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Moxibustion of Zusanli(ST36)and Shenshu(BL23)alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling

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Journal of Traditional Chinese Medicine 2024年第2期44卷 353-361页

作者： ZHANG Linlin ZHONG Yumei LU Wenting shang yanan GUO Yanding LUO Xiaochao CHEN Yang LUO Kun HU Danhui YU Huiling ZHOU Haiyan Acupuncture and Moxibustion College Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Painology First People's Hospital of ChengduChengdu 610095China Chinese Evidence-Based Medicine Centre West China HospitalSichuan UniversityChengdu 610044China Traditional Chinese Medicine College Chongqing Medical UniversityChongqing 400016China External treatment center First People's Hospital of ChengduChengdu 610095China

OBJECTIVE:To test the hypothesis that moxibustion may inhibit rheumatoid arthritis(RA)synovial inflammation by regulating the expression of macrophage migration inhibitory factor(MIF)/glucocorticoids(GCs).METHODS:Fifty male Sprague-Dawley rats were randomly divided into five groups(n=10 each):blank Control(CON)group,RA Model(RA)group,Moxibustion(MOX)group,MIF inhibitor(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester(ISO-1)group,and Moxibustion+MIF inhibitor ISO-1(MOX+ISO-1)group.Rats in the ISO-1 group and ISO-1+MOX group were intraperitoneally injected with the inhibitor ISO-1.The rats in the RA group,ISO-1 group,MOX group,and ISO-1+MOX group were injected with Freund's complete adjuvant(FCA)in the right hind footpad to establish an experimental RA rat model.In the MOX group and MOX+ISO-1 group,rats were treated with Moxa.The thickness of the footpads of the rats in each group was measured at three-time points before,after modeling and after moxibustion treatment.The contents of serum MIF,corticosterone(CORT),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were detected by enzyme-linked immunosorbent assay;and the contents of synovial MIF were detected by Western blot.Hematoxylin-eosin(HE)staining method was used to observe the pathological changes of synovial tissue under a section light microscope,and pathological scoring was performed according to the grading standard of the degree of synovial tissue disease.RESULTS:Moxibustion was found to reduce the level of MIF and alleviate inflammation in RA rats in this study.In addition,after inhibiting the expression of MIF,the level of CORT increased,and the level of TNF-α decreased.Treating RA rats with inhibited MIF by moxibustion,the level of CORT was almost unchanged,but the level of TNF-α further decreased.The correlation analysis data suggested that MIF was positively related to the expression of TNF-α and negatively correlated with the expression of CORT.CONCLUSION:Reducing MIF to increase CORT and decrease TNF-α by moxibustion

关键词： rheumatoid arthritis macrophage migration inhibitory factor moxibustion corticosterone glucocorticoids

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Stability and regeneration of metal catalytic sites with different sizes in Fenton-like system

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中国化学快报:英文版 2023年第8期34卷 142-146页

作者： yanan shang Yujiao Kan Xing Xu School of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China School of Environmental Science and Engineering Shandong UniversityQingdao 266237China

Metal-based catalysts with different site sizes(e.g.,metal nanoparticles(NPs)and single atom catalysts(SACs))demonstrated outstanding catalytic activities in versatile Fenton-like reactions.However,the surface/structural instability is a critical issue,which will result in rapid passivation in Fenton-like reaction and fail in long-term operation.The catalytic stability of the catalysts with different metal sizes considering versatile peroxides(H_(2)O_(2),peroxymonosulfate(PMS),and peroxodisulfate(PDS))should be analyzed.In addition,strategies for catalyst regeneration and recyclability improvement are also important to realize the metal-based catalysts for practical applications.In this review,catalytic stability of catalysts with different metal sizes in the backgrounds of versatile peroxides and water matrixes in Fenton-like reactions were first evaluated.Regeneration of metal catalytic sites with different methods were also reviewed.Finally,major challenges and development of methods concerning the stability and regeneration of metal catalytic sites with different sizes were discussed to understand the future researches of metal catalytic sites in Fenton-like reactions.

