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Mechanism of oxidative damage to DNA by Fe-loaded MCM-41 irradiated with visible light

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Chinese Science Bulletin 2012年第13期57卷 1504-1509页

作者： WANG XiaoXing GU Yan fang yanfen HUANG YingPing Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of EducationChina Three Gorges UniversityYichang 443002China

The mechanism of oxidative damage to deoxyribonucleic acid (DNA) by iron-containing mesoporous molecular sieves (MCM-41) irradiated with visible light was elucidated. Fe-loaded MCM-41 (Fe/MCM-41) was used as a photocatalyst and the damage to calf thymus DNA caused by hydrogen peroxide (H2O2) was studied. The damage and extent of oxidation of DNA were measured by high-performance liquid chromatography (HPLC) and intermediate products were detected by HPLC/electrospray ionization tandem mass spectrometry. Electron spin resonance was used to detect changes in reactive oxygen species and peroxidase catalytic spectrophotometry was used to determine the concentration of H2O2. The results indicated that Fe/MCM-41 efficiently activated H2O2 in solution at pH 4.0-8.0 under irradiation with visible light. The photocatalytic system degraded DNA most effectively at pH 5.0-6.0 but also operated at pH 8.0. At pH 4.2, the degree of DNA damage reached 25.65% after 5 h and the kinetic constant was 5.89×10 2 min 1. Damage to DNA was predominantly caused by hydroxyl radicals generated in the system. The mechanism of DNA damage is of potential concern to human health because it can occur in neutral solutions irradiated by visible light.

关键词： DNA氧化损伤 MCM-41 可见光照射含铁机制过氧化氢溶液高效液相色谱 DNA损伤

Preliminary study on the electrocatalytic performance of an iron biochar catalyst prepared from iron-enriched plants

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Journal of Environmental Sciences 2020年第2期32卷 81-89页

作者： Xinqiang Cao Yingping Huang Changcun Tang Jianzhu Wang David Jonson yanfen fang College of Biological and Pharmaceutical Sciences China Three Gorges UniversityYichang 443002China China Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of EducationChina Three Gorges UniversityYichang 443002China College of Hydraulic and Environmental Engineering China Three Gorges UniversityYichang 443002China

Eichhornia crassipes is a hyperaccumulator of metals and has been widely used to remove metal pollutants from water, but disposal of contaminated plants is *** prepared from plants is commonly used to remediate soils and sequester ***, the catalytic activity of biochar prepared from plants enriched with iron was investigated as a potentially beneficial use of metal-contaminated *** a 30-day hydroponic experiment, *** was exposed to different concentrations of Fe(Ⅲ)(0, 4, 8, 16, 32 and 64 mg/L), and Fe-biochar(Fe-BC) was prepared by pyrolysis of the plant *** biochar was characterized using X-ray diffraction(XRD), scanning electron microscopy(SEM), energy dispersive X-ray spectrometry(EDS), Brunauer–Emmett–Teller(BET) analysis, X-ray photoelectron spectroscopy(XPS) and atomic absorption spectrometry(AAS).The original root morphology was visible and iron was present as γ-Fe2O3 and *** biochar enriched with Fe(Ⅲ) at 8 mg/L(8-Fe-BC) had the smallest specific surface area(SSA, 13.54 m^2/g) and the highest Fe content(27.9 mg/g).Fe-BC catalytic activity was tested in the electrocatalytic reduction of H2O2 using cyclic voltammetry(CV).The largest reduction current(1.82 mA/cm^2) was displayed by 8-Fe-BC, indicating the highest potential catalytic *** report here, for the first time, on the catalytic activity of biochar made from iron-enriched plants and demonstrate the potential for reusing metalcontaminated plants to produce a biochar catalyst.

