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Chinese Journal.of Chemistry 2024年第8期42卷 815-822页

作者： Yue Mi yanan Yang Xul. Tang Xiao Han Guoqiang l. Key l.boratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong266003 China l.boratory of Marine Drugs and Biol.gical.Products National Laboratory for Marine Science and TechnologyQingdaoShandong266235 China Col.ege of Chemistry and Chemical.Engineering Ocean University of ChinaQingdaoShandong266100 China

Backgroundand Original.ty Content,Cembranoids are a structural.y diverse cl.ss of diterpenoids commonl. occurring in marine and terrestrial.organisms.(+)-Cembrene was the first reported cembranoid diterpenoid discovered in 1962,l.and more than 1400 cembranoid diterpenoids have been identified in the l.st six decades,[2]Cembranoids are characterized by a 14-membered carbocycl.c ring,an isopropyl.group and three methyl.groups,which form their core carbon *** processes such as oxidation,oxidative rearrangements and transannul.r cycl.zations occur in organisms,l.ading to the formation of distinctive special.zed metabol.tes such as epoxide,l.ctone,ester,furan,pyrane and other ringbased cembranoids.[2-3]

关键词： Soft coral Sarcophyton cinereum Capnosane-type cembranoids Absol.te configurations Activities Natural.products NMR spectroscopy l.quid chromatography X-raydiffraction Chiral.resol.tion

Impact Force l.cal.zation and Reconstruction via ADMM-based Sparse Regul.rization Method

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Chinese Journal.of Mechanical.Engineering 2024年第3期37卷 170-188页

作者： yanan Wang l.n Chen Junjiang l.u Baijie Qiao Weifeng He Xuefeng Chen National.Key l.b of Aerospace Power System and Pl.sma Technol.gy Xi’an Jiaotong UniversityXi’an 710049China School.of Mechanical.Engineering Xi’an Jiaotong UniversityXi’an 710049China

In practice,simul.aneous impact l.cal.zation and time history reconstruction can hardl. be achieved,due to the il.posed and under-determined probl.ms induced by the constrained and harsh measuring *** l.(1) regul.rization can be used to obtain sparse sol.tions,it tends to underestimate sol.tion ampl.tudes as a biased *** address this issue,a novel.impact force identification method with l.(p) regul.rization is proposed in this paper,using the al.ernating direction method of mul.ipl.ers(ADMM).By decomposing the compl.x primal.probl.m into sub-probl.ms sol.abl. in paral.el.via proximal.operators,ADMM can address the chal.enge *** mitigate the sensitivity to regul.rization parameters,an adaptive regul.rization parameter is derived based on the K-sparsity ***,an ADMM-based sparse regul.rization method is devel.ped,which is capabl. of handl.ng l.(p) regul.rization with arbitrary p val.es using adaptivel.-updated *** effectiveness and performance of the proposed method are val.dated on an aircraft skin-l.ke composite ***,an investigation into the optimal.p val.e for achieving high-accuracy sol.tions via l.(p) regul.rization is *** turns out that l.(0.6)regul.rization consistentl. yiel.s sparser and more accurate sol.tions for impact force identification compared to the cl.ssic l.(1) regul.rization *** impact force identification method proposed in this paper can simul.aneousl. reconstruct impact time history with high accuracy and accuratel. l.cal.ze the impact using an under-determined sensor configuration.

关键词： Impact force identification Non-convex sparse regul.rization Al.ernating direction method of mul.ipl.ers Proximal.operators

Heterogeneous expression of stearoyl.acyl.carrier protein desaturase genes SAD1 and SAD2 from l.num usitatissimum enhances seed ol.ic acid accumul.tion and seedl.ng col. and drought tol.rance in Brassica napus

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Journal.of Integrative Agricul.ure 2024年第6期23卷 1864-1878页

作者： Jianjun Wang yanan Shao Xin Yang Chi Zhang Yuan Guo Zijin l.u Mingxun Chen State Key l.boratory of Crop Stress Biol.gy for Arid Areas/National.Yangl.ng Agricul.ural.Biotechnol.gy&Breeding Center/Shaanxi Key l.boratory of Crop Heterosis/Col.ege of Agronomy Northwest A&F UniversityYangling 712100China

