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What happens in the smooth muscle cell for lower vasoreactivity in severe shock

中国病理生理杂志 2001年第8期 66-67页

作者： Zhao KS Liu J yang gy Department of Pathophysiology First Military Medical University Guangzhou 510515 China

It is very difficult for doctor to treat patient with persistent hypotension in the late stage of shock. The aim of present study was to elucidate the reason for lower vasoreactivity in severe shock. Irreversible hemorrhagic shock of rat was reproduced and the vasoreactivity of arteriole in spinotrapezius muscle to norepinephrine (NE) was measured. The resting membrane potential of isolated arterial strips was detected with a microelectrode. The effect of NO on the membrane potential and intracellular ［Ca2＋］i level in isolated arteriolar smooth muscle cells (ASMCs) was determined with fluorescent probes under confocal microscope. KATP channel of ASMCs was measured with patch clamp method. It was shown that membrane hyperpolarization appeared in arteroles 2 h post hemorrhage, while the resting potential was increased from (-36.9±6.3) mV of control value to (-51.0±9.1) mV with the NE threshold increased to 15 times more than preshock value. The hyperpolarization of ASMCs was closely related to vascular hyporeactivity (correlation coefficient 0.96, P＜0.01). The hyperpolarization was enhanced by lack of ATP, increase in H＋，and OONO- in ASMCs. Single KATP channel conducatance, mean open time and open probability was increased in ASMCs, and the increased ［Ca2＋］i level of ASMCs stimulated by NE was reduced to 50% of normal value. The vasoreactivity, blood pressure and survival rate could be improved by the treatment of glybenclamide and NaHCO3. The study indicates that hyperpolarization of ASMCs is a major reason for lower vasoreactivity in severe shock, since it inhibits the voltage dependent Ca2＋ channel (POC) with the reduction of NE stimulated ［Ca2＋］i increase. The decrease in ATP and increase in H+, and OONO- in ASMCs involves in the activation of KATP channel, leading to the ASMCs hyperpolarization.

关键词： cell

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THE SYNTHESIS AND CHARACTERIZATION OF A NOVELMIXED-VALENCE ISOPOLYVANADATE

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Chinese Chemical Letters 1996年第6期7卷 565-566页

作者： Xu, JN yang, gy Ma, WY Sun, ZZ Xu, JQ Huang, XY JILIN UNIV DEPT CHEMCHANGCHUN 130023PEOPLES R CHINA STATE KEY LAB STRUCT CHEM FUZHOU 350002PEOPLES R CHINA

The present paper covers the synthesis and characterization of a mixed valence vanadate, (H(2)En) V4O10(Compound I, H(2)En = H3NCH2CH2NH3), in which the V-N/V-V ratio is unity. The X-Ray diffraction pattern and DTA-TG... 详细信息

关键词： CLUSTERS

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Ghrelin与能量代谢和肥胖的关系

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世界华人消化杂志 2005年第17期13卷 2125-2127页

作者：张兴渝杨刚毅重庆医科大学附属第二医院内分泌科重庆市400010

Ghrelin是含28个氨基酸残基的具有多种生理功能的脑肠肽,其中一个重要功能就是参与代谢的调节.Ghrelin具有启动摄食、增进食欲、增加营养物质尤其是脂类的吸收、促进脂肪形成等多方面的作用,分泌过多可导致代谢紊乱和肥胖.因此,Ghrelin... 详细信息

Ghrelin是含28个氨基酸残基的具有多种生理功能的脑肠肽,其中一个重要功能就是参与代谢的调节.Ghrelin具有启动摄食、增进食欲、增加营养物质尤其是脂类的吸收、促进脂肪形成等多方面的作用,分泌过多可导致代谢紊乱和肥胖.因此,Ghrelin系统被认为是能量代谢紊乱和肥胖形成的分子生物学靶点之一.

关键词： Ghrelin 能量代谢肥胖

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Isomeric fluorescence sensors for wide range detection of ionizing radiations

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Defence Technology（防务技术） 2024年第4期34卷 247-257页

作者： Jimin Han Tianyu yang Li yang Yuanjian Li State Key Laboratory of Explosion Science and Technology of China Beijing Institute of TechnologyBeijing 100081China Chongqing Innovation Center Beijing Institute of TechnologyChongqing 401120China