关键词： Hyperaccumulator Eichhornia crassipes Fe-doped biochar H2O2 electrocatalysis

Heterogeneous degradation of toxic organic pollutants by hydrophobic copper Schiff-base complex under visible irradiation

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Science China Chemistry 2013年第12期56卷 1775-1782页

作者： SONG Quan JIA ManKe MA WanHong fang yanfen HUANG YingPing Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of Education China Three Gorges University Collaborative Innovation Center for Geo-Hazards and Eco-Environment in Three Gorges Area

A hydrophobic complex of Cu2＋[bis-salicylic aldehyde-o-phenylenediamine], Cu-SPA, was prepared and used as a heterogeneous photocatalyst to degrade organic pollutants in water under visible irradiation （λ≥420 nm） at neutral pH. The structure of complex was characterized by using nuclear magnetic resonance （NMR）, elemental analysis, IR and UV-vis spectrometries. Degradation of Rhodamine B （RhB）, Sulforhodamine B （SRB） and Benzoic acid （BA） in water were used as model reactions to evaluate the photocatalytic activities of Cu-SPA. The results indicated that RhB and SRB were easily adsorbed on the hydrophobic surface of Cu-SPA from aqueous solution （the maximum adsorption amount： Qmax = 11.09 and 8.05 μmol/g, respectively）. Under visible irradiation, RhB and SRB were decolorized completely after 210 and 240 min, respectively, and BA was removed completely after 5 h. The efficiency of H202 was 〉 95%, in contrast to that of the reaction without catalyst or light （〈 20%）. In water soluble medium, the hydrophobic Cu-SPA can be used more than 6 cycles. ESR results and the behavior of cy- clic voltammetry showed that, in the reaction process, Cu2＋-SPA was reduced to intermediate state Cu＋-SPA firstly, which was extremely unstable and reacted rapidly with H2O2, leading to high reactive oxygen species （.OH radical ） to degrade the substrate.

关键词： hydrophobic copper Schiff-base photocatalysis toxic organic pollutant

Green and efficient degradation of cefoperazone sodium by Bi_(4)O_(5)Br_(2) leading to the production of non-toxic products:Performance and degradation pathway

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Journal of Environmental Sciences 2021年第2期33卷 203-215页

作者： Yingying Chen Ruiping Li Yan Gu Hailin Tian Yingping Huang Junsong Chen yanfen fang Changying Yang College of Biology and Pharmacy China Three Gorges UniversityYichang443002China College of Hydraulic and Enuironmental Engineering China Three Gorges UniversityYichang443002China Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of EducationChina Three Gorges UniversityYichang443002China

Photocatalytic process represents a promising approach to overcome the pollution challenge associated with the antibiotics-containing *** study provides a green,efficient and novel approach to remove cephalosporins,particularly cefoperazone sodium(CFP).Bi_(4)O_(5)Br_(2) was chosen for the first time to systematically study its degradation for CFP,including the analysis of material structure,degradation performance,the structure and toxicity of the transformation products,*** degradation rate results indicated that Bi_(4)O_(5)Br_(2) had an excellent catalytic activity leading to 78%CFP removal compared with the pure BiOBr(38%)within 120 min of visible light *** addition,the Bi_(4)O_(5)Br_(2) presents high stability and good organic carbon removal *** effects of the solution p H(3.12-8.75)on catalytic activity revealed that CFP was mainly photocatalyzed under acidic conditions and hydrolyzed under alkaline *** with active species and degradation product identification,the photocatalytic degradation pathways of CFP by Bi_(4)O_(5)Br_(2) was proposed,including hydrolysis,oxidation,reduction and *** importantly,the identified products were all hydrolysis rather than oxidation byproducts transformed from the intermediate ofβ-lactam bond cleavage in CFP molecule,quite different from the mostly previous ***,the final products were demonstrated to be less toxic through the toxicity ***,this study illustrates the detailed mechanism of CFP degradation by Bi_(4)O_(5)Br_(2) and confirms Bi_(4)O_(5)Br_(2) to be a promising material for the photodegradation of CFP.

