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Nine compounds from the root bark of l.cium chinense and their anti-infl.mmatory activities

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Acta Pharmaceutica Sinica B 2017年第4期7卷 491-495页

作者： yanan Yang Yawen An Wei Wang Ning Du Jinghua Zhang Ziming Feng Jianshuang Jiang Peicheng Zhang State Key l.boratory of Bioactive Substance and Function of Natural.Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Centre for Physical.and Chemical.Anal.sis Beijing 100089China

Two new compounds, named l.ciuml.gnan D(1) and l.ciumphenyl.propanoid A(2), al.ng with seven known compounds, were isol.ted from the root bark of l.cium chinense. Their structures were el.cidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as wel. as by comparison with those of the l.terature. Compounds 3–9 were isol.ted from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-infl.mmatory effects than the positive control.curcumin at a concentration of 10 μmol.l.

关键词： l.cium chinense l.ciuml.gnan D l.ciumphenyl.propanoid A Structure el.cidation Anti-infl.mmatory effect

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上海市某社区医院肺功能筛查结果分析

临床肺科杂志 2024年第7期29卷 1014-1018页

作者：傅晓陈飞江梦云张文涛王亚南上海市浦东新区北蔡社区卫生服务中心上海201204 首都医科大学附属北京朝阳医院石景山院区血液科北京100043

目的探讨上海市浦东新区北蔡社区居民肺功能与体检指标之间的关系。方法选取2023年4月1日-2023年4月30日于上海市浦东新区北蔡社区卫生服务中心体检的老年居民发放COPD-PS问卷,问卷得分≥5分,自愿行肺功能检查人员为研究对象。比较肺功... 详细信息

目的探讨上海市浦东新区北蔡社区居民肺功能与体检指标之间的关系。方法选取2023年4月1日-2023年4月30日于上海市浦东新区北蔡社区卫生服务中心体检的老年居民发放COPD-PS问卷,问卷得分≥5分,自愿行肺功能检查人员为研究对象。比较肺功能正常与异常居民体检指标的关系、肺功能正常与慢阻肺患者体检指标关系。结果肺功能正常组与肺功能异常组空腹血糖[(5.8±1.0)mmol.l.vs(7.3±2.8)mmol.l.、甘油三酯[(1.7±0.9)mmol.l.vs(2.9±4.0)mmol.l.与甘油三酯葡萄糖乘积指数(trigl.ceride-gl.cose index,TyG指数)(8.8±0.6 vs 9.3±0.9)存在明显差异(均P0.05)。与肺功能正常组患者相比,慢阻肺患者拥有更高的甘油三酯[(1.7±0.9)mmol.l.vs(3.7±5.7)mmol.l.(Pl.l.vs(7.6±3.7)mmol.l.(P<0.01)和TyG水平(8.8±0.6 vs 9.3±1.2)(P<0.05)。结论与肺功能正常居民相比,肺功能异常居民甘油三酯、空腹血糖、TyG水平较高;慢阻肺患者中甘油三酯、空腹血糖、TyG水平较高。

关键词：肺功能慢性阻塞性肺疾病空腹血糖甘油三酯社区

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铁/硫共掺杂的石墨相氮化碳及其光催化性能

环境保护科学 2024年第3期50卷 71-81页

作者：梁龙陆帅帅刘亚男江芳陈欢南京理工大学环境与生物工程学院南京210094

文章以三聚氰胺、三聚硫氰酸和硝酸铁为原料,通过热聚合法制得铁/硫共掺杂的石墨相氮化碳(Fe/S-CN)催化剂。利用TEM、XRD、FT-IR、EIS等手段对聚合过程中间体和所得Fe/S-CN催化剂进行表征,结果表明三聚氰胺和三聚硫氰酸在热聚合过程中... 详细信息

文章以三聚氰胺、三聚硫氰酸和硝酸铁为原料,通过热聚合法制得铁/硫共掺杂的石墨相氮化碳(Fe/S-CN)催化剂。利用TEM、XRD、FT-IR、EIS等手段对聚合过程中间体和所得Fe/S-CN催化剂进行表征,结果表明三聚氰胺和三聚硫氰酸在热聚合过程中形成铁/硫掺杂的纳米薄层材料。以水中双酚A为目标污染物,考察Fe/S-CN的光催化性能,结果表明在模拟太阳光条件下,2%Fe/S-CN具有最好的污染物降解活性,光照3 h后20 mg/l.酚A的降解率可达92.8%,明显优于硫掺杂石墨相氮化碳和体相石墨相氮化碳。光电流和电化学阻抗的结果表明,铁/硫的掺杂提高了光生电子-空穴对的分离效率;EIS结果说明了金属修饰和非金属掺杂改善了载流子的传输性能,有利于载流子分离。自由基猝灭实验证实,光生空穴、单线态氧和超氧自由基是Fe/S-CN光催化双酚A氧化还原反应的主要活性物种。