关键词： Size effect Metal nanoparticles catalysts Single atom catalysts Fenton-like

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Carbon-based single atom catalyst: Synthesis, characterization, DFT calculations

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Chinese Chemical Letters 2022年第2期33卷 663-673页

作者： yanan shang Xiaoguang Duan Shaobin Wang Qinyan Yue Baoyu Gao Xing Xu Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityJi’nan 250100China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Carbon-based single-atom catalysts(SACs) with atomic sizes of active sites have become the promising candidates for a variety of catalytic systems because of their high atom utilization, and unique electronic structures. Different types of single-atom sites can be fabricated via multiple preparation strategies, which would demonstrate distinct different coordination configurations and electronic features, and ultimately affected the structure-catalysis relationship of SACs in targeted reactions. As a result, it is necessary to identify the active sites of SACs and understand the structure-catalysis relationship of SACs at the atomic scale. In this review, a variety of preparation strategies of carbon-based SACs were documented. Then, the recent development on versatile characterization techniques and computational achievements were summarized regarding in understanding the electronic and geometric characteristics of carbon-based SACs.Finally, major challenges and development directions concerning single-atom sites identification and advanced tools development are discussed to shed light on future research of carbon-based SACs.

关键词： Single atom Synthesis DFT calculations Characterization Catalysis

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Study on the anti-inflammatory mechanism of moxibustion in rheumatoid arthritis in rats based on phospholipaseA2 signaling inhibition by Annexin 1

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Journal of Traditional Chinese Medicine 2024年第4期 753-761页

作者： GUO Yanding LUO Kun ZHANG Linlin LU Wenting shang yanan ZHONG Yumei HU Danhui YANG Xin ZHOU Haiyan Department of Acupuncture-Moxibustion and Tuina the Third Affiliated HospitalChengdu University of Traditional Chinese Medicine External Treatment Center First People's Hospital of Chengdu Department of Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital Department of Health Rehabilitation School Chengdu University of Traditional Chinese Medicine

OBJECTIVE: To determine whether moxibustion had an anti-inflammatory effect on rheumatoid arthritis(RA) by regulating Annexin 1 expression and interfering with the phospholipaseA2 signaling pathway. METHODS: Thirty male Sprague-Dawley rats were randomly categorized into five groups(six rats per group): blank control(CON) group, RA model(RA) group, moxibustion(MOX) group, Annexin 1 lentiviral intervention(RNAi-Anxa1) group, and Annexin 1 lentiviral intervention + moxibustion(RNAi-Anxa1 + MOX) group. The rats in the RNAi-Anxa1 and the RNAi-Anxa1 + MOX groups were injected with the lentiviral vector-mediated RNAi-Anxa1 into the rat foot pad. An experimental RA rat model was established by injecting Freund's complete adjuvant(FCA) into the RA, MOX, RNAi-Anxa1, and RNAi-Anxa1 + MOX groups. Rats in the MOX and RNAiAnxa1 + MOX groups received moxibustion treatment. After modeling, using moxibustion “Shenshu(BL23)” and “Zusanli(ST36)”, each point is 5 times, bilateral alternating, once a day, 6 times for a course of treatment, between the courses of rest for a one day. A total of three treatment courses were conducted. Both bilateral pad thicknesses were measured using Vernier calipers on experimental days 1, 7, 14, 21, and 28. The expression of cPLA2α signaling in the synovium of diseased joints was observed using Western blot. The pathology of the rat ankle synovium was observed using hematoxylineosin(HE) staining. Interleukin(IL)-1β, IL-10, prostaglandin E2(PGE2), and leukotriene B4(LTB4) were detected using enzyme-linked immunosorbent assay. RESULTS: Moxibustion increased the levels of Annexin 1 and decreased the inflammatory response in rats with RA. After increasing the expression of Annexin 1, the phosphorylated expression of cPLA2α was inhibited, the serum levels of IL-1β, PGE2, and LTB4 decreased, and the level of IL-10 increased. In moxibustion treated RA rats after the Annexin 1 lentiviral intervention, the serum levels of IL-1β, PGE2, LTB4, and IL-10 were almost unchanged. CONCLUSION: Moxibustion enhanced the

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Machine learning and microstructure design of polymer nanocomposites for energy storage application

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High Voltage 2022年第2期7卷 242-250页

作者： Yu Feng Wenxin Tang Yue Zhang Tiandong Zhang yanan shang Qingguo Chi Qingguo Chen Qingquan Lei Department of High Voltage Key Laboratory of Engineering Dielectrics and Its ApplicationMinistry of EducationHarbin University of Science and TechnologyHarbinChina School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbinChina

Film dielectric capacitors have been widely used in high‐power electronic equipment.The design of microstructure and the choice of fillers play an important role in nano-composites'energy storage density.Machine learning methods can classify and summarise the limited data and then explore the promising composite structure.In this work,a dataset has been established,which contained a large amount of data on the maximum energy storage density of nanocomposites.Though using processed visual image infor-mation to express the internal information of composite,the prediction accuracy of the prediction models built by three machine learning algorithms increase from 84.1%to 91.9%,80.9%to 68.9%,70.6%to 81.6%,respectively.By calculating the branch weight in the random forest prediction model,the influence degree of different descriptors on the energy storage performance of nanocomposites is analysed.A total of 10 groups of composites with different structure and filler amount were prepared in the laboratory,which were used to verify the reliability of prediction models.Finally,the effective filler's structure is explored by three prediction models and some suggestions for the interface design of filler are given.