In order to achieve a wider range of ionizing radiations detection,novel fluorescence sensing materials have been developed that utilize the fluorescence enhancement phenomenon caused by the intramolecular photoinduced electron transfer(PET)*** perylene diimide isomers PDI-P and PDI-B were designed and synthesized,and their molecular structures were characterized by high-resolution Fourier transform mass spectrometry(HRMS),nuclear magnetic resonance hydrogen and carbon spectroscopy(~1H and~(13)C NMR).The interaction between ionizing radiation and fluorescent molecules was simulated by HCl *** results show that combining PDIs and HCl can improve fluorescence through the retro-PET *** the similarities in chemical structures,the fluorescent enhancement multiple of PDI-B with aromatic amine as electron donor is much higher than that of PDI-P with alkyl *** the direct irradiation experiments of ionizing radiation,the emission enhancement multiples of PDI-P and PDI-B are 2.01 and 45.4,***,density functional theory(DFT)and time-dependent density functional theory(TDDFT)calculations indicate that the HOMO and HOMO-1 energy ranges of PDI-P and PDI-B are 0.54 e V and 1.13 e V,respectively.A wider energy range has a stronger driving force on electrons,which is conducive to fluorescence *** femtosecond transient absorption spectroscopy(fs-TAS)and transient fluorescence spectroscopy(TFS)tests show that PDI-B has shorter charge separation lifetime and higher electron transfer rate *** both isomers can significantly reduce LOD during PET process,PDI-B with aromatic amine has a wider detection range of 0.118—240 gy due to its larger emission enhancement,which is a leap of three orders of *** breaks through the detection range of gamma radiation reported in existing studies,and provides theoretical support for the further study of sensitive and effective new materials for ionizing radiation dete

关键词： Perylene imide Intramolecular PET Ionizing radiation detection Fluorescence sensor Isomers

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Mapping the geography of editors-in-chief

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Journal of Data and Information Science 2024年第1期9卷 124-137页

作者： gyorgy Csomos Department of Civil Engineering University of Debrecen4028 DebrecenOtemeto utca.2-4Hungary

Purpose:This study aims to explore the geography of editors-in-chief to demonstrate which countries exercise the highest-level decision-making in scholarly *** addition,the study seeks to investigate the potential relationships between the origin and nationality of academic publishers and the geography of ***/methodology/approach:The analysis involves 11,915 journals listed in Web of Science’s Social Sciences Citation Index(SSCI)and Science Citation Index Expanded(SCIE).These journals employ 15,795 scholars as *** geographical locations of the institutions the editors-in-chief are affiliated with were identified;then,the data were aggregated at the country ***:The results show that most editors-in-chief are located in countries of the Anglosphere,primarily the United States and the United *** addition,most academic publishers and professional organizations that publish academic journals were found to be based in the United States and the United Kingdom,where most editors-in-chief are also *** limitations:The analysis involves journals indexed in the Web of Science’s SCIE/SSCI databases,which are demonstrably biased toward the English ***,the study only takes a snapshot of the geography of editors-in-chief for the year 2022,but it does not investigate *** implications:The study maps the highest-level decision-making in scholarly ***/value:The study explores and maps the geography of editors-in-chief by using a massive dataset.

关键词： Editor-in-chief Highest-level decision-making Academic publisher Web of Science Anglosphere

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Mitigate noisy data for smart IoT via GAN based machine unlearning

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Science China(Information Sciences) 2024年第3期67卷 62-78页

作者： Zhuo MA Yilong yang yang LIU Xinjing LIU Jianfeng MA School of Cyber Engineering Xidian University State Key Laboratory of Integrated Services Networks (ISN)

With the development of IoT applications, machine learning dramatically improves the utility of variable IoT systems such as autonomous driving. Although the pretrain-finetune framework can cope well with data heterogeneity in complex IoT scenarios, the data collected by sensors often contain unexpected noisy data, e.g., out-of-distribution(OOD) data, which leads to the reduced performance of fine-tuned models. To resolve the problem, this paper proposes Mu GAN, a method that can mitigate the side-effect of OOD data via the generative adversarial network(GAN)-based machine unlearning. Mu GAN follows a straightforward but effective idea to mitigate the performance loss caused by OOD data, i.e., “flashbacking” the model to the condition where OOD data are excluded from model training. To achieve the goal, we design an adversarial game, where a discriminator is trained to identify whether a sample belongs to the training set by observing the confidence score. Meanwhile, a generator(i.e., the target model) is updated to fool the discriminator into believing that the OOD data are not included in the training set but others do. The experimental results show that benefiting from the high unlearning rate(more than 90%) and retention rate(99%), Mu GAN succeeds in lowering the model performance degradation caused by OOD data from 5.88% to 0.8%.