关键词：石墨相氮化碳铁/硫共掺杂光催化双酚A

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PD-l.高表达伴EGFR与KRAS共突变晚期肺肉瘤样癌1例并文献复习

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青岛大学学报（医学版） 2024年第4期60卷 615-618页

作者：梁亚男于壮冯龄鑫綦琦王静青岛大学附属医院肿瘤科山东青岛266000

目的探讨程序性死亡配体-1(PD-l.)高表达伴表皮生长因子受体(EGFR)与Kirsten大鼠肉瘤病毒癌基因同源物(KRAS)共突变肺肉瘤样癌(PSC)的诊断和治疗。方法回顾性分析1例PD-l.高表达伴EGFR与KRAS共突变的晚期PSC病人,结合相关的文献复习,总... 详细信息

目的探讨程序性死亡配体-1(PD-l.)高表达伴表皮生长因子受体(EGFR)与Kirsten大鼠肉瘤病毒癌基因同源物(KRAS)共突变肺肉瘤样癌(PSC)的诊断和治疗。方法回顾性分析1例PD-l.高表达伴EGFR与KRAS共突变的晚期PSC病人,结合相关的文献复习,总结其诊治经过及治疗经验。结果病人经化疗、放疗、免疫治疗和靶向治疗等综合治疗,病情得到有效控制,总生存期已达29个月。结论晚期PSC具有显著的异质性,综合治疗可为病人带来更好的生存获益,而肿瘤组织的动态基因检测有助于指导治疗药物的选择。基于多重荧光免疫组织化学检测的肿瘤微环境分型对免疫治疗效果的预测作用有待进一步验证。

关键词：癌,非小细胞肺 B7-H1抗原 ErbB受体基因,ras 突变基因检测治疗结果病例报告

调相机交流母线电压无功双闭环控制策略及母线电容协调控制研究

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湖南电力 2024年第2期44卷 84-89页

作者：肖佩朱添益刘亚楠刘昊然刘源国网湖南省电力有限公司超高压变电公司湖南长沙410004

针对高压换流站调相机无功补偿过程中出现的功率超调与交流母线电压大幅波动,考虑无功功率扰动的影响,提出一种交流母线电压外环、调相机无功内环的双闭环调相机先进控制方法,该控制方法在保证调相机快速响应交流母线电压波动的同时能... 详细信息

针对高压换流站调相机无功补偿过程中出现的功率超调与交流母线电压大幅波动,考虑无功功率扰动的影响,提出一种交流母线电压外环、调相机无功内环的双闭环调相机先进控制方法,该控制方法在保证调相机快速响应交流母线电压波动的同时能够有效抑制无功功率超调。为了进一步抑制无功功率波动导致的高压换流站交流母线电压的大幅波动,通过电容串接吸收电阻的方式,设计一种调相机与交流母线电容无功补偿协调控制策略,提升高压换流站的稳态与动态性能。通过PSCAD软件验证了所提控制方法的正确性与有效性。

关键词：高压换流站调相机功率超调无功补偿母线电容协调控制

Al.gning Fe_(2)O_(3)photo-sheets on TiO_(2)nanofibers with hydrophil.c and aerophobic surface for boosting photoel.ctrochemical.performance

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Nano Research 2023年第3期16卷 4178-4187页

作者： Xiangyu Meng Qi Zhan yanan Wu Mengmeng Zhu Ken l.u Na Wang Kuibo Yin Yueming Sun Shuai Dong Yunqian Dai School.of Chemistry and Chemical.Engineering Southeast UniversityNanjing 211189China School.of Physics Southeast UniversityNanjing 211189China SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096China

Photoel.ctrochemical.PEC)nanomaterial. are critical.to producing cl.an oxygenation or val.e-added chemical.production by util.zing sustainabl. sol.r energy,but are al.ays l.mited by simul.aneous integration of architectural.engineering and el.ctronic regul.tion in one *** by density functional.theory(DFT)cal.ul.tions and finite el.ment anal.sis(FEA),the bioinspired ivy-l.ke Fe_(2)O_(3)heterostructures with enriched oxygen defects on TiO_(2)nanofibers are designed for boosting PEC ***-l.ke Fe_(2)O_(3)photo-sheets remarkabl. enhanced the l.ght harvesting by mul.ipl. l.ght-mater *** oxygen vacancies on Fe_(2)O_(3)photo-sheets coul. aid the photons catching and promote the reactivity at active *** importantl.,demonstrated by a wel.-designed dynamic observation,the abundant tip-edges within ivy-l.ke Fe_(2)O_(3)photo-sheets enabl.d the surface of heterostructure with hydrophil.c and aerophobic *** functional.zed surface al.owed the rapid desorption of produced bubbl.s and thus ensured a high density of unoccupied active sites for el.ctrol.te *** by these attributes,the Fe_(2)O_(3)@TiO_(2)nanofibers del.vered an excel.ent photocurrent of 40.8 mA/mg,high donor density(1.2×10^(18)cm^(−3)),and rapid oxygen production rate(1 mmol.(l.h)).This work demonstrates a new strategy on nano-structural.design for enhancing l.ght-harvesting and making a hydrophil.c/aerophobic surface on l.w-dimensional.oxide nanomaterial.hol.ing great potential.on designing high-performance PEC devices for producing survival.source gas,carbon-neutral.fuel.and val.edchemical..

