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Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma

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BIOCELL 2024年第3期48卷 463-471页

作者： yanan ma SHANSHAN WANG HUIGUO DING Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China Beijing Institute of Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China

Background:Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality *** cystathionine-gamma-lyase(CSE)plays an important role in the development of multiple tumors,the clinical implication and potential mechanisms of CSE in HCC development remain ***:In our study,the CSE expression in HCC was analyzed in Gene Expression Omnibus(GEO)and The Cancer Genome Atlas(TCGA)datasets and further conﬁrmed by RT-qPCR and immunohistochemistry assays in HCC ***,the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated in HCC ***,the biological functions of CSE in HCC cells was assessed by CCK-8,ﬂow cytometry and Western ***:Lower transcriptional and proteomic CSE expressions were found in HCC tissues in contrast to adjacent normal *** CSE mRNA expression was signiﬁcantly associated with advanced clinicopathological features and poor outcomes in HCC patients from public database and our *** univariate and multivariate analyses of GSE14520 data showed that CSE expression was an independent prognostic indicator for the overall survival(OS)and recurrence-free survival(RFS)of HCC *** vitro experiments further explained that CSE might trigger HCC cell apoptosis by ***:In summary,the present study identiﬁed the relationship between CSE expression and HCC malignancy as well as OS and RFS,indicating that CSE might be a potential prognostic biomarker and a novel therapeutic target for HCC.

关键词： Hepatocellular carcinoma Cystathionine-gamma-lyase Hydrogen sulfide Prognosis Apoptosis

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A Nonlinear Representation of Model Uncertainty in a Convective-Scale Ensemble Prediction System

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Advances in Atmospheric Sciences 2022年第9期39卷 1432-1450页

作者： Zhizhen XU Jing CHEN Mu MU Guokun DAI yanan ma Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Numerical Weather Prediction Center China Meteorological AdministrationBeijing 100081China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China

How to accurately address model uncertainties with consideration of the rapid nonlinear error growth characteristics in a convection-allowing system is a crucial issue for performing convection-scale ensemble *** this study,a new nonlinear model perturbation technique for convective-scale ensemble forecasts is developed to consider a nonlinear representation of model errors in the Global and Regional Assimilation and Prediction Enhanced System(GRAPES)Convection-Allowing Ensemble Prediction System(CAEPS).The nonlinear forcing singular vector(NFSV)approach,that is,conditional nonlinear optimal perturbation-forcing(CNOP-F),is applied in this study,to construct a nonlinear model perturbation method for *** experiments are performed:One of them is the CTL experiment,without adding any model perturbation;the other two are NFSV-perturbed experiments,which are perturbed by NFSV with two different groups of constraint radii to test the sensitivity of the perturbation magnitude *** results show that the NFSV-perturbed experiments achieve an overall improvement and produce more skillful forecasts compared to the CTL experiment,which indicates that the nonlinear NFSV-perturbed method can be used as an effective model perturbation method for convection-scale ensemble ***,the NFSV-L experiment with large perturbation constraints generally performs better than the NFSV-S experiment with small perturbation constraints in the verification for upper-air and surface weather *** for precipitation verification,the NFSV-S experiment performs better in forecasts for light precipitation,and the NFSV-L experiment performs better in forecasts for heavier precipitation,indicating that for different precipitation events,the perturbation magnitude constraint must be carefully *** the findings above lay a foundation for the design of nonlinear model perturbation methods for future CAEPSs.

关键词： Convection-Allowing Ensemble Prediction System model uncertainty nonlinear forcing singular vector

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A New Free-Standing Aqueous Zinc-Ion Capacitor Based on MnO2–CNTs Cathode and MXene Anode

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Nano-Micro Letters 2019年第4期11卷 227-238页

作者： Siliang Wang Qiang Wang Wei Zeng Min Wang Limin Ruan yanan ma Key Laboratory of Intelligent Computing and Signal Processing Ministry of EducationAnhui UniversityNo.3 Feixi RoadHefei 230039Anhui ProvincePeople’s Republic of China National Engineering Research Center for Agro-Ecological Big Data Analysis and Application School of Electronics and Information EngineeringAnhui UniversityNo.111 Jiulong RoadHefei 230601Anhui ProvincePeople’s Republic of China School of Sciences Hubei University of Automotive TechnologyNo.167 Checheng West RoadShiyan 442002Hubei ProvincePeople’s Republic of China

