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A study on vector mediator top-philic dark matter

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Communications in Theoretical Physics 2024年第8期76卷 67-78页

作者： Yanyan Hu yandong Liu Yuanyuan Liu College of Nuclear Science and Technology Beijing Normal UniversityJoint Laboratory of Jinping Ultra-low Radiation Background Measurement of Ministry of Ecology and EnvironmentJinping Deep Underground Frontier Science and Dark Matter Key Laboratory of Sichuan ProvinceKey Laboratory of Beam Technology of Ministry of EducationBeijing 100875China Beijing Radiation Center Beijing 100875China

We conducted a study on a simplified dark matter model that introduces a vector-like intermediate particle,facilitating exclusive interactions between dark matter and the top quark in the Standard *** analysis focused on the relic density of Dirac-type fermion dark matter and highlighted the complementary role of direct detection in constraining the dark matter ***,in instances when dark matter mass is small,the tree-level two-body annihilation process experiences *** such scenarios,the contributions of the threebody process(χχ→tbW-)and the one-loop process(χχ→gg)dominate the relic *** regard to direct detection,calculations were performed for the two-loop contribution to the dark-matter-gluon interaction,yielding the corresponding spin-independent scattering cross section.

关键词： dark matter new physics effective field theory

TibetanGoTinyNet:a lightweight U-Net style network for zero learning of Tibetan Go

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Frontiers of Information Technology & Electronic Engineering 2024年第7期25卷 924-937页

作者： Xiali LI Yanyin ZHANG Licheng WU yandong CHEN Junzhi YU Key Laboratory of Ethnic Language Intelligent Analysis and Security Governance Ministry of EducationMinzu University of ChinaBeijing 100081China School of Information Engineering Minzu University of ChinaBeijing 100081China Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijing 100871China

The game of Tibetan Go faces the scarcity of expert knowledge and research ***,we study the zero learning model of Tibetan Go under limited computing power resources and propose a novel scaleinvariant U-Net style two-headed output lightweight network *** lightweight convolutional neural networks and capsule structure are applied to the encoder and decoder of TibetanGoTinyNet to reduce computational burden and achieve better feature extraction *** autonomous self-attention mechanisms are integrated into TibetanGoTinyNet to capture the Tibetan Go board’s spatial and global information and select important *** training data are generated entirely from self-play *** achieves 62%–78%winning rate against other four U-Net style models including Res-UNet,Res-UNet Attention,Ghost-UNet,and Ghost *** also achieves 75%winning rate in the ablation experiments on the attention mechanism with embedded positional *** model saves about 33%of the training time with 45%–50%winning rate for different Monte–Carlo tree search(MCTS)simulation counts when migrated from 9×9 to 1.×1. *** for our model is available at https://***/paulzyy/TibetanGoTinyNet.

关键词： Zero learning Tibetan Go U-Net Self-attention mechanism Capsule network Monte-Carlo tree search

Microstructures and micromechanical behaviors of high -entropy alloys investigated by synchrotron X-ray and neutron diffraction techniques: A review

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1333-1349页

作者： Yubo Huang Ning Xu Huaile Lu Yang Ren Shilei Li yandong Wang Beijing Advanced Innovation Center of Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China AnSteel Beijing Research Institute Co.Ltd. Beijing 102200China Spallation Neutron Source Science Center Dongguan 523803China Department of Physics City University of Hong KongHong Kong 999077China Institute for Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

High-entropy alloys(HEAs)possess outstanding features such as corrosion resistance,irradiation resistance,and good mechan-ical properties.A few HEAs have found applications in the fields of aerospace and *** studies on the deformation mech-anisms of HEAs can guide microstructure control and toughness design,which is vital for understanding and studying state-of-the-art structural *** X-ray and neutron diffraction are necessary techniques for materials science research,especially for in situ coupling of physical/chemical fields and for resolving macro/microcrystallographic information on ***,several re-searchers have applied synchrotron X-ray and neutron diffraction methods to study the deformation mechanisms,phase transformations,stress behaviors,and in situ processes of HEAs,such as variable-temperature,high-pressure,and hydrogenation *** this review,the principles and development of synchrotron X-ray and neutron diffraction are presented,and their applications in the deformation mechanisms of HEAs are *** factors that influence the deformation mechanisms of HEAs are also *** review fo-cuses on the microstructures and micromechanical behaviors during tension/compression or creep/fatigue deformation and the application of synchrotron X-ray and neutron diffraction methods to the characterization of dislocations,stacking faults,twins,phases,and intergrain/interphase stress *** on future developments of synchrotron X-ray and neutron diffraction and on research directions on the deformation mechanisms of novel metals are discussed.

