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Evaluation of the dynamic sealing performance of cap rocks of underground gas storage under multi-cycle alternating loads

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Energy Geoscience 2024年第4期5卷 125-132页

作者： lidong Mi Yandong Guo yanfeng li Daqian Zeng Chunhua Lu Guangquan Zhang Research Institute of Petroleum Exploration and Production SINOPECBeijing100083China Shanxi Institute of Energy TaiyuanShanxi030600China

The static sealing of underground gas storage(UGS),including the integrity of cap rocks and the stability of faults,is analyzed from a macro perspective using a comprehensive geological evaluation *** in pore structure,permeability,and mechanical strength of cap rocks under cyclic loads may impact the rock sealing integrity during the injection and recovery phases of *** this work,the mechanical deformation and failure tests of rocks,as well as rock damage tests under alternating loads,are conducted to analyze the changes in the strength and permeability of rocks under multiple-cycle intense injection and recovery of ***,this study proposes an evaluation method for the dynamic sealing performance of UGS cap rocks under multi-cycle alternating *** findings suggest that the failure strength(70%)can be used as the critical value for rock failure,thus providing theoretical support for determining the upper limit of operating pressure and the number of injection-recovery cycles for the safe operation of a UGS system.

关键词： Alternating load Cap rock Dynamic sealing performance Underground gas storage

Asymmetric frequency multiplexing topological devices based on a floating edge band

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Photonics Research 2024年第6期12卷 1201-1212页

作者： JIAJUN MA CHUNMEI OUYANG YUTING YANG DONGYANG WANG HONGYI li li NIU YI liU QUAN XU yanfeng li ZHEN TIAN JIAGUANG HAN WEIli ZHANG Center for Terahertz Waves and College of Precision Instrument and Optoelectronics Engineering and Key Laboratory of Optoelectronics Information and TechnologyTianjin UniversityTianjin 300072China School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Guangxi Key Laboratory of Optoelectronic Information Processing School of Optoelectronic EngineeringGuilin University of Electronic TechnologyGuilin 541004China School of Electrical and Computer Engineering Oklahoma State UniversityStillwaterOklahoma 74078USA

Topological photonics provides a platform for robust energy transport regardless of sharp corners and ***,the frequency multiplexing topological devices have attracted much attention due to the ability to separate optical signals by wavelength and hence the potential application in optical communication *** frequency multiplexing topological devices are generally based on the slow light ***,the resulting static local spatial mode or finely tuned flat band has zero-group velocity,making it difficult for both experimental excitation and channel ***,we propose and experimentally demonstrate an alternative prototype of asymmetric frequency multiplexing devices including a topological rainbow and frequency router based on floating topological edge mode(instead of localized ones);hence the multiple wavelength channels can be collectively excited with a point source and efficiently routed to separate output *** channel separation in our design is achieved by gradually tuning the band gap truncation on a topological edge band over a wide range of frequencies.A crucial feature lies in that the topological edge band is detached from bulk states and floating within the upper and lower photonic band *** interestingly,due to the sandwiched morphology of the edge band,the top and bottom band gaps will each truncate into transport channels that support topological propagation towards opposite directions,and the asymmetrical transportation is realized for the frequency multiplexing topological devices.

关键词： tuning floating hence

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu liu Michael Chopp Michael Millman yanfeng li Pasquale Cepparulo Amy Kemper Chao li li Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

微管相关蛋白tau基因突变相关额颞叶痴呆临床研究进展

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中华老年医学杂志 2024年第7期43卷 930-934页

作者：李航李延峰中国医学科学院北京协和医院神经科北京100730

额颞叶痴呆(FTD)是仅次于阿尔茨海默病的第二大早发型痴呆。30%~50%的FTD患者与遗传相关。微管相关蛋白tau(MAPT)基因突变是一种常见的常染色体显性基因突变,是遗传性额颞叶痴呆的第三大常见原因。本文就MAPT基因的结构、编码蛋白、致... 详细信息

额颞叶痴呆(FTD)是仅次于阿尔茨海默病的第二大早发型痴呆。30%~50%的FTD患者与遗传相关。微管相关蛋白tau(MAPT)基因突变是一种常见的常染色体显性基因突变,是遗传性额颞叶痴呆的第三大常见原因。本文就MAPT基因的结构、编码蛋白、致病机制、病理特点、MAPT基因突变所致FTD的临床表型,影像特点及治疗作出综述。