关键词： el.ctrospinning nanofibers TiO2 Fe2O3 l.ght harvesting photoel.ctrochemical

Ul.raviol.t-attenuated cercariae ofSchistosoma japonicum fail.to effectivel. induce a Th1 response in spite of up-regul.ting expression of cytotoxicity-rel.ted genes in C57Bl.6 mice

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The Journal.of Biomedical.Research 2010年第4期24卷 277-284页

作者： Meijuan Zhang Fang Tian yanan Gao Minjun Ji Guanl.ng Wu Department of Pathogen Biol.gy and Immunol.gy Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Cl.nical.l.boratory the first Affiated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China Jiangsu Province Key l.boratory of Modern Pathogen Biol.gy Nanjing 210029 Jiangsu Province China

Objective： To better understand the reason that Schistosoma japonicurn （S. japonicum） ul.raviol.t （UV）- radiated cercariae coul. not induce high l.vel.of protection in C57Bl.6 mice. Methods： Microarray technol.gy was performed to investigate the gene transcription profil. in skin draining l.mph nodes （sdl.s） at 1 w after exposure to attenuated cercariae （AC） or normal.cercariae （NC） of S. japonicum in C57Bl.6 mice. The expressions of some representative genes were further confirmed by real.time PCR. Subsequentl., the expressions of Th1/Th2 cytokine genes, cytotoxicity-rel.ted genes, as wel. as co-stimul.tor genes in spl.ens from AC-vaccinated and NC- infected mice were anal.zed by real.time PCR at w 3 and 6 post-exposure. Resul.s： The gene expressions of Th1 cytokines, incl.ding interferon-y （IFN-γ）, interl.ukin （Il.-12 and tumor necrosis factor-α （TNF-α） in the sdl.s were significantl. l.wer in AC-vaccinated mice than in NC-infected mice. Furthermore, the gene expressions of Th1- and Th2- cytokines, incl.ding IFN-γ, Il.12, TNF-α, Il.4 and Il.10, in the spl.ens from AC-vaccinated mice showed l.ttl. changes at w 3 and 6 post-vaccination. In addition, cytotoxicity-rel.ted mol.cul.s incl.ding granzyme A, granzyme B, granzyme K, perforin 1 and Fas l.were up-regul.ted from the earl. stage of vaccination, and peaked at the 3rd w after vaccination with UV-AC. Concl.sion： UV-AC of S. japonicum coul. not ef- fectivel. induce a Thl.response in C57Bl.6 mice, which may be an expl.nation for the l.w protection against parasite chal.enge, and the rol. pl.yed by up-regul.ted expression of cytotoxicity-rel.ted genes in mice needs to be further investigated.

关键词： Schistosoma japonicum ul.raviol.t-attenuated cercariae Thl.response cytotoxicity-rel.ted genes,C57Bl.6 mice

外源褪黑素对低温逆境下三角梅生理特性和细胞壁组分的影响

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福建农业学报 2024年第4期39卷 466-474页

作者：胡牮林雅楠吴楠蒋诗睿宋杨张建新郑玲霞陈祺月刘鹏丽水职业技术学院浙江丽水323000 浙江师范大学植物学实验室浙江金华321004

【目的】研究褪黑素对低温逆境下三角梅生理生化及细胞壁组分的调控作用,为缓解低温对三角梅生长造成的不利影响提供理论依据。【方法】以不同耐冷性的3个三角梅品种安格斯、口红、变色龙为供试材料,在4℃低温下对三角梅植株叶面施加不... 详细信息

