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动物营养学“多模一体化”教学模式改革与实践

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安徽农学通报 2024年第5期30卷 96-99页

作者：赵磊姜宁李雁冰杨伟光郭庆刘东宇李沐阳黑龙江八一农垦大学动物科技学院黑龙江大庆163319 黑龙江省寒区饲料资源高效利用与营养调控重点实验室黑龙江大庆163319

为了适应新时代高等教育人才培养的需要,本文剖析了动物营养学教学实践中教学方法、教学手段和考核方案等环节存在的问题。以“多模一体化”教学模式为培养目标,对动物营养学课程进行实践教学改革与探索,旨在优化传统教学模式,完善课堂... 详细信息

为了适应新时代高等教育人才培养的需要,本文剖析了动物营养学教学实践中教学方法、教学手段和考核方案等环节存在的问题。以“多模一体化”教学模式为培养目标,对动物营养学课程进行实践教学改革与探索,旨在优化传统教学模式,完善课堂教学结构,提升课堂教学质量。

关键词：动物营养学农业院校教学农业人才培养

Evaluation on Spatial Adaptability of Historic Urban Blocks for Commercial Regeneration

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Journal of Building Construction and Planning Research 2020年第3期8卷 203-216页

作者： Guopeng li yanbing li lingxi Wang School of Architecture and Fine Arts Dalian University of Technology Dalian China School of Architecture and Art Hebei University of Architecture Zhangjiakou China

In view of the current situation of aging, functional decline and protection difficulties in historic blocks, the feasibility of commercial regeneration is discussed. Referring to the relevant theories of protection and renewal of historic blocks, field investigation and expert consultation, fuzzy evaluation method and analytic hierarchy process are introduced to carry out a research study on the spatial adaptability of historic blocks for commercial regeneration and establish a preliminary evaluation system. An example of Dongguan Street Historic Block in Dalian is used to test the evaluation system. This provides a basis for the formulation of commercial regeneration strategy in the next stage.

关键词： Historic Block Commercial Regeneration Adaptability Evaluation System

Open Building as a Design Approach for Adaptability in Chinese Public Housing

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World Journal of Engineering and Technology 2019年第4期7卷 598-611页

作者： Guopeng li Zhubin li yanbing li School of Architecture and Fine Arts Dalian University of Technology Dalian China

Surveys on public housing in Northern China indicated that the common aim of Chinese public housing, which is to provide affordable housing, had been mostly satisfied. However, more than one fourth (29.9%) of the public housing units that were investigated were structurally modified by their occupiers for different layouts. This situation indicated that a fixed plan could not fulfill housing occupiers’ various requirements on spacing layout, and critical awareness had been shown that the adaptability of the public housing units was always ignored. Open Building is well organized and implemented in the field of residential area to increase adaptability and sustainability of dwellings. This paper reviewed the development of residential Open Building and attempted to reveal solutions for the design of adaptability in Chinese public housing. Based on the dwelling unit types, dwelling spaces, living modes and demographic conditions of the public housing units were investigated;and concerning the actual carried out adaptations in the public housing units, this research explored two levels of design and control methods: prototyping unit for possible layouts and flexible partitions for space-function reconfiguration. By adding design values of adaptability in public housing, key aspects showing?the potentials and challenges for the design of public housing were summarized for future reference.

关键词： Chinese Public Housing Adaptability Layout Flexible Partition Open Build-ing

Characteristics and mechanism of Ni2+and Cd2+adsorption by recovered perlite from agar extraction residue

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CHINESE JOURNAL OF CHEMICAL ENGINEERING 2024年第8期72卷 141-152页

作者： Wang, Juan Zhu, yanbing Jiang, Zedong Du, Xiping Zheng, Mingjing li, lijun Ni, Hui Wang, Yuanpeng li, Zhipeng li, Qingbiao Jimei Univ Coll Ocean Food & Biol Engn Xiamen 361021 Peoples R China Fujian Prov Key Lab Food Microbiol & Enzyme Engn Xiamen 361021 Peoples R China Res Ctr Food Biotechnol Xiamen City Xiamen 361021 Peoples R China Xiamen Ocean Vocat Coll Xiamen 361012 Peoples R China Xiamen Univ Coll Chem & Chem Engn Xiamen 361021 Peoples R China