关键词： high-entropy alloys microstructures micromechanical behaviors synchrotron X-ray diffraction neutron diffraction

Synthetic Studies toward Pseudolaric Acids:Radical Cyclization to Form Bridged Scaffold

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Chinese Journal of Chemistry 2024年第15期42卷 1699-1705页

作者： Yujie Niu Minggui Lin Hao Cui Yanji Huang Yang Shen yandong Zhang State Key Laboratoryof Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian ProvinceicHEMCollege of Chemistryand Chemical EngineeringXiamen UniversityXiamenFujian 361005China

Pseudolaric acids are a family of diterpenoid natural products that exhibit a broad spectrum of biological *** main structural feature of their framework is a trans-fused perhydroazulene bearing a bridged lactone positioned at the junction of the ***,we have developed a radical cyclization strategy that allows flexible tuning of the cyclization process through diverse silicon substitutions on the *** strategy can assist in constructing a series of skeletons with structural resemblance to pseudolaric acids and expedites the construction of the bridged ***,it facilitates the synthesis of the entire skeletal structure of the pseudolaric acidfamily of natural products,excludingthe B-ringfunctionalization.

关键词： Terpenoids Total synthesis Radical cyclization Bridged cycles Regioselectivity

Abnormal mechanochemical effect in ultraprecision machining of an additively manufactured precipitation-strengthened high-entropy alloy

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Journal of Materials Science & Technology 2024年第3期170卷 221-237页

作者： Long Xu Yuchao Bai Yunfa Guo Chang Ren Xiaohua Tan yandong Jia Gang Wang Hao Wang Institute of Materials Shanghai UniversityShanghai 200444China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314100China Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore

Recently,researchers have explored the use of precipitation strengthening and finer microstructures with high-density dislocations in additive manufacturing to produce high-entropy alloys(HEAs)with adjustable ***,the inherent surface roughness and lack of machinability research in AMed HEAs limit their engineering *** this study,we systematically investigated the microstructural characteristics,mechanical properties,and machinability of Fe_(29.3)Co_(28.7)Ni_(28.6)Al_(6.8)Ti_(6.6)(at.%)HEAs with three different structures:single FCC phase cellular(SPC),dual precipitation-strengthened(DPS),and single precipitation-strengthened(SPS).These structures were fabricated by selective laser melting and isothermally annealing at 780 and 940℃.Compared to SPC HEA,DPS HEA exhibits a significant increase in yield strength and ultimate tensile strength but with a dramatic sacrifice in *** HEA exhibits similar mechanical properties to SPC HEA due to the pronounced coarsening of L21.*** ultraprecision machining micro-cutting test showed that SPC HEA had a significant mechanochem-ical effect,as evidenced by a sharp drop in cutting force for inked workpieces,but not DPS *** abnormal finding was that the negligible reflection of cutting force for SPS HEAs suggested a negative mechanochemical effect,even though SPS HEA had equally excellent plasticity like SPC *** was found that nanocrystallization-induced strength enhancement and ductility reduction of SPS HEA lead to chips’deformation dominated by shear avalanche rather than chip folding of SPC HEA,which involves the reduction of surface energy and friction of chips’***,these results and our research findings may guide the machining of AMed precipitation-strengthened HEAs and accelerate their engineering ap-plication.

关键词： High-entropy alloy Selective laser melting Precipitation strengthening Machinability Mechanochemical effect

Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei

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Cancer Biology & Medicine 2024年第7期21卷 586-605页

作者： Qidi Zhao Tian Wei Ru Ma Yubin Fu Rui Yang yandong Su Yang Yu Bing Li Yan Li School of Clinical Medicine Tsinghua UniversityBeijing 100084China Department of Surgical Oncology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Peritoneal Cancer Surgery Bejing Shijitan HospitalCapital Medical UniversityBejing 100038China

Pseudomyxoma peritonei(PMP) is an indolent malignant syndrome. The standard treatment for PMP is cytoreductive surgery combined with intraperitoneal hyperthermic chemotherapy(CRS + HIPEC). However, the high recurrence rate and latent clinical symptoms and signs are major obstacles to further improving clinical outcomes. Moreover, patients in advanced stages receive little benefit from CRS + HIPEC due to widespread intraperitoneal metastases. Another challenge in PMP treatment involves the progressive sclerosis of PMP cell-secreted mucus, which is often increased due to activating mutations in the gene coding for guanine nucleotide-binding protein alpha subunit(GNAS). Consequently, the development of other PMP therapies is urgently needed. Several immune-related therapies have shown promise, including the use of bacterium-derived non-specific immunogenic agents, radioimmunotherapeutic agents, and tumor cell-derived neoantigens, but a well-recognized immunotherapy has not been established. In this review the roles of GNAS mutations in the promotion of mucin secretion and disease development are discussed. In addition, the immunologic features of the PMP microenvironment and immune-associated treatments are discussed to summarize the current understanding of key features of the disease and to facilitate the development of immunotherapies.

