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Self-assembling peptide nanofibrous hydrogel as a promising strategy in nerve repair after traumatic injury in the nervous system

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Neural Regeneration Research 2016年第5期11卷 717-718页

作者： Na Zhang Liumin he Wutian Wu Guangdong-Hongkong-Macao Institute of CNS Regeneration Jinan University Guangzhou Guangdong Province China School of Biomedical Science LKS Faculty of Medicine the University of Hong Kong Pokfulam Hong Kong Special Administrative Region China State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Pokfulam Hong Kong Special Administrative Region China Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical Engineering College of Life Science and Technology Jinan University Guangzhou Guangdong Province China

Following injury in central nervous system（CNS）,there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial *** pro... 详细信息

关键词： NSCs Self-assembling peptide nanofibrous hydrogel as a promising strategy in nerve repair after traumatic injury in the nervous system RGD

Cooperative effect of polyvinylpyrrolidone and HPMC E5 on dissolution and bioavailability of nimodipine solid dispersions and tablets

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 668-676页

作者： Zhisu Sun Huicong Zhang Huiyang he Lingling Sun Xiaorui Zhang Qun Wang Kexin Li Zhonggui he Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Examination and Certification Center Liaoning InspectionShenyang 110036China

Solid dispersion(SD)systems have been extensively used to increase the dissolution and bioavailability of poorly water-soluble *** circumvent the limitations of polyvinylpyrrolidone(PVP)dispersions,HPMC E5 was applied in the formulation process and scaling-up techniques,*** this study,SD of nimodipine(NMP)and corresponding tablets were prepared through solvent method and fluid bed granulating one step technique,*** dissolution media were used to obtain reliable dissolution ***,the stability study of SDs was investigated with storage under high temperature and humidity ***,the solubility of SDs was measured to explore the effect of *** preparations were characterized by DSC,PXRD,and *** improvements in the dissolution rate of NMP were achieved by the ingenious combination of the two *** NMP/PVP/HPMC-SDs released steadily,while the dissolution of single NMP/PVP-SDs decreased rapidly in *** fluid-bed tablets(FB-T)possessed a similar dissolution behavior to the commercial Nimotop TM *** characterization patterns implied that NMP existed in an amorphous state in our ***,the results of stability tests suggested a better stability of the binary SDs.A special cooperative effect of PVP and HPMC was discovered on dissolution characteristics of NMP SDs and tablets,which could be extended to other drugs ***,the bioavailability of FB-T was evaluated in beagle dogs with Nimotop TM as the reference,and the results showed a higher AUC 0–12h value for FB-T.

关键词： Solid dispersion Nimodipine HPMC E5 Fluid-bed Bioavailability

Engineering organoid microfluidic system for biomedical and health engineering:A review

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Chinese Journal of Chemical Engineering 2021年第2期34卷 244-254页

作者： Yifan Xing Junyu Liu Xiaojie Guo Haipeng Liu Wen Zeng Yi Wang Chong Zhang Yuan Lu Dong he Shaohua Ma Yonghong he Xin-Hui Xing Key Laboratory for Industrial Biocatalysis Ministry of Education of ChinaDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Centre for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Institute of Biopharmaceutical and health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518055China

In recent years,organoid technology,i.e.,in vitro three-dimensional(3D)tissue culture,has attracted increasing attention in biomedical *** are cell complexes induced by differentiation of stem cells or organ-progenitor cells in vitro using 3D culture *** can replicate the key structural and functional characteristics of the target organs in *** the opening up of this new field of health engineering,there is a need for engineering-system approaches to the production,control,and quantitative analysis of organoids and their *** organoid technology has limitations,including lack of physical and chemical microenvironment control,high heterogeneity,complex manual operation,imperfect nutritional supply system,and lack of feasible online analytical technology for the *** introduction of microfluidic chip technology into organoids has overcome many of these limitations and greatly expanded the scope of *** organoid microfluidic system has become an interdisciplinary field in biomedical and health *** this review,we summarize the development and culture system of organoids,discuss how microfluidic technology has been used to solve the main technical challenges in organoid research and development,and point out new opportunities and prospects for applications of organoid microfluidic system in drug development and screening,food safety,precision medicine,and other biomedical and health engineering fields.

关键词： Organoids Stem cell Culture system Microfluidics Biomedical engineering Human health

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SUMS OF MORAN SETS

Approximation Theory and Its Applications 2002年第2期18卷 72-75页

作者： Wang yanbo (PLA University of Sci. & Tech, China) Institute of Communications Engineering PLA University of Sci. & Tech. Nanjing PRC

We find conditions on the dissection of Moran set so that the group it generates under addition has positive Lebesgue measure.

关键词： SUMS OF MORAN SETS

GWAS promotes precision medicine in China

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Journal of Genetics and Genomics 2016年第8期43卷 477-479页

作者： Liangdan Sun Xuejun Zhang Lin he Department of Dermatology No.1 HospitalKey Laboratory of DermatologyMinistry of EducationAnhui Medical UniversityHefei 230032China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China

Most common diseases and genetic traits are associated with multiple genetic and environmental factors as well as conse- quences of their interactions （Chakravarti and Little, 2003;Guttmacher et al., 2004）. In recent years, genetic analyses of human diseases with quantitative traits were primarily focused on identi- fying common variants through genome-wide association studies （GWASs）, and many novel susceptibility genes implicating specific biological pathways have been identified. As of May 2016,

关键词： GWAS promotes precision medicine in China

A Pressure Parametric Dark Energy Model

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Communications in Theoretical Physics 2018年第12期69卷 713-720页