关键词： composites composite prediction

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Comparative study of raw and HNO_(3)-modified porous carbon from waste printed circuit boards for sulfadiazine adsorption: Experiment and DFT study

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Chinese Chemical Letters 2023年第7期34卷 256-259页

作者： Yujiao Kan Ruxin Zhang Xing Xu Bo Wei yanan shang School of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China Faculty of Light Industry Qilu University of Technology(Shandong Academy of Sciences)Ji'nan 250353China Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityQingdao 266237China Environment Research Institute ShandongUniversityQingdao266237China

A huge amount of waste printed circuit boards(WPCBs) was produced while the electronic manufacturing industry developed rapidly. WPCBs mainly consist of organic compounds, which makes it possible to prepare them into porous carbon as valuable adsorbent. However, WPCBs are also rich in valuable metals.Cu makes up the most of these metals. It is worth studying whether the residual metal will affect the application of carbon materials. In this study, the porous active carbon(AC) was prepared from WPCBs as an adsorbent. Sulfadiazine(SD), a widely detected antibiotic contaminant, was used as a target pollutant.Nitric acid(HNO_(3)) was used to modify AC(AC-HNO_(3)) to remove the residual Cu. The experiment results showed that the adsorption kinetics of SD by AC(k = 0.0025) and AC-HNO_(3)(k = 0.0029) can be described better using a pseudo-second-order kinetic equation. The adsorption isotherms of AC and AC-HNO_(3) on SD could be fitted by the Langmuir model. AC had a larger adsorption capacity than AC-HNO_(3). Density functional theory(DFT) calculation results suggested that the-OH group and Cu on the surface of AC could be the adsorption sites and promote the SD adsorption. This work provides practical methods to recycle WPCBs into wealth and realized waste control by waste.

关键词： WPCBs DFT Sulfadiazine Porous carbon

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22 kW near-diffraction-limited Yb:YAG slab laser amplifier without adaptive optics correction

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Chinese Optics Letters 2024年第3期22卷 65-70页

作者：汪丹何平周唐建李密邬映臣王亚楠尚建力高清松张凯唐淳朱日宏 School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China Institute of Applied Electronics China Academy of Engineering PhysicsMianyang 430079China Graduate School of China Academy of Engineering Physics Beijing 100193China

A high-power CW Yb:YAG slab laser amplifier with no adaptive optics correction has been experimentally established.At room temperature,the amplifier emits a power of 22 kW with an average beam quality(β)of less than 3 in 0.5 min.To our knowledge,this is the brightest slab laser without closed-loop adaptive optics demonstrated to date.In addition,an extracted power of 17 kW with an optical extraction efficiency of 33%,corresponding to a residual optical path difference of less than 0.5μm,is achieved with the single Yb:YAG slab gain module.The slab gain module has the potential to be scalable to higher powers while maintaining good beam quality.This makes a high-power solid-state laser system simpler and more robust.

关键词： laser amplifier Yb:YAG slab laser surface quality pumping uniformity

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2020年京津冀1 km格网沟渠密度数据集

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中国科学数据（中英文网络版） 2024年第1期9卷 296-303页

作者：彭晋福张定祥李亚南尚梦佳中国国土勘测规划院北京100035

沟渠作为农田生态系统中重要的生态廊道,不仅具有汇水、持水和水流通道的作用,而且具备生物多样性保育和多种湿地生态价值,发挥着水质净化和维持生物多样性的作用,沟渠密度是表现一定区域沟渠结构的重要指标,可直接反映沟渠的配置情况... 详细信息

沟渠作为农田生态系统中重要的生态廊道,不仅具有汇水、持水和水流通道的作用,而且具备生物多样性保育和多种湿地生态价值,发挥着水质净化和维持生物多样性的作用,沟渠密度是表现一定区域沟渠结构的重要指标,可直接反映沟渠的配置情况和农田的排灌能力。本数据集以2020年全国国土变更调查数据为数据源,利用软件提取沟渠骨架线,使用公里格网生产工具,通过格网空间计算,得到2020年京津冀1 km格网沟渠密度数据集。本数据集可用于乡村规划编制、农田灌排便利度、耕地质量评价、耕地资产评估等方面研究。