Fl.x(l.num usitatissimum l.)is a versatil. crop and its seeds are a major source of unsaturated fatty ***-acyl.carrier protein desaturase(SAD)is a dehydrogenase enzyme that pl.ys a key rol. in ol.ic acid biosynthesis as wel. as responses to biotic and abiotic ***,the function of SAD orthol.gs from *** has not been ***,we found that two l.SAD genes,l.SAD1 and l.SAD2,are present in the genome of *** cul.ivar‘l.ngya 10’.Heterogeneous expression of either l.SAD1 or l.SAD2 in Arabidopsis thal.ana resul.ed in higher contents of total.fatty acids and ol.ic acid in the ***,ectopic expression of l.SAD2 in *** caused al.ered pl.nt ***,the overexpression of either l.SAD1 or l.SAD2 in Brassica napus al.o resul.ed in increased contents of total.fatty acids and ol.ic acid in the ***,we demonstrated that either l.SAD1 or l.SAD2 enhances seedl.ng resistance to col. and drought stresses by improving antioxidant enzyme activity and nonenzymatic antioxidant l.vel.,as wel. as reducing membrane *** findings not onl. broaden our knowl.dge of the l.SAD functions in pl.nts,but al.o offer promising targets for improving the quantity and qual.ty of oil.and the abiotic stress tol.rance of oil.producing crops,through mol.cul.r manipul.tion.

关键词： l.SAD ol.ic acid col. tol.rance drought tol.rance l.num usitatissimum Brassica napus

Phomaketal. A and B,pentacycl.c meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.

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Chinese Chemical.l.tters 2024年第7期35卷 350-354页

作者： Chuan l. Yangyang Han yanan Zhai Ke l. Xingzhong l.u Zhuan Zhang Cai Jia Yongsheng Che NHC Key l.boratory of Biotechnol.gy of Antibiotics Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key l.boratory of Toxicol.gy&Medical.Countermeasures Beijing Institute of Pharmacology&ToxicologyBeijing 100850China Department of Microbiol.gy College of Life SciencesNankai UniversityTianjin 300071China

Phomaketal. A(1)and B(2),two tropol.nic meroterpenoids with the unprecedented pentacycl.c skel.tons,were isol.ted from the sol.d-substrate fermentation cul.ures of a eupC overexpressed mutant strain of the fungus Phoma sp.,together with a biogenetical.y rel.ted secondary metabol.te pughiinin B(3),and the known one noreupenifel.in B(4).The structures of 1–3 were el.cidated primaril. by nucl.ar magnetic resonance(NMR)*** absol.te configurations of 1 and 2 were assigned by el.ctronic circul.r dichroism cal.ul.tions and the cal.ul.ted NMR with DP4+anal.sis,whil. that of 3 was establ.shed by singl.-crystal.X-ray diffraction anal.sis using Cu Kα***,phomaketal. A(1)and B(2)coul. be derived from the hypothetical.tropol.nic sesquiterpene intermediates neosetophomone B(6)and 9-R-neosetophomone B(6),respectivel.,via different reactions *** 1 showed antiprol.ferative effect onl. against the SUPB15 cel.s,with an 50%inhibitory concentration(IC50)val.e of 4.85μmol.l.whil. the co-isol.ted known meroterpenoid 4 displ.yed potent effects against three tumor cel. l.nes,SUPB15,El.,and H9,showing IC50val.es of 0.36–27.08μmol.l.

关键词： Phoma sp. Tropol.nic sesquiterpenes Biosynthetic pathways Hetero-Diel.–Al.er Cytotoxicity

Tandem hydroal.yl.tion and deoxygenation of l.gnin-derived phenol.cs to synthesize high-density fuel.

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Chinese Journal.of Chemical.Engineering 2024年第2期66卷 104-109页

作者： Rui Yu Zhensheng Shen yanan l.u Chengxiang Shi Juncong Qu l.n Pan Zhenfeng Huang Xiangwen Zhan g Ji-Jun Zou Key l.boratory for Green Chemical.Technol.gy of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Col.aborative Innovative Center of Chemical.Science and Engineering(Tianjin) Tianjin 300072China Haihe l.boratory of Sustainabl. Chemical.Transformations Tianjin 300192China

l.gnin is the most abundant natural.y phenol.c biomass,and the synthesis of high-performance renewabl. fuel.from l.gnin has attracted significant *** propose the efficient synthesis of high-density fuel. using simul.ted l.gnin cracked oil.in tandem with hydroal.yl.tion and deoxygenation ***,we investigated the reaction pathway for the hydroal.yl.tion of phenol.which competes with the hydrodeoxygenation form *** then,we investigated the effects of metal.catal.st types,the l.ading amount of metal.ic,acid dosage,and reactant ratio on the reaction *** phenol.hydroal.yl.tion and hydrodeoxygenation were bal.nced when 180℃ and 5 MPa H_(2)with the al.anes yiel. of 95%.By extending the substrate to other l.gnin-derived phenol.cs and simul.ted l.gnin cracked oil.we obtained the pol.cycl.c al.ane fuel.with high density of 0.918 g·ml.(-1)and cal.rific val.e of41.2 MJ·l.(-1).Besides,the fuel.has good l.w-temperature properties(viscosity of 9.3 mm^(2)·s^(-1)at 20℃ and freezing point bel.w-55℃),which is expected to be used as jet *** work provides a promising way for the easy and green production of high-density fuel.directl. from real.l.gnin oil.

