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Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases

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World Journal of Gastroenterology 2016年第35期22卷 7938-7950页

作者： Ferenc Sipos Gábor Firneisz györgyi Mũzes 2nd Department of Internal Medicine Semmelweis UniversityH-1088 Budapest Hungary

Colonic inflammation is required to heal infections, wounds, and maintain tissue homeostasis. As the seventh hallmark of cancer, however, it may affect all phases of tumor development, including tumor initiation, promotion, invasion and metastatic dissemination, and also evasion immune surveillance. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability, and, further, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Both sporadical and colitis-associated colorectal carcinogenesis are multi-step, complex processes arising from the uncontrolled proliferation and spreading of malignantly transformed cell clones with the obvious ability to evade the host's protective immunity. In cells upon DNA damage several protooncogenes, including c-MYC are activated in parelell with the inactivation of tumor suppressor genes. The target genes of the c-MYC protein participate in different cellular functions, including cell cycle, survival, protein synthesis, cell adhesion, and microRNA expression. The transcriptional program regulated by c-MYC is context dependent, therefore the final cellular response to elevated c-MYC levels may range from increased proliferation to augmented apoptosis. Considering physiological intestinal homeostasis, c-MYC displays a fundamental role in the regulation of cell proliferation and crypt cell number. However, c-MYC gene is frequently deregulated in inflammation, and overexpressed in both sporadic and colitis-associated colon adenocarcinomas. Recent results demonstrated that endogenous c-MYC is essential for efficient induction of p53-dependent apoptosis following DNA damage, but c-MYC function is also involved in and regulated by autophagy-related mechanisms, while its expression is affected by DNA-methylation, or histone acetylation. Molecules directly targeting c-MYC, or agents acting on other genes involved in the c-MYC pathway could be sele

关键词： c-MYC Therapy Apoptosis Autophagy Colon Inflammation Colorectal cancer

Molecular organic geochemical evidence for paleoenvironmental changes at 11.87—12.28 m in GS-1 sedimentary core,Gucheng Lake,East China

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Chinese Science Bulletin 1999年第15期44卷 1407-1411页

作者： Zhang, G Sheng, gy Fu, JM Wang, SM Chinese Acad Sci Guangzhou Inst Geochem State Key Lab Organ Geochem Canton 510640 Peoples R China Chinese Acad Sci Nanjing Inst Geog & Liminol Nanjing 210008 Peoples R China

Organic lipids with different occurrence modes in a sedimentary core in a subtropicalfreshwater lake, Gucheng Lake, were sequentially extracted, separated and analyzed. Thedown-core variations of OEP index of alkanes, C18:2/C18:0 ratios of fatty acids, ratios of boundfatty acids to free fatty acids, thermo-maturity indices of hopanoid hydrocarbons and relativeconcentrations of sedimentary minerals revealed an evident increasing in allochthonous inputfrom rock detritus below 12.28 m in the sedimentary profile. The distribution pattern of tightly-bound β-hydroxy fatty acids indicated a difference in bacterial communities above and below theboundary, as well as the gammacerane index may assign a significant change in lake watersalinity. The evidence, in general, suggested that a significant paleoenvironmental change hadtaken place in ca. 9.6 kaBP on the regional basis.

关键词： Gucheng Lake paleoenvironmental change molecular organic geochemical evidence.

Measurement of liver volume and its clinical significance in cirrhotic portal hypertensive patients

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World Journal of Gastroenterology 1999年第6期5卷 525-526页

作者： Zhu JY Leng XS Dong N Qi gy Du RY Beijing Med Univ Peoples Hosp Dept Surg Beijing 100044 Peoples R China

INTRODUCTIONAccurate assessment of hepatic reserve function in cirrhotic portal hypertensive patients is important for selection of surgical procedure and evaluation of prognosis. The measurement of liver volume has been applied in clinic as widely as Child's class[1,2]. Limited by technical condition, measurement of liver volume in vivo has seldom been reported in China. Using double helix-spiral CT (Elscint CT Twin), the liver volume of 25 cirrhotic patients and 30 patients in controls was assessed, and a correlation analysis was made between the liver volume and preoperative natural shunting rate, portal vein flow, portal pressure and prognosis of cirrhotic patients.