关键词： Pseudomyxoma peritonei tumor immuno-microenvironment immune-related therapy mucin 2 GNAS mutation

Mass transfer process of peanut protein extracted by bis(2-ethylhexyl)sodium sulfosuccinate reverse micelles

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Grain & Oil Science and Technology 2024年第1期7卷 60-67页

作者： Chenxian Yang Tianci Li Tingwei Zhu Xiaojie Duan Yibao Chen yandong Xu Fusheng Chen Kunlun Liu College of Food Science and Engineering Henan University of TechnologyZhengzhouHenan 450001China

The liquid-liquid extraction method using reverse micelles can simultaneously extract lipid and protein of oilseeds,which have become increasingly popular in recent ***,there are few studies on mass transfer processes and models,which are helpful to better control the extraction process of oils and *** this paper,mass transfer process of peanut protein extracted by bis(2-ethylhexyl)sodium sulfosuccinate(AOT)/isooctane reverse micelles was *** effects of stirring speed(0,70,1.0,and 21. r/min),temperature of extraction(30,35,40,45,and 50℃),peanut flour particle size(0.355,0.450,0.600,and 0.900 mm)and solidliquid ratio(0.01.,0.01.5,0.01.,0.01.5,and 0.020 g/mL)on extraction rate were *** results showed that extraction rate increased with temperature rising,particle size reduction as well as solid-liquid ratio increase respectively,while little effect of stirring speed(P>0.05)was *** apparent activation energy of extraction process was calculated as 1..02 kJ/mol and Arrhenius constant(A)was 1.91.by Arrhenius *** was a linear relationship between reaction rate constant and the square of the inverse of initial particle radius(1.r_(0)^(2))(P<0.05).This phenomenon and this shrinking core model were *** brief,the extraction process was controlled by the diffusion of protein from the virgin zone interface of particle through the reacted zone and it was in line with the first order *** transfer kinetics of peanut protein extracted by reverse micelles was established and it was verified by experimental *** results provide an important theoretical guidance for industrial production of peanut protein separation and purification.

关键词： AOT reverse micelles Peanut protein Kinetics Shrinking core model Mass transfer

Versatile photonic molecule switch in multimode microresonators

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Light(Science & Applications) 2024年第3期13卷 498-509页

作者： Zihan Tao Bitao Shen Wencan Li Luwen Xing Haoyu Wang Yichen Wu Yuansheng Tao Yan Zhou yandong He Chao Peng Haowen Shu Xingjun Wang State Key Laboratory of Advanced Optical Communications System and Networks School of ElectronicsPeking UniversityBeijing 100871China College of Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking University100871 BejingChina Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China Peng Cheng Laboratory Shenzhen 518055China

Harnessing optical supermode interaction to construct artificial photonic molecules has uncovered a series of fundamental optical phenomena analogous to atomic ***,the distinct energy levels and interactions in such two-level systems were provided by coupled *** reconfigurability is limited,as they often require delicate external field stimuli or mechanically altering the geometric *** highly specific approaches also limit potential ***,we propose a versatile on-chip photonic molecule in a multimode microring,utilizing a flexible regulation methodology to dynamically control the existence and interaction strength of spatial *** transition between single/multi-mode states enables the“switched-off/on”functionality of the photonic molecule,supporting wider generalized applications *** particular,“switched-on”state shows flexible and multidimensional mode splitting control in aspects of both coupling strength and phase difference,equivalent to the *** *** effect.“Switched-off”state allows for perfect low-loss single-mode transition(Qi~1. million)under an ultra-compact bend size(FSR~1.5 GHz)in a foundry-based silicon *** breaks the stereotyped image of the FSR-Q factor trade-off,enabling ultra-wideband and high-resolution millimeter-wave photonic *** demonstration provides a flexible and portable solution for the integrated photonic molecule system,extending its research scope from fundamental physics to real-world applications such as nonlinear optical signal processing and sixth-generation wireless communication.

关键词： switched multimode millimeter

YKL40 potentially via activating the P38 pathway in decreasing atherosclerotic plaque stability

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Chinese Medical Journal 2024年第8期137卷 1003-1005页

作者： Chao Wang yandong Liu Wei Huan Jianjin Wu Jie Jin Sili Zou Yu Chen Lefeng Qu Department of Vascular and Endovascular Surgery Changzheng Hospital Affiliated to the Naval Medical UniversityShanghai 200003China Department of Emergency Navy 905th HospitalShanghai 200050China Clinical Research Institute of Integrative Medicine Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghai 200437China

To the Editor:Atherosclerosis is the main pathological feature of ischemic stroke,which remains a major cause of disability and death worldwide.[1.Vulnerable plaque,was characterized by ulceration,platelet activation,and thrombosis,potentially leading to emboli detachment and stroke.[2]Vascular smooth muscle cells(VSMCs),a major cellular component within lesions,can display pleiotropic phenotypes,including osteogenic or inammatory phenotypes,which may be harmful in maintaining advanced atherosclerotic plaque stability.[3]The modulation of the function of VSMCs,including proliferation,migration,and synthesizing the extracellular matrix(ECM)and matrix metalloproteinase(MMP),is thought to markedly affect plaque formation and vulnerability.[4]Therefore,it is of considerable signicance to drive harmful VSMCs toward VSMCs having benecial properties to strengthen plaque stability and retard plaque development.

关键词： YKL40 markedly stability