, such as humus-rich composts, is necessary during vegetable crop production. This study aimed at determining the effects of humus-rich composts on either indigenous or inoculated AM fungal colonisation in roots, lettuce(Lactuca sativa L. var. Quechua) growth, and soil fertility improvement. Four different humus-rich composts with varying humus contents were applied at the same standard rate to lettuce grown under glasshouse conditions for 10 weeks after sowing and compared with two low-humus composts and non-amended soil(control). Humus-rich composts significantly increased lettuce shoot growth, root growth, and AM fungal colonisation in roots. Humus contents in the composts were also correlated with lettuce shoot and root growth. Soil dissolved organic carbon, microbial biomass carbon, and fertility were increased with the application of humus-rich composts. These humus-rich composts, especially the compost of higher humic acid with and without AM inoculation, might have a significant role in sustainable vegetable production, for example lettuce growth. Overall, the results indicate that supplementation with humus-rich compost is highly beneficial to enhance soil fertility and potentially maintain the sustainability of vegetable production.

关键词： arbuscular mycorrhizal fungi humus nitrogen phosphorus vegetable production

Microbial residues as the nexus transforming inorganic carbon to organic carbon in coastal saline soils

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Soil Ecology Letters 2022年第4期4卷 328-336页

作者： Pengshuai Shao Tian Li Kaikai Dong hongjun yang Jingkuan Sun Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Binzhou UniversityBinzhou 256603China

Soil inorganic carbon(SIC),including mainly carbonate,is a key component of terrestrial soil C *** microorganisms can assimilate carbonate as the main or unique C source,how microorganisms convert SIC to soil organic carbon(SOC)remains unclear.A systematic field survey(n=94)was performed to evaluate the shift in soil C components(i.e.,SIC,SOC,and microbial residues)along a natural salinity gradient(ranging from 0.5‰to 19‰),and further to explore how microbial necromass as an indicator converting SIC into SOC in the Yellow River *** observed that SIC levels linearly decreased with increasing salinity,ranging from~12 g kg^(-1)(salinity6‰).Additionally,the concentrations of SOC and microbial residues exponentially decreased from salinity6‰,with the decline of 39%and 70%,*** residues and SOC was tightly related to the variations in *** structural equation model showed the causality on explanation of SOC variations with SIC through microbial residues,which can contribute 89% of the variance in SOC storage combined with *** together,these two statistical analyses can support that microbial residues can serve as an indicator of SIC transition to *** study highlights the regulation of microbial residues in SIC cycling,enhancing the role of SIC playing in C biogeochemical cycles and enriching organic C reservoirs in coastal saline soils.

关键词： Soil inorganic carbon Microbial necromass Soil organic carbon Costal saline lands Carbon sequestration

An Optimized-based Ion Etch Yield Modeling Method in Plasma Etching

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An Optimized-based Ion Etch Yield Modeling Method in Plasma ...

玄武岩纤维纳米改性对增强环氧复合材料绝缘与力学性能的影响

第25届中国控制与决策会议

作者： hongjun yang Yixu Song Shulin Zheng Lihua Wang Peifa Jia State Key Laboratory on Intelligent Technology and Systems Tsinghua National Laboratory for Information Science and Technology Chinese Department of Computer Science and Technology Tsinghua University Shenyang Artillery Academy

ISBN: (纸本)9781467355339

In order to study the physics mechanism of surface etching process in low pressure plasmas, we propose a method to optimize etching yield model, which combines optimization technology with surface evolution algorithm. In plasma etching process, the surface effect of the ions are controlled by etch yield which may be measured by the elaborate experiment. But measuring tool or instrument affect measuring result, which will lead to etch yield model’s inaccuracy. In order to avoid the problems caused by measuring method, we adopt optimization technology to calculate the etch yield model. By defining an error function between the actual etching profile and simulation profile, etch yield modeling problem is transformed into an optimization problem;Then we use the genetic algorithm and surface evolution algorithm to solve this problem. The experimental results illustrate that simulation profile using the etch yield model by this method is very similar with the actual etching profile in surface topography. It also proves that our proposed method is effective and can be used to model etch yield.