关键词： Bi_(4)O_(5)Br_(2) Cefoperazone sodium Photocatalytic activity Degradation products

Visible light-induced degradation of organic pollutants using Fe(II) supported on silica gel as an effective catalyst

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Chinese Science Bulletin 2008年第10期53卷 1497-1502页

作者： ZHAO Chao HUANG YingPing fang yanfen JIANG LiRong LIU LiMing King Tong Lau Center for Ecologic and Environment Science China Three Gorges University Yichang 443002 China College of Chemistry Central China Normal University Wuhan 430070 China School of Chemical -Sciences National Centre for Sensor Research Dublin City University Dublin Ireland

Silica gel-supported Fe(II) (SiOFe) was prepared and used for heterogeneous degradation of sulforho-damine B (SRB) and 2,4-dichlorophenol (DCP) under visible irradiation (λ > 420 nm) as an effective catalyst. UVvisible spectra, and infrared Spectrophotometry (IR), fluorescence, total organic carbon (TOC) and electron spin resonance (ESR) measurements were employed to analyze the photoreaction products. The results showed that SRB could be efficiently degraded by SiOFe/H2O2 system under visible irradiation with 100% decolorization and 72.3% TOC removal after 180 min illumination. The results of ESR and fluorescence measurements indicated that the oxidative process was predominated mainly by the hydroxyl radical (·OH) generated in the system.

关键词：二氧化硅凝胶剂异质性光催化剂辐射度

The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer

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Cancer Biology & Medicine 2022年第8期19卷 1172-1192页

作者： Ting He Yinglei Gao yanfen fang Yangming Zhang Shuwei Zhang Fajun Nan Jian Ding Yi Chen Division of Anti-Tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Drug Research the National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Objective:The novel compound GCJ-490A has been discovered as a pan-histone deacetylase(HDAC)inhibitor that exerts potent inhibitory activity against HDAC1,HDAC3,and *** of the important roles of HDACs in lung cancer development and the high distribution of GCJ-490A in lung tissue,we explored the anti-tumor potency of GCJ-490A against non-small cell lung cancer(NSCLC)in vitro and in vivo in this ***:The in vitro effects of GCJ-490A alone or combined with the EGFR inhibitor gefitinib against NSCLC were measured with proliferation,apoptosis,and colony formation *** xenograft models were used to investigate the efficacy of GCJ-490A combined with gefitinib for the treatment of NSCLC in *** blot assays,luciferase reporter assays,chromatin immunoprecipitation assays,quantitative real time-PCR,immunohistochemistry,and transcription factor activity assays were used to elucidate possible ***:GCJ-490A effectively inhibited NSCLC cell proliferation and induced apoptosis in vitro and in ***,inhibition of HDAC1 and HDAC6 by GCJ-490A increased histone acetylation at the IKKαpromoter and enhanced IKKαtranscription,thus decreasing ***,this c-Met downregulation was found to be essential for the synergistic anti-tumor activity of GCJ-490A and ***:These findings highlight the promising potential of HDAC inhibitors in NSCLC treatment and provide a rational basis for the application of HDAC inhibitors in combination with EGFR inhibitors in clinical trials.

关键词： HDAC inhibitor c-Met IKKα NSCLC gefitinib

Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression

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Signal Transduction and Targeted Therapy 2023年第2期8卷 692-704页

作者： Zonglong Hu Fan Wei Yi Su Yafang Wang Yanyan Shen yanfen fang Jian Ding Yi Chen Division of Anti-Tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing100049China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China

Histone deacetylase(HDAC)is a kind of protease that modifies histone to regulate gene expression,and is usually abnormally activated in *** approved pan-HDAC inhibitors have demonstrated clinical benefits for patients in some hematologic *** limited therapeutic success in breast cancer has been observed in clinical *** this study,we declare that pan-HDAC inhibitors targeting NEDD9-FAK pathway exacerbate breast cancer metastasis in preclinical models,which may severely impede their clinical ***9 is not an oncogene,however,it has been demonstrated recently that there are high level or activity changes of NEDD9 in a variety of cancer,including leukemia,colon cancer,and breast ***,pan-HDAC inhibitors enhance H3K9 acetylation at the nedd9 gene promoter via inhibition of HDAC4 activity,thus increase NEDD9 expression,and then activate FAK *** realization that pan-HDAC inhibitors can alter the natural history of breast cancer by increasing invasion warrants clinical *** addition,although NEDD9 has been reported to have a hand in breast cancer metastasis,it has not received much attention,and no therapeutic strategies have been ***,we demonstrate that FAK inhibitors can reverse breast cancer metastasis induced by upregulation of NEDD9 via pan-HDAC inhibitors,which may offer a potential combination therapy for breast cancer.

