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State-of-the-art on resistance of bearing-type bolted connections in high strength steel

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Frontiers of Structural and Civil Engineering 2020年第3期14卷 569-585页

作者： Guoqiang LI Yifan LYU yanbo wang State Key Laboratory for Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China College of Civil Engineering Tongji UniversityShanghai 200092China

With the recent development of material science,high strength steel(HSS)has become a practical solution for landmark buildings and major *** current codes for design of bearing-type bolted connections of steel constructions were established based on the research of conventional *** the mechanical properties of HSS are different from those of conventional steels,more works should be done to develop the appropriate approach for the design of bearing-type bolted connections in HSS.A review of the research carried out on bearing-type bolted connections fabricated from conventional steel and HSS is *** up-to-date tests conducted at Tongji University on four connection types fabricated from three grades of HSS with nominal yield strengths of 550,690,and 890 MPa are *** previous research on failure modes,bearing resistance and the design with consideration of bolt hole elongation are *** is found that the behavior of bolted connections in HSS have no drastic difference compared to that of conventional steel *** the ductility is reduced,plastic deformation capacity of HSS is sufficient to ensure the load redistribution between different bolts with normal construction *** is also found that behavior of each bolt of multi-bolt connections arranged in perpendicular to load direction is almost identical to that of a single-bolt connection with the same end *** connections with bolts arranged in parallel to load direction,the deformation capacity of the whole connection depends on the minimum value between the end distance and the spacing distances in load *** comparison with existing design codes shows that Eurocode3 and Chinese GB50017-2017 are conservative for the design of bolted connections in HSS while AISC 360-16 may overestimate the bearing resistance of bolted connections.

关键词： High strength steel bolted connection bearing behavior design codes

Intrinsic Strengthening of Coherent Twin Boundaries in Copper

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Journal of Materials Science & Technology 2009年第2期25卷 211-214页

作者： Yanfen Luo Yuchen wang yanbo wang Yuanming wang Manling Sui Shenyang National Laboratory for Materials Science （SYNL） Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Molecular dynamics （MD） simulations were applied to simulate the deformation process of copper with different density of parallel coherent twin boundaries （TBs）. It is shown that the strength of perfect copper crystal enhances with increasing coherent TB density. Based on the local hydrostatic pressure analysis, we found that stress concentrations are more likely to form in the interior of the crystal rather than around the TBs. Since the dislocation nucleation is suppressed in the vicinity of the coherent TBs and each TB plane hinders dislocations from propagating, the coherent TBs can be regarded as an intrinsic strengthening phase relative to perfect crystal.

关键词： Twin boundary Dislocation Molecular dynamic simulation

D-tryptophan triggered epithelial-mesenchymal transition by activating TGF-βsignaling pathway

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Food Science and Human Wellness 2022年第5期11卷 1215-1221页

作者： Chong wang Fangting wang yanbo wang Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

D-tryptophan is a special kind of nonprotein amino acid showing multiple physiological functions,but the detailed mechanisms are not fully revealed,impairing its further development and *** work was to investigate D-tryptophan physiological function and demonstrate the underlying mechanisms.D-tryptophan suppressed HaCaT cell proliferation but increased cell ***,D-tryptophan decreased E-cadherin and increased Snail,Twist,and Slug expression,resulting in the development of an epithelial-mesenchymal transitions(EMT)***,D-tryptophan promoted the expression of transforming growth factor-β(TGF-β)1,and Smad4 knockout damages D-tryptophan’s *** results indicated that D-tryptophan stimulated HaCaT cells to produce TGF-β1 and thus activated the TGF-β/Samd pathway,resulting in the triggering of *** study revealed the molecular mechanisms of D-tryptophan activity,provided D-tryptophan as a potential approach for cancer treatment,wound healing,organ development and other relevant applications.

关键词： D-tryptophan Epithelial-mesenchymal transitions Smad4 Transforming growth factor-β

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Site-specific N-glycosylation characterization and allergenicity analysis of globulin-1 S allele from wheat

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Food Science and Human Wellness 2023年第5期12卷 1601-1608页

作者： Linglin Fu Rongrong wang Jinru Zhou Chong wang yanbo wang Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Zhejiang Engineering Research Institute of Food&Drug Quality and Safety School of Management and E-BusinessZhejiang Gongshang UniversityHangzhou 310018China

N-glycans in many proteins are of great concern because of their strong association with food allergies. Triticum aestivum(bread wheat), a major food crop, is known as one of the “Big Eight” allergenic groups. However, little research has been done about N-glycans in wheat glycoproteins. In this study, a soluble wheat glycoprotein was purified from wheat and further identified as globulin-1 S allele(GSA). The wheat GSA displayed significant IgE-binding activity. Moreover, one N-glycosylation site and 6 kinds of N-glycans were identified by mass spectrometry, including 3 high mannose types and 3 complex types. Furthermore, the IgE-binding activity of wheat GSA is proved to be reduced by the removal of N-glycan, thermal treatment(temperatures > 80 ℃), and strong acidic treatment(pH 3.0). These findings would provide a better understanding of the effects of N-glycosylation, thermal treatment, and acidic treatment on the molecular characteristics of GSA, and further provide new insights into the development of hypoallergenic wheat products.

