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Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma

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BIOCELL 2024年第3期48卷 463-471页

作者： yanan ma SHANSHAN WANG HUIGUO DING Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China Beijing Institute of Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China

Background:Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality *** cystathionine-gamma-lyase(CSE)plays an important role in the development of multiple tumors,the clinical implication and potential mechanisms of CSE in HCC development remain ***:In our study,the CSE expression in HCC was analyzed in Gene Expression Omnibus(GEO)and The Cancer Genome Atlas(TCGA)datasets and further conﬁrmed by RT-qPCR and immunohistochemistry assays in HCC ***,the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated in HCC ***,the biological functions of CSE in HCC cells was assessed by CCK-8,ﬂow cytometry and Western ***:Lower transcriptional and proteomic CSE expressions were found in HCC tissues in contrast to adjacent normal *** CSE mRNA expression was signiﬁcantly associated with advanced clinicopathological features and poor outcomes in HCC patients from public database and our *** univariate and multivariate analyses of GSE14520 data showed that CSE expression was an independent prognostic indicator for the overall survival(OS)and recurrence-free survival(RFS)of HCC *** vitro experiments further explained that CSE might trigger HCC cell apoptosis by ***:In summary,the present study identiﬁed the relationship between CSE expression and HCC malignancy as well as OS and RFS,indicating that CSE might be a potential prognostic biomarker and a novel therapeutic target for HCC.

关键词： Hepatocellular carcinoma Cystathionine-gamma-lyase Hydrogen sulfide Prognosis Apoptosis

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An Initial Perturbation Method for the Multiscale Singular Vector in Global Ensemble Prediction

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Advances in Atmospheric Sciences 2024年第3期41卷 545-563页

作者： Xin LIU Jing CHEN Yongzhu LIU Zhenhua HUO Zhizhen XU Fajing CHEN Jing WANG yanan ma Yumeng HAN School of Atmospheric Sciences Nanjing University of Information Science&TechnologyNanjing 210044China Chinese Academy of Meteorological Sciences Beijing 100081China Cma Earth System Modeling and Prediction Centre(CEMC) Beijing 100081China Key Laboratory of Earth System Modeling and Prediction of China Meteorological Administration Beijing 100081China Tianjin Meteorological Observatory Tianjin 300074China China Meteorological Administration Xiong’an Atmospheric Boundary Layer Key Laboratory Hebei 071799China

Ensemble prediction is widely used to represent the uncertainty of single deterministic Numerical Weather Prediction(NWP) caused by errors in initial conditions(ICs). The traditional Singular Vector(SV) initial perturbation method tends only to capture synoptic scale initial uncertainty rather than mesoscale uncertainty in global ensemble prediction. To address this issue, a multiscale SV initial perturbation method based on the China Meteorological Administration Global Ensemble Prediction System(Cma-GEPS) is proposed to quantify multiscale initial uncertainty. The multiscale SV initial perturbation approach entails calculating multiscale SVs at different resolutions with multiple linearized physical processes to capture fast-growing perturbations from mesoscale to synoptic scale in target areas and combining these SVs by using a Gaussian sampling method with amplitude coefficients to generate initial perturbations. Following that, the energy norm,energy spectrum, and structure of multiscale SVs and their impact on GEPS are analyzed based on a batch experiment in different seasons. The results show that the multiscale SV initial perturbations can possess more energy and capture more mesoscale uncertainties than the traditional single-SV method. Meanwhile, multiscale SV initial perturbations can reflect the strongest dynamical instability in target areas. Their performances in global ensemble prediction when compared to single-scale SVs are shown to(i) improve the relationship between the ensemble spread and the root-mean-square error and(ii) provide a better probability forecast skill for atmospheric circulation during the late forecast period and for short-to medium-range precipitation. This study provides scientific evidence and application foundations for the design and development of a multiscale SV initial perturbation method for the GEPS.

关键词： multiscale uncertainty singular vector initial perturbation global ensemble prediction system

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Associations between parental adherence to healthy lifestyles and cognitive performance in offspring:A prospective cohort study in China

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Chinese Medical Journal 2024年第6期137卷 683-693页

作者： Rongxia Lv Yuhui Huang Siyi Huang Shiyi Wu Siwen Wang Guangyu Hu yanan ma Peige Song Jorge E.Chavarro S.V.Subramanian Chunling Lu Zhihui Li Changzheng Yuan School of Public Health the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115USA Institute of Medical Information/Center for Health Policy and management Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Biostatistics and Epidemiology School of Public HealthChina Medical UniversityShenyangLiaoning 110122China Department of Social and Behavioral Sciences Harvard T.H.Chan School of Public HealthBostonMA 02115USA Division of Global Health Equity Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Global Health and Social Medicine Harvard Medical SchoolBostonMA 02115USA Vanke School of Public Health Tsinghua UniversityBeijing 100084China Department of Global Health and Population Harvard T.H.Chan School of Public HealthBostonMA 02115USA