Ni2+ and Cd2+ in wastewater accumulated through the ecological chain and could jeopardize human health. Adsorption of Ni2+ and Cd2+ from wastewater using recovered perlite was an important way to solve the problem of resource utilization of solid waste from agar production. Our previous study confirmed that recovered perlite from agar extraction residue had better pore size and specific surface area than commercial perlite. However, the adsorption efficiency and adsorption mechanism of recovered perlite were the main factors limiting its adsorption application. The adsorption process of Ni2+ and Cd2+ by recovered perlite in aqueous solution was described by the pseudo-second-order kinetic equation, and the relevant adsorption mechanism was mainly chemisorption. Compared with commercial perlite, the adsorption removal rate of Ni2+ and Cd2+ by enzymatic recovered perlite could reach 92.9% and 89.2%, respectively, and were improved by 12.63% and 13.03%. Langmuir isothermal adsorption model could better describe the isothermal adsorption process of recovered perlite on heavy metal Ni2+ and Cd2+, and the relevant adsorption mechanism was mainly monolayer adsorption. The X-ray photoelectron spectroscopy (XPS) results indicated that the decrease of Si-O Si2+ hydroxyl coordination bond and the increase of C-Si bond might make the binding effect of recovered perlite with heavy metals stronger. The competitive adsorption of Ni2+ and Cd2+ by recovered perlite was still dominated by chemisorption and monolayer adsorption. This study was expected to provide a theoretical basis and technical support for the removal of Ni2+ and Cd2+ from wastewater using recovered perlite from seaweed residue. (c) 2024 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Agar extraction residue Recovered perlite Heavy metal ion Adsorption property HEAVY-METAL IONS AQUEOUS-SOLUTIONS EXPANDED PERliTE DOPED CARBON ADSORPTION REMOVAL ELECTROCOAGULATION COMPOSITES KINETICS FEATURES

Large-Scale CRISPR Screen of LDLR Pathogenic Variants

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Research 2024年第2期2023卷 213-225页

作者： Mengjing li Lerong Ma Yiwu Chen Jianing li yanbing Wang Wenni You Hongming Yuan Xiaochun Tang Hongsheng Ouyang Daxin Pang Key Lab for Zoonoses Research Ministry of EducationAnimal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin Province 130062China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300071China Chongqing ResearchInstitute Jilin UniversityChongqing 401123China Chongqing Jitang Biotechnology Research Institute Co.Ltd. ChongqingChina

Familial hypercholesterolemia(FH)is a frequently occurring genetic disorder that is linked to early-onset cardiovascular *** left untreated,patients with this condition can develop severe cardiovascular ***,many patients remain undiagnosed,and even when diagnosed,the treatment is often not *** mutations in the LDLR gene are the primary cause of FH,predicting whether novel variants are pathogenic is not a straightforward *** the functionality of LDLR variants is crucial in uncovering the genetic basis of *** study utilized CRISPR/Cas9 cytosine base editors in pooled screens to establish a novel approach for functionally assessing tens of thousands of LDLR variants on a large scale.A total of more than 100 single guide RNAs(sgRNAs)targeting LDLR pathogenic mutations were successfully screened with relatively high *** of these,5 sgRNAs were further subjected to functional verification studies,including 1 in the promoter,1 in the antisense RNA,1 in the exon,and 2 in the *** for the variant caused by the sgRNA located at intron 16,the functionalities of the other LDLR variants were all *** high similarity of LDLR intron sequences may lead to some false ***,these results confirm the reliability of the large-scale screening strategy for functional analysis of LDLR variants,and the screened candidate pathogenic mutations could be used as an auxiliary means of clinical gene detection to prevent FH-induced heart disease.

关键词： LDLR Screen straight

灵孢多糖对过氧化氢致SH-SY5Y细胞凋亡及线粒体功能障碍的调控

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中国组织工程研究 2024年第25期28卷 4041-4047页

作者：李雁冰王记委刘晓琴郭敏芳牛晓洁孟涛苏琴王瀚斌杨立志马存根尉杰忠山西中医药大学神经生物学研究中心/国家中医药管理局益气活血法治疗多发性硬化重点研究室山西省晋中市030619 山西大同大学脑科学研究所山西省大同市037009 山西国润制药有限公司山西省大同市038100 大同市第五人民医院山西省大同市037009

背景:目前研究证实,灵孢多糖可促进神经退行性相关疾病的神经再生。神经退行性疾病的发生与线粒体功能失调密切相关,但灵孢多糖对神经退行性疾病的细胞凋亡及线粒体功能的调控作用尚不明确。目的:探索灵孢多糖对过氧化氢诱导的SH-SY5Y... 详细信息