关键词： Triticum aestivum Allergen Glycoprotein N-glycans N-glycosylation C_(18)-RPLC-MS/MS

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Interactions of Phenanthroline Compounds with i-Motif DNA

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Chemical Research in Chinese Universities 2014年第3期30卷 495-499页

作者： GAO Ning wang yanbo WEI Chunying Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular Science Shanxi University Taiyuan 030006 P. R. China

The interactions of each of three phenanthroline derivatives 1, 2 and 3 with the human telomeric/-motif DNA were investigated. The results suggest these compounds are potent binders. The compounds could stabilize the structure of i-motif DNA by π-π stacking. Moreover, the binding constants of the compounds with/-motif DNA were （2.71-8.12）×10^4 L·mol^-1, and the binding stoichiometry ratio was 1：1. CD studies reveal that the binding by phenanthroline comoounds perturbs the conformation of i-motif DNA.

关键词： i-Motif DNA Phenanthroline derivative Interaction

ON DISPLACEMENT OSCILLATION OF VISCOELASTICAL COLLAPSIBLE TUBE

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Journal of Hydrodynamics 1996年第2期8卷 17-26页

作者： Ding, Guanghong Le, Jiachun wang, yanbo Liu, Zhaorong Fudan Univ Shanghai China

The experimental and theoretical model of studying the displacement oscillation of collapsible tube were set up. The governing equations of displacement oscillation was solved by using perturbation theory. A criterion was presented for the prediction on a new type oscillation. Three different regions of flow state were shown. The influence of the flow velocity and wall viscosity on these regions was discussed finally.

关键词： Approximation theory Hydrodynamics Mathematical models Oscillations Viscoelasticity Viscous flow

Centrifugal casting processes of manufacturing in situ functionally gradient composite materials of Al-19Si-5Mg alloy

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Rare Metals 2009年第4期28卷 405-411页

作者： XIE Yong LIU Changming ZHAI yanbo wang Kai LING Xuedong College of Materials Science and Engineering Chongqing University Chongqing 400045 China

Cylindrical components of in situ functionally gradient composite materials of Al-19Si-5Mg alloy were manufactured by centrifugal casting. Microstructure characteristics of the manufactured components were observed and the effects of the used process factors on these characteristics were analyzed. The results of observations shows that, in thickness, the components possess microstructures accumulating lots of Mg2Si particles and a portion of primary silicon particles in the inner layer, a little MgzSi and primary silicon particles in the outer layer, and without any Mg2Si and primary silicon particle in the middle layer. The results of the analysis indicate that the rotation rate of centrifugal casting, mould temperature, and melt pouring temperature have evidently affected the accumulation of the second phase particles. Also, the higher the centrifugal rotation rate, mould temperature, and melt pouring temperature are, the more evident in the inner layer the degree of accumulation of Mg2Si and primary silicon particles is.

关键词： centrifugal casting Al-Si-Mg alloys Mg2Si particles silicon particles functionally gradient composites

A novel AgNPs/MOF substrate-based SERS sensor for high-sensitive on-site detection of wheat gluten

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Food Science and Human Wellness 2024年第2期13卷 681-687页

作者： Linglin Fu Yanzhuo Du Jinru Zhou Huan Li Minzi wang yanbo wang Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Zhejiang Engineering Research Institute of Food&Drug Quality and Safety School of Management and E-BusinessZhejiang Gongshang UniversityHangzhou 310018China Zhejiang Dien Biotech Co. Ltd.Hangzhou 310030China

Gluten,known as the major allergen in wheat,has gained increasing concerns in industrialized countries,resulting in an urgent need for accurate,high-sensitive,and on-site detection of wheat gluten in complex food ***,we proposed a silver nanoparticles(AgNPs)/metal-organic framework(MOF)substrate-based surface-enhanced Raman scattering(SERS)sensor for the high-sensitive on-site detection of wheat *** detection occurred on the newly in-situ synthesized AgNPs/MOF-modified SERS substrate,providing an enhancement factor(EF)of 1.89×10^(5).Benefitting from the signal amplification function of AgNPs/MOF and the superiority of SERS,this sensor represented high sensitivity performance and a wide detection range from 1×10^(-15)mol/L to 2×10^(-6)mol/L with a detection limit of 1.16×10^(-16)mol/L,which allowed monitoring the trace of wheat gluten in complex food system without matrix *** reliable sandwich SERS sensor may provide a promising platform for high-sensitive,accurate,and on-site detection of allergens in the field of food safety.

关键词： Wheat allergy Gluten Surface-enhanced Raman scattering Metal-organic framework DNA recognition

An antifouling polydopamine-based fluorescent aptasensor for determination of arginine kinase

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Food Science and Human Wellness 2023年第3期12卷 737-744页

作者： yanbo wang Huan Li Jinru Zhou Fangting wang Yifan Qian Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Simple yet efficient detection methods for food allergens are in urgent need to help people avoid the risks imposed by allergenic *** this work,a polydopamine(PDA)-based fluorescent aptasensor was developed to detect arginine kinase(AK),one of the major allergens in *** aptamer towards AK was firstly selected via systematic evolution of ligands by exponential enrichment method and labeled with fluorescein amidite(FAM)to build a fluorescence resonance energy transfer(FRET)system with PDA *** glycol(PEG)was employed to construct an antifouling surface for the aptasensor to eliminate food matrix *** the presence of AK,the PDA-based aptasensor exhibited elevated fluorescent signals as the FAM-labeled aptamer bound to AK and detached from the PDA *** aptasensor showed great stability and resistance to nonspecific interference of background proteins and had a limit of detection(LOD)of 0.298μg/*** proposed aptasensor was further proved to be feasible for quantitative analysis of AK in nine species of shrimps and five commercial processed products,which indicated its high potential in tracing the presence of AK in complex aquatic products.

关键词： Food allergy Aptasensor Antifouling Polydopamine FRET effect

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