Background:Previous studies have reported associations of specific maternal and paternal lifestyle factors with offspring’s cognitive development during early *** study aimed to investigate the prospective associations between overall parental lifestyle and offspring’s cognitive performance during adolescence and young adulthood in ***:We included 2531 adolescents aged 10-15 years at baseline in 2010 from the China Family Panel Studies.A healthy parental lifestyle score(ranged 0-5)was constructed based on the following five modifiable lifestyle factors:Smoking,drinking,exercise,sleep,and *** estimating equation models were used to examine the association between baseline parental healthy lifestyle scores and offspring’s fluid and crystallized intelligence in subsequent years(2012,2014,2016,and 2018).Results:Offspring in the top tertile of parental healthy lifestyle scores performed better in overall fluid intelligence(multivariable-adjusted β=0.53,95%confidence interval[CI]:0.29-0.77)and overall crystallized intelligence(multivariable-adjusted β=0.35,95%CI:0.16-0.54)than those in the bottom tertile of parental healthy lifestyle *** results were similar after further adjustment for the offspring’s healthy lifestyle scores and persisted across the subgroups of parental socioeconomic ***,maternal and paternal healthy lifestyle scores were independently associated with better offspring’s cognitive performance,with significant contribution observed for paternal never-smoking,weekly exercise,and diversified *** both parents and offspring adhered to a healthier lifestyle,we observed the highest level of the offspring’s overall crystallized ***:Our study indicates that parental adherence to a healthier lifestyle is associated with significantly better offspring’s cognitive performance during adolescence and early adulthood,regardless of socioeconomic *** findings highlight the poten

关键词： Cohort study Parental healthy lifestyle Offspring Cognitive performance Intelligence Adolescence

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经阴道彩色多普勒超声成像对卵巢早衰的诊断价值

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实用妇科内分泌电子杂志 2024年第5期11卷 98-100页

作者：马亚楠新疆维吾尔自治区人民医院超声科新疆乌鲁木齐830000

目的探讨经阴道彩色多普勒超声成像对卵巢早衰的诊断效果。方法选取本院收治的68例卵巢早衰患者为研究组,同期进行健康体检的68例体检者为对照组,进行经阴道彩色多普勒超声成像检查,比较两组的超声声像图特征、血流动力学指标及双侧卵... 详细信息

目的探讨经阴道彩色多普勒超声成像对卵巢早衰的诊断效果。方法选取本院收治的68例卵巢早衰患者为研究组,同期进行健康体检的68例体检者为对照组,进行经阴道彩色多普勒超声成像检查,比较两组的超声声像图特征、血流动力学指标及双侧卵巢左右径和前后径。结果研究组内膜厚度、卵泡大小、子宫体积小于对照组,卵泡数量少于对照组,差异有统计学意义(P<0.05);研究组收缩期峰值流速、舒张末期流速、搏动指数、阻力指数小于对照组,差异有统计学意义(P<0.05);研究组左侧、右侧卵巢前后径、左右径小于对照组,差异有统计学意义(P<0.05)。结论经阴道彩色多普勒超声的应用,可以使超声图像特征更加清晰,以更好地观察子宫内部情况,为早期卵巢早衰提供诊断依据,效果显著。

关键词：经阴道彩色多普勒超声卵巢早衰血流动力学指标超声声像图特征

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乙型病毒性肝炎相关性肝细胞癌肝切除术后感染列线图的构建与评估

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中华肝胆外科杂志 2024年第1期30卷 21-26页

作者：谭兵马亚楠于珍任超逸张健东天津市第三中心医院检验科、天津市重症疾病体外生命支持重点实验室、天津市人工细胞工程技术研究中心、天津市肝胆疾病研究所天津300170 天津市第三中心医院肝胆外科天津300170

目的:构建乙型病毒性肝炎相关性肝细胞癌患者肝切除术后感染列线图并对其进行评估。方法:回顾性分析2014年1月至2022年12月在天津市第三中心医院肝胆外科实施肝切除手术的肝细胞癌患者资料。共入组229例患者,其中男性174例,女性55例,年... 详细信息