关键词：痴呆微管相关蛋白质类额颞叶痴呆基因突变

On-chip terahertz orbital angular momentum demultiplexer

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Photonics Research 2024年第5期12卷 1044-1054页

作者： XIAOHAN JIANG WANYING liU QUAN XU YUANHAO LANG YIKAI FU FAN HUANG HAITAO DAI yanfeng li XUEQIAN ZHANG JIANQIANG GU JIAGUANG HAN WEIli ZHANG Center for Terahertz Waves College of Precision Instrument and Optoelectronics Engineeringand Key Laboratory of Optoelectronics Information and Technology(Ministry of Education)Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of ScienceTianjin UniversityTianjin 300072China Guangxi Key Laboratory of Optoelectronic Information Processing School of Optoelectronic EngineeringGuilin University of Electronic TechnologyGuilin 541004China School of Electrical and Computer Engineering Oklahoma State UniversityStillwaterOklahoma 74078USA

The terahertz regime is widely recognized as a fundamental domain with significant potential to address the demands of next-generation wireless *** parallel,mode division multiplexing based on orbital angular momentum(OAM)shows promise in enhancing bandwidth utilization,thereby expanding the overall communication channel *** this study,we present both theoretical and experimental demonstrations of an on-chip terahertz OAM *** device effectively couples and steers seven incident terahertz vortex beams into distinct high-quality focusing surface plasmonic beams,and the focusing directions can be arbitrarily *** proposed design strategy integrates space-to-chip mode conversion,OAM recognition,and on-chip routing in a compact space with subwavelength thickness,exhibiting versatility and superior performance.

关键词： demultiplexer momentum angular

分支定价算法求解携带医疗资源的家庭医护人员调度问题

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运筹与管理 2024年第7期33卷 130-136页

作者：李妍峰罗楠西南交通大学经济管理学院四川成都610031 服务科学与创新四川省重点实验室四川成都610031

针对携带医疗资源的家庭医护人员调度优化问题,综合考虑医疗资源、弹性服务时间窗、医患技能等级匹配等特征,以最小化运营成本和弹性时间窗惩罚成本为目标构建数学模型。并根据Dantzig-Wolfe分解原理将模型重构为基于访问路径的主问题... 详细信息

针对携带医疗资源的家庭医护人员调度优化问题,综合考虑医疗资源、弹性服务时间窗、医患技能等级匹配等特征,以最小化运营成本和弹性时间窗惩罚成本为目标构建数学模型。并根据Dantzig-Wolfe分解原理将模型重构为基于访问路径的主问题和若干带资源约束的最短路子问题模型。根据问题特征设计了分支定价算法来求解该问题。小规模算例结果表明医疗资源特性对医护人员路径调度有重要影响,而弹性时间窗可以有效降低总成本;多种算例的运算结果证明了分支定价算法求解的高效性。

关键词：家庭医护人员调度医疗资源车辆路径问题分支定价

牡荆素调控Sirt1/FoxO1通路介导的铁死亡对变应性鼻炎大鼠鼻黏膜损伤的保护作用

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现代药物与临床 2024年第1期39卷 14-22页

作者：李艳峰卢振民新乡医学院第一附属医院耳鼻咽喉科河南新乡453100

目的探究牡荆素对变应性鼻炎大鼠鼻黏膜损伤的保护作用及其调控机制。方法将SD大鼠随机分为对照组、模型组、牡荆素(3、6、12 mg/kg),及牡荆素(12 mg/kg)+EX527(5 mg/kg)组,每组各10只。除对照组外,其余各组大鼠均采用卵清白蛋白诱导建... 详细信息