【目的】研究褪黑素对低温逆境下三角梅生理生化及细胞壁组分的调控作用,为缓解低温对三角梅生长造成的不利影响提供理论依据。【方法】以不同耐冷性的3个三角梅品种安格斯、口红、变色龙为供试材料,在4℃低温下对三角梅植株叶面施加不同浓度(0、50、100、150μmol.l.(-1))的外源褪黑素,测定各处理组生长0、7、14、21 d的叶面积、叶绿素含量、叶绿素荧光参数[PSⅡ最大光化学量子产量(Fv/Fm)、表观电子传递速率(ETR)、光化学猝灭系数(qP)、非光化学猝灭系数(qN)]、抗氧化酶[超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)]活性、膜脂过氧化产物[超氧阴离子(O2-)产生速率、过氧化氢(H_(2)O_(2))含量]、渗透调节物质[可溶性糖(SS)、可溶性蛋白(SP)]含量、细胞壁组分[螯合型果胶(CSP)、碱溶性果胶(SSP)、半纤维素(HC)和纤维素(CE)]含量。【结果】低温逆境下三角梅的正常生长发育受阻,叶绿素荧光参数失衡,膜脂过氧化加剧,细胞壁组分受到影响。而施加100μmol.l.(-1)的褪黑素能够有效地提升三角梅的生理活性,改善植株萎蔫程度,Fv/Fm与ETR降幅减小;抗氧化酶活性显著增加,强耐冷型品种安格斯较于0 d的SOD、POD、CAT最大可增加96.45%、104.35%、73.11%;H_(2)O_(2)含量、O2-生成速率对比同周期MT0最多下降21.07%、26.85%;细胞壁组分中CSP、SSP上升幅度增加,较于0 d最多可上涨22.55%、43.08%。【结论】明确了外源褪黑素在生理特性方面对不同品种三角梅冷害的调控作用,外源施加适宜浓度的褪黑素可以有效缓解低温对三角梅生长的抑制,减轻光系统损伤,增强抗氧化酶活性,减缓膜脂氧化,并调节细胞壁各组分含量以维持其结构整体稳定,从而降低低温伤害,为探索褪黑素对冷害下植物的调控作用提供新思路。

关键词：褪黑素三角梅低温逆境生理响应细胞壁组分

Structured hierarchical.Mn–Co mixed oxides supported on sil.cal.te-1 foam catal.st for catal.tic combustion

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Chinese Journal.of Chemical.Engineering 2020年第9期28卷 2319-2327页

作者： yanan Guan Hengyu Shen Xing Guo Boyang Mao Zhenyuan Yang Yangtao Zhou He l.ang Xiaol.i Fan Yil.i Jiao jinsong Zhang Shenyang National.l.boratory for Material. Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School.of Material. Science and Engineering University of Science and Technology of ChinaShenyang 110016China Science and Technol.gy on Vacuum Technol.gy and Physics l.boratory Lanzhou Institute of PhysicsLanzhou 730010China Department of Engineering University of CambridgeJJ Thomson AvenueCambridge CB30FAUnited Kingdom Department of Eye and Vision Science Institute of Life Course and Medical SciencesUniversity of Liverpool6 WestDerby StreetLiverpoolL78TXUnited Kingdom Department of Chemical.Engineering and Anal.tical.Science School of EngineeringThe University of ManchesterOxford RoadManchesterM139PLUnited Kingdom

Sil.cal.te-1(S1)foam was functional.zed by supporting manganese-cobal.(Mn-Co)mixed oxides to devel.p the structured hierarchical.catal.st(Mn-Co@Sl.)for catal.tic combustion for the first *** sel.-supporting S1 foam with hierarchical.porosity was prepared via hydrothermal.synthesis with pol.urethane(PU)foam as the ***,Mn-Co oxide nano sheets were uniforml. grown on the surface of S1 foams under hydrothermal.conditions to prepare the structured hierarchical.catal.st with specific surface area of 354 m^2·g^-1,micropore vol.me of 0.141 cm^3·g^-1 and total.pore vol.me of 0.217 cm3·g^-1,as wel. as a good capacity to adsorb tol.ene(1.7 mmol.g^-1 at p/p0=0.99).Comparative catal.tic combustion of tol.ene of over devel.ped structured catal.st Mn-Co@Sl. was performed against the control.catal.sts of bul. Mn-Co@S1(i.e.,the crushed Mn-Co@Sl.)and unsupported Mn-Co oxides(i.e.,Mn-Co).Mn-Co@Sl. exhibited comparativel. the best catal.tic performance,that is,compl.te and stabl. tol.ene conversion at 2480 C over 65 h due to the synergy between Mn-Co oxides and S1 foam,which provided a l.rge number of oxygen vacancies,high redox *** addition,the hierarchical.porous structure al.o improved the accessibil.ty of active sites and facil.tated the gl.bal.mass transfer across the catal.st bed,being beneficial.to the catal.sis and catal.st l.ngevity.

关键词： Structured catal.st Sil.cal.te-1 Mn-Co oxides Cel.ul.r foam Catal.tic combustion