关键词： metastasis breast cancer

Catalysis of organic pollutant photodegradation by metal phthalocyanines immobilized on TiO_2@SiO_2

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Chinese Science Bulletin 2011年第10期56卷 969-976页

作者： WANG ShuLian fang yanfen YANG Yong LIU JunZi DENG AnPing ZHAO XiaoRong HUANG YingPing Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of Education China Three Gorges University Yichang 443002 China Shanghai Institute of Ceramics Chinese Academic of Sciences Shanghai 200050 China

A TiO2@SiO2 hybrid support was prepared by the sol-precipitation method using n-octylamine as a *** photocatalyst manganese phthalocyanine tetrasulfonic acid (MnPcS) was immobilized on the support to form MnPcS-TiO2@SiO2.X-ray diffraction (XRD) and UV-Visible diffuse reflectance spectra (UV-Vis DRS) were employed to characterize the *** photocatalytic degradation of rhodamine B (RhB) and the catalytic oxidation of o-phenylenediamine (OPDA) under visible light irradiation were used as probe *** mineralization efficiency and the degradation mechanism were evaluated using chemical oxygen demand (COD Cr) assays and electron spin resonance (ESR),*** was efficiently degraded by immobilized MnPcS-TiO2@SiO2 under visible light *** decolorization of RhB occurred after 240 min of irradiation and 64.02% COD Cr removal occurred after 24 h of *** results indicated that the oxidation process was dominated by the hydroxyl radical (·OH) and superoxide radical (O-·2) generated in the system.

关键词： TiO2 光降解催化剂有机污染物金属酞菁 SiO2 CODcr去除率可见光照射

Degradation of organic pollutants by a Co_3O_4 -graphite composite electrode in an electro-Fenton-like system

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Chinese Science Bulletin 2013年第19期58卷 2340-2346页

作者： LIU Shuan GU Yan WANG ShuLian ZHANG Yu fang yanfen JOHNSON David M HUANG YingPing Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of EducationChina Three Gorges University Institute of Oceanology Chinese Academy of Sciences School of Natural Science & Mathematics Ferrum College

A novel composite electrode was constructed by pressing together Co3O4 and graphite and it was used as the cathode in an electro-Fenton-like (EFL) system. The poor electron transport characteristic of Co3O4 was overcome by incorporating graphite. In situ electro-catalytic generation of hydroxyl radicals (·OH) occurred at high current efficiencies from pH 2-10, extending the traditional Fenton reaction pH range. Cyclic voltammetry and AC impedance spectrometry were used to characterize the composite electrode. The ability of the EFL system to degrade organic compounds was investigated using sulforhodamine B (SRB) and 2,4-dichlorophenol (2,4-DCP) as probes. Decoloration of SRB (1.0×10-5 mol/L) was complete (100%) in 150 min and SRB was effectively degraded from pH 2-10. The decomposition of SRB was studied using Fourier transform infrared spectroscopy (FT-IR) and total organic carbon (TOC) analysis and results indicated that the final degradation products were carbon dioxide, carboxylic acids and amines. The EFL system also decomposed 2,4-DCP and the degradation was 98.6% in 240 min. Electro-catalytic degradation of SRB occurs by a ·OH mechanism. After 5 times reused, the degradation rate of SRB did not significantly slow down. The electrode shows excellent potential for use in advanced oxidation processes (AOPs) used to treat persistent organic pollutants (POPs) in wastewater.

关键词：污染物降解复合电极 L系统石墨傅里叶变换红外光谱 Fenton反应持久性有机污染物硫酸盐还原菌