目的探究牡荆素对变应性鼻炎大鼠鼻黏膜损伤的保护作用及其调控机制。方法将SD大鼠随机分为对照组、模型组、牡荆素(3、6、12 mg/kg),及牡荆素(12 mg/kg)+EX527(5 mg/kg)组,每组各10只。除对照组外,其余各组大鼠均采用卵清白蛋白诱导建立变应性鼻炎大鼠模型,模型构建成功后,各组大鼠ip相应剂量药物,对照组和模型组大鼠ip等量的生理盐水,1次/d,连续14 d。末次给药结束后30 min,记录各组大鼠行为学评分,观察鼻黏膜组织病理形态学变化;检测鼻黏膜组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH)、丙二醛(MDA)、活性氧气簇(ROS)、铁离子(Fe^(2+))水平,铁死亡相关蛋白溶质载体家族7成员11(SLC7A11)、谷胱甘肽过氧化物酶4(GPX4)、酰基辅酶A合成酶长链家族成员4(ACSL4)以及沉默信息调节因子1(Sirt1)、叉头框蛋白O1(FoxO1)、p-FoxO1、Ac-FoxO1蛋白表达。结果与模型组相比,牡荆素各剂量组大鼠行为学评分均显著降低,鼻黏膜损伤显著改善(P<0.05);大鼠鼻黏膜组织匀浆SOD、GSH活性显著升高,MDA、ROS、Fe^(2+)含量均显著降低(P<0.05);大鼠鼻黏膜组织SLC7A11、GPX4、Sirt1、FoxO1蛋白表达显著升高,p-FoxO1、Ac-FoxO1、ACSL4蛋白表达显著降低(P<0.05),且呈剂量相关性。结论牡荆素能够改善变应性鼻炎大鼠鼻黏膜损伤,其机制与激活鼻黏膜组织Sirt1/FoxO1通路,抑制细胞铁死亡有关。

关键词：牡荆素变应性鼻炎铁死亡沉默信息调节因子1/叉头框蛋白O1通路溶质载体家族7成员11

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操作链视角下的赤栏桥遗址铸铜遗存分析

考古与文物 2024年第2期 130-139页

作者：胡佳琪李彦峰李建西西北大学文化遗产学院陕西省考古研究院

赤栏桥遗址是关中地区新发现的一处商文化遗址,出土了较丰富的铸铜遗存。本文按照铸铜操作链流程,通过分析原料制备、制范、熔铜铸造、脱范与铸后处理等四个工序环节相关的遗迹和遗物,重建了铸铜作坊的铜器生产过程,并讨论了作坊的空间... 详细信息

赤栏桥遗址是关中地区新发现的一处商文化遗址,出土了较丰富的铸铜遗存。本文按照铸铜操作链流程,通过分析原料制备、制范、熔铜铸造、脱范与铸后处理等四个工序环节相关的遗迹和遗物,重建了铸铜作坊的铜器生产过程,并讨论了作坊的空间布局发展变化情况,最后指出赤栏桥遗址及铸铜遗存的发现对商代关中区域社会研究的意义。

关键词：赤栏桥遗址商文化操作链铸铜作坊

7075–O铝合金搅拌摩擦焊接头微观组织与力学性能

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航空制造技术 2024年第10期67卷 95-101页

作者：朱海晏小龙李砚峰刘琪东北林业大学哈尔滨150040

时效硬化态7075铝合金搅拌摩擦焊接头塑性较低,给进一步变形加工带来困难。本文采用3 mm厚的7075–O铝合金板进行搅拌摩擦对接焊,研究焊接速度对接头组织和强塑性的影响,为获得高塑性的搅拌摩擦接头提供解决方案。结果表明,7075–O铝合... 详细信息

时效硬化态7075铝合金搅拌摩擦焊接头塑性较低,给进一步变形加工带来困难。本文采用3 mm厚的7075–O铝合金板进行搅拌摩擦对接焊,研究焊接速度对接头组织和强塑性的影响,为获得高塑性的搅拌摩擦接头提供解决方案。结果表明,7075–O铝合金接头焊核区为细小的等轴晶粒,随焊接速度的增加,焊核区平均晶粒尺寸呈先减小后缓慢增加的趋势,当焊接速度为40 mm/min时,焊核区晶粒尺寸最小,约为1.96μm。不同焊接速度下接头横截面显微硬度呈“凸”形分布,接头区域发生明显硬化,其中焊核区硬度最高,约为145HV。7075–O铝合金搅拌摩擦焊工艺窗口较宽,焊接速度在20~80 mm/min范围内接头强度均高于母材强度,焊接件伸长率达母材的82%,采用7075–O铝合金不仅能够克服时效硬化态7075铝合金搅拌摩擦焊接头的软化问题,而且能够获得更高的伸长率。接头弯曲试验结果表明,7075–O铝合金搅拌摩擦焊接头能够承受更大的弯曲角度,极限弯曲角达105°,具备更加出色的塑性变形能力。

关键词： 7075–O铝合金搅拌摩擦焊接头组织拉伸性能弯曲性能