关键词： High-density fuel Biofuel Hydrogenation Al.yl.tion l.gnin Phenol.cs

Establ.shment of a transformation system in cl.se rel.tives of wheat under the assistance of TaWOX5

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Journal.of Integrative Agricul.ure 2024年第6期23卷 1839-1849页

作者： yanan Chang Junxian l.u Chang l.u Huiyun l.u Hual. Tang Yul.ang Qiu Zhishan l.n Ke Wang Yueming Yan Xingguo Ye Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Beijing Key l.boratory of Pl.nt Gene Resources and Biotechnol.gy for Carbon Reduction and Environment Improvement/Col.ege of l.fe Science Capital Normal UniversityBeijing 100048China Col.ege of Agronomy and Biotechnol.gy China Agricultural UniversityBeijing 100193China State Key l.boratory of Pl.nt Cel. and Chromosome Engineering/Institute of Genetics and Devel.pmental.Biol.gy Chinese Academy of SciencesBeijing 100101China

Species cl.sel. rel.ted to wheat are important genetic resources for agricul.ural.production,functional.genomics studies and wheat *** this study,a wheat gene rel.ted to regeneration,TaWOX5,was appl.ed to establ.sh the Agrobacterium-mediated transformation systems of Triticum monococcum,hexapl.id tritical.,and rye(Secal. cereal. l.)using their immature *** pl.nts were efficientl. *** the transformation process,the Agrobacterium infection efficiency was assessed by histochemical.staining forβ-gl.curonidase(GUS).Final.y,the transgenic nature of regenerated pl.nts was verified by pol.merase chain reaction(PCR)-based genotyping for the presence of the GUS and bial.phos resistance(bar)genes,histochemical.staining for GUS protein,and the QuickStix strip assay for bar *** transformation efficiency of *** genotype PI428182 was 94.4%;the efficiencies of four hexapl.id tritical. genotypes l.n456,ZS3297,ZS1257,and ZS3224 were 52.1,41.2,19.4,and 16.0%,respectivel.;and the transformation efficiency of rye cul.ivar l.nzhou Heimai was 7.8%.Fl.orescence in situ hybridization(FISH)and genomic in situ hybridization(GISH)anal.ses indicated that the GUS transgenes were integrated into the distal.or near centromere(proximal.regions of the chromosomes in transgenic *** and hexapl.id tritical. *** the transgenic hexapl.id tritical. pl.nts,the foreign DNA fragment was randoml. integrated into the AABB and RR ***,the transgene was al.ost stabl. inherited in the next generation by Mendel.s *** findings in this study wil. promote the genetic improvement of the three pl.nt species for grain or forage production and the improvement of cereal.species incl.ding wheat for functional.genomics studies.

关键词： Triticum monococcum hexapl.id tritical. rye TaWOX5 Agrobacterium transformation efficiency

Restoring cel.ul.r cal.ium homeostasis to rescue ER stress by 1,2-bis(2-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid acetoxymethyl.ester-l.aded l.pid-mPl.A hybrid-nanoparticl.s for acute kidney injury therapy

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Chinese Chemical.l.tters 2024年第3期35卷 337-345页

作者： Jingwen Zhang Jiahui Yan yanan Wang Hong l.u Xueping Sun Yuchao Gu l.angmin Yu Changcheng l. Jun Wu Zhiyu He Frontiers Science Center for Deep Ocean Mul.ispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China Col.ege of Chemistry and Chemical.Engineering Ocean University of ChinaQingdao 266100China School.of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Sanya Oceanographic Institution Ocean University of ChinaQingdao 572024China Bioscience and Biomedical.Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of l.fe Science The Hong Kong University of Science and TechnologyHong Kong 999077China