Restricted by their energy storage mechanism,current energy storage devices have certain drawbacks,such as low power density for batteries and low energy density for ***,the nearest ion capacitors,such as lithium-ion and sodium-ion capacitors containing battery-type and capacitor-type electrodes,may allow achieving both high energy and power *** the inspiration,a new zinc-ion capacitor(ZIC)has been designed and realized by assembling the free-standing manganese dioxide-carbon nanotubes(MnO2-CNTs)battery-type cathode and MXene(Ti3C2Tx)capacitortype anode in an aqueous *** ZIC can avoid the insecurity issues that frequently occurred in lithium-ion and sodium-ion capacitors in organic *** expected,the ZIC in an aqueous liquid electrolyte exhibits excellent electrochemical performance(based on the total weight of cathode and anode),such as a high specific capacitance of 115.1 F g?1(1 mV s?1),high energy density of 98.6 Wh kg?1(77.5 W kg?1),high power density of 2480.6 W kg?1(29.7 Wh kg?1),and high capacitance retention of^83.6%of its initial capacitance(15,000 cycles).Even in an aqueous gel electrolyte,the ZIC also exhibits excellent *** work provides an essential strategy for designing next-generation high-performance energy storage devices.

关键词： Energy storage Zinc-ion capacitor Battery-type and capacitor-type electrodes MXene Electrochemical performance

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Construction of a Nano-rectangular Zn(Ⅱ)-Yb(Ⅲ)Complex with Near-Infrared Luminescent Response towards Metallons

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Chinese Journal of Chemistry 2020年第12期38卷 1585-1588页

作者： Xia Liu Xiaoping Yang yanan ma Jieni Liu Dongliang Shi Mengyu Niu College of Chemistry and materials Engineering Wenzhou UniversityWenzhouZhejiang 325035China

of main observation and conclusion One six-metal Zn(Ⅱ)-Yb(Ⅲ)complex[Zn2Yb4L2(OAC).(OH)2(CH3OH)2](1)was constructed from Schiff baseligand bis(3-methoxysalicylidenelethylene-1,2-pherylenediamine(HL4).1 shows a nanoscale rectangular structure with dimensions of approximately 0.8nm×1.1 nm×2.8 *** by lgand-centered absorption bands,1 shows typical near-infrared emission of Yb^3+***,1 exhits lanthanideluminescent response towards metal ions,especially to Cd^2+at ppm level.

关键词： Zn(Ⅱ) rectangular Infrared

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Construction of a nano-rectangular Zn-Nd complex with near-infrared luminescent response towards metal ions

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Chinese Chemical Letters 2021年第1期32卷 569-572页

作者： Xia Liu Xiaoping Yang yanan ma Jieni Liu Dongliang Shi Desmond Schipper College of Chemistry and materials Engineering Zhejiang Key Laboratory of Carbon MaterialsWenzhou UniversityWenzhou 325035China College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China Department of Chemistry and Biochemistry The University of Texas at AustinAustin 78712United States

One 6-metal Zn-Nd complex[Zn_(2)Nd_(4)L_(2)(OAc)_(10)(OH)_(2)(CH_(3)OH)_(2)](1)with Schiff base ligand bis(3-methoxysalicylidene)ethylene-1,2-phenylenediamine(H_(2)L)was constructed,and it has nanoscale rectangular structure(8×11×28 A).Excited by ligand-centered absorption bands,1 shows NIRemission of Nd^(3+)***,1 exhibits lanthanide luminescent response towards metal ions,especially to alkali metal ions(Li^(+),Na^(+) and K^(+))at ppm level.

关键词： Construction Zn-Ln complexes Schiff base ligand NIR luminescence properties Luminescent response

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Bimetallic ZIFs-derived electrospun carbon nanofiber membrane as bifunctional oxygen electrocatalyst for rechargeable zinc-air battery

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Journal of Energy Chemistry 2023年第8期83卷 138-149,I0006页

作者： yanan ma Shaoru Tang Haimeng Wang Yuxuan Liang Dingyu Zhang Xiaoyang Xu Qian Wang Wei Li Department of Chemistry Capital Normal UniversityBeijing 100048China