关键词：沟渠国土调查格网栅格京津冀

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基于国家专利的中药治疗癫痫组方规律数据挖掘研究

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中国中医药信息杂志 2024年第7期31卷 44-49页

作者：林蓉高旅肖亚楠黄爽尚菁史正刚甘肃中医药大学甘肃兰州730000 山西中医药大学山西太原030619

目的基于国家专利探析中药治疗癫痫的组方规律,为临床治疗提供参考。方法搜集中国专利公布公告网建库至2023年8月21日符合纳入标准的中药处方治疗癫痫的专利数据,通过Excel2021建立处方药物数据库,采用Python、SPSS Modeler 18.0、Cytos... 详细信息

目的基于国家专利探析中药治疗癫痫的组方规律,为临床治疗提供参考。方法搜集中国专利公布公告网建库至2023年8月21日符合纳入标准的中药处方治疗癫痫的专利数据,通过Excel2021建立处方药物数据库,采用Python、SPSS Modeler 18.0、Cytoscape3.10.1、R语言软件进行频次统计、数据建模、复杂网络分析、关联规则分析、聚类分析,探究组方规律。结果纳入符合标准的中药处方治疗癫痫专利数据376项,涉及中药827味,使用总频次为4911;用药频次前5位为天麻、石菖蒲、僵蚕、全蝎、钩藤;高频药物功效类别以平肝息风药、安神药、化痰止咳平喘药为主,药性以平、温、寒为主,药味以甘、辛、苦为主,归经以肝经、心经、肺经、脾经为主;中药核心复杂网络筛选得到核心组合天麻-石菖蒲-僵蚕。关联规则分析得到常用药物组合28条,其中支持度最高为全蝎-僵蚕。聚类分析得到4条数据。相似性分析得出专利复方治疗癫痫具有独特性。结论中药处方治疗癫痫国家专利的高频药物及常用药物组合以息风止痉、豁痰开窍为主,可为临床提供参考。

关键词：癫痫中药复方专利数据挖掘用药规律

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中医药干预铁死亡治疗炎症性肠病的研究进展

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中国实验方剂学杂志 2024年第11期30卷 245-254页

作者：商铭溶赵亚男张旭阳崔惠方赵义静刘明赵德杰山东中医药大学济南250014 山东中医药大学附属医院济南250014

炎症性肠病(IBD)主要包括溃疡性结肠炎(UC)和克罗恩病(CD),是一种常见的消化道慢性炎症性疾病,发病率逐年攀升,因其治疗周期长,治疗难度大,迁延难愈,费用高昂,备受全球关注。探索安全有效持久的治疗方案已成为全球亟待解决的问题。IBD... 详细信息

炎症性肠病(IBD)主要包括溃疡性结肠炎(UC)和克罗恩病(CD),是一种常见的消化道慢性炎症性疾病,发病率逐年攀升,因其治疗周期长,治疗难度大,迁延难愈,费用高昂,备受全球关注。探索安全有效持久的治疗方案已成为全球亟待解决的问题。IBD病机复杂,包括肠黏膜损伤、内环境紊乱、炎症反应等,近年研究发现铁死亡也是IBD的重要致病因素之一。铁死亡作为一种新的非凋亡性细胞死亡方式,主要特点表现为铁依赖性、脂质过氧化和氧化还原系统失衡,有研究表明,抑制肠上皮细胞铁死亡可以起到肠黏膜保护作用,靶向干预铁死亡或许是治疗IBD的新方向。IBD以药物治疗为主,包括皮质类固醇、氨基水杨酸盐、生物制剂和免疫调节剂等,但是易耐药、不良反应较多,而中医药具有价格低廉、耐药性低、不良反应少等独特的优势,在治疗IBD方面积累了丰富的经验。有学者证实中医药可以抑制铁死亡的发生,最新研究表明中医药一方面可以抑制肠道细胞铁依赖性脂质过氧化,另一方面可以提高肠道黏膜抗氧化、抗炎能力,从而起到治疗IBD的作用,越来越多的研究表明中医药或许通过干预铁死亡治疗IBD。该文通过探讨中医药干预铁死与中医药治疗炎症性肠病的相关性,讨论铁死亡在IBD中的可能作用机制,以期为IBD的诊疗提供依据。

关键词：炎症性肠病溃疡性结肠炎克罗恩病铁死亡中医药研究进展

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