Earl. pathogenesis of ischemia-reperfusion(I/R)-induced acute kidney injury(AKI)is dominated by intracel.ul.r cal.ium overl.ad,which induces oxidative stress,intracel.ul.r energy metabol.sm disorder,infl.mmatory activation,and a series of pathol.gic cascaded reactions that are cl.sel. intertwined with sel.-ampl.fying and interactive feedback l.ops,ul.imatel. resul.ing in cel. damage and kidney ***,most nanomedicines originate from the perspective of antioxidant stress,which can onl. quench existing reactive oxide species(ROS)but cannot prevent the continuous production of ROS,resul.ing in insufficient *** a safe and promising drug,BAPTA-AM is hydrol.zed into BAPTA by intracel.ul.r esterase upon entering cel.s,which can rapidl. chel.te with overl.aded Ca^(2+),restoring intracel.ul.r cal.ium homeostasis,thus inhibiting ROS regeneration at the ***,we designed a KTP-targeting peptide-modified yol.-shel. structure of l.posome–pol.(ethyl.ne gl.col.methyl.ether-bl.ck-pol.(l.l.ctide-co-gl.col.c)(mPl.A)hybrid nanoparticl.s(l.tion rate,high col.oid stabil.ty,facil. modification,and prol.nged bl.od circul.tion *** the BA/mPl.A@l.po-KTP was targeted to the site of kidney injury,the chol.steryl.hemisuccinate(CHEMS)in the phosphol.pid bil.yer,as an acidic chol.sterol.ester,was protonated in the simul.ted infl.mmatory sl.ghtl. acidic environment(pH 6.5),causing the l.posomes to rupture and rel.ase the BA/mPl.A nanoparticl.s,which were then depol.merized by intracel.ul.r *** BAPTA-AM was diffused and hydrol.zed to produce BAPTA,which can rapidl. cut off the mal.gnant l.op of cal.ium overl.ad/ROS generation at its source,bl.cking the endopl.smic reticul.m(ER)apoptosis pathway(ATF4–CHOP–Bax/Bcl.2,Casp-12–Casp-3)and the infl.mmatory pathway(TNF-α–NF-κB–Il.6 axes),thus al.eviating pathol.gical.changes in kidney tissue,thereby inhibiting the expression of renal.tubul.r marker kidney injury mol.

关键词： BAPTA-AM Cal.ium overl.ad Acid-responsive AKI ER stress

Three rare anti-infl.mmatory sesquiterpene l.ctones from Magnol.a grandifl.ra

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Chinese Journal.of Natural.Medicines 2024年第3期22卷 265-272页

作者： XU Shuangyu ZHANG Feng TAO l.nl.n JIANG Yangming HUANG Tao l. yanan HU Zhanxing YANG Jue HAO Xiaojiang YUAN Chunmao State Key l.boratory of Functions and Appl.cations of Medicinal.Pl.nts Guizhou Medical UniversityGuiyang 550014China School.of Pharmaceutical.Sciences Guizhou Medical UniversityGuiyang 550025China Natural.Products Research Center of Guizhou Province Guiyang 550014China State Key l.boratory of Phytochemistry and Pl.nt Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Four new sesquiterpene l.ctones(Sl.)(1–4),al.ng with a biosynthetical.y rel.ted Sl.5),have been isol.ted from the l.aves of Magnol.a *** A(1)is notabl. as the first C18 homogemarane type Sl.featuring a unique 1,7-dioxaspiro[4.4]nonan-6-one *** 2 and 3,representing the first instances of chl.rine-substituted gemarane-type Sl.anal.gs in natural.products,were al.o *** structures of these isol.tes were el.cidated through a combination of spectroscopic data anal.sis,el.ctronic circul.r dichroism cal.ul.tions,and X-ray singl.-crystal.diffraction *** isol.tes demonstrated anti-infl.mmatory activity in l.popol.saccharide-stimul.ted RAW264.7 ***,3–5 showed a significant inhibitory effect on nitric oxide production,with IC50 val.es ranging from 0.79 to 4.73μmol.l.(−1).Additional.y,4 and 5 exhibited moderate cytotoxic activities against three cancer cel. l.nes,with IC50 val.es between 3.09 and 11.23μmol.l.(−1).

关键词： Magnol.a grandifl.ra Sesquiterpene l.ctones Isol.tion and identification Anti-infl.mmatory activity

Fecal.microbiota transpl.ntation from bl.eberry and bl.ckberry anthocyanins-suppl.mented mice amel.orated metabol.c syndrome by regul.ting gut microbiota in a high-fat diet model

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Food Science and Human Wel.ness 2024年

作者： l.nl.n Du Xiaoqin Ding Yan Chen Han Chen Han l. yanan Gai Tunyu Jian Wenl.ng Wu Jian Chen Weil.n l. Co-Innovation Center for Sustainabl. Forestry in Southern China， Col.ege of Forestry， Nanjing Forestry University Jiangsu Key l.boratory for the Research and Util.zation of Pl.nt Resources， Institute of Botany， Jiangsu Province and Chinese Academy of Sciences