The recharged zinc-air battery(ZAB) has drawn significant attention owing to increasing requirement for energy conversion and storage *** the efficient bifunctional oxygen catalyst using a convenient strategy is vitally important for the rechargeable *** this study,the bimetallic ZIFs-containing electrospun(ES) carbon nanofibers membrane with hierarchically porous structure was prepared by coaxial electrospinning and carbonization process,which was expected to be a bifunctional electrocatalyst for *** to the formed dual single-atomic sites of Co-N_(4) and Zn-N_(4),the obtained ES-Co/ZnCNZIFexhibited the preferable performance toward oxygen reduction reaction(ORR) with E1/2of 0.857 V and JLof 5.52 ma cm^(-2),which were more than Pt/***,it exhibited a marked oxygen evolution reaction(OER) property with overpotential of 462 mV due to the agglomerated metallic Co ***,the ZAB based on the ES-Co/Zn-CNZIFcarbon nanofibers membranes delivered peak power density of 215 mW cm^(-2),specific capacity of 802.6 ma h g^(-1),and exceptional cycling stability,far larger than Pt/C+RuO_(2)-based ZABs.A solid-state ZAB based on ES-Co/Zn-CNZIFshowed better flexibility and stability with different bending angles.

关键词： Electrospun nanofibers membranes Zeolite imidazole framework Zinc-air battery ORR/OER bifunction Dual single-atomic sites catalysts

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Construction of an Octanuclear Zn(Ⅱ)-Yb(Ⅲ)Schiff Base Complex for the NIR Luminesce nt Sensing of Nitrofuran Antibiotics

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Chinese Journal of Chemistry 2021年第8期39卷 2083-2087页

作者： Mengyu Niu Xiaoping Yang yanan ma Chengri Wang Wenxin Hao Dongliang Shi Desmond Schipper College of Chemistry and materials Engineering Wenzhou UniversityWenzhouZhejiang 325035China Department of Chemistry and Biochemistry The University of Texas at Austin1 University Station A5300AustinTexas78712United States

One near-infrared(NIR)luminescent octanuclear Zn(Ⅱ)-Yb(Ⅲ)complex[Zn_(6)Yb_(2)L_(4)(OAc)_(2)(DMF)EtOH](1)was obtained from a new multidentate Schiff base *** exhibits interesting luminescent sensing activity to antib... 详细信息

关键词： Zn(Ⅱ)-Yb(Ⅲ)complex Schiff base Near-infrared(NIR)luminescence Luminescent sensing Antibiotics

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An Initial Perturbation Method for the Multiscale Singular Vector in Global Ensemble Prediction

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Advances in Atmospheric Sciences 2024年第3期41卷 545-563页

作者： Xin LIU Jing CHEN Yongzhu LIU Zhenhua HUO Zhizhen XU Fajing CHEN Jing WANG yanan ma Yumeng HAN School of Atmospheric Sciences Nanjing University of Information Science&TechnologyNanjing 210044China Chinese Academy of Meteorological Sciences Beijing 100081China Cma Earth System Modeling and Prediction Centre(CEMC) Beijing 100081China Key Laboratory of Earth System Modeling and Prediction of China Meteorological Administration Beijing 100081China Tianjin Meteorological Observatory Tianjin 300074China China Meteorological Administration Xiong’an Atmospheric Boundary Layer Key Laboratory Hebei 071799China

Ensemble prediction is widely used to represent the uncertainty of single deterministic Numerical Weather Prediction(NWP) caused by errors in initial conditions(ICs). The traditional Singular Vector(SV) initial perturbation method tends only to capture synoptic scale initial uncertainty rather than mesoscale uncertainty in global ensemble prediction. To address this issue, a multiscale SV initial perturbation method based on the China Meteorological Administration Global Ensemble Prediction System(Cma-GEPS) is proposed to quantify multiscale initial uncertainty. The multiscale SV initial perturbation approach entails calculating multiscale SVs at different resolutions with multiple linearized physical processes to capture fast-growing perturbations from mesoscale to synoptic scale in target areas and combining these SVs by using a Gaussian sampling method with amplitude coefficients to generate initial perturbations. Following that, the energy norm,energy spectrum, and structure of multiscale SVs and their impact on GEPS are analyzed based on a batch experiment in different seasons. The results show that the multiscale SV initial perturbations can possess more energy and capture more mesoscale uncertainties than the traditional single-SV method. Meanwhile, multiscale SV initial perturbations can reflect the strongest dynamical instability in target areas. Their performances in global ensemble prediction when compared to single-scale SVs are shown to(i) improve the relationship between the ensemble spread and the root-mean-square error and(ii) provide a better probability forecast skill for atmospheric circulation during the late forecast period and for short-to medium-range precipitation. This study provides scientific evidence and application foundations for the design and development of a multiscale SV initial perturbation method for the GEPS.