背景:目前研究证实,灵孢多糖可促进神经退行性相关疾病的神经再生。神经退行性疾病的发生与线粒体功能失调密切相关,但灵孢多糖对神经退行性疾病的细胞凋亡及线粒体功能的调控作用尚不明确。目的:探索灵孢多糖对过氧化氢诱导的SH-SY5Y细胞凋亡及线粒体功能障碍的调控作用及机制。方法:SH-SY5Y细胞分为3组:对照组,过氧化氢组,灵孢多糖组。对照组细胞正常培养,过氧化氢组细胞用300μmol/L过氧化氢处理24 h,灵孢多糖组先用300μg/μL灵孢多糖干预一两个小时,然后加入300μmol/L过氧化氢干预24 h,干预结束后用JC-1试剂盒检测线粒体膜电位,TUNEL染色试剂盒检测细胞凋亡情况,丙二醛试剂盒和超氧化物歧化酶试剂盒检测丙二醛和超氧化物歧化酶活性,免疫荧光染色法和Western blot法检测凋亡、线粒体动力学相关蛋白的表达。结果与结论:①与对照组相比,过氧化氢组线粒体膜电位和超氧化歧化酶活性显著降低,细胞凋亡率、丙二醇水平显著增高,差异均有显著性意义(P<0.05);与过氧化氢组相比,灵孢多糖组线粒体膜电位和超氧化歧化酶活性显著增高,细胞凋亡率、丙二醛水平显著下降,差异均有显著性意义(P<0.05);②与对照组相比,过氧化氢组促凋亡蛋白Bax和Caspase-3的表达显著增加,抗凋亡蛋白Bcl-2的表达显著下降,差异均有显著性意义(P<0.05);与过氧化氢组相比,灵孢多糖组促凋亡蛋白Bax、Caspase-3的表达显著降低,抗凋亡蛋白Bcl-2的表达显著增加,差异均有显著性意义(P<0.05);③与对照组相比,过氧化氢组线粒体分裂蛋白Fis1与线粒体动力学蛋白p-Drp1的表达均显著增高,线粒体融合蛋白OPA1、Mfn1、Mfn2的表达均显著降低,差异均有显著性意义(P<0.05);与过氧化氢组相比,灵孢多糖组线粒体分裂蛋白Fis1与线粒体动力学蛋白p-Drp1的表达显著降低,线粒体融合蛋白OPA1、Mfn1、Mfn2的表达显著增高,差异均有显著性意义(P<0.05);④以上结果证实,灵孢多糖可通过改善线粒体功能障碍以减轻过氧化氢诱导的SH-SY5Y细胞氧化应激损伤和细胞凋亡。

关键词：灵孢多糖 SH-SY5Y细胞细胞凋亡线粒体功能障碍氧化应激

An analysis of the structural design of highway bridges in Mountainous Areas

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International English Education Research 2016年第4期 76-78页

作者： XIN Peng li yanbing Chongqing Jiaotong University Xuefu Road N66 Chongqing China 400074

Considering the characteristics of highway bridges in Mountainous Areas, The design principles of bridge structure design, such as structure form, superstructure, span and substructure, are described, the optimal desi... 详细信息

关键词： Highway in mountain area Bridge Structure design Type of bridge

Analysis on the mechanism and characteristics of concrete strength testing methods

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International English Education Research 2016年第4期 38-40页

作者： li yanbing XIN Peng Chongqing Jiaotong Univercity Xuefu Road N.66 Chongqing China 400074

This paper mainly described five kinds of common detection methods, including the test block method, core drilling method, rebound method, dialing out method and ultrasonic testing method and systematically analyzed the mechanism of all kinds of concrete strength detection methods as well as their advantages and disadvantages, which would provide a guide for construction personnel and research institutions to choose an economical ,accurate and safe detection method.

关键词： concrete strength inspection mechanism characteristics

Detection and Analysis of 1,2-propanediol Content in Whole-crop Silage Corn

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Animal Husbandry and Feed Science 2017年第4期9卷 239-242页

作者： li yanbing li Jingchun Shan Anshan College of Animal Science and Technology Northeast Agricultural University College of Animal Science and Technology Heilongjiang Bayi Agricultural University

[ Objective ] The paper was to investigate the content of 1,2-propanediol in silage feed. [ Method ] Whole-crop corn was stored in laboratory bag silos and outdoor bunker silos. Bag silos were stored for 3, 7, 14, 28, 56 and 120 d, respectively, and fermentation products were analyzed after opening; the fermentation products, which were from three 500 t above-ground outdoor bunker silos stored for 120 d, were detected. Eight sampling points were selected for each bunker silo. [ Result] No 1,2-propanediol was detected out in laboratory bag silos, and lactic acid was dominant in fermentation products. The acetic acid content significantly increased （ P 〈 0.05 ） with the extension of storage time, whereas the acetic acid content was kept below one-third of the lactic acid content ; 1,2-propanediol and a small amount of 1-propanol were detected out in three bunker silos, and lactic acid was dominant in fermentation products, whereas the content of acetic acid was slightly lower than that of lactic acid. The differences in fermentation products from different silos and different sites in silos presented heterogeneity; except to propanediol, lactic acid bacteria and yeast, there was no significant difference in fermentation products at the top and bottom layers of silos （ P 〉0.05 ） ; there were significant differences in contents of lactic acid, acetic acid, 1,2-propanediol, and yeast between the outer and inner parts of silos （P 〈 0.05 ） ; except to pH values and acetic acid, there were significant differences in fermentation products between hunker silos （P 〈0. 05）. [ Conclusion] No 1,2-propanediol is detected out in laboratory bag silos due to relatively simple fermentation products. However, 1,2-propanediol can be detected in the bunker silos due to complex outdoor environment for silage, and the microorganisms producing 1,2-propanediol exist in silos.

关键词： Silage 1,2-propanediol Whole-crop corn Fermentation product Silo