目的:构建乙型病毒性肝炎相关性肝细胞癌患者肝切除术后感染列线图并对其进行评估。方法:回顾性分析2014年1月至2022年12月在天津市第三中心医院肝胆外科实施肝切除手术的肝细胞癌患者资料。共入组229例患者,其中男性174例,女性55例,年龄(58.2±11.4)岁。LASSO回归筛选乙型病毒性肝炎相关性肝细胞癌肝切除术后感染的相关因素,进一步纳入多因素logistic回归分析。基于多因素logistic回归分析的结果建立预测术后感染的列线图。利用一致性指数(C-index)、校准曲线及受试者工作特征(ROC)曲线评估模型,用决策曲线分析该模型的临床适用性。采用bootstrap自抽样法对模型进行内部验证。结果:使用LASSO回归筛选术后感染发生的相关因素,共筛选出9个变量,分别为性别、吸烟史、体质量指数、甲胎蛋白、手术切除方式(非解剖性/解剖性)、术中出血量、手术方式(腹腔镜/开腹)、血肌酐和术后胆瘘。多因素logistic回归分析,体质量指数、手术切除方式、术中出血量>500 ml和术后胆瘘是术后感染的危险因素(均 P500 ml和术后胆瘘构建的乙型病毒性肝炎相关性肝细胞癌肝切除术后感染列线图具有较高的预测准确度,可用于术后感染的预测。

关键词：乙型肝炎病毒癌,肝细胞列线图术后感染

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中医四诊信息采集应用软件设计与开发

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南开大学学报（自然科学版） 2024年第3期57卷 8-12页

作者：谭佳源赵国庆马亚楠刘国华南开大学电子信息与光学工程学院微电子工程系天津300350 天津市光电传感器与传感网络技术重点实验室天津300350 南开大学薄膜光电子技术教育部工程研究中心天津300350

基于Android移动终端和自行研制的脉搏信息采集器构建的硬件平台,采用Java编程语言和SQLite数据库,设计开发了中医四诊信息采集应用软件,采集四诊信息并添加诊断标签,以特定格式存储,构建临床样本数据库,用于智能中医诊疗算法的训练与验证.

关键词：智能中医中医四诊信息采集 Java SQLite

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A Nonlinear Representation of Model Uncertainty in a Convective-Scale Ensemble Prediction System

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Advances in Atmospheric Sciences 2022年第9期39卷 1432-1450页

作者： Zhizhen XU Jing CHEN Mu MU Guokun DAI yanan ma Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Numerical Weather Prediction Center China Meteorological AdministrationBeijing 100081China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China

How to accurately address model uncertainties with consideration of the rapid nonlinear error growth characteristics in a convection-allowing system is a crucial issue for performing convection-scale ensemble *** this study,a new nonlinear model perturbation technique for convective-scale ensemble forecasts is developed to consider a nonlinear representation of model errors in the Global and Regional Assimilation and Prediction Enhanced System(GRAPES)Convection-Allowing Ensemble Prediction System(CAEPS).The nonlinear forcing singular vector(NFSV)approach,that is,conditional nonlinear optimal perturbation-forcing(CNOP-F),is applied in this study,to construct a nonlinear model perturbation method for *** experiments are performed:One of them is the CTL experiment,without adding any model perturbation;the other two are NFSV-perturbed experiments,which are perturbed by NFSV with two different groups of constraint radii to test the sensitivity of the perturbation magnitude *** results show that the NFSV-perturbed experiments achieve an overall improvement and produce more skillful forecasts compared to the CTL experiment,which indicates that the nonlinear NFSV-perturbed method can be used as an effective model perturbation method for convection-scale ensemble ***,the NFSV-L experiment with large perturbation constraints generally performs better than the NFSV-S experiment with small perturbation constraints in the verification for upper-air and surface weather *** for precipitation verification,the NFSV-S experiment performs better in forecasts for light precipitation,and the NFSV-L experiment performs better in forecasts for heavier precipitation,indicating that for different precipitation events,the perturbation magnitude constraint must be carefully *** the findings above lay a foundation for the design of nonlinear model perturbation methods for future CAEPSs.

关键词： Convection-Allowing Ensemble Prediction System model uncertainty nonlinear forcing singular vector

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村镇银行普惠金融助农案例研究——以中银富登村镇银行为例

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吉林金融研究 2024年第2期 1-6页

作者：韩晨晨马延安苗淼王红雨东北师范大学吉林长春130024

作为普惠金融体系的重要组成部分,村镇银行在完善农村金融服务、激活农村金融供给、优化城乡金融资源配置等方面做出了积极贡献,已成为助力乡村振兴的生力军。但是,村镇银行在实践运行中仍然面临一些问题与挑战,对其普惠助农作用的发挥... 详细信息