关键词： machine unlearning generative adversarial network out of distribution data Internet of Thing neural network

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Secure Tracking Control via Fixed-Time Convergent Reinforcement Learning for a UAV CPS

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1699-1701页

作者： Zhenyu Gong Feisheng yang the School of Automation Northwestern Polytechnical UniversityXi’an 710129 the Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China

Dear Editor,This letter is concerned with the secure tracking control problem in the unmanned aerial vehicle(UAV) system by fixed-time convergent reinforcement learning(RL). By virtue of the zero-sum game,the false da... 详细信息

关键词： Secure Fixed false

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The age of vanadium-based nanozymes: Synthesis, catalytic mechanisms, regulation and biomedical applications

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Chinese Chemical Letters 2024年第4期35卷 52-60页

作者： Shuaiwen Li Zihui Chen Feng yang Wanqing Yue Department of Chemistry Key Laboratory of Biomedical Functional MaterialsSchool of ScienceChina Pharmaceutical UniversityNanjing 211198China Key Laboratory of Drug Quality Control and Pharmacovigilance(China Pharmaceutical University) Ministry of EducationNanjing 211198China

Nanomaterials with enzyme-mimic(nanozyme) activity have garnered considerable attention as a potential alternative to natural enzymes, thanks to their low preparation cost, high activity, ease of preservation, and unique physicochemical properties. Vanadium(V) is a transition metal that integrates the benefits of valence-richness, low cost, and non-toxicity, making it a desirable candidate for developing a range of emerging nanozymes. In this review, we provide the first systematic summary of recent research progress on V-based nanozymes. First, we summarize the preparation of V-based nanozymes using both top-down and bottom-up synthesis methods. Next, we review the mechanism of V-based nanozymes that mimic the activity of various enzymes. We then discuss methods for regulating V-based nanozyme activity, including morphology, size, valence engineering, defect engineering, external triggering, and surface engineering. Afterward, we outline various biomedical applications, including therapeutic, anti-inflammatory, antibacterial, and biosensing. Finally, we prospect the challenges and countermeasures for V-based nanozymes based on their development. By summarizing recent research progress on V-based nanozymes, we hope to provide useful insights for researchers to further explore their potential applications and overcome their existing challenges.

关键词： Vanadium Nanozymes Catalytic mechanisms Biomedical applications Regulation

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Current Loop Disturbance Suppression for Dual Three Phase Permanent Magnet Synchronous Generators Based on Modified Linear Active Disturbance Rejection Control

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Chinese Journal of Electrical Engineering 2024年第1期10卷 101-113页

作者： Dezhi Xu Hu Yao yang He Wenxiang Zhao School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China

A modified four-dimensional linear active disturbance rejection control(LADRC)strategy is proposed for a dual three-phase permanent magnet synchronous generator(DTP-PMSG)system to reduce cross-coupling between the d and q axis currents in the d-q subspace and harmonic currents in the x-y *** the d-q subspace,the proposed strategy uses a model-based LADRC to enhance the decoupling effect between the d and q axes and the disturbance rejection ability against parameter *** the x-y subspace,the 5th and 7th harmonic current suppression abilities are improved by using quasi-resonant units parallel to the extended state observer of the traditional *** proposed modified LADRC strategy improved both the steady-state performance and dynamic response of the DTP-PMSG *** experimental results demonstrate that the proposed strategy is both feasible and effective.

关键词： Dual three-phase permanent magnet synchronous generator current loop decoupling control harmonic suppression linear active disturbance rejection control

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Seamless Indoor-Outdoor Switching Localization Algorithm based on CKF

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Journal of Communications and Information Networks 2024年第1期9卷 88-98页

作者： Gang yang Guodong Hou Ningning Feng Weida Meng School of Communication and Information Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China

To solve the problem of large positioning error and discontinuous positioning of special forces members when moving in cross-region indoors and outdoors, and to compensate for the linearization error and local convergence problem that may exist in the extended Kalman filter(EKF)in nonlinear systems, that is,the iterative results may be trapped in a local optimum situation, a seamless indoor-outdoor switching localization algorithm based on cubature Kalman filter (CKF) is proposed. CKF does not require the computation of Jacobian matrices, which can improve computational efficiency and filtering accuracy to a certain extent. In the system, an inertial measurement unit (IMU) is employed to correct the positioning errors of ultra-wideband (UWB)and BeiDou navigation satellite system(BDS).The positioning data from UWB and BeiDou in cross-region are weighted fused and then fused with the data from the IMU using CKF to obtain the final accurate positioning information. This study designs a scene-switching mechanism to achieve seamless switching between indoor and outdoor positioning scenes. By jointly analyzing the positioning accuracy of UWB and BeiDou,the positioning scene is determined, and appropriate counting thresholds are set to avoid frequent erroneous scene switches. Experimental results show that the proposed algorithm achieves a positioning accuracy of approximately 21.7 cm in cross-region,which can enable seamless integration of indoor and outdoor positioning,avoid positioning jumps, and enhance positioning accuracy.

关键词： cubature Kalman filtering ultra-wideband inertial measurement unit fusion positioning seamless switching

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