关键词： Etch yield Genetic algorithm Surface evolution algorithm Plasma etching

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绝缘材料 2024年第6期57卷 29-36页

作者：刘贺晨于云飞张铭嘉于红李乐刘云鹏杨红军田正波华北电力大学河北省绿色高效电工新材料与设备重点实验室河北保定071003 华北电力大学新能源电力系统国家重点实验室北京102206 襄阳国网合成绝缘子有限责任公司湖北襄阳410000

使用纳米氧化铝对玄武岩纤维进行表面改性,采用层压法制造改性玄武岩纤维/环氧树脂复合材料(BFRP),并研究纳米Al_(2)O_(3)含量对改性复合材料绝缘与力学性能的影响。结果表明:质量分数为1.0%的纳米Al_(2)O_(3)改性的玄武岩纤维复合材料(... 详细信息

使用纳米氧化铝对玄武岩纤维进行表面改性,采用层压法制造改性玄武岩纤维/环氧树脂复合材料(BFRP),并研究纳米Al_(2)O_(3)含量对改性复合材料绝缘与力学性能的影响。结果表明:质量分数为1.0%的纳米Al_(2)O_(3)改性的玄武岩纤维复合材料(1.0K-BFRP)界面改性效果最佳。与未改性的复合材料相比,1.0K-BFRP的介质损耗因数降低了38.13%,沿面闪络电压提高了42.96%,击穿电压提高了33.96%,表现出更加优越的绝缘性能;拉伸强度、弯曲强度、层间剪切强度分别提高了26.46%、48.19%、66.06%,玻璃化转变温度提高了4.49℃。

关键词：纳米氧化铝玄武岩纤维界面改性复合材料

Traditional Costumes of Yi Ethnic Group

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China & The World Cultural Exchange 2010年第7期76卷 41-43页

作者： yang hongjun

Traditional costumes of Yi people,as symbolic carriers of their ethnic culture,record the history,traditions,customs and social life of the ethnic group.

关键词：传统服饰彝族民族文化社会生活老虎象征性服装肚兜

镰刀状小针刀微创治疗对手指屈肌腱狭窄性腱鞘炎的效果

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实用临床医药杂志 2024年第11期28卷 79-83页

作者：范文潮陈章妹徐剑杨洪军王森刘园江苏省常州市中医医院手外科江苏常州213000 江苏省常州市中医医院针灸科江苏常州213000 南京中医药大学江苏南京210023

目的探讨自制式镰刀状小针刀微创治疗对手指屈肌腱狭窄性腱鞘炎患者疼痛程度及总治愈率的影响。方法选取手指屈肌腱狭窄性腱鞘炎患者100例,按随机数字表法分为对照组和观察组,每组50例。对照组采用开放手术治疗,观察组采用自制式镰刀状... 详细信息

目的探讨自制式镰刀状小针刀微创治疗对手指屈肌腱狭窄性腱鞘炎患者疼痛程度及总治愈率的影响。方法选取手指屈肌腱狭窄性腱鞘炎患者100例,按随机数字表法分为对照组和观察组,每组50例。对照组采用开放手术治疗,观察组采用自制式镰刀状小针刀微创治疗。比较2组手术指标、疼痛程度、炎性因子、并发症发生率以及总治愈率。结果观察组各项手术指标改善均优于对照组;2组手术后视觉模拟评分法(VAS)评分均低于手术前,手术后即刻、手术后7 d、手术后6个月观察组VAS评分均低于对照组;手术后2组血清白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)均降低,且观察组低于对照组;观察组并发症发生率低于对照组,总治愈率高于对照组,以上差异均有统计学意义(P<0.05)。结论手指屈肌腱狭窄性腱鞘炎患者应用自制式镰刀状小针刀微创治疗的总治愈率较高,可减轻患者疼痛程度和机体炎症反应,降低并发症发生率,加快术后恢复。

关键词：手指屈肌腱狭窄性腱鞘炎镰刀状小针刀疼痛程度总治愈率炎症反应

Torch Festival of Yi People

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China & The World Cultural Exchange 2010年第4期76卷 38-39页

作者： yang hongjun

The Torch Festival is one of the most important traditional festivals for Yi people. Known as the Oriental Carnival, the Torch Festival carries forward Yi people’s primitive worship of fire and their time-honored fir... 详细信息

关键词：中外文化交流文化产业火把节彝族