作为普惠金融体系的重要组成部分,村镇银行在完善农村金融服务、激活农村金融供给、优化城乡金融资源配置等方面做出了积极贡献,已成为助力乡村振兴的生力军。但是,村镇银行在实践运行中仍然面临一些问题与挑战,对其普惠助农作用的发挥产生了一定的制约。本文首先对村镇银行普惠助农中存在的现实问题进行了分析;其次,对中银富登村镇银行普惠助农成果案例的成功经验进行了归纳总结;继而,结合全面推进乡村振兴的背景,为促进我国村镇银行普惠助农进一步的发展提出了相应的对策建议。

关键词：村镇银行普惠金融中银富登乡村振兴

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输电线路架设用导线提升装置设计分析

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电力设备管理 2024年第12期 274-276页

作者：李青竹樊汝岩马亚南国网山东省电力公司冠县供电公司

随着我国社会经济的不断发展,我国国民的经济水平有了显著的提高。人们逐渐追求更高品质的生活,导致其对用电的需求呈现多元化趋势。电网也因此发挥出了越来越重要的作用,通过输电线路架设用导线提升装置设计,能够将更多的新技术与新工... 详细信息

随着我国社会经济的不断发展,我国国民的经济水平有了显著的提高。人们逐渐追求更高品质的生活,导致其对用电的需求呈现多元化趋势。电网也因此发挥出了越来越重要的作用,通过输电线路架设用导线提升装置设计,能够将更多的新技术与新工艺应用到线路的结构设计当中,从而进一步增强输电线路的稳定性与经济性。本文概括了输电线路架设的步骤和输电线路架设用导线提升装置设计的必要性,并从多方面阐述了相应的有效策略,供同行参考。

关键词：输电线路架设导线装置设计

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新疆喀什某规模化安格斯牛场犊牛产气荚膜梭菌的分离鉴定及耐药性分析

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中国畜牧兽医 2024年第5期51卷 2188-2197页

作者：马紫薇马学军马亚楠孙亚伟吾买尔江·牙合甫邵白新月杨作斌王选艺王梦娇钟旗马雪连姚刚新疆农业大学动物医学学院乌鲁木齐830000 新疆昌吉市二六工镇农业(畜牧)发展服务中心昌吉831100 新疆维吾尔自治区昌吉回族自治州农产品质量安全中心昌吉831100 新疆畜牧科学院兽医研究所乌鲁木齐830000

【目的】产气荚膜梭菌(Clostridium perfringens,CP)是一种革兰阳性厌氧菌,可导致犊牛猝死、出血性坏死性肠炎、肠毒血症等,对犊牛健康造成巨大影响。本研究旨在了解新疆喀什地区某规模化肉牛场安格斯犊牛产气荚膜梭菌流行现状及耐药情... 详细信息

【目的】产气荚膜梭菌(Clostridium perfringens,CP)是一种革兰阳性厌氧菌,可导致犊牛猝死、出血性坏死性肠炎、肠毒血症等,对犊牛健康造成巨大影响。本研究旨在了解新疆喀什地区某规模化肉牛场安格斯犊牛产气荚膜梭菌流行现状及耐药情况,为该地区由产气荚膜梭菌引起的疾病的治疗提供科学依据。【方法】试验采集20份组织样品及6份圈舍粪土样品,采用分离培养、形态学观察、染色镜检、生化试验等方法进行细菌分离鉴定,并采用K-B纸片法进行药敏试验,PCR检测分离菌的毒力型及耐药基因。【结果】分离菌在FTG液体培养基中出现浑浊并产生大量气体,在TSC培养基中长出黑色边缘整齐的圆形菌落,在绵羊血平皿上长出具有典型的双溶血环菌落,革兰染色镜检可见菌体粗短、成单个或双个排列的革兰阳性直杆菌,形态学及镜检结果符合产气荚膜梭菌特点。26份样品中共分离出10株产气荚膜梭菌,检出率为38.46%。经毒素基因分型鉴定,其中,A型产气荚膜梭菌9株,检出率为90.0%,D型产气荚膜梭菌1株,检出率为10.0%。药敏试验结果显示,分离株对卡那霉素耐药率最高,为80.0%;对庆大霉素和林可霉素耐药率为50.0%,而其对美罗培南、头孢吡肟、氟苯尼考及多西环素敏感。耐药基因检测结果表明,bla TEM基因检出率最高,为100.0%;bla SHV、qnrA和aac(6′)-Ⅰb-cr基因检出率分别为20.0%(2/10)、10.0%(1/10)和20.0%(2/10);未检出bla CTX-M和qnrS 2种耐药基因。【结论】新疆喀什地区安格斯犊牛产气荚膜梭菌感染主要以A型为主,耐药情况严重,且存在多重耐药。试验结果可为后期产气荚膜梭菌流行病学研究和防控提供科学依据。

关键词：安格斯犊牛产气荚膜梭菌分离鉴定耐药性

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