关键词： liver volume hypertension, portal liver cirrhosis prognosis

Islet separation and islet cell culture in vitro from human embryo-pancreas

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World Journal of Gastroenterology 1999年第5期5卷 458-460页

作者： Yuan Z Wu gy He YS Shao CM Zhan Y Kunming Med Coll Dept Histol & Embryol Kunming 650031 Yunnan Province Peoples R China First Affiliated Hosp Kunming Med Coll Dept Nucl Med Kunming 650032 Yunnan Province Peoples R China Kunming Med Coll Dept Biol Kunming 650031 Yunnan Province Peoples R China

INTRODUCTIONDiabetes mellitus is the most common disease and its death rate ranks the 8th in the world. Up to now, its incidence has a tendency to increase[1]. Since disorder of sugar metabolism might result in microvascular degeneration and injury of important human organs, it will endanger human health seriously. In 1969, Younszai first reported the method that could decrease diabetes symptoms by islet tissue transplantation. In 1981, our country began to treat diabetes type Ⅰ by transplanting cultured islet tissues. In our study, we digested the pieces of pancreas with collagenase and made morphological observation on islet cells cultured for 3d, 5d, 7d, 9d and 13d respectively, and the contents of insulin and C-peptide in the supernatant were detected by radioimmunoassay. The experimental model of rabbit diabetes was established, and certain curative effect was achieved in the treatment of experimental diabetes in rats.

关键词： cell culture islet cell islets of langerhans transplantetion pancreas/ embryology

A physical model for the global mean surface air temperature anomalies over the past century

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Chinese Science Bulletin 1997年第8期42卷 658-662页

作者： Shi, gy Guo, JD Fan, XB Wang, LX Natiorlal Climate Center Beijing China

OBSERVATIONS show that the global mean surface air temperature has risen by about 0.62℃over the past *** rise is widely thought to be the result of increasing atmosphericconcentrations of greenhouse gases such as car... 详细信息

关键词： global-mean temperature greenhouse gases sources of natural climate variability.

A Positron Study of Hysteresis Temperature in Ti-Ni Alloy

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Journal of Materials Science & Technology 1996年第6期12卷 470-472页

作者： Wang, JC Qin, gy Zhang, GL Zheng, WH Chen, LY Gu, M ACAD SINICA SHANGHAI INST NUCL RESSHANGHAI 201800PEOPLES R CHINA TONGJI UNIV DEPT PHYSSHANGHAI 200092PEOPLES R CHINA

For Ti-Ni alloy, it is exceedingly difficult; to prepare an element that has a desired and defined hysteresis temperature for its preparing process is not perfect at present. Because the mechanism of transformation in Ti-Ni has not been fully clarified, it is far more exceedingly difficult to explain the hysteresis temperature only by using the traditional metal physics techniques. But position annihilation seems to be a suitable method for it. The positron annihilation measurements show that the hysteresis temperature may be controlled mainly by the relative fraction of the defects contained in a two-way shape memory element.

关键词： Titanium alloys

Portal Hypertension in Nonalcoholic Fatty Liver Disease: Challenges and Paradigms

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1201-1211页

作者： Emilie K.Mitten Piero Portincasa györgy Baffy Division of Gastroenterology Department of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Division of Internal Medicine and Department of Precision and Regenerative Medicine and Ionian Area University‘Aldo Moro’Medical SchoolBariItaly Division of Gastroenterology Hepatology and EndoscopyDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Section of Gastroenterology Department of MedicineVA Boston Healthcare SystemBostonMAUSA

Portal hypertension in cirrhosis is defined as an increase in the portal pressure gradient(PPG)between the portal and hepatic veins and is traditionally estimated by the hepatic venous pressure gradient(HVPG),which is the difference in pressure between the free-floating and wedged positions of a balloon catheter in the hepatic *** convention,􀀫HVPG≥10mmHg indicates clinically significant portal hypertension,which is associated with adverse clinical *** fatty liver disease(NAFLD)is a common disorder with a heterogeneous clinical course,which includes the development of portal *** is increasing evidence that portal hypertension in NAFLD deserves special ***,elevated PPG often precedes fibrosis in NAFLD,suggesting a bidirectional relationship between these pathological ***,HVPG underestimates PPG in NAFLD,suggesting that portal hypertension is more prevalent in this condition than currently ***,cellular mechanoresponses generated early in the pathogenesis of NAFLD provide a mechanistic explanation for the pressurefibrosis ***,a better understanding of liver mechanobiology in NAFLD may aid in the development of novel pharmaceutical targets for prevention and management of this disease.