关键词： multiscale uncertainty singular vector initial perturbation global ensemble prediction system

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Flexible and highly-sensitive pressure sensor based on controllably oxidized MXene

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Infomat 2022年第9期4卷 60-71页

作者： yanan ma Yongfa Cheng Jian Wang Si Fu Mengjun Zhou Yue Yang Baowen Li Xin Zhang Ce-Wen Nan State Key Laboratory of Advanced Technology for materials Synthesis and Processing Center of Smart Materials and Devices&International School of Materials Science and EngineeringWuhan University of TechnologyWuhanChina School of mathematics Physics and Optoelectronic EngineeringHubei University of Automotive TechnologyShiyanChina Center for Nanoscale Characterization&Devices(CNCD) Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and Technology(HUST)WuhanChina Information materials and Intelligent Sensing Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information TechnologyAnhui UniversityHefeiChina State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijingChina

Conductive Ti_(3)C_(2)T_(x)MXenes have been widely investigated for the construction of flexible and highly-sensitive pressure *** the inevitable oxidation of solution-processed MXene has been recognized,the effect of the irreversible oxidation of MXene on its electrical conductivity and sensing properties is yet to be ***,we construct a highly-sensitive and degradable piezoresistive pressure sensor by coating Ti_(3)C_(2)T_(x)MXene flakes with different degrees of in situ oxidation onto paper substrates using the dipping-drying *** situ oxidation can tune the intrinsic resistance and expand the interlayer distance of MXene *** partially oxidized MXene-based piezoresistive pressure sensor exhibits a high sensitivity of 28.43 kPa^(-1),which is greater than those of pristine MXene,over-oxidized MXene,and state-of-the-art paper-based pressure ***,these sensors exhibit a short response time of 98.3 ms,good durability over 5000 measurement cycles,and a low force detection limit of 0.8 ***,MXene-based sensing elements are easily degraded and environmentally *** MXene-based pressure sensor shows promise for practical applications in tracking body movements,sports coaching,remote health monitoring,and human–computer interactions.

关键词： adjustable sensitivity in situ oxidation interlayer distance MXene pressure sensor

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An Air‑Rechargeable Zn Battery Enabled by Organic–Inorganic Hybrid Cathode

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Nano-Micro Letters 2023年第4期15卷 138-152页

作者： Junjie Shi Ke mao Qixiang Zhang Zunyu Liu Fei Long Li Wen Yixin Hou Xinliang Li yanan ma Yang Yue Luying Li Chunyi Zhi Yihua Gao Wuhan National Laboratory for Optoelectronics(WNLO)and School of Physics Center for Nanoscale Characterization&Devices(CNCD)Huazhong University of Science and Technology(HUST)Wuhan 430074People’s Republic of China Guangxi Key Laboratory of Optical and Electronic materials and Devices College of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004People’s Republic of China Hong Kong Center for Cerebro-Cardiovascular Health Engineering Hong Kong SAR 999077People’s Republic of China Hubei Key Laboratory of Critical materials of New Energy Vehicles and School of mathematics Physics and Optoelectronic EngineeringHubei University of Automotive TechnologyShiyan 442002People’s Republic of China Information materials and Intelligent Sensing Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601People’s Republic of China

Self-charging power systems collecting energy harvesting technology and batteries are attracting extensive *** solve the disadvantages of the traditional integrated system,such as highly dependent on energy supply and complex structure,an airrechargeable Zn battery based on MoS_(2)/PANI cathode is *** from the excellent conductivity desolvation shield of PANI,the MoS_(2)/PANI cathode exhibits ultra-high capacity(304.98 mah g^(−1) in N_(2) and 351.25 mah g^(−1) in air).In particular,this battery has the ability to collect,convert and store energy simultaneously by an airrechargeable process of the spontaneous redox reaction between the discharged cathode and O2 from *** air-rechargeable Zn batteries display a high open-circuit voltage(1.15 V),an unforgettable discharge capacity(316.09 mah g^(−1) and the air-rechargeable depth is 89.99%)and good air-recharging stability(291.22 mah g^(−1) after 50 air recharging/galvanostatic current discharge cycle).Most importantly,both our quasi-solid zinc ion batteries and batteries modules have excellent performance and *** work will provide a promising research direction for the material design and device assembly of the next-generation self-powered system.

关键词： Air-rechargeable MoS_(2)/PANI Cathode Desolvation shield Energy storage mechanism Zn batteries module

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