作者： Jun-Chao Wang Xin-he Meng Department of Physics Nankai University

In this paper, we propose a new pressure parametric model of the total cosmos energy components in a spatially flat Friedmann-Robertson-Walker(FRW) universe and then reconstruct the model into quintessence and phantom scenarios, respectively. By constraining with the datasets of the type Ia supernova(SNe Ia), the baryon acoustic oscillation(BAO) and the observational Hubble parameter data(OHD), we find that ?_(m0)=0.270_(-0.034)^(+0.039) at the 1σ level and our universe slightly biases towards quintessence behavior. Then we use two diagnostics including Om(a) diagnostic and statefinder to discriminate our model from the cosmology constant cold dark matter(ΛCDM)model. From Om(a) diagnostic, we find that our model has a relatively large deviation from the ΛCDM model at high redshifts and gradually approaches the ΛCDM model at low redshifts and in the future evolution, but they can be easily differentiated from each other at the 1σ level all along. By the statefinder, we find that both of quintessence case and phantom case can be well distinguished from the ΛCDM model and will gradually deviate from each other. Finally,we discuss the fate of universe evolution(named the rip analysis) for the phantom case of our model and find that the universe will run into a little rip stage.

关键词： dark energy model quintessence phantom Om diagnostic statefinder the rip

Investigation of working pressure on the surface roughness controlling technology of glow discharge polymer films based on the diagnosed plasma

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Plasma Science and Technology 2017年第7期19卷 110-117页

作者： Ling ZHANG Guo CheN Zhibing he Xing AI Jinglin HUANG Lei LIU Yongjian TANG Xiaoshan he Research Center of Laser Fusion China Academy of Engineering Physics

The effects of working pressure on the component, surface morphology, surface roughness, and deposition rate of glow discharge polymer （GDP） films by a trans-2-butene/hydrogen gas mixture were investigated based on plasma characteristics diagnosis. The composition and ion energy distributions of a multi-carbon （CaHs/H2） plasma mixture at different working pressures were diagnosed by an energy-resolved mass spectrometer （MS） during the GDP film deposition process. The Fourier transform infrared spectroscopy （FT-IR）, field emission scanning electron microscope （SEM） and white-fight interferometer （WLI） results were obtained to investigate the structure, morphology and roughness characterization of the deposited films, respectively. It was found that the degree of ionization of the C4H8/H2 plasma reduces with an increase in the working pressure. At a low working pressure, the C-H fragments exhibited small-mass and high ion energy in plasma. In this case, the film had a low CH3/CH2 ratio, and displayed a smooth surface without any holes, cracks or asperities. While the working pressure increased to 15 Pa, the largest number of large-mass fragments led to the deposition rate reaching a maximum of 2.11 #m h-1, and to hole defects on the film surface. However, continuing to increase the working pressure, the film surface became smooth again, and the interface between clusters became inconspicuous without etching pits.

关键词： glow discharge polymer films plasma diagnosis working pressure surfacemorphology surface roughness

Autofluorescence of MDA-modified proteins as an in vitro and in vivo probe in oxidative stress analysis

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Protein & Cell 2014年第6期5卷 484-487页

作者： Qiang, Min Xu, Yajie Lu, Yang he, Yingge Han, Chanshuai Liu, Ying he, Rongqiao Chinese Acad Sci Inst Biophys State Key Lab Brain & Cognit Sci Beijing 100101 Peoples R China Chinese Acad Sci Inst Psychol Key Lab Mental Hlth Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Malondialdehyde （MDA） is regarded as a biomarker for oxidative stress （Del Rio et al., 2005; Stancliffe et al., 2011 ）, and is generated in the oxidative degradation process of polyunsaturated lipids （Stancliffe et al., 2011）. This compound, a reactive electrophile species, contains two aldehyde groups and exhibits cytotoxic effects. As a product of lipid peroxidation, MDA was found to accumulate during many pathophysiological processes （Miller et al., 2011 ）,

关键词： Autofluorescence MDA-modified probe

Magnetically Recoverable PEI/Titanate@Fe_3O_4 Photocatalysts: Fabrication and Photocatalytic Properties

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Journal of Wuhan University of Technology(Materials Science) 2018年第6期33卷 1387-1394页

作者： SUN Dongya he Liwen LIAN Jiqiong XIE An LIN Bizhou Key Laboratory of Functional Materials and Applications of Fujian Province College of Materials Science and Engineering Xiamen University of Technology Fujian Key Laboratory of Photoelectric Functional Materials Huaqiao University

The magnetically separable ternary polyetherimide/titanate@Fe3O4(PTF) photocatalysts of special heterostructure between magnetite(Fe3O4) microspheres and titanates nanosheets modified by polyetherimide(PEI) were successfully fabricated via a simple facile hydrothermal deposition method. The as-prepared photocatalysts were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, Transmission electron microscopy and UV-vis diffuse reflectance spectroscopy etc. The results showed that the as-fabricated material had a structure of Fe3O4microspheres coated with titanates nanosheets modified by PEI. The special interfacial contact between 3 D microsphere and 2 D nanosheets in the nanoarchitectures was formed via electrostatic attraction. Furthermore, the resulted photocatalysts were tested by degradation reaction of methylene blue under visible light irradiation and demonstrated an enhanced performance than the pure Fe3O4microspheres, and the photocatalytic activity enhanced with the molar ratio of Fe3O4microspheres and modified titanate gradually, which was attributed to the expansion of the surface area and the different electrostatic contact between the Fe3O4microspheres and titanate nanosheets. Moreover, the obtained results revealed the high yield magnetic separation and efficient reusability of PTF-5(96.7%) over 3 times reuse.

关键词： Fe3O4 microspheres titanate recyclability polyetherimide photocatalyst