关键词： Sinusoidal microcirculation Hepatic vascular resistance Portal venous pressure Hepatic venous pressure gradient Mechanobiology Mechanotransduction

PREPARATION　OF　OLIGOSACCHARIDES　FROM　THE　ENZYMATIC　HYDROLYSATES　OF　KONJAC　GLUCOMANNAN　BY　LOW－PRESSURE　COLUMN　CHROMATOGRAPHY

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Chinese Chemical Letters 1996年第2期7卷 131-132页

作者： Xu, gy Chang, LW Xu, YM Ma, YH Zhou, PJ ACAD SINICA INST CHEMBEIJING 100080PEOPLES R CHINA ACAD SINICA INST MICROBIOLBEIJING 100080PEOPLES R CHINA

Low pressure column chromatography with activated charcoal powder was used to separate the oligosaccharides and their isomers from the hydrolysates of konjac glucomannan.

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黄芪甲苷通过调节水液代谢改善辐射诱导心肌细胞水肿的研究

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中国临床药理学杂志 2024年第13期40卷 1874-1877页

作者：张尚祖张利英李启杨陈琰李洋洋刘永琦甘肃中医药大学甘肃省高校重大疾病分子医学与中医药防治研究重点实验室敦煌医学与转化教育部重点实验室甘肃兰州730000 甘肃省心血管病研究所甘肃兰州730050

目的研究黄芪甲苷(AS-Ⅳ)改善辐射诱导的心肌细胞水肿的有效性及其分子机制。方法将AC16细胞分为空白组、模型组、AS-Ⅳ辐射前给药组(Q组)、辐射后给药组(H组)和前+后给药组(Q+H组)。Q组和Q+H组用40 mol·L^(-1)的AS-Ⅳ含药培养基,其他... 详细信息

目的研究黄芪甲苷(AS-Ⅳ)改善辐射诱导的心肌细胞水肿的有效性及其分子机制。方法将AC16细胞分为空白组、模型组、AS-Ⅳ辐射前给药组(Q组)、辐射后给药组(H组)和前+后给药组(Q+H组)。Q组和Q+H组用40 mol·L^(-1)的AS-Ⅳ含药培养基,其他各组用正常培养基,培养24 h后,除空白组外,其余各组给予6 gy X射线辐射建立心肌细胞水肿模型,并将Q组更换为正常培养基,H组更换为40 mol·L^(-1)的AS-Ⅳ含药培养基,培养24 h。用钙黄绿素AM染色法观察细胞的水肿情况,用蛋白质印迹法检测水液代谢关键蛋白的表达情况,用Annexin-V/PI流式凋亡检测法检测细胞的凋亡情况。结果空白组、模型组、Q组、H组和Q+H组的细胞水肿面积分别为690.77±199.55、1184.47±307.36、713.65±152.48、809.72±262.85和897.61±213.66,缺氧诱导因子(HIF)-1α蛋白相对表达水平分别为0.94±0.02、1.35±0.03、0.91±0.03、0.69±0.02和0.86±0.03,水通道蛋白4(AQP4)蛋白相对表达水平分别为0.66±0.03、1.07±0.04、0.67±0.02、0.56±0.03和0.56±0.02,凋亡率分别为(3.90±0.76)%、(16.58±0.63)%、(12.91±0.51)%、(14.05±0.22)%和(12.13±0.38)%。空白组、Q组、H组和Q+H组的上述指标与模型组比较,在统计学上差异均有统计学意义(均P<0.05)。结论AS-Ⅳ可以通过抑制辐射后AC16细胞HIF-1α/AQP4轴的异常激活,调节水液代谢,改善辐射诱导的心肌细胞水肿,减少细胞凋亡。

关键词：黄芪甲苷辐射心肌水肿缺氧诱导因子-1α 水通道蛋白4