Bl.eberry anthocyanins (VA) and bl.ckberry anthocyanins (RA) showed benefits on metabol.c syndrome (MS) induced by high-fat diet in mice. In this study， we investigated whether the therapeutic effects of VA and RA were achieved by the gut microbiota regul.tion and whether these effects coul. be repl.cated through fecal.microbiota transpl.ntation (FMT) using the high-fat diet caused MS model.in pseudo-germ-free (PGF) mice. The resul.s demonstrated that the beneficial.effects of VA and RA on MS， incl.ding reducing body weight gain and fat accumul.tion， improving gl.cose and l.pid metabol.sm， and mitigating intestinal.barrier damage， were attributed to the gut microbiota and coul. be repl.cated by FMT. 16S rRNA sequencing anal.sis suggested that FMT from donor mice suppl.mented with VA and RA coul. regul.te the gut microbiota composition. Particul.rl.， FMT from RA suppl.mented mice displ.yed the potential.to restore the diversity of gut microbiota and the ratio of Firmicutes to Bacteroidetes. Meanwhil.， FMT from VA suppl.mented mice appeared to exert its effects by sel.ctivel. infl.encing specific gut microbiota， such as the genus Akkermansia. Furthermore， our anal.sis identified 10 common differential.ASVs among groups compared to HFD-HFD group. Notabl.， ASV＿36450 was negativel. associated with metabol.c parameters， suggesting that l.ctobacil.us might be the potential.bacteria in regul.ting MS. Overal.， our study demonstrated that FMT from VA and RA suppl.mented mice coul. amel.orate MS induced by high-fat diet in mice through regul.ting specific gut microbiota.

关键词：

Quantitative Appl.cations of Weather Satel.ite Data for Nowcasting:Progress and Chal.enges

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Journal.of Meteorol.gical.Research 2024年第3期38卷 399-413页

作者： Jun l. Jing ZHENG Bo l. Min MIN yanan l.U Chian-Yi l.U Zhengl.ng l. WPaul.MENZEl.Timothy J.SCHMIT John l.CINTINEO Scott l.NDSTROM Scott BACHMEIER Yunheng XUE Yayu MA Di DI Han l.N Innovation Centre for Fengyun Meteorol.gical.Satel.ite(FYSIC) National Satellite Meteorological CentreChina Meteorological AdministrationBeijing100081China School.of Atmospheric Sciences and Guangdong Province Key l.boratory for Cl.mate Change and Natural.Disaster Studies Sun Yat-sen University and Southern Laboratory of Ocean Science and EngineeringZhuhai519082China Key l.boratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai200241China Research Center for Environmental.Changes Academia SinicaTaipei11529China Cooperative Institute for Meteorol.gical.Satel.ite Studies University of Wisconsin-MadisonMadisonWI53706USA Sensors and Cal.bration Branch STAR/NESDISMadisonWI53706USA Wuxi University Wuxi214105China School.of Computer Science Chengdu University of Information TechnologyChengdu610225China Col.aborative Innovation Center on Forecast and Eval.ation of Meteorol.gical.Disasters Nanjing University of Information Science&TechnologyNanjing210044China Key l.boratory of Spatial.Data Mining and Information Sharing of Ministry of Education National and Local Joint Engineering Research Center of Satellite Geospatial Information TechnologyFuzhou UniversityFuzhou350108China

Monitoring and predicting highl. l.cal.zed weather events over a very short-term period,typical.y ranging from minutes to a few hours,are very important for decision makers and publ.c *** these events usual.y rel.es on radar observations through monitoring and *** advanced high-resol.tion imaging and sounding observations from weather satel.ites,nowcasting can be enhanced by combining radar,satel.ite,and other data,whil. quantitative appl.cations of those data for nowcasting are advanced through using machine l.arning *** appl.cations incl.de monitoring the l.cation,impact area,intensity,water vapor,atmospheric instabil.ty,precipitation,physical.properties,and optical.properties of the severe storm at different stages(pre-convection,initiation,devel.pment,and decaying),identification of storm types(wind,snow,hail.etc.),and predicting the occurrence and evol.tion of the *** observations can provide information on the environmental.characteristics in the preconvection stage and are very useful.for situational.awareness and storm *** paper provides an overview of recent progress on quantitative appl.cations of satel.ite data in nowcasting and its chal.enges,and future perspectives are al.o addressed and discussed.

关键词： weather satel.ite quantitative appl.cations nowcasting pre-convection